Author: Wei Zheng

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Preprints

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro

• Downloaded 2,620 times
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  • Site-wide: 5,490
  • In microbiology: 339
• Year to date:
  • Site-wide: 14,340
• Since beginning of last month:
  • Site-wide: 19,309

Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

• Downloaded 2,126 times
• Download rankings, all-time:
  • Site-wide: 7,498
  • In infectious diseases: 1,106
• Year to date:
  • Site-wide: 17,621
• Since beginning of last month:
  • Site-wide: 26,054

Identification of type 2 diabetes loci in 433,540 East Asian individuals

• Downloaded 1,852 times
• Download rankings, all-time:
  • Site-wide: 9,196
  • In genetics: 414
• Year to date:
  • Site-wide: 39,832
• Since beginning of last month:
  • Site-wide: 51,114

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

• Downloaded 1,711 times
• Download rankings, all-time:
  • Site-wide: 10,321
  • In genetics: 473
• Year to date:
  • Site-wide: 56,606
• Since beginning of last month:
  • Site-wide: 45,657

Carbon dots for efficient siRNA delivery and gene silencing in plants

• Downloaded 1,450 times
• Download rankings, all-time:
  • Site-wide: 13,202
  • In plant biology: 155
• Year to date:
  • Site-wide: 16,178
• Since beginning of last month:
  • Site-wide: 28,986

Transcriptome-wide association studies accounting for colocalization using Egger regression

• Downloaded 1,402 times
• Download rankings, all-time:
  • Site-wide: 13,893
  • In epidemiology: 943
• Year to date:
  • Site-wide: 107,867
• Since beginning of last month:
  • Site-wide: 110,268

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

• Downloaded 1,297 times
• Download rankings, all-time:
  • Site-wide: 15,613
  • In molecular biology: 427
• Year to date:
  • Site-wide: 55,966
• Since beginning of last month:
  • Site-wide: 77,933

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,288 times
• Download rankings, all-time:
  • Site-wide: 15,763
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 6,789
• Since beginning of last month:
  • Site-wide: 7,110

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

• Downloaded 1,215 times
• Download rankings, all-time:
  • Site-wide: 17,222
  • In cell biology: 539
• Year to date:
  • Site-wide: 14,586
• Since beginning of last month:
  • Site-wide: 12,414

An OpenData portal to share COVID-19 drug repurposing data in real time

• Downloaded 1,210 times
• Download rankings, all-time:
  • Site-wide: 17,344
  • In microbiology: 1,004
• Year to date:
  • Site-wide: 6,973
• Since beginning of last month:
  • Site-wide: 2,018

Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening

• Downloaded 1,130 times
• Download rankings, all-time:
  • Site-wide: 19,168
  • In pharmacology and toxicology: 105
• Year to date:
  • Site-wide: 10,428
• Since beginning of last month:
  • Site-wide: 8,863

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

• Downloaded 1,047 times
• Download rankings, all-time:
  • Site-wide: 21,425
  • In pharmacology and toxicology: 117
• Year to date:
  • Site-wide: 23,956
• Since beginning of last month:
  • Site-wide: 28,701

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,031 times
• Download rankings, all-time:
  • Site-wide: 21,923
  • In genetics: 1,026
• Year to date:
  • Site-wide: 8,296
• Since beginning of last month:
  • Site-wide: 4,538

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

• Downloaded 1,027 times
• Download rankings, all-time:
  • Site-wide: 22,040
  • In developmental biology: 394
• Year to date:
  • Site-wide: 44,396
• Since beginning of last month:
  • Site-wide: 28,872

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

• Downloaded 969 times
• Download rankings, all-time:
  • Site-wide: 24,013
  • In microbiology: 1,406
• Year to date:
  • Site-wide: 15,482
• Since beginning of last month:
  • Site-wide: 41,529

Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions

• Downloaded 925 times
• Download rankings, all-time:
  • Site-wide: 25,691
  • In microbiology: 1,501
• Year to date:
  • Site-wide: 12,702
• Since beginning of last month:
  • Site-wide: 33,992

