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Author: Shamil R. Sunyaev

  • Most recently observed institution: Broad Institute of Harvard and MIT

Rankings

  • All-time downloads: 14,296 (rank: 10,131 (tie) out of 510,677)
  • Categories:
    • bioinformatics: 2,340 (rank: 5,168 (tie) out of 36,842)
    • evolutionary biology: 5,973 (rank: 356 out of 22,259)
    • genetics: 4,683 (rank: 3,681 (tie) out of 38,674)
    • genomics: 1,300 (rank: 15,680 (tie) out of 45,521)

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Preprints

Signals of polygenic adaptation on height have been overestimated due to uncorrected population structure in genome-wide association studies

evolutionary biology more details view paper
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Non-parametric polygenic risk prediction using partitioned GWAS summary statistics

bioinformatics more details view paper
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Estimating the Selective Effect of Heterozygous Protein Truncating Variants from Human Exome Data

genomics more details view paper
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Response to a population bottleneck can be used to infer recessive selection

evolutionary biology more details view paper
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Discovery of cancer driver genes based on nucleotide context

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Shared effect modeling reveals that a fraction of autoimmune disease associations are consistent with eQTLs in three immune cell types

genetics more details view paper
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Negative selection in humans and fruit flies involves synergistic epistasis

evolutionary biology more details view paper
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Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection

evolutionary biology more details view paper
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

genetics more details view paper
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Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans

genetics more details view paper
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Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy

genetics more details view paper
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Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

genetics more details view paper
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