Author: Dennis R. Burton

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Preprints

Tumor-infiltrating immune repertoires captured by single-cell barcoding in emulsion

• Downloaded 7,068 times
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  • Site-wide: 1,991
  • In immunology: 67
• Year to date:
  • Site-wide: 49,591
• Since beginning of last month:
  • Site-wide: 76,391

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

• Downloaded 6,288 times
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  • Site-wide: 2,329
  • In immunology: 86
• Year to date:
  • Site-wide: 42,122
• Since beginning of last month:
  • Site-wide: 35,756

Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples

• Downloaded 5,030 times
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  • Site-wide: 3,146
  • In genomics: 272
• Year to date:
  • Site-wide: 42,271
• Since beginning of last month:
  • Site-wide: 41,055

Cross-reactive serum and memory B cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

• Downloaded 2,795 times
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  • Site-wide: 7,216
  • In immunology: 265
• Year to date:
  • Site-wide: 49,269
• Since beginning of last month:
  • Site-wide: 65,035

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

• Downloaded 2,648 times
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  • Site-wide: 7,835
  • In immunology: 278
• Year to date:
  • Site-wide: 59,795
• Since beginning of last month:
  • Site-wide: 89,028

A protective broadly cross-reactive human antibody defines a conserved site of vulnerability on beta-coronavirus spikes

• Downloaded 2,475 times
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  • Site-wide: 8,643
  • In immunology: 337
• Year to date:
  • Site-wide: 4,729
• Since beginning of last month:
  • Site-wide: 10,747

Structural basis of a public antibody response to SARS-CoV-2

• Downloaded 2,308 times
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  • Site-wide: 9,592
  • In microbiology: 553
• Year to date:
  • Site-wide: 46,127
• Since beginning of last month:
  • Site-wide: 44,512

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

• Downloaded 2,140 times
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  • Site-wide: 10,721
  • In immunology: 387
• Year to date:
  • Site-wide: 24,692
• Since beginning of last month:
  • Site-wide: 21,579

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

• Downloaded 1,768 times
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  • Site-wide: 14,280
  • In immunology: 645
• Year to date:
  • Site-wide: 2,321
• Since beginning of last month:
  • Site-wide: 6,884

Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19

• Downloaded 1,587 times
• Download rankings, all-time:
  • Site-wide: 16,789
  • In microbiology: 970
• Year to date:
  • Site-wide: 52,881
• Since beginning of last month:
  • Site-wide: 59,091

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

• Downloaded 1,543 times
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  • Site-wide: 17,559
  • In microbiology: 1,044
• Year to date:
  • Site-wide: 29,507
• Since beginning of last month:
  • Site-wide: 28,218

AI-guided discovery of the invariant host response to viral pandemics

• Downloaded 1,419 times
• Download rankings, all-time:
  • Site-wide: 19,945
  • In bioinformatics: 2,277
• Year to date:
  • Site-wide: 27,147
• Since beginning of last month:
  • Site-wide: 20,583

Massively scalable genetic analysis of antibody repertoires

• Downloaded 1,402 times
• Download rankings, all-time:
  • Site-wide: 20,329
  • In bioinformatics: 2,185
• Year to date:
  • Site-wide: 65,694
• Since beginning of last month:
  • Site-wide: 84,231

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

• Downloaded 1,280 times
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  • Site-wide: 23,417
  • In immunology: 778
• Year to date:
  • Site-wide: 164,802
• Since beginning of last month:
  • Site-wide: 157,020

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

• Downloaded 1,180 times
• Download rankings, all-time:
  • Site-wide: 26,547
  • In immunology: None
• Year to date:
  • Site-wide: 1,335
• Since beginning of last month:
  • Site-wide: 1,958

Site-specific steric control of SARS-CoV-2 spike glycosylation

• Downloaded 1,157 times
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  • Site-wide: 27,397
  • In biochemistry: 658
• Year to date:
  • Site-wide: 31,240
• Since beginning of last month:
  • Site-wide: 13,442

Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses

• Downloaded 1,084 times
• Download rankings, all-time:
  • Site-wide: 30,253
  • In immunology: 1,249
• Year to date:
  • Site-wide: 4,936
• Since beginning of last month:
  • Site-wide: 15,236

Reprogramming the antigen specificity of B cells using genome-editing technologies

