Author: Wei Zheng

Downloads per author, site-wide

Preprints

CAT, AGTR2, L-SIGN and DC-SIGN are potential receptors for the entry of SARS-CoV-2 into human cells

• Downloaded 5,217 times
• Download rankings, all-time:
  • Site-wide: 2,995
  • In bioinformatics: 5,390
• Year to date:
  • Site-wide: 219
• Since beginning of last month:
  • Site-wide: 22

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

• Downloaded 2,974 times
• Download rankings, all-time:
  • Site-wide: 6,593
  • In microbiology: 402
• Year to date:
  • Site-wide: 40,061
• Since beginning of last month:
  • Site-wide: 57,861

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 2,411 times
• Download rankings, all-time:
  • Site-wide: 8,967
  • In infectious diseases: 1,450
• Year to date:
  • Site-wide: 40,088
• Since beginning of last month:
  • Site-wide: 51,261

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 2,300 times
• Download rankings, all-time:
  • Site-wide: 9,616
  • In genetic and genomic medicine: 50
• Year to date:
  • Site-wide: 5,887
• Since beginning of last month:
  • Site-wide: 5,829

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 2,030 times
• Download rankings, all-time:
  • Site-wide: 11,610
  • In genetics: 433
• Year to date:
  • Site-wide: 89,387
• Since beginning of last month:
  • Site-wide: 85,739

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,854 times
• Download rankings, all-time:
  • Site-wide: 13,240
  • In genetics: 506
• Year to date:
  • Site-wide: 116,966
• Since beginning of last month:
  • Site-wide: 85,982

Carbon dots for efficient siRNA delivery and gene silencing in plants

• Downloaded 1,689 times
• Download rankings, all-time:
  • Site-wide: 15,206
  • In plant biology: 158
• Year to date:
  • Site-wide: 64,944
• Since beginning of last month:
  • Site-wide: 56,839

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,667 times
• Download rankings, all-time:
  • Site-wide: 15,523
  • In microbiology: 936
• Year to date:
  • Site-wide: 20,554
• Since beginning of last month:
  • Site-wide: 16,967

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,538 times
• Download rankings, all-time:
  • Site-wide: 17,582
  • In cell biology: 530
• Year to date:
  • Site-wide: 34,660
• Since beginning of last month:
  • Site-wide: 27,853

Transcriptome-wide association studies accounting for colocalization using Egger regression

• Downloaded 1,516 times
• Download rankings, all-time:
  • Site-wide: 17,968
  • In epidemiology: 1,169
• Year to date:
  • Site-wide: 126,268
• Since beginning of last month:
  • Site-wide: 144,253

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,496 times
• Download rankings, all-time:
  • Site-wide: 18,290
  • In pharmacology and toxicology: 101
• Year to date:
  • Site-wide: 35,333
• Since beginning of last month:
  • Site-wide: 51,198

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

• Downloaded 1,416 times
• Download rankings, all-time:
  • Site-wide: 19,966
  • In molecular biology: 489
• Year to date:
  • Site-wide: 127,390
• Since beginning of last month:
  • Site-wide: 107,377

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 1,338 times
• Download rankings, all-time:
  • Site-wide: 21,785
  • In developmental biology: 350
• Year to date:
  • Site-wide: 53,867
• Since beginning of last month:
  • Site-wide: 56,793

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,285 times
• Download rankings, all-time:
  • Site-wide: 23,199
  • In pharmacology and toxicology: 130
• Year to date:
  • Site-wide: 58,816
• Since beginning of last month:
  • Site-wide: 39,740

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,244 times
• Download rankings, all-time:
  • Site-wide: 24,415
  • In genetics: 979
• Year to date:
  • Site-wide: 90,753
• Since beginning of last month:
  • Site-wide: 118,343

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 25,877
  • In microbiology: 1,448
• Year to date:
  • Site-wide: 79,277
• Since beginning of last month:
  • Site-wide: 53,695

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 30,064
  • In genetics: 1,357
• Year to date:
  • Site-wide: 33,751
• Since beginning of last month:
  • Site-wide: 38,650

