Author: Liam Smeeth

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Preprints

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies: a nationwide cohort study in the OpenSAFELY platform

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OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients.

• Downloaded 159,139 times
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  • Site-wide: 22
  • In epidemiology: 6
• Year to date:
  • Site-wide: 317
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  • Site-wide: 877

Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England

• Downloaded 12,369 times
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  • Site-wide: 715
  • In epidemiology: 104
• Year to date:
  • Site-wide: 486
• Since beginning of last month:
  • Site-wide: 24,917

Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England

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  • Site-wide: 961
  • In infectious diseases: 300
• Year to date:
  • Site-wide: 197
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  • Site-wide: 12,689

UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records

• Downloaded 7,174 times
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  • Site-wide: 1,440
  • In epidemiology: 177
• Year to date:
  • Site-wide: 543
• Since beginning of last month:
  • Site-wide: 5,725

Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients primary care records in situ using OpenSAFELY.

• Downloaded 4,819 times
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  • Site-wide: 2,480
  • In public and global health: 87
• Year to date:
  • Site-wide: 426
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  • Site-wide: 2,581

Inhaled corticosteroid use and risk COVID-19 related death among 966,461 patients with COPD or asthma: an OpenSAFELY analysis

• Downloaded 2,607 times
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  • Site-wide: 5,899
  • In respiratory medicine: 27
• Year to date:
  • Site-wide: 15,554
• Since beginning of last month:
  • Site-wide: 38,347

Ethnic differences in COVID-19 infection, hospitalisation, and mortality: an OpenSAFELY analysis of 17 million adults in England

• Downloaded 2,126 times
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  • Site-wide: 7,990
  • In epidemiology: 644
• Year to date:
  • Site-wide: 4,248
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  • Site-wide: 28,698

What can trends in hospital deaths from COVID-19 tell us about the progress and peak of the pandemic? An analysis of death counts from England announced up to 20 April 2020

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  • Site-wide: 19,936
  • In epidemiology: 1,228
• Year to date:
  • Site-wide: 45,349
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  • Site-wide: 26,742

HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,085 times
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  • Site-wide: 21,644
  • In infectious diseases: 1,970
• Year to date:
  • Site-wide: 28,589
• Since beginning of last month:
  • Site-wide: 48,573

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

• Downloaded 1,041 times
• Download rankings, all-time:
  • Site-wide: 23,044
  • In infectious diseases: 2,022
• Year to date:
  • Site-wide: 2,933
• Since beginning of last month:
  • Site-wide: 41,444

OpenSAFELY NHS Service Restoration Observatory 1: describing trends and variation in primary care clinical activity for 23.3 million patients in England during the first wave of COVID-19

• Downloaded 982 times
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  • Site-wide: 25,057
  • In health systems and quality improvement: 39
• Year to date:
  • Site-wide: 3,201
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  • Site-wide: 18,156

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform

• Downloaded 968 times
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  • Site-wide: 25,622
  • In epidemiology: 1,465
• Year to date:
  • Site-wide: 3,254
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  • Site-wide: 25,387

OpenSAFELY: Do adults prescribed Non-steroidal anti-inflammatory drugs have an increased risk of death from COVID-19?

• Downloaded 917 times
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  • Site-wide: 27,648
  • In infectious diseases: 2,247
• Year to date:
  • Site-wide: 35,398
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  • Site-wide: 101,263

Early impact of the COVID-19 pandemic and social distancing measures on routine childhood vaccinations in England, January to April 2020

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  • Site-wide: 28,327
  • In public and global health: 506
• Year to date:
  • Site-wide: 55,387
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  • Site-wide: 19,896

Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study

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  • Site-wide: 31,220
  • In infectious diseases: 2,393
• Year to date:
  • Site-wide: 55,610
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  • Site-wide: 100,747

COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK

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  • Site-wide: 38,808
  • In primary care research: 22
• Year to date:
  • Site-wide: 21,318
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  • Site-wide: 17,394

Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records in situ using OpenSAFELY

• Downloaded 674 times
• Download rankings, all-time:
  • Site-wide: 42,243
  • In epidemiology: 2,071
• Year to date:
  • Site-wide: 5,517
• Since beginning of last month:
  • Site-wide: 805

Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19

• Downloaded 554 times
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  • Site-wide: 54,103
  • In epidemiology: 2,475
• Year to date:
  • Site-wide: 29,299
• Since beginning of last month:
  • Site-wide: 41,723

OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 60,203
  • In cardiovascular medicine: 92
• Year to date:
  • Site-wide: 17,231
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  • Site-wide: 15,569

Is glycaemia associated with poorer brain health and risk of dementia? Cross sectional and follow-up analysis of the UK Biobank

• Downloaded 477 times
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  • Site-wide: 64,221
  • In epidemiology: 2,825
• Year to date:
  • Site-wide: 50,343
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  • Site-wide: 46,617

Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

• Downloaded 409 times
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  • Site-wide: 75,392
  • In genetics: 3,281
• Year to date:
  • Site-wide: 46,836
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  • Site-wide: None

Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England: an analysis of OpenSAFELY data from 1st September to 9th November 2020

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 77,504
  • In infectious diseases: 3,714
• Year to date:
  • Site-wide: 11,882
• Since beginning of last month:
  • Site-wide: 24,750

OpenSAFELY: Risks of COVID-19 hospital admission and death for people with learning disabilities - a cohort study.

