Author: Douglas F. Easton

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Preprints

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

• Downloaded 5,438 times
• Download rankings, all-time:
  • Site-wide: 2,089
  • In genomics: 189
• Year to date:
  • Site-wide: 26,098
• Since beginning of last month:
  • Site-wide: 25,830

Improving reporting standards for polygenic scores in risk prediction studies

• Downloaded 2,444 times
• Download rankings, all-time:
  • Site-wide: 6,531
  • In genetic and genomic medicine: 29
• Year to date:
  • Site-wide: 3,485
• Since beginning of last month:
  • Site-wide: 5,564

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,736 times
• Download rankings, all-time:
  • Site-wide: 10,782
  • In genetics: 478
• Year to date:
  • Site-wide: 59,743
• Since beginning of last month:
  • Site-wide: 38,667

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,726 times
• Download rankings, all-time:
  • Site-wide: 10,867
  • In genetics: 481
• Year to date:
  • Site-wide: 61,184
• Since beginning of last month:
  • Site-wide: None

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

• Downloaded 1,428 times
• Download rankings, all-time:
  • Site-wide: 14,387
  • In genetics: 664
• Year to date:
  • Site-wide: 60,469
• Since beginning of last month:
  • Site-wide: None

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 17,323
  • In genomics: 1,697
• Year to date:
  • Site-wide: 114,934
• Since beginning of last month:
  • Site-wide: 42,620

Genetic insights into the biological mechanisms governing human ovarian ageing

• Downloaded 1,138 times
• Download rankings, all-time:
  • Site-wide: 20,204
  • In sexual and reproductive health: 15
• Year to date:
  • Site-wide: 2,598
• Since beginning of last month:
  • Site-wide: 2,181

A genetic risk score to guide age-specific, personalized prostate cancer screening

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 25,801
  • In genetics: 1,183
• Year to date:
  • Site-wide: 137,682
• Since beginning of last month:
  • Site-wide: None

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

• Downloaded 939 times
• Download rankings, all-time:
  • Site-wide: 26,737
  • In genetics: 1,227
• Year to date:
  • Site-wide: 67,523
• Since beginning of last month:
  • Site-wide: 88,285

Chromatin interactome mapping at 139 independent breast cancer risk signals

• Downloaded 937 times
• Download rankings, all-time:
  • Site-wide: 26,862
  • In molecular biology: 720
• Year to date:
  • Site-wide: 103,261
• Since beginning of last month:
  • Site-wide: None

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 884 times
• Download rankings, all-time:
  • Site-wide: 29,120
  • In genetics: 1,328
• Year to date:
  • Site-wide: 67,417
• Since beginning of last month:
  • Site-wide: 89,866

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

• Downloaded 812 times
• Download rankings, all-time:
  • Site-wide: 32,822
  • In genetics: 1,510
• Year to date:
  • Site-wide: 90,096
• Since beginning of last month:
  • Site-wide: None

Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations

• Downloaded 699 times
• Download rankings, all-time:
  • Site-wide: 40,294
  • In genetics: 1,810
• Year to date:
  • Site-wide: 40,169
• Since beginning of last month:
  • Site-wide: 104,371

Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 41,388
  • In epidemiology: 2,032
• Year to date:
  • Site-wide: 50,599
• Since beginning of last month:
  • Site-wide: 32,506

Shared heritability and functional enrichment across six solid cancers

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 54,450
  • In genomics: 4,099
• Year to date:
  • Site-wide: 125,884
• Since beginning of last month:
  • Site-wide: 81,524

High-throughput allelic expression imbalance analyses identify candidate breast cancer risk genes

• Downloaded 545 times
• Download rankings, all-time:
  • Site-wide: 55,183
  • In genetics: 2,442
• Year to date:
  • Site-wide: 93,290
• Since beginning of last month:
  • Site-wide: None

A genetic hazard score to personalize prostate cancer screening, applied to population data

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 79,535
  • In genetics: 3,479
• Year to date:
  • Site-wide: 144,344
• Since beginning of last month:
  • Site-wide: None

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 82,456
  • In epidemiology: 3,486
• Year to date:
  • Site-wide: 94,243
• Since beginning of last month:
  • Site-wide: 32,478

Detecting rare copy number variants (CNVs) from Illumina genotyping arrays with the CamCNV pipeline: segmentation of z-scores improves detection and reliability.

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 97,872
  • In bioinformatics: 8,501
• Year to date:
  • Site-wide: 65,100
• Since beginning of last month:
  • Site-wide: 67,583

A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 97,961
  • In genetic and genomic medicine: 452
• Year to date:
  • Site-wide: 30,134
• Since beginning of last month:
  • Site-wide: 13,992

Genetic architectures of proximal and distal colorectal cancer are partly distinct

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 103,018
  • In genetic and genomic medicine: 483
• Year to date:
  • Site-wide: 80,089
• Since beginning of last month:
  • Site-wide: 56,897

The effect of sample size on polygenic hazard models for prostate cancer

• Downloaded 253 times
• Download rankings, all-time:
  • Site-wide: 108,774
  • In genetics: 4,615
• Year to date:
  • Site-wide: 147,815
• Since beginning of last month:
  • Site-wide: None

Is the Association Between Smoking and Depression Mediated by Inflammation? A Mendelian Randomization Study.

• Downloaded 142 times
• Download rankings, all-time:
  • Site-wide: 135,368
  • In epidemiology: 5,604
• Year to date:
  • Site-wide: 44,827
• Since beginning of last month:
  • Site-wide: 112,437

Rare copy number variants (CNVs) and breast cancer risk

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 136,800
  • In genetics: 5,519
• Year to date:
  • Site-wide: 46,882
• Since beginning of last month:
  • Site-wide: 19,726