Author: Peter J. Campbell

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Preprints

Pan-cancer analysis of whole genomes

• Downloaded 8,049 times
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  • Site-wide: 1,371
  • In cancer biology: 12
• Year to date:
  • Site-wide: 37,382
• Since beginning of last month:
  • Site-wide: 49,242

The whole-genome panorama of cancer drivers

• Downloaded 6,910 times
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  • Site-wide: 1,641
  • In cancer biology: 15
• Year to date:
  • Site-wide: 13,937
• Since beginning of last month:
  • Site-wide: 16,598

Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

• Downloaded 5,672 times
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  • Site-wide: 2,159
  • In genomics: 185
• Year to date:
  • Site-wide: 22,381
• Since beginning of last month:
  • Site-wide: 43,616

Patterns of structural variation in human cancer

• Downloaded 5,490 times
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  • Site-wide: 2,249
  • In cancer biology: 26
• Year to date:
  • Site-wide: 45,906
• Since beginning of last month:
  • Site-wide: 56,950

The landscape of somatic mutation in normal colorectal epithelial cells

• Downloaded 4,118 times
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  • Site-wide: 3,350
  • In cancer biology: 44
• Year to date:
  • Site-wide: 10,827
• Since beginning of last month:
  • Site-wide: 13,852

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

• Downloaded 3,705 times
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  • Site-wide: 3,875
  • In genomics: 387
• Year to date:
  • Site-wide: 45,079
• Since beginning of last month:
  • Site-wide: 91,441

Mutational signatures associated with tobacco smoking in human cancer

• Downloaded 3,608 times
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  • Site-wide: 4,025
  • In cancer biology: 51
• Year to date:
  • Site-wide: 55,021
• Since beginning of last month:
  • Site-wide: 65,655

The mutational landscape of normal human endometrial epithelium

• Downloaded 3,593 times
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  • Site-wide: 4,046
  • In cancer biology: 53
• Year to date:
  • Site-wide: 11,038
• Since beginning of last month:
  • Site-wide: 7,773

Universal Patterns Of Selection In Cancer And Somatic Tissues

• Downloaded 3,372 times
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  • Site-wide: 4,428
  • In genomics: 444
• Year to date:
  • Site-wide: 137,712
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  • Site-wide: 136,288

Spatial genomics maps the structure, character and evolution of cancer clones

• Downloaded 3,322 times
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  • Site-wide: 4,512
  • In cancer biology: 61
• Year to date:
  • Site-wide: 867
• Since beginning of last month:
  • Site-wide: 1,388

Somatic mutation rates scale with lifespan across mammals

• Downloaded 3,272 times
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  • Site-wide: 4,615
  • In genomics: 464
• Year to date:
  • Site-wide: 890
• Since beginning of last month:
  • Site-wide: 338

Phylogenetic reconstruction of myeloproliferative neoplasm reveals very early origins and lifelong evolution

• Downloaded 3,096 times
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  • Site-wide: 4,984
  • In cancer biology: 71
• Year to date:
  • Site-wide: 2,470
• Since beginning of last month:
  • Site-wide: 10,996

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers

• Downloaded 2,671 times
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  • Site-wide: 6,163
  • In genomics: 636
• Year to date:
  • Site-wide: 80,317
• Since beginning of last month:
  • Site-wide: 129,566

Selective and mechanistic sources of recurrent rearrangements across the cancer genome

• Downloaded 2,461 times
• Download rankings, all-time:
  • Site-wide: 6,980
  • In cancer biology: 107
• Year to date:
  • Site-wide: 56,644
• Since beginning of last month:
  • Site-wide: 98,694

Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments

• Downloaded 2,458 times
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  • Site-wide: 6,988
  • In genomics: 730
• Year to date:
  • Site-wide: 44,261
• Since beginning of last month:
  • Site-wide: 41,376

Somatic evolution in non-neoplastic IBD-affected colon

• Downloaded 2,328 times
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  • Site-wide: 7,556
  • In genetics: 324
• Year to date:
  • Site-wide: 28,601
• Since beginning of last month:
  • Site-wide: 50,705

