Author: David D. Ho

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Preprints

The Functional Landscape of SARS-CoV-2 3CL Protease

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Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

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Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

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Emergence and Expansion of the SARS-CoV-2 Variant B.1.526 Identified in New York

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Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages

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The impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound

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Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization

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Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

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Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

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Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

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Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike

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A third COVID-19 vaccine shot markedly boosts neutralizing antibody potency and breadth

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Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

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Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite

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Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

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A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

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Real-time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

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Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

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Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

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SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease

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Structural basis for antibody resistance to SARS-CoV-2 omicron variant

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Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

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SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

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Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex

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A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

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Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

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Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529

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In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness

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Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

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Virus-Like Particle Based-Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

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Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

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