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 83,806
  • In infectious diseases: 3,878
• Year to date:
  • Site-wide: 13,469
• Since beginning of last month:
  • Site-wide: 115,188

Type 2 diabetes risks and determinants in 2nd generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK

• Downloaded 329 times
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  • Site-wide: 91,029
  • In endocrinology: 69
• Year to date:
  • Site-wide: 56,027
• Since beginning of last month:
  • Site-wide: 3,135

Association between oral anticoagulants and COVID-19 related outcomes: two cohort studies

• Downloaded 322 times
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  • Site-wide: 92,690
  • In epidemiology: 3,888
• Year to date:
  • Site-wide: 16,104
• Since beginning of last month:
  • Site-wide: 53,413

The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomization study in the UK Biobank

• Downloaded 307 times
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  • Site-wide: 96,053
  • In genetic and genomic medicine: 438
• Year to date:
  • Site-wide: 67,682
• Since beginning of last month:
  • Site-wide: 47,397

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

• Downloaded 260 times
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  • Site-wide: 106,937
  • In epidemiology: 4,470
• Year to date:
  • Site-wide: 21,557
• Since beginning of last month:
  • Site-wide: 114,040

Estimating Under Reporting of Leprosy in Brazil using a Bayesian Approach

• Downloaded 238 times
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  • Site-wide: 112,465
  • In infectious diseases: 4,641
• Year to date:
  • Site-wide: 106,123
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  • Site-wide: 103,345

Prevalence of COVID-19-related risk factors and risk of severe influenza outcomes in cancer survivors: a matched cohort study using linked English electronic health records data

• Downloaded 224 times
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  • Site-wide: 115,942
  • In oncology: 276
• Year to date:
  • Site-wide: 101,244
• Since beginning of last month:
  • Site-wide: 49,217

Endocrine therapy use and the risk of cardiovascular disease in postmenopausal breast cancer survivors: two cohort studies in the UK and US

• Downloaded 223 times
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  • Site-wide: 116,263
  • In epidemiology: 4,866
• Year to date:
  • Site-wide: 99,132
• Since beginning of last month:
  • Site-wide: 105,906

Predicting COVID-19 related death using the OpenSAFELY platform

• Downloaded 180 times
• Download rankings, all-time:
  • Site-wide: 126,894
  • In infectious diseases: 5,046
• Year to date:
  • Site-wide: 34,109
• Since beginning of last month:
  • Site-wide: 15,664

Ethnic differences in the incidence of clinically diagnosed influenza: an England population-based cohort study 2008-2018

• Downloaded 149 times
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  • Site-wide: 133,790
  • In epidemiology: 5,543
• Year to date:
  • Site-wide: 42,471
• Since beginning of last month:
  • Site-wide: 113,256

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

• Downloaded 141 times
• Download rankings, all-time:
  • Site-wide: 135,487
  • In infectious diseases: 5,323
• Year to date:
  • Site-wide: 44,990
• Since beginning of last month:
  • Site-wide: 102,274

Underlying cardiovascular risk and major adverse cardiovascular events after acute respiratory infection: a population-based cohort study of over 4.2 million individuals in England, 2008-2018

• Downloaded 89 times
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  • Site-wide: 145,638
  • In epidemiology: 5,981
• Year to date:
  • Site-wide: 70,159
• Since beginning of last month:
  • Site-wide: 52,244

Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an analysis of 4.3 million adults over the age of 65

• Downloaded 76 times
• Download rankings, all-time:
  • Site-wide: 147,468
  • In epidemiology: 6,061
• Year to date:
  • Site-wide: 79,984
• Since beginning of last month:
  • Site-wide: 42,855

Potentially inappropriate prescribing of DOACs to patients with mechanical heart valves: a federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

• Downloaded 21 times
• Download rankings, all-time:
  • Site-wide: 151,628
  • In primary care research: 117
• Year to date:
  • Site-wide: 146,084
• Since beginning of last month:
  • Site-wide: 25,473

Recording of 'COVID-19 vaccine declined' among vaccination priority groups: a cohort study on 57.9 million NHS patients' primary care records in situ using OpenSAFELY

• Downloaded 11 times
• Download rankings, all-time:
  • Site-wide: 152,334
  • In public and global health: 2,108
• Year to date:
  • Site-wide: 152,095
• Since beginning of last month:
  • Site-wide: 6,526