Author: Wei Zheng

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Preprints

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

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Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

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Identification of type 2 diabetes loci in 433,540 East Asian individuals

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Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

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Transcriptome-wide association studies accounting for colocalization using Egger regression

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Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

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Carbon dots for efficient siRNA delivery and gene silencing in plants

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Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

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Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

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Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

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  • In pharmacology and toxicology: 123 out of 1,030
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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

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Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

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An OpenData portal to share COVID-19 drug repurposing data in real time

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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

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  • In genetic and genomic medicine: 60 out of 488
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Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

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The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

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Shared heritability and functional enrichment across six solid cancers

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Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

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Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

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The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

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  • In health systems and quality improvement: 55 out of 139
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A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

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Common breast cancer risk loci predispose to distinct tumor subtypes

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Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

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Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

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Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species

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Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer

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Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

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Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

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Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

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African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

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The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

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The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

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Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

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Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

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A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

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Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

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Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

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Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

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