Author: Jie Li

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Preprints

Epidemiological and Clinical Characteristics of 17 Hospitalized Patients with 2019 Novel Coronavirus Infections Outside Wuhan, China

• Downloaded 3,275 times
• Download rankings, all-time:
  • Site-wide: 5,571
  • In epidemiology: 515
• Year to date:
  • Site-wide: 108,457
• Since beginning of last month:
  • Site-wide: None

Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

• Downloaded 2,687 times
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  • Site-wide: 7,401
  • In plant biology: 102
• Year to date:
  • Site-wide: 822
• Since beginning of last month:
  • Site-wide: 533

The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

• Downloaded 1,774 times
• Download rankings, all-time:
  • Site-wide: 13,672
  • In infectious diseases: 1,799
• Year to date:
  • Site-wide: 72,529
• Since beginning of last month:
  • Site-wide: 52,223

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

• Downloaded 1,644 times
• Download rankings, all-time:
  • Site-wide: 15,305
  • In molecular biology: 402
• Year to date:
  • Site-wide: 32,839
• Since beginning of last month:
  • Site-wide: 25,298

Non-antibiotic pharmaceuticals can enhance the spread of antibiotic resistance via conjugation

• Downloaded 1,641 times
• Download rankings, all-time:
  • Site-wide: 15,347
  • In microbiology: 857
• Year to date:
  • Site-wide: 86,337
• Since beginning of last month:
  • Site-wide: 58,862

Chromosome-level genome assembly of the greenfin horse-faced filefish (Thamnaconus septentrionalis) using Oxford Nanopore PromethION sequencing and Hi-C technology

• Downloaded 1,181 times
• Download rankings, all-time:
  • Site-wide: 25,460
  • In genomics: 2,268
• Year to date:
  • Site-wide: 14,788
• Since beginning of last month:
  • Site-wide: 34,508

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

• Downloaded 1,135 times
• Download rankings, all-time:
  • Site-wide: 27,038
  • In cancer biology: 707
• Year to date:
  • Site-wide: 26,947
• Since beginning of last month:
  • Site-wide: 17,322

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

• Downloaded 1,098 times
• Download rankings, all-time:
  • Site-wide: 28,465
  • In microbiology: 1,574
• Year to date:
  • Site-wide: 182,141
• Since beginning of last month:
  • Site-wide: 178,052

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

• Downloaded 993 times
• Download rankings, all-time:
  • Site-wide: 33,028
  • In biochemistry: 756
• Year to date:
  • Site-wide: 125,676
• Since beginning of last month:
  • Site-wide: 140,206

A body map of somatic mutagenesis in morphologically normal human tissues

• Downloaded 718 times
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  • Site-wide: 52,889
  • In genomics: 3,894
• Year to date:
  • Site-wide: 56,377
• Since beginning of last month:
  • Site-wide: 49,771

In Vivo Subcellular Mass Spectrometry Enables Proteo-Metabolomic Single-cell Systems Biology in a Chordate Embryo Developing to a Normally Behaving Tadpole (X. laevis)

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 54,175
  • In developmental biology: 1,363
• Year to date:
  • Site-wide: 28,734
• Since beginning of last month:
  • Site-wide: 24,112

GWAS using 2b-RAD sequencing identified three mastitis important SNPs via two-stage association analysis in Chinese Holstein cows.

• Downloaded 683 times
• Download rankings, all-time:
  • Site-wide: 56,595
  • In genomics: 4,026
• Year to date:
  • Site-wide: 115,344
• Since beginning of last month:
  • Site-wide: 163,766

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

• Downloaded 606 times
• Download rankings, all-time:
  • Site-wide: 66,274
  • In cell biology: 2,807
• Year to date:
  • Site-wide: 135,166
• Since beginning of last month:
  • Site-wide: None

TMC1 confers a leak conductance to modulate excitability of auditory hair cells in mammals

• Downloaded 595 times
• Download rankings, all-time:
  • Site-wide: 67,876
  • In cell biology: 2,906
• Year to date:
  • Site-wide: 127,169
• Since beginning of last month:
  • Site-wide: 166,209

Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 70,821
  • In biochemistry: 2,054
• Year to date:
  • Site-wide: 23,011
• Since beginning of last month:
  • Site-wide: 48,817

Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana

• Downloaded 558 times
• Download rankings, all-time:
  • Site-wide: 73,516
  • In plant biology: 2,807
• Year to date:
  • Site-wide: 2,993
• Since beginning of last month:
  • Site-wide: 6,295

Persistent while declined neutralizing antibody responses in the convalescents of COVID-19 across clinical spectrum during the 16 months follow up

• Downloaded 543 times
• Download rankings, all-time:
  • Site-wide: 75,941
  • In infectious diseases: 4,266
• Year to date:
  • Site-wide: 56,574
• Since beginning of last month:
  • Site-wide: 67,403

