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Estimating the respective contributions of human and viral genetic variation to HIV control

By István Bartha, Paul J McLaren, Chanson Brumme, Richard Harrigan, Amalio Telenti, Jacques Fellay

Posted 14 Oct 2015
bioRxiv DOI: 10.1101/029017 (published DOI: 10.1371/journal.pcbi.1005339)

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

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