Author: Lei Zhang

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Preprints

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

• Downloaded 291,820 times
• Download rankings, all-time:
  • Site-wide: 8
  • In microbiology: 1
• Year to date:
  • Site-wide: 238
• Since beginning of last month:
  • Site-wide: 246

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

• Downloaded 17,648 times
• Download rankings, all-time:
  • Site-wide: 504
  • In microbiology: 59
• Year to date:
  • Site-wide: 10,147
• Since beginning of last month:
  • Site-wide: 15,282

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

• Downloaded 6,909 times
• Download rankings, all-time:
  • Site-wide: 1,656
  • In pathology: 12
• Year to date:
  • Site-wide: 2,723
• Since beginning of last month:
  • Site-wide: 5,866

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 6,825 times
• Download rankings, all-time:
  • Site-wide: 1,686
  • In neuroscience: 78
• Year to date:
  • Site-wide: 17,319
• Since beginning of last month:
  • Site-wide: 35,482

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

• Downloaded 5,998 times
• Download rankings, all-time:
  • Site-wide: 2,015
  • In genomics: 163
• Year to date:
  • Site-wide: 1,881
• Since beginning of last month:
  • Site-wide: 2,568

COVID-19 Myocarditis and Severity Factors： An Adult Cohort Study

• Downloaded 3,738 times
• Download rankings, all-time:
  • Site-wide: 3,863
  • In infectious diseases: 808
• Year to date:
  • Site-wide: 5,009
• Since beginning of last month:
  • Site-wide: 12,701

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

• Downloaded 3,307 times
• Download rankings, all-time:
  • Site-wide: 4,584
  • In biophysics: 69
• Year to date:
  • Site-wide: 22,388
• Since beginning of last month:
  • Site-wide: 38,344

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV

• Downloaded 2,948 times
• Download rankings, all-time:
  • Site-wide: 5,388
  • In infectious diseases: 1,005
• Year to date:
  • Site-wide: 49,332
• Since beginning of last month:
  • Site-wide: 38,810

Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route

• Downloaded 2,912 times
• Download rankings, all-time:
  • Site-wide: 5,512
  • In infectious diseases: 1,016
• Year to date:
  • Site-wide: 3,576
• Since beginning of last month:
  • Site-wide: 52,504

Lockdown may partially halt the spread of 2019 novel coronavirus in Hubei province, China

• Downloaded 2,702 times
• Download rankings, all-time:
  • Site-wide: 6,126
  • In infectious diseases: 1,077
• Year to date:
  • Site-wide: 41,416
• Since beginning of last month:
  • Site-wide: 55,699

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

• Downloaded 2,700 times
• Download rankings, all-time:
  • Site-wide: 6,130
  • In bioinformatics: 616
• Year to date:
  • Site-wide: 2,009
• Since beginning of last month:
  • Site-wide: 4,413

AN INTERACTIVE COVID-19 MOBILITY IMPACT AND SOCIAL DISTANCING ANALYSIS PLATFORM

• Downloaded 2,467 times
• Download rankings, all-time:
  • Site-wide: 7,019
  • In infectious diseases: 1,159
• Year to date:
  • Site-wide: 5,254
• Since beginning of last month:
  • Site-wide: 12,236

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

• Downloaded 2,394 times
• Download rankings, all-time:
  • Site-wide: 7,320
  • In neuroscience: 671
• Year to date:
  • Site-wide: 42,375
• Since beginning of last month:
  • Site-wide: 50,231

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

• Downloaded 2,161 times
• Download rankings, all-time:
  • Site-wide: 8,501
  • In neuroscience: 815
• Year to date:
  • Site-wide: 34,430
• Since beginning of last month:
  • Site-wide: 40,857

Critical timing for triggering public health interventions to prevent COVID-19 resurgence: a mathematical modelling study

• Downloaded 2,028 times
• Download rankings, all-time:
  • Site-wide: 9,305
  • In infectious diseases: 1,378
• Year to date:
  • Site-wide: 1,696
• Since beginning of last month:
  • Site-wide: 31,311

What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

• Downloaded 2,000 times
• Download rankings, all-time:
  • Site-wide: 9,491
  • In infectious diseases: 1,394
• Year to date:
  • Site-wide: 74,567
• Since beginning of last month:
  • Site-wide: 66,084