HIV protease inhibitor Nelfinavir targets human DDI2 and potentiates proteasome inhibitor-based chemotherapy

• Downloaded 534 times
• Download rankings, all-time:
  • Site-wide: 77,458
  • In cancer biology: 2,238
• Year to date:
  • Site-wide: 102,985
• Since beginning of last month:
  • Site-wide: 72,619

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 81,835
  • In cancer biology: 2,304
• Year to date:
  • Site-wide: 112,334
• Since beginning of last month:
  • Site-wide: 138,375

Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice

• Downloaded 471 times
• Download rankings, all-time:
  • Site-wide: 89,399
  • In neuroscience: 12,660
• Year to date:
  • Site-wide: 108,987
• Since beginning of last month:
  • Site-wide: 138,924

Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

• Downloaded 470 times
• Download rankings, all-time:
  • Site-wide: 89,668
  • In cell biology: 4,162
• Year to date:
  • Site-wide: 58,051
• Since beginning of last month:
  • Site-wide: 115,517

Analysis of genetic signatures of tumor microenvironment yields insight into mechanisms of resistance to immunotherapy

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 90,111
  • In immunology: 2,695
• Year to date:
  • Site-wide: 124,117
• Since beginning of last month:
  • Site-wide: 117,972

Differential Expression of α,β, and γ Protocadherin Isoforms During Differentiation, Aging, and Cancer

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 92,130
  • In developmental biology: 2,644
• Year to date:
  • Site-wide: 42,141
• Since beginning of last month:
  • Site-wide: 42,818

Nilotinib, an approved leukemia drug, inhibits Smoothened signaling in Hedgehog-dependent medulloblastoma

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 93,655
  • In cancer biology: 2,660
• Year to date:
  • Site-wide: 151,004
• Since beginning of last month:
  • Site-wide: 144,322

Smad9 is a key player of follicular selection in goose via keeping the balance of LHR transcription

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 97,148
  • In developmental biology: 2,602
• Year to date:
  • Site-wide: 89,627
• Since beginning of last month:
  • Site-wide: 66,038

Biological Pathways and Gene Networks Link Inflammation and Vascular Remodeling to Both Heart Failure with Preserved and Reduced Ejection Fraction in Women across Ethnicities

• Downloaded 419 times
• Download rankings, all-time:
  • Site-wide: 100,925
  • In genetics: 3,987
• Year to date:
  • Site-wide: 96,674
• Since beginning of last month:
  • Site-wide: 58,961

LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 101,406
  • In microbiology: 6,751
• Year to date:
  • Site-wide: 66,559
• Since beginning of last month:
  • Site-wide: 158,651

Identification and validation of a ferroptosis-related genes based prognostic signature for prostate cancer

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 108,622
  • In cancer biology: 3,113
• Year to date:
  • Site-wide: 143,766
• Since beginning of last month:
  • Site-wide: 160,499

Genome-wide development of miRNA-based SSR markers in Cleistogenes songorica with their transferability analysis to gramineae and non- gramineae species

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 112,268
  • In genomics: 6,399
• Year to date:
  • Site-wide: 109,925
• Since beginning of last month:
  • Site-wide: 113,517

Laboratory Testing Implications of Risk-Stratification and Management for Improving Clinical Outcomes of COVID-19 Patients

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 113,753
  • In infectious diseases: 5,350
• Year to date:
  • Site-wide: 119,501
• Since beginning of last month:
  • Site-wide: 104,422

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 115,239
  • In molecular biology: 3,512
• Year to date:
  • Site-wide: 55,421
• Since beginning of last month:
  • Site-wide: 29,216

Sex-based clinical and immunological differences in COVID-19

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 115,294
  • In infectious diseases: 5,400
• Year to date:
  • Site-wide: 142,278
• Since beginning of last month:
  • Site-wide: 106,173

Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 117,628
  • In cell biology: 5,265
• Year to date:
  • Site-wide: 142,588
• Since beginning of last month:
  • Site-wide: 168,378

Pan-cancer analysis identified inflamed microenvironment associated multi-omics signatures

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 124,696
  • In immunology: 3,722
• Year to date:
  • Site-wide: 144,204
• Since beginning of last month:
  • Site-wide: 122,098

An ensemble prediction model for COVID-19 mortality risk

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 124,822
  • In intensive care and critical care medicine: 333
• Year to date:
  • Site-wide: 6,545
• Since beginning of last month:
  • Site-wide: 20,690

Ultra-high-throughput microbial single-cell whole genome sequencing for genome-resolved metagenomics

• Downloaded 324 times
• Download rankings, all-time:
  • Site-wide: 125,669
  • In microbiology: None
• Year to date:
  • Site-wide: 6,636
• Since beginning of last month:
  • Site-wide: 899

