Author: Lei Zhang

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Preprints

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

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  • Site-wide: 2 out of 100,737
  • In microbiology: 1 out of 8,937
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  • Site-wide: 2 out of 100,737
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  • Site-wide: 19 out of 100,737

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

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  • Site-wide: 120 out of 100,737
  • In microbiology: 37 out of 8,937
• Year to date:
  • Site-wide: 63 out of 100,737
• Since beginning of last month:
  • Site-wide: None out of 100,737

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 6,246 times
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  • Site-wide: 603 out of 100,737
  • In neuroscience: 57 out of 17,945
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  • Site-wide: 3,223 out of 100,737

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

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  • Site-wide: 856 out of 100,737
  • In pathology: 8 out of 585
• Year to date:
  • Site-wide: 272 out of 100,737
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  • Site-wide: 680 out of 100,737

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

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  • In genomics: 299 out of 6,246
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  • Site-wide: 381 out of 100,737
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  • Site-wide: 1,049 out of 100,737

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

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  • In biophysics: 58 out of 4,441
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  • Site-wide: 545 out of 100,737
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  • Site-wide: 2,367 out of 100,737

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

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  • In neuroscience: 523 out of 17,945
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  • Site-wide: 18,680 out of 100,737

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

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  • Site-wide: 4,794 out of 100,737
  • In neuroscience: 688 out of 17,945
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  • Site-wide: 11,615 out of 100,737
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  • Site-wide: 14,138 out of 100,737

TITER: predicting translation initiation sites by deep learning

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  • In bioinformatics: 967 out of 9,252
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  • Site-wide: 36,858 out of 100,737
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  • Site-wide: 32,206 out of 100,737

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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  • Site-wide: 6,778 out of 100,737
  • In neuroscience: 994 out of 17,945
• Year to date:
  • Site-wide: 18,567 out of 100,737
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  • Site-wide: 13,432 out of 100,737

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

• Downloaded 1,294 times
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  • Site-wide: 8,659 out of 100,737
  • In genomics: 1,272 out of 6,246
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  • Site-wide: 4,015 out of 100,737
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  • Site-wide: 7,616 out of 100,737

A brain network supporting social influences in human decision-making

• Downloaded 1,281 times
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  • Site-wide: 8,811 out of 100,737
  • In neuroscience: 1,332 out of 17,945
• Year to date:
  • Site-wide: 4,694 out of 100,737
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  • Site-wide: 13,150 out of 100,737

DeepHINT: Understanding HIV-1 integration via deep learning with attention

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  • Site-wide: 14,599 out of 100,737
  • In bioinformatics: 2,240 out of 9,252
• Year to date:
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  • Site-wide: 24,099 out of 100,737

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

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  • In bioinformatics: 3,000 out of 9,252
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  • Site-wide: 23,217 out of 100,737

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 707 times
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  • In neuroscience: 3,686 out of 17,945
• Year to date:
  • Site-wide: 29,328 out of 100,737
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  • Site-wide: None out of 100,737

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 681 times
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  • Site-wide: 23,870 out of 100,737
  • In genomics: 2,618 out of 6,246
• Year to date:
  • Site-wide: 8,220 out of 100,737
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  • Site-wide: 9,221 out of 100,737

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 654 times
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  • Site-wide: 25,286 out of 100,737
  • In biochemistry: 715 out of 3,442
• Year to date:
  • Site-wide: 10,186 out of 100,737
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  • Site-wide: 38,828 out of 100,737

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 600 times
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  • In systems biology: 794 out of 2,561
• Year to date:
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  • Site-wide: 22,609 out of 100,737

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

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  • In genomics: 3,084 out of 6,246
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  • Site-wide: 69,046 out of 100,737

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

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  • In bioinformatics: 4,027 out of 9,252
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  • Site-wide: 16,427 out of 100,737

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 552 times
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  • In immunology: 904 out of 3,135
• Year to date:
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  • Site-wide: 25,608 out of 100,737

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 508 times
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  • Site-wide: 35,187 out of 100,737
  • In neuroscience: 5,927 out of 17,945
• Year to date:
  • Site-wide: 14,319 out of 100,737
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  • Site-wide: 21,496 out of 100,737

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 487 times
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  • Site-wide: 37,035 out of 100,737
  • In genomics: 3,528 out of 6,246
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  • Site-wide: 9,907 out of 100,737

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 485 times
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  • In genomics: 3,535 out of 6,246
• Year to date:
  • Site-wide: 45,935 out of 100,737
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  • Site-wide: None out of 100,737

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

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  • In plant biology: 1,021 out of 3,182
• Year to date:
  • Site-wide: 61,320 out of 100,737
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  • Site-wide: 60,483 out of 100,737

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 443 times
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  • Site-wide: 41,454 out of 100,737
  • In genomics: 3,794 out of 6,246
• Year to date:
  • Site-wide: 95,367 out of 100,737
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  • Site-wide: 73,291 out of 100,737

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

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  • Site-wide: 42,000 out of 100,737
  • In cell biology: 2,078 out of 5,214
• Year to date:
  • Site-wide: 36,366 out of 100,737
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  • Site-wide: 52,875 out of 100,737

