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MiREDiBase: a manually curated database of validated and putative editing events in microRNAs

By Gioacchino P. Marceca, Rosario Distefano, Luisa Tomasello, Alessandro Laganá, Federica Calore, Francesco Russo, Marina Bagnoli, Pierluigi Gasparini, Alfredo Ferro, Mario Acunzo, Qin Ma, Carlo M. Croce, Giovanni Nigita

Posted 06 Sep 2020
bioRxiv DOI: 10.1101/2020.09.04.283689

MicroRNAs (miRNAs) are regulatory small non-coding RNAs that function as translational repressors. MiRNAs are involved in most cellular processes, and their expression and function are presided by several factors. Amongst, miRNA editing is an epitranscriptional modification that alters the original nucleotide sequence of selected miRNAs, possibly influencing their biogenesis and target-binding ability. A-to-I and C-to-U RNA editing are recognized as the canonical types, with the A-to-I type being the predominant one. Albeit some bioinformatics resources have been implemented to collect RNA editing data, it still lacks a comprehensive resource explicitly dedicated to miRNA editing. Here, we present MiREDiBase, a manually curated catalog of editing events in miRNAs. The current version includes 3,059 unique validated and putative editing sites from 626 pre-miRNAs in humans and three primates. Editing events in mature human miRNAs are supplied with miRNA-target predictions and enrichment analysis, while minimum free energy structures are inferred for edited pre-miRNAs. MiREDiBase represents a valuable tool for cell biology and biomedical research and will be continuously updated and expanded at https://ncrnaome.osumc.edu/miredibase.

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