Genetic contributions to trail making test performance in UK Biobank
Saskia P Hagenaars,
Simon R Cox,
W. David Hill,
David CM Liewald,
CHARGE consortium Cognitive Working Group,
Sarah E Harris,
Andrew M McIntosh,
Ian J Deary
Posted 25 Jan 2017
bioRxiv DOI: 10.1101/103119 (published DOI: 10.1038/mp.2017.189)
Posted 25 Jan 2017
The Trail Making Test is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the trail making test and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The SNP-based heritability estimates for trail-making measures were 7.9 % (part A), 22.4 % (part B), and 17.6 % (part B - part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg > 0.6), general cognitive function (rg > 0.6), processing speed (rg > 0.7), and memory (rg > 0.3). Polygenic profile analysis indicated considerable shared genetic aetiology between trail making, general cognitive function, processing speed, and memory (standardized β; between 0.03 and 0.08). These results suggest that trail making is both phenotypically and genetically strongly associated with general cognitive function and processing speed.
- Downloaded 504 times
- Download rankings, all-time:
- Site-wide: 66,522
- In genetics: 2,870
- Year to date:
- Site-wide: 130,068
- Since beginning of last month:
- Site-wide: 151,585
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!