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Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans

By Chayki Charar, Sally Metsuyanim-Cohen, Yosef Gruenbaum, Daniel Z Bar

Posted 27 Oct 2020
bioRxiv DOI: 10.1101/2020.10.27.357913

Animals subjected to dietary restriction (DR) have reduced body size, low fecundity, slower development, lower fat content and longer life span. We identified lamin as a regulator of multiple dietary restriction phenotypes. Downregulation of lmn-1, the single Caenorhabditis elegans lamin gene, increased animal size and fat content, specifically in DR animals. The LMN-1 protein acts in the mTOR pathway, upstream to RAPTOR and S6K, key component and target of mTOR complex 1 (mTORC1), respectively. DR excludes the mTORC1 activator RAGC-1 from the nucleus. Downregulation of lmn-1 restores RAGC-1 to the nucleus, a necessary step for the activation of the mTOR pathway. These findings further link lamin to metabolic regulation.

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