Author: Xu Zhang

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Preprints

Isolation and Characterization of 2019-nCoV-like Coronavirus from Malayan Pangolins

• Downloaded 16,749 times
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  • Site-wide: 489
  • In microbiology: 54
• Year to date:
  • Site-wide: 2,542
• Since beginning of last month:
  • Site-wide: 35,126

The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

• Downloaded 15,748 times
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  • Site-wide: 517
  • In microbiology: 57
• Year to date:
  • Site-wide: 923
• Since beginning of last month:
  • Site-wide: 55,424

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 6,767 times
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  • Site-wide: 1,568
  • In neuroscience: 75
• Year to date:
  • Site-wide: 15,123
• Since beginning of last month:
  • Site-wide: 93,520

A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila

• Downloaded 2,938 times
• Download rankings, all-time:
  • Site-wide: 5,045
  • In developmental biology: 55
• Year to date:
  • Site-wide: 118,784
• Since beginning of last month:
  • Site-wide: None

Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence

• Downloaded 2,201 times
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  • Site-wide: 7,682
  • In public and global health: 198
• Year to date:
  • Site-wide: 5,394
• Since beginning of last month:
  • Site-wide: 3,744

3D observation of large-scale subcellular dynamics in vivo at the millisecond scale

• Downloaded 1,449 times
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  • Site-wide: 14,239
  • In cell biology: 403
• Year to date:
  • Site-wide: 31,552
• Since beginning of last month:
  • Site-wide: 113,345

Single-cell RNA-seq reveals endoimmune cells in zebrafish

• Downloaded 1,009 times
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  • Site-wide: 24,351
  • In cell biology: 855
• Year to date:
  • Site-wide: 33,812
• Since beginning of last month:
  • Site-wide: 109,472

Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISH

• Downloaded 999 times
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  • Site-wide: 24,724
  • In cell biology: 882
• Year to date:
  • Site-wide: 60,152
• Since beginning of last month:
  • Site-wide: 44,979

RapidAIM: A culture- and metaproteomics-based Rapid Assay of Individual Microbiome responses to drugs

• Downloaded 937 times
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  • Site-wide: 27,191
  • In microbiology: 1,599
• Year to date:
  • Site-wide: 110,620
• Since beginning of last month:
  • Site-wide: None

A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

• Downloaded 918 times
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  • Site-wide: 27,983
  • In molecular biology: 765
• Year to date:
  • Site-wide: 77,749
• Since beginning of last month:
  • Site-wide: 67,290

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

• Downloaded 838 times
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  • Site-wide: 31,771
  • In cancer biology: 835
• Year to date:
  • Site-wide: 119,954
• Since beginning of last month:
  • Site-wide: 63,025

Control of mammalian brain aging by the unfolded protein response (UPR)

• Downloaded 823 times
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  • Site-wide: 32,566
  • In neuroscience: 4,276
• Year to date:
  • Site-wide: 25,527
• Since beginning of last month:
  • Site-wide: 6,312

Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

• Downloaded 721 times
• Download rankings, all-time:
  • Site-wide: 39,255
  • In microbiology: 2,363
• Year to date:
  • Site-wide: 33,438
• Since beginning of last month:
  • Site-wide: 115,441

MyoD is a structure organizer of 3D genome architecture in muscle cells

• Downloaded 699 times
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  • Site-wide: 40,835
  • In genomics: 3,324
• Year to date:
  • Site-wide: 26,898
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  • Site-wide: 7,847

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity

• Downloaded 690 times
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  • Site-wide: 41,580
  • In cancer biology: 1,135
• Year to date:
  • Site-wide: 95,031
• Since beginning of last month:
  • Site-wide: 62,565

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19

• Downloaded 644 times
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  • Site-wide: 45,473
  • In biochemistry: 1,152
• Year to date:
  • Site-wide: 59,861
• Since beginning of last month:
  • Site-wide: 119,466

Performance of a point of care test for detecting IgM and IgG antibodies against SARS-CoV-2 and seroprevalence in blood donors and health care workers in Panama

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 47,139
  • In infectious diseases: 2,979
• Year to date:
  • Site-wide: 29,589
• Since beginning of last month:
  • Site-wide: 6,797

Genome wide sequencing provides evidence of adaptation to heterogeneous environments for the ancient relictual Circaeaster agrestis (Circaeasteraceae, Ranunculales)

• Downloaded 615 times
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  • Site-wide: 48,192
  • In evolutionary biology: 2,381
• Year to date:
  • Site-wide: 46,935
• Since beginning of last month:
  • Site-wide: 66,448

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

• Downloaded 582 times
• Download rankings, all-time:
  • Site-wide: 51,732
  • In cancer biology: 1,461
• Year to date:
  • Site-wide: 92,720
• Since beginning of last month:
  • Site-wide: 25,272

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 53,367
  • In genomics: 4,042
• Year to date:
  • Site-wide: 111,231
• Since beginning of last month:
  • Site-wide: 74,928

