Author: Dennis R. Burton

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Preprints

Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

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  • Site-wide: 1,506
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• Year to date:
  • Site-wide: 31,454
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  • Site-wide: 21,597

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

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  • Site-wide: 1,793
  • In immunology: 58
• Year to date:
  • Site-wide: 10,947
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  • Site-wide: 15,205

Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples

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  • Site-wide: 2,440
  • In genomics: 242
• Year to date:
  • Site-wide: 25,760
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  • Site-wide: 29,377

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

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  • Site-wide: 6,103
  • In immunology: 206
• Year to date:
  • Site-wide: 3,873
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  • Site-wide: 13,713

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

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  • Site-wide: 6,586
  • In immunology: 216
• Year to date:
  • Site-wide: 19,168
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  • Site-wide: 11,276

Structural basis of a public antibody response to SARS-CoV-2

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  • Site-wide: 8,111
  • In microbiology: 484
• Year to date:
  • Site-wide: 18,084
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  • Site-wide: 19,576

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

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  • Site-wide: 11,522
  • In immunology: 370
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  • Site-wide: 4,775
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  • Site-wide: 12,443

A protective broadly cross-reactive human antibody defines a conserved site of vulnerability on beta-coronavirus spikes

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  • Site-wide: 14,113
  • In immunology: 455
• Year to date:
  • Site-wide: 1,772
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  • Site-wide: 2,103

Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19

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  • Site-wide: 15,139
  • In microbiology: 881
• Year to date:
  • Site-wide: 14,743
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  • Site-wide: 11,362

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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  • Site-wide: 17,735
  • In immunology: 572
• Year to date:
  • Site-wide: 125,864
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  • Site-wide: 84,666

Massively scalable genetic analysis of antibody repertoires

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  • Site-wide: 17,728
  • In bioinformatics: 2,054
• Year to date:
  • Site-wide: 39,907
• Since beginning of last month:
  • Site-wide: 57,035

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

• Downloaded 1,105 times
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  • Site-wide: 20,866
  • In microbiology: 1,201
• Year to date:
  • Site-wide: 2,544
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  • Site-wide: 32,969

AI-guided discovery of the invariant host response to viral pandemics

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  • Site-wide: 23,604
  • In bioinformatics: 2,710
• Year to date:
  • Site-wide: 11,606
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  • Site-wide: 17,245

Reprogramming the antigen specificity of B cells using genome-editing technologies

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  • Site-wide: 25,240
  • In immunology: 826
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  • Site-wide: 50,498
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  • Site-wide: 86,150

Site-specific steric control of SARS-CoV-2 spike glycosylation

• Downloaded 792 times
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  • Site-wide: 33,555
  • In biochemistry: 805
• Year to date:
  • Site-wide: 4,114
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  • Site-wide: 10,170

Haplotype-phased synthetic long reads from short-read sequencing

• Downloaded 735 times
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  • Site-wide: 37,243
  • In genomics: 3,129
• Year to date:
  • Site-wide: 133,679
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  • Site-wide: 118,931

HIV-1 vaccine design through minimizing envelope metastability

• Downloaded 693 times
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  • Site-wide: 40,258
  • In microbiology: 2,432
• Year to date:
  • Site-wide: 109,654
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  • Site-wide: 144,730

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

• Downloaded 620 times
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  • Site-wide: 46,521
  • In immunology: 1,399
• Year to date:
  • Site-wide: 72,299
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  • Site-wide: 131,322

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

• Downloaded 609 times
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  • Site-wide: 47,613
  • In immunology: 1,436
• Year to date:
  • Site-wide: 95,507
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  • Site-wide: 106,062

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

• Downloaded 588 times
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  • Site-wide: 49,696
  • In immunology: 1,494
• Year to date:
  • Site-wide: 90,570
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  • Site-wide: 97,468

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

• Downloaded 541 times
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  • Site-wide: 55,116
  • In immunology: 1,661
• Year to date:
  • Site-wide: 139,179
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  • Site-wide: 121,682

Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

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  • Site-wide: 57,199
  • In immunology: 1,708
• Year to date:
  • Site-wide: 105,164
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  • Site-wide: 105,480

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

• Downloaded 500 times
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  • Site-wide: 60,505
  • In immunology: 1,810
• Year to date:
  • Site-wide: 8,112
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  • Site-wide: 15,087

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

• Downloaded 466 times
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  • Site-wide: 65,185
  • In immunology: 1,957
• Year to date:
  • Site-wide: 132,397
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  • Site-wide: 132,937

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

• Downloaded 389 times
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  • Site-wide: 78,241
  • In immunology: 2,307
• Year to date:
  • Site-wide: 11,590
• Since beginning of last month:
  • Site-wide: 20,793

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

• Downloaded 341 times
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  • Site-wide: 87,526
  • In immunology: 2,574
• Year to date:
  • Site-wide: 135,491
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  • Site-wide: 146,812

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

• Downloaded 336 times
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  • Site-wide: 88,641
  • In immunology: 2,596
• Year to date:
  • Site-wide: 14,327
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  • Site-wide: 691

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 312 times
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  • Site-wide: 93,963
  • In immunology: 2,762
• Year to date:
  • Site-wide: 135,449
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  • Site-wide: 131,406