Author: Lei Zhang

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Preprints

Cost-effectiveness of the second COVID-19 booster vaccination in the United States

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Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

• Downloaded 301,160 times
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  • Site-wide: 9
  • In microbiology: 1
• Year to date:
  • Site-wide: 336
• Since beginning of last month:
  • Site-wide: 283

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

• Downloaded 17,968 times
• Download rankings, all-time:
  • Site-wide: 648
  • In microbiology: 72
• Year to date:
  • Site-wide: 23,901
• Since beginning of last month:
  • Site-wide: 76,757

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

• Downloaded 7,630 times
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  • Site-wide: 1,963
  • In pathology: 16
• Year to date:
  • Site-wide: 37,730
• Since beginning of last month:
  • Site-wide: 17,208

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

• Downloaded 7,354 times
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  • Site-wide: 2,055
  • In genomics: 152
• Year to date:
  • Site-wide: 3,475
• Since beginning of last month:
  • Site-wide: 7,160

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 7,099 times
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  • Site-wide: 2,166
  • In neuroscience: 96
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 120,779

COVID-19 Myocarditis and Severity Factors： An Adult Cohort Study

• Downloaded 4,238 times
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  • Site-wide: 4,404
  • In infectious diseases: 961
• Year to date:
  • Site-wide: 36,902
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  • Site-wide: 15,062

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

• Downloaded 3,717 times
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  • Site-wide: 5,329
  • In biophysics: 79
• Year to date:
  • Site-wide: 19,907
• Since beginning of last month:
  • Site-wide: 24,363

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

• Downloaded 3,349 times
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  • Site-wide: 6,243
  • In bioinformatics: 580
• Year to date:
  • Site-wide: 17,279
• Since beginning of last month:
  • Site-wide: 24,579

Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route

• Downloaded 3,186 times
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  • Site-wide: 6,711
  • In infectious diseases: 1,265
• Year to date:
  • Site-wide: 28,655
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  • Site-wide: 38,679

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV

• Downloaded 3,164 times
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  • Site-wide: 6,782
  • In infectious diseases: 1,274
• Year to date:
  • Site-wide: 91,030
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  • Site-wide: 30,362

Lockdown may partially halt the spread of 2019 novel coronavirus in Hubei province, China

• Downloaded 2,850 times
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  • Site-wide: 7,836
  • In infectious diseases: 1,389
• Year to date:
  • Site-wide: 46,387
• Since beginning of last month:
  • Site-wide: 78,619

AN INTERACTIVE COVID-19 MOBILITY IMPACT AND SOCIAL DISTANCING ANALYSIS PLATFORM

• Downloaded 2,846 times
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  • Site-wide: 7,859
  • In infectious diseases: 1,390
• Year to date:
  • Site-wide: 80,015
• Since beginning of last month:
  • Site-wide: 81,792

Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

• Downloaded 2,823 times
• Download rankings, all-time:
  • Site-wide: 7,953
  • In infectious diseases: 1,399
• Year to date:
  • Site-wide: 47,428
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  • Site-wide: 86,023

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

• Downloaded 2,567 times
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  • Site-wide: 9,185
  • In neuroscience: 838
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  • Site-wide: None
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  • Site-wide: 118,001

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

• Downloaded 2,509 times
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  • Site-wide: 9,504
  • In neuroscience: 908
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  • Site-wide: None
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  • Site-wide: 117,691

Critical timing for triggering public health interventions to prevent COVID-19 resurgence: a mathematical modelling study

• Downloaded 2,190 times
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  • Site-wide: 11,723
  • In infectious diseases: 1,742
• Year to date:
  • Site-wide: 41,979
• Since beginning of last month:
  • Site-wide: 112,484

What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

• Downloaded 2,124 times
• Download rankings, all-time:
  • Site-wide: 12,261
  • In infectious diseases: 1,788
• Year to date:
  • Site-wide: 154,854
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  • Site-wide: 129,633

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

• Downloaded 2,064 times
• Download rankings, all-time:
  • Site-wide: 12,792
  • In genomics: 1,172
• Year to date:
  • Site-wide: 61,110
• Since beginning of last month:
  • Site-wide: 14,949

