Author: Wei Zheng

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Preprints

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

• Downloaded 2,475 times
• Download rankings, all-time:
  • Site-wide: 5,100
  • In microbiology: 294
• Year to date:
  • Site-wide: 8,314
• Since beginning of last month:
  • Site-wide: 7,001

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 1,962 times
• Download rankings, all-time:
  • Site-wide: 7,141
  • In infectious diseases: 948
• Year to date:
  • Site-wide: 17,873
• Since beginning of last month:
  • Site-wide: 11,340

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 1,777 times
• Download rankings, all-time:
  • Site-wide: 8,298
  • In genetics: 404
• Year to date:
  • Site-wide: 28,833
• Since beginning of last month:
  • Site-wide: 26,940

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,658 times
• Download rankings, all-time:
  • Site-wide: 9,257
  • In genetics: 456
• Year to date:
  • Site-wide: 43,695
• Since beginning of last month:
  • Site-wide: 49,446

Transcriptome-wide association studies accounting for colocalization using Egger regression

• Downloaded 1,384 times
• Download rankings, all-time:
  • Site-wide: 12,070
  • In epidemiology: 820
• Year to date:
  • Site-wide: 76,954
• Since beginning of last month:
  • Site-wide: 77,957

Carbon dots for efficient siRNA delivery and gene silencing in plants

• Downloaded 1,298 times
• Download rankings, all-time:
  • Site-wide: 13,267
  • In plant biology: 165
• Year to date:
  • Site-wide: 11,771
• Since beginning of last month:
  • Site-wide: 12,655

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

• Downloaded 1,247 times
• Download rankings, all-time:
  • Site-wide: 14,093
  • In molecular biology: 395
• Year to date:
  • Site-wide: 38,336
• Since beginning of last month:
  • Site-wide: 37,788

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 995 times
• Download rankings, all-time:
  • Site-wide: 19,779
  • In cell biology: 680
• Year to date:
  • Site-wide: 25,899
• Since beginning of last month:
  • Site-wide: None

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 980 times
• Download rankings, all-time:
  • Site-wide: 20,217
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 6,473
• Since beginning of last month:
  • Site-wide: 6,351

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 959 times
• Download rankings, all-time:
  • Site-wide: 20,830
  • In developmental biology: 383
• Year to date:
  • Site-wide: 33,064
• Since beginning of last month:
  • Site-wide: 26,967

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 899 times
• Download rankings, all-time:
  • Site-wide: 22,864
  • In pharmacology and toxicology: 120
• Year to date:
  • Site-wide: 34,648
• Since beginning of last month:
  • Site-wide: None

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 880 times
• Download rankings, all-time:
  • Site-wide: 23,613
  • In pharmacology and toxicology: 124
• Year to date:
  • Site-wide: 12,663
• Since beginning of last month:
  • Site-wide: None

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 831 times
• Download rankings, all-time:
  • Site-wide: 25,591
  • In microbiology: 1,483
• Year to date:
  • Site-wide: 9,066
• Since beginning of last month:
  • Site-wide: 9,426

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 822 times
• Download rankings, all-time:
  • Site-wide: 25,973
  • In genetics: 1,292
• Year to date:
  • Site-wide: 39,674
• Since beginning of last month:
  • Site-wide: 42,584

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 814 times
• Download rankings, all-time:
  • Site-wide: 26,348
  • In microbiology: 1,530
• Year to date:
  • Site-wide: 22,113
• Since beginning of last month:
  • Site-wide: 56,584

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 28,082
  • In microbiology: 1,649
• Year to date:
  • Site-wide: 6,805
• Since beginning of last month:
  • Site-wide: 4,997

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 31,775
  • In genetics: 1,578
• Year to date:
  • Site-wide: 14,335
• Since beginning of last month:
  • Site-wide: 10,256

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 42,571
  • In cell biology: 1,808
• Year to date:
  • Site-wide: 19,878
• Since beginning of last month:
  • Site-wide: 13,505

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 44,105
  • In genetics: 2,130
• Year to date:
  • Site-wide: 88,623
• Since beginning of last month:
  • Site-wide: 80,092

Shared heritability and functional enrichment across six solid cancers

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 46,791
  • In genomics: 3,779
• Year to date:
  • Site-wide: 103,525
• Since beginning of last month:
  • Site-wide: 65,213

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 48,747
  • In genomics: 3,888
• Year to date:
  • Site-wide: 117,749
• Since beginning of last month:
  • Site-wide: 95,946

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 501 times
• Download rankings, all-time:
  • Site-wide: 49,473
  • In genomics: 3,916
• Year to date:
  • Site-wide: 107,853
• Since beginning of last month:
  • Site-wide: 95,163

Common breast cancer risk loci predispose to distinct tumor subtypes

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 53,022
  • In genetics: 2,517
• Year to date:
  • Site-wide: 13,852
• Since beginning of last month:
  • Site-wide: 5,463