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

• Downloaded 2,217 times
• Download rankings, all-time:
  • Site-wide: 8,112
  • In genomics: 828
• Year to date:
  • Site-wide: 100,697
• Since beginning of last month:
  • Site-wide: 90,949

Mutational signatures are jointly shaped by DNA damage and repair

• Downloaded 2,046 times
• Download rankings, all-time:
  • Site-wide: 9,113
  • In genomics: 915
• Year to date:
  • Site-wide: 69,284
• Since beginning of last month:
  • Site-wide: 84,780

Personally tailored cancer management based on knowledge banks of genomic and clinical data

• Downloaded 1,967 times
• Download rankings, all-time:
  • Site-wide: 9,630
  • In cancer biology: 172
• Year to date:
  • Site-wide: 106,055
• Since beginning of last month:
  • Site-wide: 79,274

Elevated somatic mutation burdens in normal human cells due to defective DNA polymerases

• Downloaded 1,355 times
• Download rankings, all-time:
  • Site-wide: 16,877
  • In genomics: 1,639
• Year to date:
  • Site-wide: 9,448
• Since beginning of last month:
  • Site-wide: 15,306

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

• Downloaded 1,314 times
• Download rankings, all-time:
  • Site-wide: 17,673
  • In cancer biology: 382
• Year to date:
  • Site-wide: 81,189
• Since beginning of last month:
  • Site-wide: 141,117

Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations

• Downloaded 1,291 times
• Download rankings, all-time:
  • Site-wide: 18,105
  • In genomics: 1,736
• Year to date:
  • Site-wide: 11,786
• Since beginning of last month:
  • Site-wide: 53,952

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

• Downloaded 1,265 times
• Download rankings, all-time:
  • Site-wide: 18,684
  • In cancer biology: 421
• Year to date:
  • Site-wide: 28,795
• Since beginning of last month:
  • Site-wide: 37,298

Principles governing A-to-I RNA editing in the breast cancer transcriptome

• Downloaded 1,123 times
• Download rankings, all-time:
  • Site-wide: 22,289
  • In genomics: 2,092
• Year to date:
  • Site-wide: 119,845
• Since beginning of last month:
  • Site-wide: 127,875

APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

• Downloaded 1,118 times
• Download rankings, all-time:
  • Site-wide: 22,436
  • In molecular biology: 595
• Year to date:
  • Site-wide: 56,143
• Since beginning of last month:
  • Site-wide: 36,997

Multi-site clonality analyses uncovers pervasive subclonal heterogeneity and branching evolution across melanoma metastases

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 37,571
  • In genomics: 3,094
• Year to date:
  • Site-wide: 80,333
• Since beginning of last month:
  • Site-wide: 64,051

Revealing the impact of recurrent and rare structural variants in multiple myeloma

• Downloaded 739 times
• Download rankings, all-time:
  • Site-wide: 40,699
  • In genomics: 3,284
• Year to date:
  • Site-wide: 42,465
• Since beginning of last month:
  • Site-wide: 63,859

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

• Downloaded 630 times
• Download rankings, all-time:
  • Site-wide: 50,367
  • In cancer biology: 1,432
• Year to date:
  • Site-wide: 8,698
• Since beginning of last month:
  • Site-wide: 4,041

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 88,821
  • In cancer biology: 2,635
• Year to date:
  • Site-wide: 18,691
• Since beginning of last month:
  • Site-wide: 23,645

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 101,030
  • In cancer biology: 3,037
• Year to date:
  • Site-wide: 81,517
• Since beginning of last month:
  • Site-wide: 74,276

Drivers underpinning the malignant transformation of giant cell tumour of bone

• Downloaded 207 times
• Download rankings, all-time:
  • Site-wide: 130,721
  • In genetic and genomic medicine: 730
• Year to date:
  • Site-wide: 115,537
• Since beginning of last month:
  • Site-wide: 123,136