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HUGIn: Hi-C Unifying Genomic Interrogator

By Joshua S. Martin, Zheng Xu, Alex P Reiner, Karen L. Mohlke, Patrick Sullivan, Bing Ren, Ming Hu, Yun Li

Posted 16 Mar 2017
bioRxiv DOI: 10.1101/117531 (published DOI: 10.1093/bioinformatics/btx359)

Motivation: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability. Results: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell liens. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTLs results and functional genomics data.

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