The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 56,194
  • In health systems and quality improvement: 64
• Year to date:
  • Site-wide: 50,497
• Since beginning of last month:
  • Site-wide: 31,955

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 57,559
  • In genetics: 2,721
• Year to date:
  • Site-wide: 34,374
• Since beginning of last month:
  • Site-wide: 33,140

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 429 times
• Download rankings, all-time:
  • Site-wide: 58,530
  • In epidemiology: 2,495
• Year to date:
  • Site-wide: 114,478
• Since beginning of last month:
  • Site-wide: None

Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 60,558
  • In plant biology: 1,548
• Year to date:
  • Site-wide: 52,651
• Since beginning of last month:
  • Site-wide: None

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 60,943
  • In genetic and genomic medicine: 183
• Year to date:
  • Site-wide: 31,797
• Since beginning of last month:
  • Site-wide: 37,074

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 63,805
  • In genetics: 2,999
• Year to date:
  • Site-wide: 42,694
• Since beginning of last month:
  • Site-wide: 32,579

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

• Downloaded 393 times
• Download rankings, all-time:
  • Site-wide: 64,033
  • In cell biology: 2,895
• Year to date:
  • Site-wide: 79,577
• Since beginning of last month:
  • Site-wide: None

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 71,714
  • In bioinformatics: 6,784
• Year to date:
  • Site-wide: 37,795
• Since beginning of last month:
  • Site-wide: 27,960

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 71,889
  • In bioengineering: 1,329
• Year to date:
  • Site-wide: 114,782
• Since beginning of last month:
  • Site-wide: 82,601

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 333 times
• Download rankings, all-time:
  • Site-wide: 74,078
  • In epidemiology: 3,059
• Year to date:
  • Site-wide: 78,251
• Since beginning of last month:
  • Site-wide: 71,808

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 75,483
  • In microbiology: 5,229
• Year to date:
  • Site-wide: 63,379
• Since beginning of last month:
  • Site-wide: 89,846

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 320 times
• Download rankings, all-time:
  • Site-wide: 76,541
  • In epidemiology: 3,147
• Year to date:
  • Site-wide: 99,397
• Since beginning of last month:
  • Site-wide: 86,519

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 84,096
  • In molecular biology: 2,487
• Year to date:
  • Site-wide: 18,874
• Since beginning of last month:
  • Site-wide: 10,721

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

• Downloaded 260 times
• Download rankings, all-time:
  • Site-wide: 88,751
  • In genetic and genomic medicine: 298
• Year to date:
  • Site-wide: 59,850
• Since beginning of last month:
  • Site-wide: 69,109

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 89,536
  • In bioinformatics: 7,931
• Year to date:
  • Site-wide: 16,979
• Since beginning of last month:
  • Site-wide: 12,953

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

• Downloaded 205 times
• Download rankings, all-time:
  • Site-wide: 100,644
  • In epidemiology: 4,098
• Year to date:
  • Site-wide: 114,713
• Since beginning of last month:
  • Site-wide: 91,130

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 101,916
  • In genomics: 6,014
• Year to date:
  • Site-wide: 99,026
• Since beginning of last month:
  • Site-wide: 100,787

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

• Downloaded 192 times
• Download rankings, all-time:
  • Site-wide: 103,368
  • In epidemiology: 4,223
• Year to date:
  • Site-wide: 107,206
• Since beginning of last month:
  • Site-wide: 91,132

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 156 times
• Download rankings, all-time:
  • Site-wide: 110,736
  • In cancer biology: 3,421
• Year to date:
  • Site-wide: 78,585
• Since beginning of last month:
  • Site-wide: 70,713

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

• Downloaded 133 times
• Download rankings, all-time:
  • Site-wide: 115,120
  • In epidemiology: 4,663
• Year to date:
  • Site-wide: 35,100
• Since beginning of last month:
  • Site-wide: 31,049

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 115,694
  • In plant biology: 3,229
• Year to date:
  • Site-wide: 8,145
• Since beginning of last month:
  • Site-wide: None

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 112 times
• Download rankings, all-time:
  • Site-wide: 119,067
  • In genetic and genomic medicine: 537
• Year to date:
  • Site-wide: 91,417
• Since beginning of last month:
  • Site-wide: 68,483

Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

• Downloaded 96 times
• Download rankings, all-time:
  • Site-wide: 121,558
  • In cell biology: 5,608
• Year to date:
  • Site-wide: 65,378
• Since beginning of last month:
  • Site-wide: 45,357

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 78 times
• Download rankings, all-time:
  • Site-wide: 124,288
  • In genetic and genomic medicine: 573
• Year to date:
  • Site-wide: 15,175
• Since beginning of last month:
  • Site-wide: 12,423