Author: Douglas F. Easton

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Preprints

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,336 times
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  • Site-wide: 1,811
  • In genomics: 177
• Year to date:
  • Site-wide: 19,242
• Since beginning of last month:
  • Site-wide: 23,099

Improving reporting standards for polygenic scores in risk prediction studies

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  • Site-wide: 6,857
  • In genetic and genomic medicine: 23
• Year to date:
  • Site-wide: 2,230
• Since beginning of last month:
  • Site-wide: 1,527

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,678 times
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  • Site-wide: 9,687
  • In genetics: 463
• Year to date:
  • Site-wide: 50,503
• Since beginning of last month:
  • Site-wide: 40,158

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,660 times
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  • Site-wide: 9,833
  • In genetics: 469
• Year to date:
  • Site-wide: 62,155
• Since beginning of last month:
  • Site-wide: 39,926

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,356 times
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  • Site-wide: 13,274
  • In genetics: 650
• Year to date:
  • Site-wide: 69,117
• Since beginning of last month:
  • Site-wide: 89,231

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,243 times
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  • Site-wide: 15,145
  • In genomics: 1,572
• Year to date:
  • Site-wide: 86,564
• Since beginning of last month:
  • Site-wide: 118,106

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 949 times
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  • Site-wide: 22,485
  • In genetics: 1,088
• Year to date:
  • Site-wide: 120,972
• Since beginning of last month:
  • Site-wide: 113,739

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

• Downloaded 905 times
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  • Site-wide: 24,142
  • In genetics: 1,168
• Year to date:
  • Site-wide: 42,262
• Since beginning of last month:
  • Site-wide: 24,111

Chromatin interactome mapping at 139 independent breast cancer risk signals

• Downloaded 901 times
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  • Site-wide: 24,263
  • In molecular biology: 665
• Year to date:
  • Site-wide: 108,066
• Since beginning of last month:
  • Site-wide: 98,199

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 842 times
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  • Site-wide: 26,665
  • In genetics: 1,293
• Year to date:
  • Site-wide: 48,561
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  • Site-wide: 41,297

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 781 times
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  • Site-wide: 29,630
  • In genetics: 1,437
• Year to date:
  • Site-wide: 67,986
• Since beginning of last month:
  • Site-wide: 79,349

Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations

• Downloaded 623 times
• Download rankings, all-time:
  • Site-wide: 40,143
  • In genetics: 1,909
• Year to date:
  • Site-wide: 31,000
• Since beginning of last month:
  • Site-wide: 36,189

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 605 times
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  • Site-wide: 41,684
  • In epidemiology: 1,980
• Year to date:
  • Site-wide: 54,185
• Since beginning of last month:
  • Site-wide: 41,774

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 587 times
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  • Site-wide: 43,368
  • In sexual and reproductive health: 18
• Year to date:
  • Site-wide: 2,236
• Since beginning of last month:
  • Site-wide: 6,223

Shared heritability and functional enrichment across six solid cancers

• Downloaded 530 times
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  • Site-wide: 49,035
  • In genomics: 3,871
• Year to date:
  • Site-wide: 117,853
• Since beginning of last month:
  • Site-wide: 117,791

High-throughput allelic expression imbalance analyses identify candidate breast cancer risk genes

• Downloaded 510 times
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  • Site-wide: 51,275
  • In genetics: 2,396
• Year to date:
  • Site-wide: 80,943
• Since beginning of last month:
  • Site-wide: 117,545

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 70,515
  • In genetics: 3,229
• Year to date:
  • Site-wide: 122,398
• Since beginning of last month:
  • Site-wide: 131,130

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 331 times
• Download rankings, all-time:
  • Site-wide: 78,551
  • In epidemiology: 3,267
• Year to date:
  • Site-wide: 96,635
• Since beginning of last month:
  • Site-wide: 75,489

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 97,313
  • In genetic and genomic medicine: 381
• Year to date:
  • Site-wide: 57,653
• Since beginning of last month:
  • Site-wide: 56,930

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 240 times
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  • Site-wide: 97,690
  • In genetics: 4,365
• Year to date:
  • Site-wide: 132,050
• Since beginning of last month:
  • Site-wide: 131,712

Detecting rare copy number variants (CNVs) from Illumina genotyping arrays with the CamCNV pipeline: segmentation of z-scores improves detection and reliability.

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 98,264
  • In bioinformatics: 8,475
• Year to date:
  • Site-wide: 65,018
• Since beginning of last month:
  • Site-wide: 55,792

A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors

• Downloaded 162 times
• Download rankings, all-time:
  • Site-wide: 114,740
  • In genetic and genomic medicine: 528
• Year to date:
  • Site-wide: 39,630
• Since beginning of last month:
  • Site-wide: 52,508

Is the Association Between Smoking and Depression Mediated by Inflammation? A Mendelian Randomization Study.

• Downloaded 75 times
• Download rankings, all-time:
  • Site-wide: 130,526
  • In epidemiology: 5,280
• Year to date:
  • Site-wide: 33,362
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  • Site-wide: 28,243