• Downloaded 1,066 times
• Download rankings, all-time:
  • Site-wide: 30,992
  • In immunology: 1,002
• Year to date:
  • Site-wide: 140,581
• Since beginning of last month:
  • Site-wide: 153,635

HIV-1 vaccine design through minimizing envelope metastability

• Downloaded 1,038 times
• Download rankings, all-time:
  • Site-wide: 32,260
  • In microbiology: 1,761
• Year to date:
  • Site-wide: 131,486
• Since beginning of last month:
  • Site-wide: 77,944

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

• Downloaded 841 times
• Download rankings, all-time:
  • Site-wide: 44,148
  • In immunology: 1,496
• Year to date:
  • Site-wide: 43,979
• Since beginning of last month:
  • Site-wide: 38,275

Haplotype-phased synthetic long reads from short-read sequencing

• Downloaded 775 times
• Download rankings, all-time:
  • Site-wide: 49,702
  • In genomics: 3,515
• Year to date:
  • Site-wide: 186,050
• Since beginning of last month:
  • Site-wide: 187,524

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

• Downloaded 707 times
• Download rankings, all-time:
  • Site-wide: 56,641
  • In immunology: 1,934
• Year to date:
  • Site-wide: 28,744
• Since beginning of last month:
  • Site-wide: 30,481

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

• Downloaded 701 times
• Download rankings, all-time:
  • Site-wide: 57,276
  • In immunology: 1,718
• Year to date:
  • Site-wide: 129,206
• Since beginning of last month:
  • Site-wide: 122,095

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 57,901
  • In bioengineering: 1,447
• Year to date:
  • Site-wide: 3,076
• Since beginning of last month:
  • Site-wide: 14,063

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

• Downloaded 681 times
• Download rankings, all-time:
  • Site-wide: 59,623
  • In immunology: 1,779
• Year to date:
  • Site-wide: 117,320
• Since beginning of last month:
  • Site-wide: 108,356

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

• Downloaded 629 times
• Download rankings, all-time:
  • Site-wide: 66,289
  • In immunology: 1,908
• Year to date:
  • Site-wide: 188,307
• Since beginning of last month:
  • Site-wide: 165,893

Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 74,135
  • In immunology: 2,172
• Year to date:
  • Site-wide: 125,660
• Since beginning of last month:
  • Site-wide: 98,689

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 74,384
  • In immunology: 2,146
• Year to date:
  • Site-wide: 170,036
• Since beginning of last month:
  • Site-wide: 125,601

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

• Downloaded 571 times
• Download rankings, all-time:
  • Site-wide: 74,947
  • In immunology: 2,448
• Year to date:
  • Site-wide: 57,045
• Since beginning of last month:
  • Site-wide: 23,510

Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

• Downloaded 510 times
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  • Site-wide: 85,851
  • In immunology: 2,520
• Year to date:
  • Site-wide: 141,550
• Since beginning of last month:
  • Site-wide: 133,878

A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related viruses

• Downloaded 473 times
• Download rankings, all-time:
  • Site-wide: 93,606
  • In immunology: 2,971
• Year to date:
  • Site-wide: 15,975
• Since beginning of last month:
  • Site-wide: 53,432

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

• Downloaded 398 times
• Download rankings, all-time:
  • Site-wide: 111,027
  • In immunology: 3,606
• Year to date:
  • Site-wide: 17,859
• Since beginning of last month:
  • Site-wide: 48,429

Neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 115,467
  • In immunology: 3,320
• Year to date:
  • Site-wide: 151,914
• Since beginning of last month:
  • Site-wide: 162,287

HIV Envelope Trimer-Elicited Autologous Neutralizing Antibodies Bind a Region Overlapping the N332 Glycan Supersite

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 124,958
  • In immunology: 3,561
• Year to date:
  • Site-wide: 179,017
• Since beginning of last month:
  • Site-wide: 162,212

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 131,213
  • In microbiology: None
• Year to date:
  • Site-wide: 9,825
• Since beginning of last month:
  • Site-wide: 24,792

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 148,648
  • In microbiology: None
• Year to date:
  • Site-wide: 13,259
• Since beginning of last month:
  • Site-wide: 16,082

Therapeutic neutralizing monoclonal antibody administration protects against lethal viscerotropic Yellow Fever infection

• Downloaded 171 times
• Download rankings, all-time:
  • Site-wide: 173,982
  • In immunology: None
• Year to date:
  • Site-wide: 25,034
• Since beginning of last month:
  • Site-wide: 3,777