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

• Downloaded 874 times
• Download rankings, all-time:
  • Site-wide: 27,816
  • In genetics: 1,308
• Year to date:
  • Site-wide: 55,664
• Since beginning of last month:
  • Site-wide: 57,221

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

• Downloaded 622 times
• Download rankings, all-time:
  • Site-wide: 44,063
  • In cell biology: 1,837
• Year to date:
  • Site-wide: 40,032
• Since beginning of last month:
  • Site-wide: 54,769

Common variants in breast cancer risk loci predispose to distinct tumor subtypes

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 48,418
  • In genetics: 2,212
• Year to date:
  • Site-wide: 23,180
• Since beginning of last month:
  • Site-wide: 16,072

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 49,107
  • In genetics: 2,244
• Year to date:
  • Site-wide: 113,226
• Since beginning of last month:
  • Site-wide: 108,077

Shared heritability and functional enrichment across six solid cancers

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 51,733
  • In genomics: 3,989
• Year to date:
  • Site-wide: 113,019
• Since beginning of last month:
  • Site-wide: 117,660

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 55,239
  • In genomics: 4,180
• Year to date:
  • Site-wide: 139,711
• Since beginning of last month:
  • Site-wide: 116,707

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 55,688
  • In genomics: 4,201
• Year to date:
  • Site-wide: 132,300
• Since beginning of last month:
  • Site-wide: 119,128

The impact of goggle-associated harms to health and working status of nurses during management of COVID-19

• Downloaded 502 times
• Download rankings, all-time:
  • Site-wide: 57,069
  • In health systems and quality improvement: 72
• Year to date:
  • Site-wide: 58,064
• Since beginning of last month:
  • Site-wide: 57,844

Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species

• Downloaded 492 times
• Download rankings, all-time:
  • Site-wide: 58,485
  • In plant biology: 1,432
• Year to date:
  • Site-wide: 47,357
• Since beginning of last month:
  • Site-wide: 41,506

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 61,866
  • In genetics: 2,790
• Year to date:
  • Site-wide: 67,684
• Since beginning of last month:
  • Site-wide: 93,534

Polygenic hazard score predicts aggressive and fatal prostate cancer in multi-ethnic populations

• Downloaded 458 times
• Download rankings, all-time:
  • Site-wide: 63,149
  • In genetic and genomic medicine: 239
• Year to date:
  • Site-wide: 54,935
• Since beginning of last month:
  • Site-wide: 62,718

Evaluating causal associations between previously reported risk factors and epithelial ovarian cancer: a Mendelian randomization analysis

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 64,695
  • In epidemiology: 2,809
• Year to date:
  • Site-wide: 122,639
• Since beginning of last month:
  • Site-wide: 113,308

Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 66,377
  • In cell biology: 2,948
• Year to date:
  • Site-wide: 74,620
• Since beginning of last month:
  • Site-wide: 74,220

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies new candidate susceptibility genes for breast and ovarian cancer

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 67,882
  • In genetics: 3,070
• Year to date:
  • Site-wide: 71,318
• Since beginning of last month:
  • Site-wide: 74,349

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid

• Downloaded 402 times
• Download rankings, all-time:
  • Site-wide: 72,079
  • In microbiology: 4,865
• Year to date:
  • Site-wide: 48,767
• Since beginning of last month:
  • Site-wide: 61,531

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 72,916
  • In bioinformatics: 6,852
• Year to date:
  • Site-wide: 55,000
• Since beginning of last month:
  • Site-wide: 71,810

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 78,293
  • In epidemiology: 3,295
• Year to date:
  • Site-wide: 86,229
• Since beginning of last month:
  • Site-wide: 104,020

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 78,303
  • In molecular biology: 2,306
• Year to date:
  • Site-wide: 30,410
• Since beginning of last month:
  • Site-wide: 61,052