Growth phase-dependent responses of an in vitro gut microbiome to metformin

• Downloaded 561 times
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  • Site-wide: 54,061
  • In microbiology: 3,402
• Year to date:
  • Site-wide: 31,576
• Since beginning of last month:
  • Site-wide: 100,846

MetaLab 2.0 enables accurate post-translational modifications profiling in metaproteomics

• Downloaded 556 times
• Download rankings, all-time:
  • Site-wide: 54,765
  • In bioinformatics: 5,509
• Year to date:
  • Site-wide: 78,357
• Since beginning of last month:
  • Site-wide: 99,532

Cholecystokinin release triggered by presynaptic NMDA receptors produces LTP and sound-sound associative memory formation

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 58,231
  • In neuroscience: 8,406
• Year to date:
  • Site-wide: 137,059
• Since beginning of last month:
  • Site-wide: None

Non-invasive Amelioration of Essential Tremor via Phase-Locked Disruption of its Temporal Coherence

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 59,117
  • In neuroscience: 8,570
• Year to date:
  • Site-wide: 29,183
• Since beginning of last month:
  • Site-wide: 116,279

A Chemoenzymatic Method for Glycoproteomic N-glycan Type Quantitation

• Downloaded 492 times
• Download rankings, all-time:
  • Site-wide: 63,010
  • In systems biology: 1,455
• Year to date:
  • Site-wide: 59,880
• Since beginning of last month:
  • Site-wide: 17,357

Systematic transcriptomics reveals a biphasic mode of sarcomere morphogenesis in flight muscles regulated by Spalt

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 65,055
  • In developmental biology: 1,603
• Year to date:
  • Site-wide: 124,722
• Since beginning of last month:
  • Site-wide: 50,015

Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 67,280
  • In bioengineering: 1,285
• Year to date:
  • Site-wide: 36,513
• Since beginning of last month:
  • Site-wide: 9,488

Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 hours before COVID-19 clinical tests and 96 hours before hospitalizations

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 68,032
  • In epidemiology: 2,997
• Year to date:
  • Site-wide: 40,449
• Since beginning of last month:
  • Site-wide: 86,386

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 68,543
  • In cancer biology: 1,990
• Year to date:
  • Site-wide: 120,871
• Since beginning of last month:
  • Site-wide: 51,354

Metaproteomic responses of in vitro gut microbiomes to resistant starches: the role of resistant starch type and inter-individual variations

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 70,575
  • In microbiology: 4,703
• Year to date:
  • Site-wide: 64,780
• Since beginning of last month:
  • Site-wide: 95,714

pepFunk, a tool for peptide-centric functional analysis in metaproteomic human gut microbiome studies

• Downloaded 438 times
• Download rankings, all-time:
  • Site-wide: 71,421
  • In bioinformatics: 6,730
• Year to date:
  • Site-wide: 48,574
• Since beginning of last month:
  • Site-wide: 16,073

In Vitro Potent Activity of ε-poly-L-lysine against Candida albicans and the Underlying Mechanisms

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 76,905
  • In microbiology: 5,168
• Year to date:
  • Site-wide: 108,432
• Since beginning of last month:
  • Site-wide: 40,241

Real-time environmental monitoring of contaminants using living electronic sensors

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 79,187
  • In synthetic biology: 886
• Year to date:
  • Site-wide: 12,766
• Since beginning of last month:
  • Site-wide: 4,525

De novo assembly of trachidermus fasciatus genome by nanopore sequencing

• Downloaded 382 times
• Download rankings, all-time:
  • Site-wide: 81,512
  • In genomics: 5,331
• Year to date:
  • Site-wide: 89,954
• Since beginning of last month:
  • Site-wide: 125,569

An in vitro model maintaining taxon-specific functional activities of the gut microbiome

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 81,708
  • In microbiology: 5,568
• Year to date:
  • Site-wide: 147,789
• Since beginning of last month:
  • Site-wide: None

Different Incidence of Acute Kidney Injury In Adult Patients Receiving Different types Extracorporeal Membrane Oxygenation: A Meta-Analysis

• Downloaded 373 times
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  • Site-wide: 83,266
  • In intensive care and critical care medicine: 194
• Year to date:
  • Site-wide: 54,606
• Since beginning of last month:
  • Site-wide: 41,641

Deep characterization of the protein lysine acetylation in human gut microbiome and its alterations in patients with Crohn's disease

• Downloaded 364 times
• Download rankings, all-time:
  • Site-wide: 85,094
  • In systems biology: 1,947
• Year to date:
  • Site-wide: 88,926
• Since beginning of last month:
  • Site-wide: 20,114

The draft genome of the endangered, relictual plant Kingdonia uniflora (Circaeasteraceae, Ranunculales) reveals potential mechanisms and perils of evolutionary specialization

• Downloaded 339 times
• Download rankings, all-time:
  • Site-wide: 90,138
  • In genomics: 5,686
• Year to date:
  • Site-wide: 107,689
• Since beginning of last month:
  • Site-wide: 39,072

CHRAC/ACF Contribute to the Repressive Ground State of Chromatin

• Downloaded 319 times
• Download rankings, all-time:
  • Site-wide: 94,614
  • In molecular biology: 2,770
• Year to date:
  • Site-wide: 144,132
• Since beginning of last month:
  • Site-wide: None

Studying the dynamics of the gut microbiota using metabolically stable isotopic labeling and metaproteomics.

