Author: Lei Zhang

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Preprints

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

• Downloaded 284,122 times
• Download rankings, all-time:
  • Site-wide: 7
  • In microbiology: 1
• Year to date:
  • Site-wide: 231
• Since beginning of last month:
  • Site-wide: 345

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

• Downloaded 17,300 times
• Download rankings, all-time:
  • Site-wide: 390
  • In microbiology: 44
• Year to date:
  • Site-wide: 8,508
• Since beginning of last month:
  • Site-wide: 13,020

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 6,602 times
• Download rankings, all-time:
  • Site-wide: 1,355
  • In neuroscience: 64
• Year to date:
  • Site-wide: 11,970
• Since beginning of last month:
  • Site-wide: 16,461

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

• Downloaded 5,980 times
• Download rankings, all-time:
  • Site-wide: 1,550
  • In pathology: 13
• Year to date:
  • Site-wide: 2,904
• Since beginning of last month:
  • Site-wide: 5,469

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

• Downloaded 4,931 times
• Download rankings, all-time:
  • Site-wide: 2,013
  • In genomics: 204
• Year to date:
  • Site-wide: 1,518
• Since beginning of last month:
  • Site-wide: 1,330

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

• Downloaded 3,110 times
• Download rankings, all-time:
  • Site-wide: 3,916
  • In biophysics: 62
• Year to date:
  • Site-wide: 16,063
• Since beginning of last month:
  • Site-wide: 14,379

COVID-19 Myocarditis and Severity Factors： An Adult Cohort Study

• Downloaded 3,095 times
• Download rankings, all-time:
  • Site-wide: 3,951
  • In infectious diseases: 691
• Year to date:
  • Site-wide: 6,351
• Since beginning of last month:
  • Site-wide: 5,622

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV

• Downloaded 2,828 times
• Download rankings, all-time:
  • Site-wide: 4,481
  • In infectious diseases: 766
• Year to date:
  • Site-wide: 39,649
• Since beginning of last month:
  • Site-wide: 38,179

Lockdown may partially halt the spread of 2019 novel coronavirus in Hubei province, China

• Downloaded 2,585 times
• Download rankings, all-time:
  • Site-wide: 5,103
  • In infectious diseases: 830
• Year to date:
  • Site-wide: 26,295
• Since beginning of last month:
  • Site-wide: 19,637

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

• Downloaded 2,272 times
• Download rankings, all-time:
  • Site-wide: 6,199
  • In neuroscience: 595
• Year to date:
  • Site-wide: 28,825
• Since beginning of last month:
  • Site-wide: 18,938

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

• Downloaded 2,006 times
• Download rankings, all-time:
  • Site-wide: 7,414
  • In neuroscience: 751
• Year to date:
  • Site-wide: 27,392
• Since beginning of last month:
  • Site-wide: 31,114

What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

• Downloaded 1,927 times
• Download rankings, all-time:
  • Site-wide: 7,884
  • In infectious diseases: 1,056
• Year to date:
  • Site-wide: 50,222
• Since beginning of last month:
  • Site-wide: 36,843

AN INTERACTIVE COVID-19 MOBILITY IMPACT AND SOCIAL DISTANCING ANALYSIS PLATFORM

• Downloaded 1,923 times
• Download rankings, all-time:
  • Site-wide: 7,907
  • In infectious diseases: 1,058
• Year to date:
  • Site-wide: 4,632
• Since beginning of last month:
  • Site-wide: 3,734

Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route

• Downloaded 1,862 times
• Download rankings, all-time:
  • Site-wide: 8,314
  • In infectious diseases: 1,092
• Year to date:
  • Site-wide: 20,949
• Since beginning of last month:
  • Site-wide: 23,126

TITER: predicting translation initiation sites by deep learning

• Downloaded 1,779 times
• Download rankings, all-time:
  • Site-wide: 8,906
  • In bioinformatics: 1,078
• Year to date:
  • Site-wide: 44,264
• Since beginning of last month:
  • Site-wide: 45,132

