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A chemical biology view of bioactive small molecules and a binder-based approach to connect biology to precision medicines

By Stuart L Schreiber

Posted 07 Aug 2018
bioRxiv DOI: 10.1101/386904 (published DOI: 10.1002/ijch.201800113)

Evidence is provided that the discovery of small-molecule binders can yield compounds that alter interactomes, protein modifications, cellular lifetimes, and ultimately the specific functions of proteins relevant to human health. These novel mechanisms of action are needed to accelerate the translation of insights from human biology into medicines.

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