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

• Downloaded 1,029 times
• Download rankings, all-time:
  • Site-wide: 32,547
  • In microbiology: 1,781
• Year to date:
  • Site-wide: 129,126
• Since beginning of last month:
  • Site-wide: 156,834

Common variants in breast cancer risk loci predispose to distinct tumor subtypes

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 47,186
  • In genetics: 2,071
• Year to date:
  • Site-wide: 51,260
• Since beginning of last month:
  • Site-wide: 15,645

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 49,091
  • In cell biology: 1,941
• Year to date:
  • Site-wide: 81,215
• Since beginning of last month:
  • Site-wide: 88,032

Evolution of a chordate-specific mechanism for myoblast fusion

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 49,825
  • In developmental biology: 1,373
• Year to date:
  • Site-wide: 18,002
• Since beginning of last month:
  • Site-wide: 14,798

The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 58,478
  • In health systems and quality improvement: 84
• Year to date:
  • Site-wide: 74,430
• Since beginning of last month:
  • Site-wide: 63,404

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 681 times
• Download rankings, all-time:
  • Site-wide: 59,387
  • In genomics: 4,597
• Year to date:
  • Site-wide: 24,261
• Since beginning of last month:
  • Site-wide: 70,873

Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species

• Downloaded 661 times
• Download rankings, all-time:
  • Site-wide: 61,872
  • In plant biology: 1,331
• Year to date:
  • Site-wide: 101,052
• Since beginning of last month:
  • Site-wide: 134,022

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

• Downloaded 613 times
• Download rankings, all-time:
  • Site-wide: 68,281
  • In genetics: 2,611
• Year to date:
  • Site-wide: 180,456
• Since beginning of last month:
  • Site-wide: 170,029

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 69,476
  • In bioinformatics: 6,765
• Year to date:
  • Site-wide: 50,109
• Since beginning of last month:
  • Site-wide: 42,804

Shared heritability and functional enrichment across six solid cancers

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 69,864
  • In genomics: 4,568
• Year to date:
  • Site-wide: 163,296
• Since beginning of last month:
  • Site-wide: 174,673

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 70,537
  • In genomics: 4,622
• Year to date:
  • Site-wide: 145,015
• Since beginning of last month:
  • Site-wide: 129,673

Evolution of myoglobin in avian lineages: positive selection for aggregation resistance in penguins and high purifying selection in galliforms

• Downloaded 593 times
• Download rankings, all-time:
  • Site-wide: 71,294
  • In bioinformatics: 9,325
• Year to date:
  • Site-wide: 13,092
• Since beginning of last month:
  • Site-wide: 5,013

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 571 times
• Download rankings, all-time:
  • Site-wide: 74,670
  • In genomics: 4,836
• Year to date:
  • Site-wide: 153,671
• Since beginning of last month:
  • Site-wide: 104,745

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 74,963
  • In genetic and genomic medicine: 377
• Year to date:
  • Site-wide: 136,838
• Since beginning of last month:
  • Site-wide: 103,297

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

• Downloaded 540 times
• Download rankings, all-time:
  • Site-wide: 79,920
  • In genetics: 3,073
• Year to date:
  • Site-wide: 142,270
• Since beginning of last month:
  • Site-wide: 165,729

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 81,085
  • In epidemiology: 3,438
• Year to date:
  • Site-wide: 144,986
• Since beginning of last month:
  • Site-wide: 140,208

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 81,804
  • In genetics: 3,185
• Year to date:
  • Site-wide: 141,150
• Since beginning of last month:
  • Site-wide: 107,800

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 85,548
  • In microbiology: 5,414
• Year to date:
  • Site-wide: 106,884
• Since beginning of last month:
  • Site-wide: 66,204

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 86,111
  • In cell biology: 3,583
• Year to date:
  • Site-wide: 178,509
• Since beginning of last month:
  • Site-wide: 157,327

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, A Potential Oral Drug Candidate for COVID-19 Treatment

• Downloaded 474 times
• Download rankings, all-time:
  • Site-wide: 92,904
  • In pharmacology and toxicology: 1,091
• Year to date:
  • Site-wide: 5,369
• Since beginning of last month:
  • Site-wide: 12,841

