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BackgroundAnxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with lifetime depression or anxiety, with broad assessment of risks to facilitate future research. MethodsThe Genetic Links to Anxiety and Depression (GLAD) Study (www.gladstudy.org.uk) recruits individuals with depression or anxiety into the NIHR Mental Health BioResource. Participants invited to join the study (via media campaigns) provide demographic, environmental and genetic data, and consent for medical record linkage and recontact. ResultsOnline recruitment was effective; 41,892 consented and 26,877 participants completed the questionnaire by July 2019. Participants questionnaire data identified very high rates recurrent depression, severe anxiety and comorbidity. Participants reported high rates of treatment receipt. The age profile of sample is biased toward young adults, with higher recruitment of females and the better educated, especially at younger ages. DiscussionThis paper describes the study methodology and descriptive data for GLAD, which represents a large, recontactable resource that will enable future research into risks, outcomes and treatment for anxiety and depression. HighlightsO_LIOnline recruitment of 40,000 individuals with lifetime depression or anxiety (77 characters) C_LIO_LIDetailed online phenotyping combined with genetic and clinical data (66 characters) C_LIO_LIThe study sample is severe, highly comorbid, with chronic psychopathology (62 characters) C_LIO_LIThe study protocol enables recall of participants for future research and trials (82 characters) C_LI The views expressed are those of the authors and not necessarily those of the NHS, NIHR, Department of Health or Kings College London

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