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Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

By Aysu Okbay, Bart M.L. Baselmans, Patrick Turley, Mark A. Fontana, Cornelius A. Rietveld, Jaime Derringer, Jimmy Z. Liu, Ronald de Vlaming, Tarunveer S. Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C. Frazier-Wood, Nicholas A. Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W. van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J. van der Lee, Penelope A. Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B. Miller, Camelia C. Minica, Ilja M. Nolte, Dennis Mook-Kanamori, Peter J van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Dalton Conley, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M Willems, Wei Zhao, Behrooz Z. Alizadeh, Philipp D. Koellinger, Andrew Bakshi, Patricia A. Boyle, Simon Cox, Gail Davies, Oliver S.P. Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T. Emeny, Ghazaleh Fatemifar, Jessica D. Faul, Luigi Ferrucci, Andreas J Forstner, Christian Gieger, Tamara B. Harris, Juliette M. Harris, Elizabeth G. Holliday, Jouke-Jan Hottenga, Philip L. De Jager, Marika A. Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J. Launer, LifeLines Cohort Study, Ruifang Li-Gao, Marisa Loitfelder, Anu Loukola, Pedro Marques-Vidal, Grant W. Montgomery, Lavinia Paternoster, Alison Pattie, Katja E. Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J. Scott, Jennifer A. Smith, Angelina R. Sutin, Maciej Trzaskowski, Anna E. Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Dorret Boomsma, Ute Bultmann, Shun-Chiao Chang, Francesco Cucca, Ian J. Deary, Cornelia M. van Duijn, Johan G. Eriksson, Lude Franke, Eco JC de Geus, Patrick JF Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A. Hartman, Claire M.A. Haworth, Caroline Hayward, Andrew C. Heath, David Hinds, Elina Hyppönen, William G Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko A. Kaprio, Sharon LR Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura Kubzansky, Terho Lehtimäki, Patrik Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J. Oldehinkel, Gerard Pasterkamp, Nancy L. Pedersen, R. Plomin, Ozren Polasek, Christine Power, Stephen S. Rich, Frits R Rosendaal, Hester M. den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Harold Snieder, Thorkild IA Sørensen, Tim D Spector, Andrew Steptoe, Antonio Terracciano, A Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, André G. Uitterlinden, Peter Vollenweider, Gert Wagner, David R. Weir, Sara Lindström, George Davey Smith, Albert Hofman, David I. Laibson, Sarah E. Medland, Tõnu Esko, Daniel J Benjamin, David Cesarini

Posted 24 Nov 2015
bioRxiv DOI: 10.1101/032789

We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms ("DS"; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB (ρ≈-0.8). We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.

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