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 79,315
  • In bioengineering: 1,480
• Year to date:
  • Site-wide: 126,821
• Since beginning of last month:
  • Site-wide: 90,193

Identifying 31 novel breast cancer susceptibility loci using data from genome-wide association studies conducted in Asian and European women

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 82,221
  • In epidemiology: 3,439
• Year to date:
  • Site-wide: 101,285
• Since beginning of last month:
  • Site-wide: 103,823

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 85,232
  • In bioinformatics: 7,665
• Year to date:
  • Site-wide: 31,173
• Since beginning of last month:
  • Site-wide: 73,711

African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 95,013
  • In genetic and genomic medicine: 410
• Year to date:
  • Site-wide: 87,740
• Since beginning of last month:
  • Site-wide: 93,938

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 106,464
  • In genomics: 6,217
• Year to date:
  • Site-wide: 86,352
• Since beginning of last month:
  • Site-wide: 62,129

The association between low-density lipoprotein cholesterol predicted by HMGCR genetic variants and breast cancer risk may be mediated by body mass index

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 109,949
  • In epidemiology: 4,578
• Year to date:
  • Site-wide: 126,709
• Since beginning of last month:
  • Site-wide: 99,703

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation

• Downloaded 203 times
• Download rankings, all-time:
  • Site-wide: 114,577
  • In epidemiology: 4,757
• Year to date:
  • Site-wide: 134,735
• Since beginning of last month:
  • Site-wide: 117,867

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 115,239
  • In epidemiology: 4,783
• Year to date:
  • Site-wide: 21,562
• Since beginning of last month:
  • Site-wide: 37,029

Polygenic Risk Modelling for Prediction of Epithelial Ovarian Cancer Risk

• Downloaded 189 times
• Download rankings, all-time:
  • Site-wide: 117,963
  • In epidemiology: 4,891
• Year to date:
  • Site-wide: 51,275
• Since beginning of last month:
  • Site-wide: 38,533

High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana

• Downloaded 187 times
• Download rankings, all-time:
  • Site-wide: 118,412
  • In plant biology: 3,276
• Year to date:
  • Site-wide: 23,618
• Since beginning of last month:
  • Site-wide: 52,214

A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer

• Downloaded 183 times
• Download rankings, all-time:
  • Site-wide: 119,223
  • In cancer biology: 3,639
• Year to date:
  • Site-wide: 96,071
• Since beginning of last month:
  • Site-wide: 92,857

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

• Downloaded 173 times
• Download rankings, all-time:
  • Site-wide: 121,490
  • In cell biology: 5,602
• Year to date:
  • Site-wide: 25,834
• Since beginning of last month:
  • Site-wide: 3,976

Additional SNPs improve the performance of a polygenic hazard score for prostate cancer

• Downloaded 138 times
• Download rankings, all-time:
  • Site-wide: 129,179
  • In genetic and genomic medicine: 672
• Year to date:
  • Site-wide: 101,558
• Since beginning of last month:
  • Site-wide: 92,336

Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration

• Downloaded 116 times
• Download rankings, all-time:
  • Site-wide: 133,521
  • In cell biology: 6,093
• Year to date:
  • Site-wide: 100,907
• Since beginning of last month:
  • Site-wide: 104,158

Rare copy number variants (CNVs) and breast cancer risk

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 134,009
  • In genetics: 5,482
• Year to date:
  • Site-wide: 41,185
• Since beginning of last month:
  • Site-wide: 7,089

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24

• Downloaded 113 times
• Download rankings, all-time:
  • Site-wide: 134,200
  • In genetic and genomic medicine: 705
• Year to date:
  • Site-wide: 41,303
• Since beginning of last month:
  • Site-wide: 92,615

Decoding microbiome and protein family linkage to improve protein structure prediction

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 139,007
  • In bioinformatics: 10,741
• Year to date:
  • Site-wide: 54,509
• Since beginning of last month:
  • Site-wide: 30,498