Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 54,982 bioRxiv papers from 253,713 authors.

Fulfilling the promise of Mendelian randomization

By Joseph Pickrell

Posted 16 Apr 2015
bioRxiv DOI: 10.1101/018150

Many important questions in medicine involve questions about causality, For example, do low levels of high-density lipoproteins (HDL) cause heart disease? Does high body mass index (BMI) cause type 2 diabetes? Or are these traits simply correlated in the population for other reasons? A popular approach to answering these problems using human genetics is called "Mendelian randomization". We discuss the prospects and limitations of this approach, and some ways forward.

Download data

  • Downloaded 4,302 times
  • Download rankings, all-time:
    • Site-wide: 447 out of 54,982
    • In genetics: 49 out of 3,181
  • Year to date:
    • Site-wide: 28,970 out of 54,982
  • Since beginning of last month:
    • Site-wide: 31,965 out of 54,982

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News