Author: Liam Smeeth

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Preprints

OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients.

• Downloaded 163,428 times
• Download rankings, all-time:
  • Site-wide: 33
  • In epidemiology: 7
• Year to date:
  • Site-wide: 637
• Since beginning of last month:
  • Site-wide: 546

Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England

• Downloaded 13,240 times
• Download rankings, all-time:
  • Site-wide: 891
  • In epidemiology: 130
• Year to date:
  • Site-wide: 17,591
• Since beginning of last month:
  • Site-wide: 24,284

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England

• Downloaded 10,942 times
• Download rankings, all-time:
  • Site-wide: 1,149
  • In infectious diseases: 371
• Year to date:
  • Site-wide: 7,316
• Since beginning of last month:
  • Site-wide: 4,529

UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records

• Downloaded 7,681 times
• Download rankings, all-time:
  • Site-wide: 1,770
  • In epidemiology: 220
• Year to date:
  • Site-wide: 20,919
• Since beginning of last month:
  • Site-wide: 39,906

Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients primary care records in situ using OpenSAFELY.

• Downloaded 6,284 times
• Download rankings, all-time:
  • Site-wide: 2,328
  • In public and global health: 90
• Year to date:
  • Site-wide: 4,064
• Since beginning of last month:
  • Site-wide: 2,970

Inhaled corticosteroid use and risk COVID-19 related death among 966,461 patients with COPD or asthma: an OpenSAFELY analysis

• Downloaded 2,852 times
• Download rankings, all-time:
  • Site-wide: 7,013
  • In respiratory medicine: 28
• Year to date:
  • Site-wide: 51,913
• Since beginning of last month:
  • Site-wide: 62,824

Ethnic differences in COVID-19 infection, hospitalisation, and mortality: an OpenSAFELY analysis of 17 million adults in England

• Downloaded 2,481 times
• Download rankings, all-time:
  • Site-wide: 8,591
  • In epidemiology: 707
• Year to date:
  • Site-wide: 23,906
• Since beginning of last month:
  • Site-wide: 30,056

Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England: a cohort study using OpenSAFELY

• Downloaded 1,805 times
• Download rankings, all-time:
  • Site-wide: 13,763
  • In epidemiology: 1,021
• Year to date:
  • Site-wide: 17,975
• Since beginning of last month:
  • Site-wide: 41,936

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform

• Downloaded 1,488 times
• Download rankings, all-time:
  • Site-wide: 18,457
  • In epidemiology: 1,344
• Year to date:
  • Site-wide: 10,368
• Since beginning of last month:
  • Site-wide: 9,986

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,479 times
• Download rankings, all-time:
  • Site-wide: 18,619
  • In infectious diseases: 2,149
• Year to date:
  • Site-wide: 22,879
• Since beginning of last month:
  • Site-wide: 42,079

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: A cohort study from OpenSAFELY

• Downloaded 1,356 times
• Download rankings, all-time:
  • Site-wide: 21,345
  • In epidemiology: 1,607
• Year to date:
  • Site-wide: 4,197
• Since beginning of last month:
  • Site-wide: 16,019

What can trends in hospital deaths from COVID-19 tell us about the progress and peak of the pandemic? An analysis of death counts from England announced up to 20 April 2020

• Downloaded 1,334 times
• Download rankings, all-time:
  • Site-wide: 21,881
  • In epidemiology: 1,356
• Year to date:
  • Site-wide: 61,955
• Since beginning of last month:
  • Site-wide: 63,032

OpenSAFELY NHS Service Restoration Observatory 1: describing trends and variation in primary care clinical activity for 23.3 million patients in England during the first wave of COVID-19

• Downloaded 1,246 times
• Download rankings, all-time:
  • Site-wide: 24,356
  • In health systems and quality improvement: 41
• Year to date:
  • Site-wide: 53,410
• Since beginning of last month:
  • Site-wide: 69,884

HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,225 times
• Download rankings, all-time:
  • Site-wide: 25,021
  • In infectious diseases: 2,441
• Year to date:
  • Site-wide: 65,439
• Since beginning of last month:
  • Site-wide: 46,264

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY

• Downloaded 1,175 times
• Download rankings, all-time:
  • Site-wide: 26,639
  • In epidemiology: 1,592
• Year to date:
  • Site-wide: 34,982
• Since beginning of last month:
  • Site-wide: 27,425

OpenSAFELY: Do adults prescribed Non-steroidal anti-inflammatory drugs have an increased risk of death from COVID-19?

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 30,049
  • In infectious diseases: 2,680
• Year to date:
  • Site-wide: 73,415
• Since beginning of last month:
  • Site-wide: 111,109

Early impact of the COVID-19 pandemic and social distancing measures on routine childhood vaccinations in England, January to April 2020

• Downloaded 1,034 times
• Download rankings, all-time:
  • Site-wide: 32,322
  • In public and global health: 601
• Year to date:
  • Site-wide: 123,955
• Since beginning of last month:
  • Site-wide: 168,206

Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study

• Downloaded 940 times
• Download rankings, all-time:
  • Site-wide: 37,306
  • In infectious diseases: 2,978
• Year to date:
  • Site-wide: 115,550
• Since beginning of last month:
  • Site-wide: 109,961

COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK

• Downloaded 877 times
• Download rankings, all-time:
  • Site-wide: 41,224
  • In primary care research: 28
• Year to date:
  • Site-wide: 75,411
• Since beginning of last month:
  • Site-wide: 64,353

Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 50,378
  • In epidemiology: 2,727
• Year to date:
  • Site-wide: 34,973
• Since beginning of last month:
  • Site-wide: 8,663

OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England

• Downloaded 740 times
• Download rankings, all-time:
  • Site-wide: 52,895
  • In cardiovascular medicine: 95
• Year to date:
  • Site-wide: 65,862
• Since beginning of last month:
  • Site-wide: 74,430

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies: a nationwide cohort study in the OpenSAFELY platform

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 54,101
  • In infectious diseases: 4,495
• Year to date:
  • Site-wide: 8,741
• Since beginning of last month:
  • Site-wide: 3,756

Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England: an analysis of OpenSAFELY data from 1st September to 9th November 2020

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 58,864
  • In infectious diseases: 4,131
• Year to date:
  • Site-wide: 25,022
• Since beginning of last month:
  • Site-wide: 6,946

Is glycaemia associated with poorer brain health and risk of dementia? Cross sectional and follow-up analysis of the UK Biobank

• Downloaded 610 times
• Download rankings, all-time:
  • Site-wide: 68,643
  • In epidemiology: 3,048
• Year to date:
  • Site-wide: 106,530
• Since beginning of last month:
  • Site-wide: 70,942

OpenSAFELY: Risks of COVID-19 hospital admission and death for people with learning disabilities - a cohort study.

• Downloaded 590 times
• Download rankings, all-time:
  • Site-wide: 71,756
  • In infectious diseases: 4,311
• Year to date:
  • Site-wide: 50,796
• Since beginning of last month:
  • Site-wide: 31,301

Association between oral anticoagulants and COVID-19 related outcomes: two cohort studies

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 85,481
  • In epidemiology: 3,699
• Year to date:
  • Site-wide: 59,274
• Since beginning of last month:
  • Site-wide: 64,066

The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomization study in the UK Biobank

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 93,962
  • In genetic and genomic medicine: 510
• Year to date:
  • Site-wide: 84,870
• Since beginning of last month:
  • Site-wide: 95,693

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 95,139
  • In genetics: 3,545
• Year to date:
  • Site-wide: 182,894
• Since beginning of last month:
  • Site-wide: 189,302

Type 2 diabetes risks and determinants in 2nd generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK

• Downloaded 463 times
• Download rankings, all-time:
  • Site-wide: 95,302
  • In endocrinology: 85
• Year to date:
  • Site-wide: 96,175
• Since beginning of last month:
  • Site-wide: 70,890

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 98,259
  • In epidemiology: 4,551
• Year to date:
  • Site-wide: 44,183
• Since beginning of last month:
  • Site-wide: 18,695

Potentially inappropriate prescribing of DOACs to patients with mechanical heart valves: a federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 108,539
  • In primary care research: 95
• Year to date:
  • Site-wide: 50,643
• Since beginning of last month:
  • Site-wide: 64,831

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 111,051
  • In infectious diseases: 5,619
• Year to date:
  • Site-wide: 41,548
• Since beginning of last month:
  • Site-wide: 58,794

Predicting COVID-19 related death using the OpenSAFELY platform

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 129,879
  • In infectious diseases: 5,943
• Year to date:
  • Site-wide: 71,234
• Since beginning of last month:
  • Site-wide: 40,326

Estimating Under Reporting of Leprosy in Brazil using a Bayesian Approach

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 133,650
  • In infectious diseases: 5,749
• Year to date:
  • Site-wide: 162,441
• Since beginning of last month:
  • Site-wide: 166,042

Endocrine therapy use and the risk of cardiovascular disease in postmenopausal breast cancer survivors: two cohort studies in the UK and US

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 133,620
  • In epidemiology: 5,307
• Year to date:
  • Site-wide: 161,985
• Since beginning of last month:
  • Site-wide: 150,066

Prevalence of COVID-19-related risk factors and risk of severe influenza outcomes in cancer survivors: a matched cohort study using linked English electronic health records data

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 142,087
  • In oncology: 422
• Year to date:
  • Site-wide: 136,127
• Since beginning of last month:
  • Site-wide: 110,492

Recording of 'COVID-19 vaccine declined' among vaccination priority groups: a cohort study on 57.9 million NHS patients' primary care records in situ using OpenSAFELY

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 144,276
  • In public and global health: 1,952
• Year to date:
  • Site-wide: 80,007
• Since beginning of last month:
  • Site-wide: 99,129

Underlying cardiovascular risk and major adverse cardiovascular events after acute respiratory infection: a population-based cohort study of over 4.2 million individuals in England, 2008-2018

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 153,238
  • In epidemiology: 6,571
• Year to date:
  • Site-wide: 57,302
• Since beginning of last month:
  • Site-wide: 19,808

Ethnic differences in the incidence of clinically diagnosed influenza: an England population-based cohort study 2008-2018

• Downloaded 212 times
• Download rankings, all-time:
  • Site-wide: 163,527
  • In epidemiology: 6,445
• Year to date:
  • Site-wide: 146,027
• Since beginning of last month:
  • Site-wide: 109,490

Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an analysis of 4.3 million adults over the age of 65

• Downloaded 168 times
• Download rankings, all-time:
  • Site-wide: 174,233
  • In epidemiology: 6,867
• Year to date:
  • Site-wide: 109,003
• Since beginning of last month:
  • Site-wide: 80,661