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 94,248
  • In molecular biology: 2,598
• Year to date:
  • Site-wide: 151,526
• Since beginning of last month:
  • Site-wide: 151,572

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 98,305
  • In epidemiology: 3,970
• Year to date:
  • Site-wide: 168,965
• Since beginning of last month:
  • Site-wide: 157,479

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 101,134
  • In bioengineering: 1,832
• Year to date:
  • Site-wide: 143,332
• Since beginning of last month:
  • Site-wide: 162,113

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 436 times
• Download rankings, all-time:
  • Site-wide: 101,458
  • In epidemiology: 4,121
• Year to date:
  • Site-wide: 152,310
• Since beginning of last month:
  • Site-wide: 136,268

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 102,278
  • In pharmacology and toxicology: 746
• Year to date:
  • Site-wide: 51,501
• Since beginning of last month:
  • Site-wide: 59,761

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 107,748
  • In bioinformatics: 8,591
• Year to date:
  • Site-wide: 169,122
• Since beginning of last month:
  • Site-wide: 182,425

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 109,503
  • In epidemiology: 4,541
• Year to date:
  • Site-wide: 62,725
• Since beginning of last month:
  • Site-wide: 111,507

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

• Downloaded 391 times
• Download rankings, all-time:
  • Site-wide: 112,338
  • In genetic and genomic medicine: 624
• Year to date:
  • Site-wide: 147,957
• Since beginning of last month:
  • Site-wide: 136,498

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

• Downloaded 390 times
• Download rankings, all-time:
  • Site-wide: 112,570
  • In plant biology: 3,409
• Year to date:
  • Site-wide: 43,026
• Since beginning of last month:
  • Site-wide: 13,084

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 115,010
  • In epidemiology: 4,925
• Year to date:
  • Site-wide: 70,604
• Since beginning of last month:
  • Site-wide: 49,389

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 322 times
• Download rankings, all-time:
  • Site-wide: 131,672
  • In cell biology: 5,769
• Year to date:
  • Site-wide: 151,093
• Since beginning of last month:
  • Site-wide: 155,028

Decoding microbiome and protein family linkage to improve protein structure prediction

• Downloaded 306 times
• Download rankings, all-time:
  • Site-wide: 136,213
  • In bioinformatics: 10,837
• Year to date:
  • Site-wide: 73,593
• Since beginning of last month:
  • Site-wide: 81,730

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 141,799
  • In epidemiology: 5,587
• Year to date:
  • Site-wide: 182,111
• Since beginning of last month:
  • Site-wide: 147,715

Rare copy number variants (CNVs) and breast cancer risk

• Downloaded 270 times
• Download rankings, all-time:
  • Site-wide: 146,921
  • In genetics: 5,469
• Year to date:
  • Site-wide: 109,115
• Since beginning of last month:
  • Site-wide: 121,922

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 147,598
  • In cancer biology: 4,237
• Year to date:
  • Site-wide: 158,271
• Since beginning of last month:
  • Site-wide: 107,472

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 155,263
  • In genetic and genomic medicine: 953
• Year to date:
  • Site-wide: 140,716
• Since beginning of last month:
  • Site-wide: 123,332

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 156,411
  • In epidemiology: 6,093
• Year to date:
  • Site-wide: 175,893
• Since beginning of last month:
  • Site-wide: 163,659

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 158,153
  • In genetic and genomic medicine: 959
• Year to date:
  • Site-wide: 150,593
• Since beginning of last month:
  • Site-wide: 125,092

Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 169,545
  • In cell biology: 7,346
• Year to date:
  • Site-wide: 168,633
• Since beginning of last month:
  • Site-wide: 125,649

Protein structural features predict responsiveness to pharmacological chaperone treatment for three lysosomal storage disorders

• Downloaded 152 times
• Download rankings, all-time:
  • Site-wide: 177,611
  • In biophysics: 6,464
• Year to date:
  • Site-wide: 135,959
• Since beginning of last month:
  • Site-wide: 155,623

Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians

• Downloaded 148 times
• Download rankings, all-time:
  • Site-wide: 178,435
  • In gastroenterology: 286
• Year to date:
  • Site-wide: 29,156
• Since beginning of last month:
  • Site-wide: 48,195