Author: John E. Bowen

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Preprints

Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020

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  • Site-wide: 100
  • In epidemiology: 23
• Year to date:
  • Site-wide: 1,189
• Since beginning of last month:
  • Site-wide: 2,295

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

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  • Site-wide: 123
  • In immunology: 3
• Year to date:
  • Site-wide: 755
• Since beginning of last month:
  • Site-wide: 550

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

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  • Site-wide: 890
  • In immunology: 42
• Year to date:
  • Site-wide: 17,785
• Since beginning of last month:
  • Site-wide: 10,003

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

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  • Site-wide: 1,042
  • In microbiology: 106
• Year to date:
  • Site-wide: 22,028
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  • Site-wide: 22,506

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

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  • Site-wide: 1,161
  • In biochemistry: 11
• Year to date:
  • Site-wide: 48,212
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  • Site-wide: 17,705

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

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  • Site-wide: 1,978
  • In immunology: 76
• Year to date:
  • Site-wide: 33,666
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  • Site-wide: 25,630

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

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  • Site-wide: 2,407
  • In immunology: 101
• Year to date:
  • Site-wide: 2,394
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  • Site-wide: 1,999

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

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  • Site-wide: 4,971
  • In immunology: 204
• Year to date:
  • Site-wide: 17,539
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  • Site-wide: 17,058

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants

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  • Site-wide: 5,709
  • In immunology: 231
• Year to date:
  • Site-wide: 32,589
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  • Site-wide: 36,143

SARS-CoV-2 spike conformation determines plasma neutralizing activity

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  • Site-wide: 5,838
  • In immunology: 239
• Year to date:
  • Site-wide: 24,114
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  • Site-wide: 68,917

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

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  • Site-wide: 7,376
  • In microbiology: 464
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 57,557

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

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  • Site-wide: 10,579
  • In immunology: 404
• Year to date:
  • Site-wide: 80,614
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  • Site-wide: 103,429

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

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  • Site-wide: 10,797
  • In synthetic biology: 119
• Year to date:
  • Site-wide: 12,498
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  • Site-wide: 26,138

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

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  • Site-wide: 14,036
  • In immunology: 538
• Year to date:
  • Site-wide: 33,659
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  • Site-wide: 32,697

Membrane lectins enhance SARS-CoV-2 infection and influence the neutralizing activity of different classes of antibodies

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  • Site-wide: 14,326
  • In microbiology: 834
• Year to date:
  • Site-wide: 68,153
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  • Site-wide: 67,019

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

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  • Site-wide: 21,439
  • In immunology: 798
• Year to date:
  • Site-wide: 64,571
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  • Site-wide: 47,721

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

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  • Site-wide: 22,099
  • In immunology: 822
• Year to date:
  • Site-wide: 84,670
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  • Site-wide: 102,321

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

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  • Site-wide: 22,967
  • In microbiology: 1,331
• Year to date:
  • Site-wide: 119,262
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  • Site-wide: 35,081

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

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  • Site-wide: 30,673
  • In immunology: 1,100
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 83,485

Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

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  • Site-wide: 61,749
  • In biochemistry: 1,634
• Year to date:
  • Site-wide: 88,262
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  • Site-wide: 56,624

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

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  • Site-wide: 105,097
  • In immunology: 3,560
• Year to date:
  • Site-wide: 56,812
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  • Site-wide: 10,627