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

• Downloaded 1,646 times
• Download rankings, all-time:
  • Site-wide: 9,993
  • In neuroscience: 1,085
• Year to date:
  • Site-wide: 31,069
• Since beginning of last month:
  • Site-wide: 34,163

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

• Downloaded 1,535 times
• Download rankings, all-time:
  • Site-wide: 11,065
  • In bioinformatics: 1,352
• Year to date:
  • Site-wide: 2,215
• Since beginning of last month:
  • Site-wide: 3,017

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

• Downloaded 1,508 times
• Download rankings, all-time:
  • Site-wide: 11,336
  • In genomics: 1,230
• Year to date:
  • Site-wide: 20,405
• Since beginning of last month:
  • Site-wide: 18,522

A brain network supporting social influences in human decision-making

• Downloaded 1,404 times
• Download rankings, all-time:
  • Site-wide: 12,631
  • In neuroscience: 1,445
• Year to date:
  • Site-wide: 44,428
• Since beginning of last month:
  • Site-wide: 32,755

DeepHINT: Understanding HIV-1 integration via deep learning with attention

• Downloaded 1,014 times
• Download rankings, all-time:
  • Site-wide: 20,542
  • In bioinformatics: 2,449
• Year to date:
  • Site-wide: 60,722
• Since beginning of last month:
  • Site-wide: 73,344

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

• Downloaded 922 times
• Download rankings, all-time:
  • Site-wide: 23,578
  • In microbiology: 1,354
• Year to date:
  • Site-wide: 7,190
• Since beginning of last month:
  • Site-wide: 7,585

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 874 times
• Download rankings, all-time:
  • Site-wide: 25,480
  • In genomics: 2,414
• Year to date:
  • Site-wide: 20,468
• Since beginning of last month:
  • Site-wide: 19,810

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 26,655
  • In neuroscience: 3,529
• Year to date:
  • Site-wide: 51,169
• Since beginning of last month:
  • Site-wide: 51,652

Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

• Downloaded 810 times
• Download rankings, all-time:
  • Site-wide: 28,315
  • In infectious diseases: 1,998
• Year to date:
  • Site-wide: 11,583
• Since beginning of last month:
  • Site-wide: 19,372

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 28,707
  • In bioinformatics: 3,301
• Year to date:
  • Site-wide: 101,087
• Since beginning of last month:
  • Site-wide: 95,077

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

• Downloaded 754 times
• Download rankings, all-time:
  • Site-wide: 31,292
  • In bioinformatics: 3,531
• Year to date:
  • Site-wide: 23,773
• Since beginning of last month:
  • Site-wide: 92,037

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 751 times
• Download rankings, all-time:
  • Site-wide: 31,484
  • In biochemistry: 745
• Year to date:
  • Site-wide: 35,755
• Since beginning of last month:
  • Site-wide: 34,798

Development and clinical application of a rapid and sensitive loop-mediated isothermalamplification test for SARS-CoV-2 infection

• Downloaded 730 times
• Download rankings, all-time:
  • Site-wide: 32,792
  • In infectious diseases: 2,160
• Year to date:
  • Site-wide: 53,100
• Since beginning of last month:
  • Site-wide: 50,286

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 672 times
• Download rankings, all-time:
  • Site-wide: 36,596
  • In systems biology: 825
• Year to date:
  • Site-wide: 57,362
• Since beginning of last month:
  • Site-wide: 60,459

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 40,153
  • In neuroscience: 5,698
• Year to date:
  • Site-wide: 41,503
• Since beginning of last month:
  • Site-wide: 31,431

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 42,185
  • In immunology: 1,179
• Year to date:
  • Site-wide: 75,946
• Since beginning of last month:
  • Site-wide: 75,421

