Reconstructing Genetic History of Siberian and Northeastern European Populations
By
Emily H.M. Wong,
Andrey Khrunin,
Larissa Nichols,
Dmitry Pushkarev,
Denis Khokhrin,
Dmitry Verbenko,
Oleg Evgrafov,
James Knowles,
John Novembre,
Svetlana Limborska,
Anton Valouev
Posted 18 Oct 2015
bioRxiv DOI: 10.1101/029421
(published DOI: 10.1101/gr.202945.115)
Siberia and Western Russia are home to over 40 culturally and linguistically diverse indigenous ethnic groups. Yet, genetic variation of peoples from this region is largely uncharacterized. We present whole-genome sequencing data from 28 individuals belonging to 14 distinct indigenous populations from that region. We combine these datasets with additional 32 modern-day and 15 ancient human genomes to build and compare autosomal, Y-DNA and mtDNA trees. Our results provide new links between modern and ancient inhabitants of Eurasia. Siberians share 38% of ancestry with descendants of the 45,000-year-old Ust-Ishim people, who were previously believed to have no modern-day descendants. Western Siberians trace 57% of their ancestry to the Ancient North Eurasians, represented by the 24,000-year-old Siberian Malta boy. In addition, Siberians admixtures are present in lineages represented by Eastern European hunter-gatherers from Samara, Karelia, Hungary and Sweden (from 8,000-6,600 years ago), as well as Yamnaya culture people (5,300-4,700 years ago) and modern-day northeastern Europeans. These results provide new evidence of ancient gene flow from Siberia into Europe.
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