Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 73,470 bioRxiv papers from 319,827 authors.

Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture: a study in Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)

By Eleanor M. Wigmore, Toni-Kim Clarke, Mark J. Adams, Ana M Fernandez-Pujals, Jude Gibson, David M Howard, Gail Davies, Lynsey S. Hall, Yanni Zeng, Pippa A. Thomson, Caroline Hayward, Blair H Smith, Lynne J. Hocking, Sandosh Padmanabhan, Ian J Deary, David J. Porteous, Kristin K. Nicodemus, Andrew M. McIntosh

Posted 16 Jun 2016
bioRxiv DOI: 10.1101/059352 (published DOI: 10.1038/tp.2017.148)

Major depressive disorder (MDD) is a heritable and highly debilitating condition. It is commonly associated with subcortical volumetric abnormalities, the most replicated of these being reduced hippocampal volume. Using the most recent published data from ENIGMA consortiums genome-wide association study (GWAS) of regional brain volume, we sought to test whether there is shared genetic architecture between 8 subcortical brain volumes and MDD. Using LD score regression utilising summary statistics from ENIGMA and the Psychiatric Genomics Consortium, we demonstrated that hippocampal volume was positively genetically correlated with MDD (rG=0.46, P=0.02), although this did not survive multiple comparison testing. None of other six brain regions studied were genetically correlated and amygdala volume heritability was too low for analysis. We also generated polygenic risk scores (PRS) to assess potential pleiotropy between regional brain volumes and MDD in three cohorts (Generation Scotland; Scottish Family Health Study (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766). We used logistic regression to examine volumetric PRS and MDD and performed a meta-analysis across the three cohorts. No regional volumetric PRS demonstrated significant association with MDD or recurrent MDD. In this study we provide some evidence that hippocampal volume and MDD may share genetic architecture, albeit this did not survive multiple testing correction and was in the opposite direction to most reported phenotypic correlations. We therefore found no evidence to support a shared genetic architecture for MDD and regional subcortical volumes.

Download data

  • Downloaded 648 times
  • Download rankings, all-time:
    • Site-wide: 16,844 out of 73,470
    • In genetics: 1,140 out of 4,032
  • Year to date:
    • Site-wide: 54,756 out of 73,470
  • Since beginning of last month:
    • Site-wide: 54,756 out of 73,470

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News