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biMM: Efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements

By Matti Pirinen, Christian Benner, Pekka Marttinen, Marjo-Riitta Järvelin, Manuel A. Rivas, Samuli Ripatti

Posted 15 Nov 2016
bioRxiv DOI: 10.1101/087932 (published DOI: 10.1093/bioinformatics/btx166)

Genetic research utilizes a decomposition of trait variances and covariances into genetic and environmental parts. Our software package biMM is a computationally efficient implementation of a bivariate linear mixed model for settings where hundreds of traits have been measured on partially overlapping sets of individuals. Implementation in R freely available at www.iki.fi/mpirinen.

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