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 592 times
• Download rankings, all-time:
  • Site-wide: 43,040
  • In genomics: 3,509
• Year to date:
  • Site-wide: 127,023
• Since beginning of last month:
  • Site-wide: 111,904

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 592 times
• Download rankings, all-time:
  • Site-wide: 43,006
  • In genomics: 3,505
• Year to date:
  • Site-wide: 73,883
• Since beginning of last month:
  • Site-wide: 108,659

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 47,196
  • In genomics: 3,754
• Year to date:
  • Site-wide: 72,390
• Since beginning of last month:
  • Site-wide: 76,059

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 534 times
• Download rankings, all-time:
  • Site-wide: 48,809
  • In bioinformatics: 5,067
• Year to date:
  • Site-wide: 26,299
• Since beginning of last month:
  • Site-wide: 26,890

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 49,796
  • In cell biology: 2,146
• Year to date:
  • Site-wide: 44,137
• Since beginning of last month:
  • Site-wide: 37,745

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

• Downloaded 523 times
• Download rankings, all-time:
  • Site-wide: 50,056
  • In plant biology: 1,194
• Year to date:
  • Site-wide: 97,693
• Since beginning of last month:
  • Site-wide: 107,756

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 50,272
  • In biophysics: 1,700
• Year to date:
  • Site-wide: 54,745
• Since beginning of last month:
  • Site-wide: 57,654

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 50,638
  • In genomics: 3,957
• Year to date:
  • Site-wide: 33,117
• Since beginning of last month:
  • Site-wide: 24,808

The impact of containment measures and air temperature on mitigating the transmission of COVID-19: a novel data-based comprehensive modeling analysis

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 55,244
  • In public and global health: 703
• Year to date:
  • Site-wide: 65,601
• Since beginning of last month:
  • Site-wide: 63,592

Rational design of hepatitis C virus E2 core nanoparticle vaccines

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 55,364
  • In microbiology: 3,583
• Year to date:
  • Site-wide: 71,783
• Since beginning of last month:
  • Site-wide: 113,268

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 56,880
  • In genomics: 4,274
• Year to date:
  • Site-wide: 111,061
• Since beginning of last month:
  • Site-wide: 90,831

Characterization of fluorescent proteins with intramolecular photostabilization

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 58,321
  • In biophysics: 2,045
• Year to date:
  • Site-wide: 41,729
• Since beginning of last month:
  • Site-wide: 46,627

Genome-wide association study of appendicular lean mass in UK Biobank cohort

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 60,320
  • In genetics: 2,801
• Year to date:
  • Site-wide: 103,196
• Since beginning of last month:
  • Site-wide: 120,911

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 64,587
  • In genomics: 4,620
• Year to date:
  • Site-wide: 123,227
• Since beginning of last month:
  • Site-wide: 106,667

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 64,709
  • In genomics: 4,637
• Year to date:
  • Site-wide: 40,015
• Since beginning of last month:
  • Site-wide: 30,195

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 64,990
  • In oncology: 82
• Year to date:
  • Site-wide: 47,286
• Since beginning of last month:
  • Site-wide: 41,643

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 66,327
  • In cancer biology: 1,899
• Year to date:
  • Site-wide: 24,686
• Since beginning of last month:
  • Site-wide: 19,976

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 66,548
  • In biochemistry: 1,826
• Year to date:
  • Site-wide: 103,276
• Since beginning of last month:
  • Site-wide: 74,084

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 69,011
  • In molecular biology: 2,026
• Year to date:
  • Site-wide: 94,394
• Since beginning of last month:
  • Site-wide: 86,534

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

• Downloaded 385 times
• Download rankings, all-time:
  • Site-wide: 69,189
  • In systems biology: 1,675
• Year to date:
  • Site-wide: 61,522
• Since beginning of last month:
  • Site-wide: 44,134

Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 72,161
  • In infectious diseases: 3,160
• Year to date:
  • Site-wide: 47,242
• Since beginning of last month:
  • Site-wide: 47,646