TITER: predicting translation initiation sites by deep learning

• Downloaded 1,846 times
• Download rankings, all-time:
  • Site-wide: 10,710
  • In bioinformatics: 1,214
• Year to date:
  • Site-wide: 73,509
• Since beginning of last month:
  • Site-wide: 127,052

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

• Downloaded 1,765 times
• Download rankings, all-time:
  • Site-wide: 11,445
  • In neuroscience: 1,171
• Year to date:
  • Site-wide: 44,591
• Since beginning of last month:
  • Site-wide: 56,430

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

• Downloaded 1,708 times
• Download rankings, all-time:
  • Site-wide: 11,992
  • In genomics: 1,203
• Year to date:
  • Site-wide: 24,575
• Since beginning of last month:
  • Site-wide: 30,279

A brain network supporting social influences in human decision-making

• Downloaded 1,502 times
• Download rankings, all-time:
  • Site-wide: 14,546
  • In neuroscience: 1,592
• Year to date:
  • Site-wide: 59,508
• Since beginning of last month:
  • Site-wide: 53,154

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

• Downloaded 1,429 times
• Download rankings, all-time:
  • Site-wide: 15,702
  • In microbiology: 919
• Year to date:
  • Site-wide: 6,635
• Since beginning of last month:
  • Site-wide: 20,436

Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

• Downloaded 1,204 times
• Download rankings, all-time:
  • Site-wide: 20,285
  • In infectious diseases: 2,020
• Year to date:
  • Site-wide: 10,190
• Since beginning of last month:
  • Site-wide: 6,364

DeepHINT: Understanding HIV-1 integration via deep learning with attention

• Downloaded 1,135 times
• Download rankings, all-time:
  • Site-wide: 22,147
  • In bioinformatics: 2,511
• Year to date:
  • Site-wide: 57,202
• Since beginning of last month:
  • Site-wide: 52,799

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 1,051 times
• Download rankings, all-time:
  • Site-wide: 24,882
  • In genomics: 2,292
• Year to date:
  • Site-wide: 27,149
• Since beginning of last month:
  • Site-wide: 36,888

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 911 times
• Download rankings, all-time:
  • Site-wide: 30,566
  • In neuroscience: 3,927
• Year to date:
  • Site-wide: 79,618
• Since beginning of last month:
  • Site-wide: 126,347

Development and clinical application of a rapid and sensitive loop-mediated isothermalamplification test for SARS-CoV-2 infection

• Downloaded 848 times
• Download rankings, all-time:
  • Site-wide: 33,884
  • In infectious diseases: 2,658
• Year to date:
  • Site-wide: 55,764
• Since beginning of last month:
  • Site-wide: 42,497

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 843 times
• Download rankings, all-time:
  • Site-wide: 34,135
  • In biochemistry: 834
• Year to date:
  • Site-wide: 56,272
• Since beginning of last month:
  • Site-wide: 70,874

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 823 times
• Download rankings, all-time:
  • Site-wide: 35,352
  • In bioinformatics: 3,827
• Year to date:
  • Site-wide: 146,064
• Since beginning of last month:
  • Site-wide: 153,740

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

• Downloaded 820 times
• Download rankings, all-time:
  • Site-wide: 35,550
  • In bioinformatics: 3,846
• Year to date:
  • Site-wide: 53,283
• Since beginning of last month:
  • Site-wide: 123,786

DAISM-DNNXMBD: Highly accurate cell type proportion estimation with in silico data augmentation and deep neural networks

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 38,774
  • In bioinformatics: 4,150
• Year to date:
  • Site-wide: 20,227
• Since beginning of last month:
  • Site-wide: 22,052

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 738 times
• Download rankings, all-time:
  • Site-wide: 41,166
  • In neuroscience: 5,577
• Year to date:
  • Site-wide: 52,719
• Since beginning of last month:
  • Site-wide: 55,490

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 42,319
  • In systems biology: 906
• Year to date:
  • Site-wide: 92,835
• Since beginning of last month:
  • Site-wide: 113,210

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 43,313
  • In bioinformatics: 4,565
• Year to date:
  • Site-wide: 30,419
• Since beginning of last month:
  • Site-wide: 38,706

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

• Downloaded 666 times
• Download rankings, all-time:
  • Site-wide: 47,327
  • In genomics: 3,681
• Year to date:
  • Site-wide: 38,763
• Since beginning of last month:
  • Site-wide: 51,774

