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Characterization of LC-MS based urine metabolomics in healthy subjects across the life span

By Wei Sun, Xiaoyan Liu, Qinghong Shi, Haidan Sun, Jing Li, Xiaoyue Tang, Zhengguang Guo, Ying Liu, Jie Ma, Na Ren, Fang Jin, Chengyan He, Wenqi Song

Posted 13 Nov 2020
bioRxiv DOI: 10.1101/2020.11.12.379131

Previous studies reported that gender and age could influence urine metabolomics, which should be considered in biomarker discovery. As a consequence, for the baseline of urine metabolomics characteristics, it becomes critical to avoid confounding effects in clinical cohort studies. In this study, we provided a comprehensive lifespan characterization of urine metabolomics in a cohort of 348 healthy children and 315 adults aged 1 to 70 years using liquid chromatography coupled with high resolution mass spectrometry. Our results suggested that gender-dependent urine metabolites are much greater in adults than in children. The pantothenate and CoA biosynthesis and alanine metabolism pathways were enriched in early life. Androgen and estrogen metabolism showed high activity during adolescence and youth stages. Pyrimidine metabolism was enriched in the old stage. Based on the above analysis, metabolomic characteristics of each age stage were provided. This work could help us understand the baseline of urine metabolism characteristics and contribute to further studies of clinical disease biomarker discovery. ### Competing Interest Statement The authors have declared no competing interest.

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