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Commentary on "Limitations of GCTA as a solution to the missing heritability problem"

By Jian Yang, Sang Hong Lee, Naomi R. Wray, Michael E Goddard, Peter M Visscher

Posted 20 Jan 2016
bioRxiv DOI: 10.1101/036574 (published DOI: 10.1073/pnas.1602743113)

In a recent publication entitled "Limitations of GCTA as a solution to the missing heritability problem" Krishna Kumar et al. (2015 PNAS) claim that "GCTA applied to current SNP data cannot produce reliable or stable estimates of heritability". Here we show that those claims are false and that results presented by Krishna Kumar et al. are in fact entirely consistent with and can be predicted from the theory underlying GCTA.

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