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 96,763
  • In microbiology: 6,803
• Year to date:
  • Site-wide: 119,056
• Since beginning of last month:
  • Site-wide: 97,946

Proteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 96,798
  • In immunology: 2,866
• Year to date:
  • Site-wide: 47,058
• Since beginning of last month:
  • Site-wide: 47,515

Global proteome and phosphoproteome alterations in third generation EGFR TKI resistance reveal drug targets to circumvent resistance

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 100,937
  • In cancer biology: 3,054
• Year to date:
  • Site-wide: 60,455
• Since beginning of last month:
  • Site-wide: 117,312

Plastome phylogenomic study of Gentianeae (Gentianaceae): widespread gene tree discordance and its association with evolutionary rate heterogeneity of plastid genes

• Downloaded 249 times
• Download rankings, all-time:
  • Site-wide: 111,122
  • In evolutionary biology: 5,627
• Year to date:
  • Site-wide: 138,114
• Since beginning of last month:
  • Site-wide: 116,945

Identification of a new orthonairovirus associated with human febrile illness in China

• Downloaded 243 times
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  • Site-wide: 112,701
  • In microbiology: 8,157
• Year to date:
  • Site-wide: 52,746
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  • Site-wide: None

Revealing Protein-Level Functional Redundancy in the Human Gut Microbiome using Ultra-deep Metaproteomics

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 128,828
  • In systems biology: 2,783
• Year to date:
  • Site-wide: 36,850
• Since beginning of last month:
  • Site-wide: 3,649

Insights into the drivers of radiating diversification in biodiversity hotspots using Saussurea (Asteraceae) as a case

• Downloaded 164 times
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  • Site-wide: 132,057
  • In evolutionary biology: 6,537
• Year to date:
  • Site-wide: 40,606
• Since beginning of last month:
  • Site-wide: 115,365

Genomic characterization of a lumpy skin disease virus isolated in southeast China

• Downloaded 152 times
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  • Site-wide: 134,733
  • In genomics: 7,146
• Year to date:
  • Site-wide: 44,162
• Since beginning of last month:
  • Site-wide: 7,864

Parvalbumin interneurons in the nucleus accumbens regulate impairment of risk avoidance in DISC1 transgenic mice

• Downloaded 151 times
• Download rankings, all-time:
  • Site-wide: 135,090
  • In neuroscience: 20,362
• Year to date:
  • Site-wide: 91,749
• Since beginning of last month:
  • Site-wide: None

Exploring the microbiome-wide lysine acetylation, succinylation and propionylation in human gut microbiota

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 135,393
  • In microbiology: 10,198
• Year to date:
  • Site-wide: 75,460
• Since beginning of last month:
  • Site-wide: 28,780

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

• Downloaded 134 times
• Download rankings, all-time:
  • Site-wide: 138,715
  • In cancer biology: 4,270
• Year to date:
  • Site-wide: 50,593
• Since beginning of last month:
  • Site-wide: 35,807

Understanding of the 2-oxoglutarate dehydrogenase and 2-oxoadipate dehydrogenase assembly with the E2o core relevant to a hybrid complex formation

• Downloaded 115 times
• Download rankings, all-time:
  • Site-wide: 142,618
  • In biochemistry: 4,333
• Year to date:
  • Site-wide: 59,165
• Since beginning of last month:
  • Site-wide: 123,597

Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis

• Downloaded 102 times
• Download rankings, all-time:
  • Site-wide: 145,043
  • In systems biology: 3,047
• Year to date:
  • Site-wide: 65,811
• Since beginning of last month:
  • Site-wide: 128,136

MetaProClust-MS1: A tool for clustering metaproteomes using rapid MS1 profiling

• Downloaded 85 times
• Download rankings, all-time:
  • Site-wide: 147,692
  • In bioinformatics: 11,247
• Year to date:
  • Site-wide: 77,492
• Since beginning of last month:
  • Site-wide: 18,356

Examining the effects of an anti-Salmonella bacteriophage preparation, BAFASAL, on ex vivo human gut microbiome composition and function using a multi-omics approach

• Downloaded 80 times
• Download rankings, all-time:
  • Site-wide: 148,395
  • In microbiology: 11,412
• Year to date:
  • Site-wide: 81,223
• Since beginning of last month:
  • Site-wide: 126,941

Tropomyosin in mugwort cross-reacts to house dust mite, eliciting non-Th2 response in allergic rhinitis patients sensitized to house dust mite

• Downloaded 70 times
• Download rankings, all-time:
  • Site-wide: 149,624
  • In immunology: 4,508
• Year to date:
  • Site-wide: 143,682
• Since beginning of last month:
  • Site-wide: 47,461