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 419 times
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  • Site-wide: 44,075 out of 100,737
  • In biophysics: 1,796 out of 4,441
• Year to date:
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  • Site-wide: 20,720 out of 100,737

Genome-wide association study of appendicular lean mass in UK Biobank cohort

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  • In genetics: 2,550 out of 5,016
• Year to date:
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  • Site-wide: 27,236 out of 100,737

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

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  • In genomics: 4,140 out of 6,246
• Year to date:
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  • Site-wide: 9,640 out of 100,737

Rational design of hepatitis C virus E2 core nanoparticle vaccines

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  • Site-wide: 48,871 out of 100,737
  • In microbiology: 3,539 out of 8,937
• Year to date:
  • Site-wide: 37,312 out of 100,737
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  • Site-wide: None out of 100,737

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

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  • In genomics: 4,212 out of 6,246
• Year to date:
  • Site-wide: 91,441 out of 100,737
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  • Site-wide: None out of 100,737

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 365 times
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  • Site-wide: 50,747 out of 100,737
  • In bioinformatics: 5,803 out of 9,252
• Year to date:
  • Site-wide: 11,685 out of 100,737
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  • Site-wide: 6,810 out of 100,737

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

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  • Site-wide: 51,105 out of 100,737
  • In biochemistry: 1,562 out of 3,442
• Year to date:
  • Site-wide: 45,239 out of 100,737
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  • Site-wide: 49,078 out of 100,737

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

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  • Site-wide: 51,351 out of 100,737
  • In microbiology: 3,753 out of 8,937
• Year to date:
  • Site-wide: 15,703 out of 100,737
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  • Site-wide: None out of 100,737

Characterization of fluorescent proteins with intramolecular photostabilization

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  • Site-wide: 54,059 out of 100,737
  • In biophysics: 2,297 out of 4,441
• Year to date:
  • Site-wide: 12,956 out of 100,737
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  • Site-wide: 13,409 out of 100,737

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 334 times
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  • Site-wide: 55,135 out of 100,737
  • In molecular biology: 1,829 out of 3,497
• Year to date:
  • Site-wide: 74,815 out of 100,737
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  • Site-wide: 51,187 out of 100,737

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

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  • Site-wide: 56,022 out of 100,737
  • In systems biology: 1,621 out of 2,561
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  • Site-wide: 22,002 out of 100,737
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  • Site-wide: 32,623 out of 100,737

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

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  • In genomics: 4,605 out of 6,246
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  • Site-wide: 18,111 out of 100,737

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 283 times
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  • In genetics: 3,411 out of 5,016
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  • Site-wide: 63,121 out of 100,737

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

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  • Site-wide: 68,147 out of 100,737
  • In cancer biology: 2,271 out of 3,609
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  • Site-wide: 11,999 out of 100,737

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

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  • Site-wide: 68,228 out of 100,737
  • In bioengineering: 1,437 out of 2,344
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  • Site-wide: 67,722 out of 100,737

Performance of bitumen coating sheet using biomass pyrolysis oil

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  • In bioengineering: 1,442 out of 2,344
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  • Site-wide: 73,886 out of 100,737

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

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  • Site-wide: 72,652 out of 100,737
  • In molecular biology: 2,452 out of 3,497
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  • Site-wide: 22,336 out of 100,737

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

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  • In systems biology: 2,205 out of 2,561
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  • Site-wide: 30,313 out of 100,737
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  • Site-wide: 49,925 out of 100,737

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

• Downloaded 186 times
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  • Site-wide: 80,005 out of 100,737
  • In genomics: 5,477 out of 6,246
• Year to date:
  • Site-wide: 30,474 out of 100,737
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  • Site-wide: None out of 100,737

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 178 times
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  • Site-wide: 81,260 out of 100,737
  • In bioinformatics: 8,010 out of 9,252
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  • Site-wide: 35,056 out of 100,737

CNSA: a data repository for archiving omics data

• Downloaded 161 times
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  • Site-wide: 84,068 out of 100,737
  • In genomics: 5,616 out of 6,246
• Year to date:
  • Site-wide: 36,375 out of 100,737
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  • Site-wide: 32,493 out of 100,737

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 147 times
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  • Site-wide: 86,292 out of 100,737
  • In microbiology: 7,151 out of 8,937
• Year to date:
  • Site-wide: 40,645 out of 100,737
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  • Site-wide: 17,658 out of 100,737

VirusDIP: Virus Data Integration Platform

• Downloaded 144 times
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  • Site-wide: 86,700 out of 100,737
  • In bioinformatics: 8,367 out of 9,252
• Year to date:
  • Site-wide: 41,483 out of 100,737
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  • Site-wide: 40,800 out of 100,737

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 99 times
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  • Site-wide: 92,439 out of 100,737
  • In neuroscience: 16,380 out of 17,945
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  • Site-wide: 13,014 out of 100,737

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

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  • Site-wide: 94,534 out of 100,737
  • In developmental biology: 2,883 out of 3,009
• Year to date:
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  • Site-wide: 7,407 out of 100,737

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

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  • Site-wide: 98,112 out of 100,737
  • In bioinformatics: 9,071 out of 9,252
• Year to date:
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  • Site-wide: 22,548 out of 100,737