The COP9 Signalosome Suppresses Cardiomyocyte Necroptosis

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 128,042
  • In cell biology: 5,766
• Year to date:
  • Site-wide: 170,702
• Since beginning of last month:
  • Site-wide: 137,452

MYPT1 O-GlcNAcylation Dictates Timely Disjunction of Centrosomes

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 134,809
  • In biochemistry: 3,847
• Year to date:
  • Site-wide: 179,825
• Since beginning of last month:
  • Site-wide: 156,959

Cardiometabolic risk factors and preclinical target organ damage among adults in Ghana: Findings from a national study

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 139,385
  • In cardiovascular medicine: 374
• Year to date:
  • Site-wide: 162,333
• Since beginning of last month:
  • Site-wide: 136,627

Inferring Ecosystem Networks as Information Flows

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 141,505
  • In ecology: 4,462
• Year to date:
  • Site-wide: 87,128
• Since beginning of last month:
  • Site-wide: 59,736

Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 142,154
  • In genetic and genomic medicine: 917
• Year to date:
  • Site-wide: 54,904
• Since beginning of last month:
  • Site-wide: 50,384

Template-independent genome editing and repairing correct frameshift disease in vivo

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 143,598
  • In neuroscience: 20,454
• Year to date:
  • Site-wide: 183,080
• Since beginning of last month:
  • Site-wide: 172,878

Double nicking by RNA-directed Cascade-nCas3 for high-efficiency large-scale genome engineering

• Downloaded 252 times
• Download rankings, all-time:
  • Site-wide: 146,684
  • In microbiology: 10,243
• Year to date:
  • Site-wide: 75,780
• Since beginning of last month:
  • Site-wide: 153,070

Alleviation of neuropathic pain by over-expressing a soluble colony-stimulating factor 1 receptor

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 146,870
  • In neuroscience: 21,526
• Year to date:
  • Site-wide: 99,887
• Since beginning of last month:
  • Site-wide: 56,263

Temperature Increase Drives Critical Slowing Down of Fish Ecosystems

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 150,540
  • In ecology: 4,811
• Year to date:
  • Site-wide: 94,571
• Since beginning of last month:
  • Site-wide: 135,298

Constitutive signal bias mediated by the human GHRHR splice variant 1

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 155,473
  • In molecular biology: 4,482
• Year to date:
  • Site-wide: 91,587
• Since beginning of last month:
  • Site-wide: 131,709

aCPSF1 in synergy with terminator U-tract dictates archaeal transcription termination efficiency via the KH domains recognizing U-tract

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 161,884
  • In microbiology: 11,774
• Year to date:
  • Site-wide: 91,688
• Since beginning of last month:
  • Site-wide: 86,372

Functional stemness-related genes revealed by single-cell profiling of naïve and stimulated human CD34+ cells from CB and mPB

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 165,251
  • In cell biology: None
• Year to date:
  • Site-wide: 14,923
• Since beginning of last month:
  • Site-wide: 16,797

Gene networks under circadian control exhibit diurnal organization in primate organs

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 165,848
  • In systems biology: 3,306
• Year to date:
  • Site-wide: 57,526
• Since beginning of last month:
  • Site-wide: 55,195

Low frequency somatic copy number alterations in normal human lymphocytes revealed by large scale single-cell whole genome profiling

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 167,300
  • In genomics: 8,069
• Year to date:
  • Site-wide: 63,824
• Since beginning of last month:
  • Site-wide: 67,459

BSCL2/Seipin Deficiency in Heart Causes Energy Deficit and Heart Failure via Inducing Excessive Lipid Catabolism

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 169,905
  • In physiology: 1,976
• Year to date:
  • Site-wide: 102,684
• Since beginning of last month:
  • Site-wide: 116,440

Predicting Axillary Lymph Node Metastasis in Early Breast Cancer Using Deep Learning on Primary Tumor Biopsy Slides

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 170,584
  • In pathology: 1,001
• Year to date:
  • Site-wide: 117,369
• Since beginning of last month:
  • Site-wide: 167,912

Golgi structural defect impairs glycosaminoglycan synthesis, sulfation, and secretion

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 170,902
  • In cell biology: 7,619
• Year to date:
  • Site-wide: 68,017
• Since beginning of last month:
  • Site-wide: 76,091

Genomes of Two Flying Squid Species Provide Novel Sights into Adaptations of Cephalopods to Pelagic Life

• Downloaded 108 times
• Download rankings, all-time:
  • Site-wide: 180,145
  • In genomics: None
• Year to date:
  • Site-wide: 29,202
• Since beginning of last month:
  • Site-wide: 18,441

Calcium-independent but voltage-dependent secretion (CiVDS) mediates synaptic transmission in a mammalian central synapse

• Downloaded 95 times
• Download rankings, all-time:
  • Site-wide: 181,749
  • In neuroscience: 25,764
• Year to date:
  • Site-wide: 101,182
• Since beginning of last month:
  • Site-wide: 135,156