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 661 times
• Download rankings, all-time:
  • Site-wide: 47,794
  • In genomics: 3,706
• Year to date:
  • Site-wide: 89,533
• Since beginning of last month:
  • Site-wide: 121,009

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 48,684
  • In biophysics: 1,592
• Year to date:
  • Site-wide: 52,364
• Since beginning of last month:
  • Site-wide: 38,295

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 649 times
• Download rankings, all-time:
  • Site-wide: 48,947
  • In immunology: 1,523
• Year to date:
  • Site-wide: 108,829
• Since beginning of last month:
  • Site-wide: 146,021

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 51,879
  • In genomics: 3,922
• Year to date:
  • Site-wide: 148,447
• Since beginning of last month:
  • Site-wide: 140,221

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 53,175
  • In cancer biology: 1,531
• Year to date:
  • Site-wide: 25,906
• Since beginning of last month:
  • Site-wide: 31,598

Characterization of fluorescent proteins with intramolecular photostabilization

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 53,672
  • In biophysics: 1,773
• Year to date:
  • Site-wide: 42,876
• Since beginning of last month:
  • Site-wide: 30,317

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

• Downloaded 590 times
• Download rankings, all-time:
  • Site-wide: 55,311
  • In cell biology: 2,422
• Year to date:
  • Site-wide: 74,486
• Since beginning of last month:
  • Site-wide: 114,443

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 577 times
• Download rankings, all-time:
  • Site-wide: 56,975
  • In genomics: 4,211
• Year to date:
  • Site-wide: 126,845
• Since beginning of last month:
  • Site-wide: 146,070

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 58,664
  • In genomics: 4,308
• Year to date:
  • Site-wide: 41,472
• Since beginning of last month:
  • Site-wide: 27,439

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 58,590
  • In plant biology: 1,390
• Year to date:
  • Site-wide: 125,513
• Since beginning of last month:
  • Site-wide: 130,462

The impact of containment measures and air temperature on mitigating the transmission of COVID-19: a novel data-based comprehensive modeling analysis

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 59,025
  • In public and global health: 891
• Year to date:
  • Site-wide: 78,745
• Since beginning of last month:
  • Site-wide: 62,415

Rational design of hepatitis C virus E2 core nanoparticle vaccines

• Downloaded 512 times
• Download rankings, all-time:
  • Site-wide: 65,531
  • In microbiology: 4,232
• Year to date:
  • Site-wide: 119,810
• Since beginning of last month:
  • Site-wide: 126,263

Genome-wide association study of appendicular lean mass in UK Biobank cohort

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 66,862
  • In genetics: 2,882
• Year to date:
  • Site-wide: 106,660
• Since beginning of last month:
  • Site-wide: 72,139

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 67,723
  • In genomics: 4,744
• Year to date:
  • Site-wide: 141,785
• Since beginning of last month:
  • Site-wide: 112,422

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 498 times
• Download rankings, all-time:
  • Site-wide: 67,666
  • In oncology: 102
• Year to date:
  • Site-wide: 65,906
• Since beginning of last month:
  • Site-wide: 80,466

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 69,489
  • In neuroscience: 10,102
• Year to date:
  • Site-wide: 25,878
• Since beginning of last month:
  • Site-wide: 31,564

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 70,843
  • In biochemistry: 1,921
• Year to date:
  • Site-wide: 92,786
• Since beginning of last month:
  • Site-wide: 90,728

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 73,433
  • In systems biology: 1,672
• Year to date:
  • Site-wide: 78,857
• Since beginning of last month:
  • Site-wide: 88,976

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 73,594
  • In molecular biology: 2,136
• Year to date:
  • Site-wide: 91,831
• Since beginning of last month:
  • Site-wide: 42,796

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 446 times
• Download rankings, all-time:
  • Site-wide: 76,244
  • In genomics: 5,107
• Year to date:
  • Site-wide: 144,076
• Since beginning of last month:
  • Site-wide: 127,165

Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

• Downloaded 445 times
• Download rankings, all-time:
  • Site-wide: 76,408
  • In infectious diseases: 3,946
• Year to date:
  • Site-wide: 70,935
• Since beginning of last month:
  • Site-wide: 99,251

Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 78,843
  • In systems biology: 1,780
• Year to date:
  • Site-wide: 15,982
• Since beginning of last month:
  • Site-wide: 19,596