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 77,820
  • In molecular biology: 2,293
• Year to date:
  • Site-wide: 35,098
• Since beginning of last month:
  • Site-wide: 50,893

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 79,419
  • In genetics: 3,618
• Year to date:
  • Site-wide: 81,291
• Since beginning of last month:
  • Site-wide: 86,662

Performance of bitumen coating sheet using biomass pyrolysis oil

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 87,877
  • In bioengineering: 1,652
• Year to date:
  • Site-wide: 103,066
• Since beginning of last month:
  • Site-wide: 79,148

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

• Downloaded 278 times
• Download rankings, all-time:
  • Site-wide: 89,840
  • In bioengineering: 1,698
• Year to date:
  • Site-wide: 121,121
• Since beginning of last month:
  • Site-wide: 90,707

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 90,697
  • In genomics: 5,670
• Year to date:
  • Site-wide: 54,659
• Since beginning of last month:
  • Site-wide: 56,427

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 92,096
  • In neuroscience: 14,274
• Year to date:
  • Site-wide: 28,549
• Since beginning of last month:
  • Site-wide: 24,498

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 96,674
  • In bioinformatics: 8,394
• Year to date:
  • Site-wide: 61,845
• Since beginning of last month:
  • Site-wide: 57,774

CNSA: a data repository for archiving omics data

• Downloaded 238 times
• Download rankings, all-time:
  • Site-wide: 98,601
  • In genomics: 5,944
• Year to date:
  • Site-wide: 53,045
• Since beginning of last month:
  • Site-wide: 42,929

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 99,787
  • In microbiology: 7,270
• Year to date:
  • Site-wide: 54,877
• Since beginning of last month:
  • Site-wide: 34,389

Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 100,456
  • In systems biology: 2,330
• Year to date:
  • Site-wide: 9,005
• Since beginning of last month:
  • Site-wide: 16,099

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 102,618
  • In systems biology: 2,368
• Year to date:
  • Site-wide: 117,111
• Since beginning of last month:
  • Site-wide: 98,878

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 103,133
  • In infectious diseases: 3,855
• Year to date:
  • Site-wide: 40,229
• Since beginning of last month:
  • Site-wide: 29,297

VirusDIP: Virus Data Integration Platform

• Downloaded 204 times
• Download rankings, all-time:
  • Site-wide: 106,134
  • In bioinformatics: 8,945
• Year to date:
  • Site-wide: 68,236
• Since beginning of last month:
  • Site-wide: 56,700

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 193 times
• Download rankings, all-time:
  • Site-wide: 108,666
  • In developmental biology: 2,952
• Year to date:
  • Site-wide: 98,507
• Since beginning of last month:
  • Site-wide: 102,582

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 169 times
• Download rankings, all-time:
  • Site-wide: 113,685
  • In microbiology: 8,552
• Year to date:
  • Site-wide: 44,976
• Since beginning of last month:
  • Site-wide: 30,712

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 107 times
• Download rankings, all-time:
  • Site-wide: 125,989
  • In physiology: 1,496
• Year to date:
  • Site-wide: 95,714
• Since beginning of last month:
  • Site-wide: 57,116

Membrane Env liposomes for immunization with HIV spikes

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 126,492
  • In immunology: 3,644
• Year to date:
  • Site-wide: 73,752
• Since beginning of last month:
  • Site-wide: 47,707

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

• Downloaded 97 times
• Download rankings, all-time:
  • Site-wide: 127,783
  • In plant biology: 3,618
• Year to date:
  • Site-wide: 75,566
• Since beginning of last month:
  • Site-wide: 102,042

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 86 times
• Download rankings, all-time:
  • Site-wide: 129,460
  • In genetics: 5,383
• Year to date:
  • Site-wide: 113,647
• Since beginning of last month:
  • Site-wide: 114,350