Author: Douglas F. Easton

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Preprints

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

• Downloaded 6,160 times
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  • Site-wide: 2,573
  • In genetics: 83
• Year to date:
  • Site-wide: 244
• Since beginning of last month:
  • Site-wide: 641

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,771 times
• Download rankings, all-time:
  • Site-wide: 2,799
  • In genomics: 227
• Year to date:
  • Site-wide: 38,053
• Since beginning of last month:
  • Site-wide: 24,623

Improving reporting standards for polygenic scores in risk prediction studies

• Downloaded 2,962 times
• Download rankings, all-time:
  • Site-wide: 7,220
  • In genetic and genomic medicine: 40
• Year to date:
  • Site-wide: 34,494
• Since beginning of last month:
  • Site-wide: 33,510

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 2,556 times
• Download rankings, all-time:
  • Site-wide: 8,972
  • In sexual and reproductive health: 13
• Year to date:
  • Site-wide: 23,565
• Since beginning of last month:
  • Site-wide: 50,327

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,921 times
• Download rankings, all-time:
  • Site-wide: 13,830
  • In genetics: 549
• Year to date:
  • Site-wide: 65,978
• Since beginning of last month:
  • Site-wide: 27,789

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,898 times
• Download rankings, all-time:
  • Site-wide: 14,077
  • In genetics: 540
• Year to date:
  • Site-wide: 116,564
• Since beginning of last month:
  • Site-wide: 69,602

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,586 times
• Download rankings, all-time:
  • Site-wide: 18,558
  • In genetics: 749
• Year to date:
  • Site-wide: 104,283
• Since beginning of last month:
  • Site-wide: 61,012

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,403 times
• Download rankings, all-time:
  • Site-wide: 22,572
  • In genomics: 1,934
• Year to date:
  • Site-wide: 122,778
• Since beginning of last month:
  • Site-wide: 67,221

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 1,151 times
• Download rankings, all-time:
  • Site-wide: 30,843
  • In genetics: 1,245
• Year to date:
  • Site-wide: 45,886
• Since beginning of last month:
  • Site-wide: 99,787

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 1,062 times
• Download rankings, all-time:
  • Site-wide: 34,942
  • In genetics: 1,382
• Year to date:
  • Site-wide: 179,458
• Since beginning of last month:
  • Site-wide: 89,841

Chromatin interactome mapping at 139 independent breast cancer risk signals

• Downloaded 1,024 times
• Download rankings, all-time:
  • Site-wide: 36,912
  • In molecular biology: 948
• Year to date:
  • Site-wide: 173,469
• Since beginning of last month:
  • Site-wide: 150,321

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

• Downloaded 1,011 times
• Download rankings, all-time:
  • Site-wide: 37,674
  • In genetics: 1,464
• Year to date:
  • Site-wide: 188,109
• Since beginning of last month:
  • Site-wide: 149,496

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 43,807
  • In genetics: 1,717
• Year to date:
  • Site-wide: 156,477
• Since beginning of last month:
  • Site-wide: 129,465

Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations

• Downloaded 915 times
• Download rankings, all-time:
  • Site-wide: 43,874
  • In genetics: 1,757
• Year to date:
  • Site-wide: 74,542
• Since beginning of last month:
  • Site-wide: 47,584

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 864 times
• Download rankings, all-time:
  • Site-wide: 47,900
  • In epidemiology: 2,387
• Year to date:
  • Site-wide: 124,842
• Since beginning of last month:
  • Site-wide: 100,933

A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 70,122
  • In genetic and genomic medicine: 407
• Year to date:
  • Site-wide: 41,512
• Since beginning of last month:
  • Site-wide: 113,700

High-throughput allelic expression imbalance analyses identify candidate breast cancer risk genes

• Downloaded 646 times
• Download rankings, all-time:
  • Site-wide: 72,884
  • In genetics: 2,783
• Year to date:
  • Site-wide: 162,728
• Since beginning of last month:
  • Site-wide: 94,209

Shared heritability and functional enrichment across six solid cancers

• Downloaded 638 times
• Download rankings, all-time:
  • Site-wide: 74,232
  • In genomics: 4,896
• Year to date:
  • Site-wide: 153,602
• Since beginning of last month:
  • Site-wide: 44,319

Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1, updates to tumour pathology and cancer incidences.

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 75,511
  • In genetic and genomic medicine: 560
• Year to date:
  • Site-wide: 7,308
• Since beginning of last month:
  • Site-wide: 12,824

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 103,911
  • In epidemiology: 4,447
• Year to date:
  • Site-wide: 164,268
• Since beginning of last month:
  • Site-wide: 104,246

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 109,189
  • In genetics: 4,059
• Year to date:
  • Site-wide: 202,810
• Since beginning of last month:
  • Site-wide: 185,600

Is the Association Between Smoking and Depression Mediated by Inflammation? A Mendelian Randomization Study.

• Downloaded 434 times
• Download rankings, all-time:
  • Site-wide: 115,743
  • In epidemiology: 4,866
• Year to date:
  • Site-wide: 42,231
• Since beginning of last month:
  • Site-wide: 157,383

Detecting rare copy number variants (CNVs) from Illumina genotyping arrays with the CamCNV pipeline: segmentation of z-scores improves detection and reliability.

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 122,677
  • In bioinformatics: 10,054
• Year to date:
  • Site-wide: 120,942
• Since beginning of last month:
  • Site-wide: 139,202

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 134,200
  • In genetic and genomic medicine: 902
• Year to date:
  • Site-wide: 151,661
• Since beginning of last month:
  • Site-wide: 141,533

Rare copy number variants (CNVs) and breast cancer risk

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 154,475
  • In genetics: 5,734
• Year to date:
  • Site-wide: 133,402
• Since beginning of last month:
  • Site-wide: 115,085

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 154,582
  • In genetics: 5,664
• Year to date:
  • Site-wide: 201,203
• Since beginning of last month:
  • Site-wide: 171,266

Exome sequencing identifies novel susceptibility genes and defines the contribution of coding variants to breast cancer risk.

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 194,376
  • In genetic and genomic medicine: 1,444
• Year to date:
  • Site-wide: 69,478
• Since beginning of last month:
  • Site-wide: 106,065

Segregation analysis of 17,425 population-based breast cancer families: evidence for genetic susceptibility and risk prediction

• Downloaded 109 times
• Download rankings, all-time:
  • Site-wide: 199,325
  • In genetic and genomic medicine: 1,489
• Year to date:
  • Site-wide: 86,588
• Since beginning of last month:
  • Site-wide: 105,839