TITER: predicting translation initiation sites by deep learning

• Downloaded 2,018 times
• Download rankings, all-time:
  • Site-wide: 13,242
  • In bioinformatics: 1,420
• Year to date:
  • Site-wide: 114,633
• Since beginning of last month:
  • Site-wide: 118,882

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

• Downloaded 2,013 times
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  • Site-wide: 13,298
  • In microbiology: 788
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 24,335

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

• Downloaded 2,005 times
• Download rankings, all-time:
  • Site-wide: 13,381
  • In neuroscience: 1,359
• Year to date:
  • Site-wide: 60,874
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  • Site-wide: 51,998

The first sheep graph-based pan-genome reveals the spectrum of structural variations and their effects on tail phenotypes

• Downloaded 1,913 times
• Download rankings, all-time:
  • Site-wide: 14,379
  • In genomics: 1,364
• Year to date:
  • Site-wide: 2,799
• Since beginning of last month:
  • Site-wide: 6,677

A brain network supporting social influences in human decision-making

• Downloaded 1,681 times
• Download rankings, all-time:
  • Site-wide: 17,580
  • In neuroscience: 1,933
• Year to date:
  • Site-wide: 137,619
• Since beginning of last month:
  • Site-wide: 144,729

DeepHINT: Understanding HIV-1 integration via deep learning with attention

• Downloaded 1,363 times
• Download rankings, all-time:
  • Site-wide: 24,572
  • In bioinformatics: 2,837
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 94,049

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 1,251 times
• Download rankings, all-time:
  • Site-wide: 28,189
  • In genomics: 2,388
• Year to date:
  • Site-wide: 95,286
• Since beginning of last month:
  • Site-wide: 104,227

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

• Downloaded 1,113 times
• Download rankings, all-time:
  • Site-wide: 33,816
  • In molecular biology: 929
• Year to date:
  • Site-wide: 22,551
• Since beginning of last month:
  • Site-wide: 29,274

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 1,039 times
• Download rankings, all-time:
  • Site-wide: 37,583
  • In neuroscience: 4,800
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 199,334

Development and clinical application of a rapid and sensitive loop-mediated isothermalamplification test for SARS-CoV-2 infection

• Downloaded 1,033 times
• Download rankings, all-time:
  • Site-wide: 37,943
  • In infectious diseases: 3,245
• Year to date:
  • Site-wide: 156,030
• Since beginning of last month:
  • Site-wide: 82,093

DAISM-DNNXMBD: Highly accurate cell type proportion estimation with in silico data augmentation and deep neural networks

• Downloaded 994 times
• Download rankings, all-time:
  • Site-wide: 40,270
  • In bioinformatics: 4,196
• Year to date:
  • Site-wide: 48,715
• Since beginning of last month:
  • Site-wide: 121,601

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 989 times
• Download rankings, all-time:
  • Site-wide: 40,602
  • In biochemistry: 1,005
• Year to date:
  • Site-wide: 61,861
• Since beginning of last month:
  • Site-wide: 120,947

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

• Downloaded 931 times
• Download rankings, all-time:
  • Site-wide: 44,519
  • In bioinformatics: 4,579
• Year to date:
  • Site-wide: 80,466
• Since beginning of last month:
  • Site-wide: 192,491

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 926 times
• Download rankings, all-time:
  • Site-wide: 44,893
  • In biophysics: 1,410
• Year to date:
  • Site-wide: 28,192
• Since beginning of last month:
  • Site-wide: 101,972

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 902 times
• Download rankings, all-time:
  • Site-wide: 46,761
  • In neuroscience: 6,133
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 210,981

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 897 times
• Download rankings, all-time:
  • Site-wide: 47,126
  • In bioinformatics: 4,756
• Year to date:
  • Site-wide: 160,108
• Since beginning of last month:
  • Site-wide: 121,658

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 888 times
• Download rankings, all-time:
  • Site-wide: 47,957
  • In bioinformatics: 4,858
• Year to date:
  • Site-wide: 61,145
• Since beginning of last month:
  • Site-wide: 200,116

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 886 times
• Download rankings, all-time:
  • Site-wide: 48,091
  • In neuroscience: 6,600
• Year to date:
  • Site-wide: 48,760
• Since beginning of last month:
  • Site-wide: 24,619

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 864 times
• Download rankings, all-time:
  • Site-wide: 49,989
  • In systems biology: 991
• Year to date:
  • Site-wide: 70,107
• Since beginning of last month:
  • Site-wide: 118,987

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

• Downloaded 849 times
• Download rankings, all-time:
  • Site-wide: 51,298
  • In genomics: 3,777
• Year to date:
  • Site-wide: 122,118
• Since beginning of last month:
  • Site-wide: 53,812

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

• Downloaded 844 times
• Download rankings, all-time:
  • Site-wide: 51,827
  • In genomics: 3,812
• Year to date:
  • Site-wide: 27,990
• Since beginning of last month:
  • Site-wide: 102,032

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

• Downloaded 838 times
• Download rankings, all-time:
  • Site-wide: 52,339
  • In cancer biology: 1,525
• Year to date:
  • Site-wide: 88,382
• Since beginning of last month:
  • Site-wide: 52,988

Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

• Downloaded 805 times
• Download rankings, all-time:
  • Site-wide: 55,530
  • In developmental biology: 1,276
• Year to date:
  • Site-wide: 54,426
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  • Site-wide: 55,343

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 60,343
  • In genomics: 4,247
• Year to date:
  • Site-wide: 73,672
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  • Site-wide: 146,793

Characterization of fluorescent proteins with intramolecular photostabilization

• Downloaded 749 times
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  • Site-wide: 61,842
  • In biophysics: 2,038
• Year to date:
  • Site-wide: 161,298
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  • Site-wide: 186,274

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

• Downloaded 727 times
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  • Site-wide: 64,634
  • In cell biology: 2,831
• Year to date:
  • Site-wide: 62,312
• Since beginning of last month:
  • Site-wide: 154,166

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 723 times
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  • Site-wide: 65,116
  • In immunology: 2,167
• Year to date:
  • Site-wide: 91,504
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  • Site-wide: 81,001

The impact of containment measures and air temperature on mitigating the transmission of COVID-19: a novel data-based comprehensive modeling analysis

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 69,683
  • In public and global health: 1,185
• Year to date:
  • Site-wide: 90,959
• Since beginning of last month:
  • Site-wide: 81,680

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 671 times
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  • Site-wide: 72,204
  • In genomics: 4,814
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  • Site-wide: None
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  • Site-wide: 180,912

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

• Downloaded 666 times
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  • Site-wide: 72,951
  • In neuroscience: 10,684
• Year to date:
  • Site-wide: 104,447
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  • Site-wide: 9,537

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 649 times
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  • Site-wide: 75,614
  • In microbiology: 4,924
• Year to date:
  • Site-wide: 81,477
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  • Site-wide: 18,555

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 645 times
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  • Site-wide: 76,249
  • In oncology: 154
• Year to date:
  • Site-wide: 88,994
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  • Site-wide: 137,458

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

• Downloaded 643 times
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  • Site-wide: 76,626
  • In plant biology: 1,854
• Year to date:
  • Site-wide: 139,176
• Since beginning of last month:
  • Site-wide: 117,572

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 77,967
  • In genomics: 5,104
• Year to date:
  • Site-wide: 153,975
• Since beginning of last month:
  • Site-wide: 121,751

Genome-wide association study of appendicular lean mass in UK Biobank cohort

• Downloaded 621 times
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  • Site-wide: 80,117
  • In genetics: 3,085
• Year to date:
  • Site-wide: 138,747
• Since beginning of last month:
  • Site-wide: 89,186

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

• Downloaded 599 times
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  • Site-wide: 83,766
  • In biochemistry: 2,324
• Year to date:
  • Site-wide: 63,029
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  • Site-wide: 204,112

Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

• Downloaded 598 times
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  • Site-wide: 83,946
  • In systems biology: 1,726
• Year to date:
  • Site-wide: 162,260
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  • Site-wide: 86,307

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 598 times
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  • Site-wide: 84,037
  • In molecular biology: 2,473
• Year to date:
  • Site-wide: 23,334
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  • Site-wide: 146,464

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

• Downloaded 590 times
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  • Site-wide: 85,459
  • In systems biology: 1,753
• Year to date:
  • Site-wide: 113,562
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  • Site-wide: 120,960

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 579 times
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  • Site-wide: 87,562
  • In genomics: 5,558
• Year to date:
  • Site-wide: 94,430
• Since beginning of last month:
  • Site-wide: 154,366

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 88,008
  • In immunology: 2,923
• Year to date:
  • Site-wide: 16,637
• Since beginning of last month:
  • Site-wide: 170,454

Rational design of hepatitis C virus E2 core nanoparticle vaccines

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 90,044
  • In microbiology: 5,706
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 199,576

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 526 times
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  • Site-wide: 98,419
  • In genomics: 5,972
• Year to date:
  • Site-wide: 167,511
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  • Site-wide: 180,923

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 98,337
  • In systems biology: 2,067
• Year to date:
  • Site-wide: 64,116
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  • Site-wide: 163,453

Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

• Downloaded 520 times
• Download rankings, all-time:
  • Site-wide: 99,569
  • In infectious diseases: 5,380
• Year to date:
  • Site-wide: 125,954
• Since beginning of last month:
  • Site-wide: 172,232

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

• Downloaded 503 times
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  • Site-wide: 103,529
  • In molecular biology: 3,076
• Year to date:
  • Site-wide: 23,827
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  • Site-wide: 192,342

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

• Downloaded 481 times
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  • Site-wide: 108,677
  • In infectious diseases: 5,693
• Year to date:
  • Site-wide: 125,610
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  • Site-wide: 94,571

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 467 times
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  • Site-wide: 112,054
  • In genetics: 4,231
• Year to date:
  • Site-wide: 93,196
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  • Site-wide: 209,624

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 466 times
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  • Site-wide: 112,360
  • In bioinformatics: 9,542
• Year to date:
  • Site-wide: 156,397
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  • Site-wide: 78,210

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

• Downloaded 451 times
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  • Site-wide: 116,109
  • In genomics: 6,680
• Year to date:
  • Site-wide: 83,982
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  • Site-wide: 190,298

Performance of bitumen coating sheet using biomass pyrolysis oil

• Downloaded 444 times
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  • Site-wide: 118,050
  • In bioengineering: 2,373
• Year to date:
  • Site-wide: 168,318
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  • Site-wide: 145,861

Network design principle for robust oscillatory behaviors with respect to biological noise

• Downloaded 407 times
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  • Site-wide: 127,958
  • In systems biology: 2,605
• Year to date:
  • Site-wide: 54,754
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  • Site-wide: 169,583

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 128,044
  • In microbiology: 8,772
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 112,325

CNSA: a data repository for archiving omics data

• Downloaded 398 times
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  • Site-wide: 130,597
  • In genomics: 7,189
• Year to date:
  • Site-wide: 81,103
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  • Site-wide: 192,688

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

• Downloaded 378 times
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  • Site-wide: 136,572
  • In bioengineering: 2,822
• Year to date:
  • Site-wide: 70,093
• Since beginning of last month:
  • Site-wide: 142,667

VirusDIP: Virus Data Integration Platform

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 145,090
  • In bioinformatics: 11,491
• Year to date:
  • Site-wide: 83,248
• Since beginning of last month:
  • Site-wide: 122,467

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

• Downloaded 346 times
• Download rankings, all-time:
  • Site-wide: 145,944
  • In plant biology: 4,009
• Year to date:
  • Site-wide: 106,070
• Since beginning of last month:
  • Site-wide: 57,143

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 341 times
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  • Site-wide: 147,591
  • In developmental biology: 3,922
• Year to date:
  • Site-wide: 148,238
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  • Site-wide: 64,969

Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

• Downloaded 334 times
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  • Site-wide: 149,932
  • In evolutionary biology: 6,865
• Year to date:
  • Site-wide: 75,181
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  • Site-wide: 25,890

mRNA-based COVID-19 booster vaccination is highly effective and cost-effective in Australia

• Downloaded 321 times
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  • Site-wide: 153,535
  • In infectious diseases: 7,038
• Year to date:
  • Site-wide: 101,571
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  • Site-wide: 47,950

Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study

• Downloaded 310 times
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  • Site-wide: 157,016
  • In microbiology: 11,034
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  • Site-wide: None
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  • Site-wide: 108,568

Efficient identification of trait-associated loss-of-function variants in the UK Biobank cohort by exome-sequencing based genotype imputation

• Downloaded 303 times
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  • Site-wide: 159,066
  • In genetics: 5,943
• Year to date:
  • Site-wide: 60,038
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  • Site-wide: 98,571

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 258 times
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  • Site-wide: 172,391
  • In genetics: 6,291
• Year to date:
  • Site-wide: 67,064
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  • Site-wide: 163,762

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

• Downloaded 250 times
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  • Site-wide: 174,654
  • In plant biology: 4,846
• Year to date:
  • Site-wide: 185,053
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  • Site-wide: 163,589

Membrane Env liposomes for immunization with HIV spikes

• Downloaded 233 times
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  • Site-wide: 179,284
  • In immunology: 5,678
• Year to date:
  • Site-wide: 151,514
• Since beginning of last month:
  • Site-wide: 173,104

Trans-Driver: a deep learning approach for cancer driver gene discovery with multi-omics data

• Downloaded 231 times
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  • Site-wide: 179,695
  • In bioinformatics: 13,027
• Year to date:
  • Site-wide: None
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  • Site-wide: None

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 230 times
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  • Site-wide: 179,902
  • In physiology: 2,068
• Year to date:
  • Site-wide: 124,046
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  • Site-wide: 124,529

Lip movements enhance speech representations and effective connectivity in speech dorsal stream and its relationship with neurite architecture

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 185,326
  • In neuroscience: 27,054
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 135,082

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

• Downloaded 124 times
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  • Site-wide: 203,148
  • In bioengineering: 4,403
• Year to date:
  • Site-wide: 174,709
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  • Site-wide: 166,953

Network-based hub biomarker discovery for glaucoma

• Downloaded 124 times
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  • Site-wide: 203,193
  • In bioinformatics: 14,896
• Year to date:
  • Site-wide: 129,513
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  • Site-wide: 31,577

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

• Downloaded 116 times
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  • Site-wide: 204,573
  • In pharmacology and toxicology: 1,763
• Year to date:
  • Site-wide: 98,543
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  • Site-wide: 87,349

Effect of TSS on anti-CVB3 through TLR3 pathway

• Downloaded 109 times
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  • Site-wide: 205,785
  • In pharmacology and toxicology: 1,768
• Year to date:
  • Site-wide: 178,278
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  • Site-wide: 68,303

Global genomic analysis reveals the genetic origin and secondary invasion of fall armyworm in the Eastern hemisphere

• Downloaded 103 times
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  • Site-wide: 206,996
  • In molecular biology: 6,362
• Year to date:
  • Site-wide: 51,843
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  • Site-wide: 34,676

The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2

• Downloaded 100 times
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  • Site-wide: 207,439
  • In cell biology: 9,570
• Year to date:
  • Site-wide: 24,883
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  • Site-wide: 15,446

Identification of Causal Pathways among Gut Microbiota, Food Intake and Telomere Length: A Mendelian Randomization Study

• Downloaded 86 times
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  • Site-wide: 209,986
  • In epidemiology: 8,173
• Year to date:
  • Site-wide: 69,476
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  • Site-wide: 66,644

Cost-effectiveness of testing for Mycoplasma genitalium among men who have sex with men in Australia

• Downloaded 80 times
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  • Site-wide: 211,120
  • In infectious diseases: 8,562
• Year to date:
  • Site-wide: 186,824
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  • Site-wide: 140,635

Musical expertise enhances neural alignment-to-young in sensorimotor regions that predicts older adults' audiovisual speech-in-noise perception

• Downloaded 77 times
• Download rankings, all-time:
  • Site-wide: 211,775
  • In neuroscience: 30,543
• Year to date:
  • Site-wide: 187,447
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  • Site-wide: 66,687

Metabolic signature of the ganglion cell inner plexiform layer thickness and the risks of mortality and morbidity: a population-based study in UK Biobank

• Downloaded 54 times
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  • Site-wide: 215,392
  • In epidemiology: 8,304
• Year to date:
  • Site-wide: 129,630
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  • Site-wide: 167,378

A single-cell atlas depicting the cellular and molecular features in human ligamental degeneration: a single cell combined spatial transcriptomics study

• Downloaded 23 times
• Download rankings, all-time:
  • Site-wide: 217,205
  • In sports medicine: None
• Year to date:
  • Site-wide: 8,867
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  • Site-wide: None