Does the metabolic syndrome exist? The identification of cardio-metabolic profiles in a South Asian population study
Fruhling V Rijsdijk,
Helena M.S. Zavos,
Matthew H Hotopf
Posted 29 Nov 2019
medRxiv DOI: 10.1101/19012195
Posted 29 Nov 2019
OBJECTIVEResearch testing the validity of the metabolic syndrome (MetS) as a clinical construct associated with cardiovascular disease risk has produced inconsistent results. This study tested the existence of the MetS, explored alternative cardiometabolic risk characterisations, and examined the relative influence of genetic and environmental factors in a South Asian sample. RESEARCH DESIGN AND METHODSData came from the Colombo Twin and Singleton follow-up Study, CoTaSS-2 (N=3969). Latent class analysis tested the clustering of MetS indicators (waist circumference, high-density-lipoprotein cholesterol (HDL-C), triglycerides (TG), blood pressure, fasting plasma glucose (FPG), medications and diabetes). Regression analyses tested cross-sectional associations between identified latent classes and covariates. Structural equation modelling estimated genetic and environmental influences on these classes. Analyses were stratified by gender (n=1681 men, n=2288 women). RESULTSThree classes were identified in men: 1) "Healthy" (52.3%), 2) "Central obesity, high TG, high FPG" (40.2%), and 3) "Central obesity, high TG, diabetes" (7.6%). Four classes were identified in women: 1) "Healthy" (53.2%), 2) "Very high central obesity, low HDL-C, raised FPG" (32.8%), 3) "Very high central obesity, diabetes" (7.2%) and 4) "Central obesity, hypertension, raised FPG" (6.8%). Older age in men and women, and high socioeconomic status in men, was associated with cardiometabolic risk categories, compared to the "Healthy" classes. In men, individual differences in cardiometabolic class membership were due to environmental effects. In females, genetic differences significantly predicted class membership. CONCLUSIONSThe findings did not support the MetS construct. Instead, distinct clinical profiles were identified in men and women, suggesting different aetiological pathways.
- Downloaded 283 times
- Download rankings, all-time:
- Site-wide: 112,382
- In endocrinology: 93
- Year to date:
- Site-wide: 101,091
- Since beginning of last month:
- Site-wide: 97,063
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!