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

• Downloaded 391 times
• Download rankings, all-time:
  • Site-wide: 86,907
  • In molecular biology: 2,567
• Year to date:
  • Site-wide: 72,251
• Since beginning of last month:
  • Site-wide: 116,424

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 90,173
  • In genetics: 3,834
• Year to date:
  • Site-wide: 111,214
• Since beginning of last month:
  • Site-wide: 139,090

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 93,858
  • In infectious diseases: 4,423
• Year to date:
  • Site-wide: 44,039
• Since beginning of last month:
  • Site-wide: 36,259

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 94,046
  • In genomics: 5,843
• Year to date:
  • Site-wide: 71,414
• Since beginning of last month:
  • Site-wide: 76,542

Performance of bitumen coating sheet using biomass pyrolysis oil

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 97,455
  • In bioengineering: 1,879
• Year to date:
  • Site-wide: 111,118
• Since beginning of last month:
  • Site-wide: 59,709

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 97,906
  • In bioinformatics: 8,473
• Year to date:
  • Site-wide: 69,338
• Since beginning of last month:
  • Site-wide: 75,775

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 98,672
  • In microbiology: 6,876
• Year to date:
  • Site-wide: 61,536
• Since beginning of last month:
  • Site-wide: 58,517

CNSA: a data repository for archiving omics data

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 106,586
  • In genomics: 6,299
• Year to date:
  • Site-wide: 79,957
• Since beginning of last month:
  • Site-wide: 81,799

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 107,169
  • In bioengineering: 2,087
• Year to date:
  • Site-wide: 150,581
• Since beginning of last month:
  • Site-wide: 136,771

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

• Downloaded 280 times
• Download rankings, all-time:
  • Site-wide: 112,956
  • In systems biology: 2,475
• Year to date:
  • Site-wide: 111,753
• Since beginning of last month:
  • Site-wide: 100,866

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 113,585
  • In microbiology: 8,127
• Year to date:
  • Site-wide: 56,090
• Since beginning of last month:
  • Site-wide: 99,086

VirusDIP: Virus Data Integration Platform

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 118,855
  • In bioinformatics: 9,708
• Year to date:
  • Site-wide: 99,414
• Since beginning of last month:
  • Site-wide: 71,515

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 120,442
  • In developmental biology: 3,282
• Year to date:
  • Site-wide: 107,655
• Since beginning of last month:
  • Site-wide: 65,334

Efficient identification of trait-associated loss-of-function variants in the UK Biobank cohort by exome-sequencing based genotype imputation

• Downloaded 202 times
• Download rankings, all-time:
  • Site-wide: 133,116
  • In genetics: 5,359
• Year to date:
  • Site-wide: 44,804
• Since beginning of last month:
  • Site-wide: 19,191

Membrane Env liposomes for immunization with HIV spikes

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 143,632
  • In immunology: 4,326
• Year to date:
  • Site-wide: 101,142
• Since beginning of last month:
  • Site-wide: 130,834

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 157 times
• Download rankings, all-time:
  • Site-wide: 143,881
  • In genetics: 5,684
• Year to date:
  • Site-wide: 100,409
• Since beginning of last month:
  • Site-wide: 70,435

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 149 times
• Download rankings, all-time:
  • Site-wide: 145,474
  • In physiology: 1,694
• Year to date:
  • Site-wide: 122,553
• Since beginning of last month:
  • Site-wide: 132,875

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

• Downloaded 147 times
• Download rankings, all-time:
  • Site-wide: 145,930
  • In plant biology: 4,104
• Year to date:
  • Site-wide: 105,693
• Since beginning of last month:
  • Site-wide: 93,566

Lip movements enhance speech representations and effective connectivity in speech dorsal stream and its relationship with neurite architecture

• Downloaded 107 times
• Download rankings, all-time:
  • Site-wide: 153,549
  • In neuroscience: 22,831
• Year to date:
  • Site-wide: 85,069
• Since beginning of last month:
  • Site-wide: 11,317

Regulation of drought tolerance in Arabidopsis involves PLATZ4-mediated transcriptional suppression of PIP2;8

• Downloaded 58 times
• Download rankings, all-time:
  • Site-wide: 159,115
  • In plant biology: 4,498
• Year to date:
  • Site-wide: 129,332
• Since beginning of last month:
  • Site-wide: 25,469