Rxivist logo

Patterns of Autism Symptoms: Hidden Structure in the ADOS and ADI-R instruments

By Jérémy Lefort-Besnard, Kai Vogeley, Leonhard Schilbach, Gaël Varoquaux, Bertrand Thirion, Guillaume Dumas, Danilo Bzdok

Posted 27 Sep 2019
medRxiv DOI: 10.1101/19007419

We simultaneously revisited the ADI-R and ADOS with a comprehensive data-analytics strategy. Here, the combination of pattern analysis algorithms and an extensive data resources (n=266 patients aged 7 to 49 years) allowed identifying coherent clinical constellations in and across ADI-R and ADOS assessments widespread in clinical practice. The collective results of the clustering and sparse regression approaches suggest that identifying autism subtypes and severity for a given individual may be most manifested in the social and communication domains of the ADI-R. Additionally, our quantitative investigation revealed that disease-specific patterns of ADI-R and ADOS scores can be uncovered when studying sex, age or level of FIQ in patients.

Download data

  • Downloaded 649 times
  • Download rankings, all-time:
    • Site-wide: 52,972
    • In psychiatry and clinical psychology: 201
  • Year to date:
    • Site-wide: 80,774
  • Since beginning of last month:
    • Site-wide: 120,235

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide