Author: Wei Zheng

Downloads per author, site-wide

Preprints

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

• Downloaded 2,680 times
• Download rankings, all-time:
  • Site-wide: 5,674
  • In microbiology: 360
• Year to date:
  • Site-wide: 15,361
• Since beginning of last month:
  • Site-wide: 43,623

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 2,160 times
• Download rankings, all-time:
  • Site-wide: 7,809
  • In infectious diseases: 1,179
• Year to date:
  • Site-wide: 20,806
• Since beginning of last month:
  • Site-wide: 47,360

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 1,885 times
• Download rankings, all-time:
  • Site-wide: 9,563
  • In genetics: 415
• Year to date:
  • Site-wide: 41,738
• Since beginning of last month:
  • Site-wide: 87,205

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,736 times
• Download rankings, all-time:
  • Site-wide: 10,781
  • In genetics: 478
• Year to date:
  • Site-wide: 59,713
• Since beginning of last month:
  • Site-wide: 33,938

Carbon dots for efficient siRNA delivery and gene silencing in plants

• Downloaded 1,504 times
• Download rankings, all-time:
  • Site-wide: 13,256
  • In plant biology: 146
• Year to date:
  • Site-wide: 17,626
• Since beginning of last month:
  • Site-wide: 88,350

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,440 times
• Download rankings, all-time:
  • Site-wide: 14,198
  • In genetic and genomic medicine: 60
• Year to date:
  • Site-wide: 6,285
• Since beginning of last month:
  • Site-wide: 13,265

Transcriptome-wide association studies accounting for colocalization using Egger regression

• Downloaded 1,410 times
• Download rankings, all-time:
  • Site-wide: 14,661
  • In epidemiology: 999
• Year to date:
  • Site-wide: 119,339
• Since beginning of last month:
  • Site-wide: 75,297

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

• Downloaded 1,320 times
• Download rankings, all-time:
  • Site-wide: 16,223
  • In molecular biology: 442
• Year to date:
  • Site-wide: 60,576
• Since beginning of last month:
  • Site-wide: None

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,316 times
• Download rankings, all-time:
  • Site-wide: 16,308
  • In microbiology: 955
• Year to date:
  • Site-wide: 7,240
• Since beginning of last month:
  • Site-wide: 1,267

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,283 times
• Download rankings, all-time:
  • Site-wide: 16,923
  • In cell biology: 507
• Year to date:
  • Site-wide: 15,118
• Since beginning of last month:
  • Site-wide: 26,049

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,198 times
• Download rankings, all-time:
  • Site-wide: 18,711
  • In pharmacology and toxicology: 103
• Year to date:
  • Site-wide: 11,458
• Since beginning of last month:
  • Site-wide: 43,936

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 1,093 times
• Download rankings, all-time:
  • Site-wide: 21,420
  • In developmental biology: 365
• Year to date:
  • Site-wide: 35,968
• Since beginning of last month:
  • Site-wide: 65,469

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,093 times
• Download rankings, all-time:
  • Site-wide: 21,428
  • In pharmacology and toxicology: 118
• Year to date:
  • Site-wide: 25,274
• Since beginning of last month:
  • Site-wide: 16,515

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,074 times
• Download rankings, all-time:
  • Site-wide: 22,003
  • In genetics: 1,004
• Year to date:
  • Site-wide: 10,170
• Since beginning of last month:
  • Site-wide: 44,082

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 1,028 times
• Download rankings, all-time:
  • Site-wide: 23,424
  • In microbiology: 1,392
• Year to date:
  • Site-wide: 16,563
• Since beginning of last month:
  • Site-wide: 36,075

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

• Downloaded 957 times
• Download rankings, all-time:
  • Site-wide: 26,054
  • In microbiology: 1,540
• Year to date:
  • Site-wide: 15,627
• Since beginning of last month:
  • Site-wide: 5,097

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 884 times
• Download rankings, all-time:
  • Site-wide: 29,104
  • In genetics: 1,328
• Year to date:
  • Site-wide: 67,575
• Since beginning of last month:
  • Site-wide: 90,221

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

• Downloaded 645 times
• Download rankings, all-time:
  • Site-wide: 44,740
  • In cell biology: 1,843
• Year to date:
  • Site-wide: 45,378
• Since beginning of last month:
  • Site-wide: 102,140

Common variants in breast cancer risk loci predispose to distinct tumor subtypes

• Downloaded 593 times
• Download rankings, all-time:
  • Site-wide: 49,771
  • In genetics: 2,212
• Year to date:
  • Site-wide: 29,189
• Since beginning of last month:
  • Site-wide: 88,803

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 51,855
  • In genetics: 2,298
• Year to date:
  • Site-wide: 128,617
• Since beginning of last month:
  • Site-wide: 72,930

Shared heritability and functional enrichment across six solid cancers

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 54,444
  • In genomics: 4,099
• Year to date:
  • Site-wide: 125,651
• Since beginning of last month:
  • Site-wide: 81,777

Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 56,667
  • In plant biology: 1,355
• Year to date:
  • Site-wide: 45,386
• Since beginning of last month:
  • Site-wide: 68,330

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 57,946
  • In genomics: 4,282
• Year to date:
  • Site-wide: 145,025
• Since beginning of last month:
  • Site-wide: None

The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 58,065
  • In health systems and quality improvement: 77
• Year to date:
  • Site-wide: 63,297
• Since beginning of last month:
  • Site-wide: 103,633

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 58,728
  • In genomics: 4,325
• Year to date:
  • Site-wide: 141,409
• Since beginning of last month:
  • Site-wide: None

CAT, AGTR2, L-SIGN and DC-SIGN are potential receptors for the entry of SARS-CoV-2 into human cells

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 59,814
  • In bioinformatics: 5,942
• Year to date:
  • Site-wide: 8,317
• Since beginning of last month:
  • Site-wide: 19,162

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 64,183
  • In genetic and genomic medicine: 258
• Year to date:
  • Site-wide: 60,860
• Since beginning of last month:
  • Site-wide: 46,465

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 64,627
  • In genetics: 2,845
• Year to date:
  • Site-wide: 81,312
• Since beginning of last month:
  • Site-wide: 95,531

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 68,033
  • In epidemiology: 2,964
• Year to date:
  • Site-wide: 134,229
• Since beginning of last month:
  • Site-wide: 61,260

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 68,889
  • In cell biology: 3,055
• Year to date:
  • Site-wide: 86,659
• Since beginning of last month:
  • Site-wide: 93,140

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 69,043
  • In genetics: 3,055
• Year to date:
  • Site-wide: 75,943
• Since beginning of last month:
  • Site-wide: 68,491

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 422 times
• Download rankings, all-time:
  • Site-wide: 73,011
  • In bioinformatics: 6,885
• Year to date:
  • Site-wide: 58,378
• Since beginning of last month:
  • Site-wide: 36,684

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 74,385
  • In microbiology: 5,057
• Year to date:
  • Site-wide: 58,985
• Since beginning of last month:
  • Site-wide: 113,369

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 382 times
• Download rankings, all-time:
  • Site-wide: 80,361
  • In epidemiology: 3,399
• Year to date:
  • Site-wide: 92,221
• Since beginning of last month:
  • Site-wide: 104,949

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

• Downloaded 376 times
• Download rankings, all-time:
  • Site-wide: 81,452
  • In molecular biology: 2,374
• Year to date:
  • Site-wide: 39,506
• Since beginning of last month:
  • Site-wide: None

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 82,319
  • In epidemiology: 3,486
• Year to date:
  • Site-wide: 94,015
• Since beginning of last month:
  • Site-wide: 40,164

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

• Downloaded 369 times
• Download rankings, all-time:
  • Site-wide: 82,800
  • In bioengineering: 1,556
• Year to date:
  • Site-wide: 134,654
• Since beginning of last month:
  • Site-wide: 84,679

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 87,850
  • In bioinformatics: 7,887
• Year to date:
  • Site-wide: 39,520
• Since beginning of last month:
  • Site-wide: 44,817

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 98,267
  • In genetic and genomic medicine: 457
• Year to date:
  • Site-wide: 98,629
• Since beginning of last month:
  • Site-wide: 104,251

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 289 times
• Download rankings, all-time:
  • Site-wide: 100,202
  • In genomics: 6,065
• Year to date:
  • Site-wide: 63,162
• Since beginning of last month:
  • Site-wide: 23,775

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

• Downloaded 228 times
• Download rankings, all-time:
  • Site-wide: 114,981
  • In epidemiology: 4,804
• Year to date:
  • Site-wide: 135,912
• Since beginning of last month:
  • Site-wide: None

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

• Downloaded 224 times
• Download rankings, all-time:
  • Site-wide: 115,912
  • In epidemiology: 4,861
• Year to date:
  • Site-wide: 26,211
• Since beginning of last month:
  • Site-wide: 115,765

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 116,587
  • In epidemiology: 4,880
• Year to date:
  • Site-wide: 51,717
• Since beginning of last month:
  • Site-wide: 116,202

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 119,171
  • In cell biology: 5,481
• Year to date:
  • Site-wide: 28,288
• Since beginning of last month:
  • Site-wide: 24,968

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

• Downloaded 205 times
• Download rankings, all-time:
  • Site-wide: 120,622
  • In epidemiology: 5,053
• Year to date:
  • Site-wide: 146,704
• Since beginning of last month:
  • Site-wide: None

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 121,136
  • In plant biology: 3,359
• Year to date:
  • Site-wide: 29,598
• Since beginning of last month:
  • Site-wide: 15,743

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 122,263
  • In cancer biology: 3,700
• Year to date:
  • Site-wide: 98,504
• Since beginning of last month:
  • Site-wide: None

Evolution of a chordate-specific mechanism for myoblast fusion

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 122,638
  • In developmental biology: 3,281
• Year to date:
  • Site-wide: 30,714
• Since beginning of last month:
  • Site-wide: 8,159

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 124,752
  • In pharmacology and toxicology: 984
• Year to date:
  • Site-wide: 32,547
• Since beginning of last month:
  • Site-wide: 55,087

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 153 times
• Download rankings, all-time:
  • Site-wide: 133,038
  • In genetic and genomic medicine: 722
• Year to date:
  • Site-wide: 104,702
• Since beginning of last month:
  • Site-wide: 48,996

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 145 times
• Download rankings, all-time:
  • Site-wide: 134,818
  • In genetic and genomic medicine: 733
• Year to date:
  • Site-wide: 43,884
• Since beginning of last month:
  • Site-wide: None

Rare copy number variants (CNVs) and breast cancer risk

• Downloaded 136 times
• Download rankings, all-time:
  • Site-wide: 136,724
  • In genetics: 5,519
• Year to date:
  • Site-wide: 47,038
• Since beginning of last month:
  • Site-wide: 18,513

Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 139,489
  • In cell biology: 6,341
• Year to date:
  • Site-wide: 113,391
• Since beginning of last month:
  • Site-wide: 109,481

Decoding microbiome and protein family linkage to improve protein structure prediction

• Downloaded 105 times
• Download rankings, all-time:
  • Site-wide: 142,883
  • In bioinformatics: 11,046
• Year to date:
  • Site-wide: 60,148
• Since beginning of last month:
  • Site-wide: 53,020

Protein structural features predict responsiveness to pharmacological chaperone treatment for three lysosomal storage disorders

• Downloaded 86 times
• Download rankings, all-time:
  • Site-wide: 146,056
  • In biophysics: 5,596
• Year to date:
  • Site-wide: 72,042
• Since beginning of last month:
  • Site-wide: 25,020