Author: Lei Zhang

Downloads per author, site-wide

Preprints

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

• Downloaded 288,824 times
• Download rankings, all-time:
  • Site-wide: 7
  • In microbiology: 1
• Year to date:
  • Site-wide: 204
• Since beginning of last month:
  • Site-wide: 171

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

• Downloaded 17,521 times
• Download rankings, all-time:
  • Site-wide: 435
  • In microbiology: 47
• Year to date:
  • Site-wide: 8,525
• Since beginning of last month:
  • Site-wide: 10,978

Variability in the analysis of a single neuroimaging dataset by many teams

• Downloaded 6,763 times
• Download rankings, all-time:
  • Site-wide: 1,507
  • In neuroscience: 72
• Year to date:
  • Site-wide: 12,716
• Since beginning of last month:
  • Site-wide: 20,478

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

• Downloaded 6,599 times
• Download rankings, all-time:
  • Site-wide: 1,557
  • In pathology: 11
• Year to date:
  • Site-wide: 2,334
• Since beginning of last month:
  • Site-wide: 3,048

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

• Downloaded 5,562 times
• Download rankings, all-time:
  • Site-wide: 1,974
  • In genomics: 178
• Year to date:
  • Site-wide: 1,690
• Since beginning of last month:
  • Site-wide: 1,630

COVID-19 Myocarditis and Severity Factors： An Adult Cohort Study

• Downloaded 3,496 times
• Download rankings, all-time:
  • Site-wide: 3,798
  • In infectious diseases: 743
• Year to date:
  • Site-wide: 4,656
• Since beginning of last month:
  • Site-wide: 6,141

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

• Downloaded 3,230 times
• Download rankings, all-time:
  • Site-wide: 4,253
  • In biophysics: 67
• Year to date:
  • Site-wide: 18,280
• Since beginning of last month:
  • Site-wide: 14,990

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV

• Downloaded 2,879 times
• Download rankings, all-time:
  • Site-wide: 4,998
  • In infectious diseases: 895
• Year to date:
  • Site-wide: 48,465
• Since beginning of last month:
  • Site-wide: 42,854

Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route

• Downloaded 2,821 times
• Download rankings, all-time:
  • Site-wide: 5,159
  • In infectious diseases: 912
• Year to date:
  • Site-wide: 2,471
• Since beginning of last month:
  • Site-wide: 6,339

Lockdown may partially halt the spread of 2019 novel coronavirus in Hubei province, China

• Downloaded 2,647 times
• Download rankings, all-time:
  • Site-wide: 5,641
  • In infectious diseases: 959
• Year to date:
  • Site-wide: 35,024
• Since beginning of last month:
  • Site-wide: 35,390

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

• Downloaded 2,330 times
• Download rankings, all-time:
  • Site-wide: 6,823
  • In neuroscience: 641
• Year to date:
  • Site-wide: 38,040
• Since beginning of last month:
  • Site-wide: 44,980

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

• Downloaded 2,307 times
• Download rankings, all-time:
  • Site-wide: 6,913
  • In bioinformatics: 772
• Year to date:
  • Site-wide: 1,757
• Since beginning of last month:
  • Site-wide: 2,196

AN INTERACTIVE COVID-19 MOBILITY IMPACT AND SOCIAL DISTANCING ANALYSIS PLATFORM

• Downloaded 2,275 times
• Download rankings, all-time:
  • Site-wide: 7,060
  • In infectious diseases: 1,081
• Year to date:
  • Site-wide: 4,465
• Since beginning of last month:
  • Site-wide: 6,627

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

• Downloaded 2,105 times
• Download rankings, all-time:
  • Site-wide: 7,908
  • In neuroscience: 776
• Year to date:
  • Site-wide: 27,716
• Since beginning of last month:
  • Site-wide: 42,285

What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

• Downloaded 1,956 times
• Download rankings, all-time:
  • Site-wide: 8,819
  • In infectious diseases: 1,238
• Year to date:
  • Site-wide: 68,497
• Since beginning of last month:
  • Site-wide: 70,167

TITER: predicting translation initiation sites by deep learning

• Downloaded 1,813 times
• Download rankings, all-time:
  • Site-wide: 9,858
  • In bioinformatics: 1,152
• Year to date:
  • Site-wide: 60,569
• Since beginning of last month:
  • Site-wide: 82,909

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

• Downloaded 1,715 times
• Download rankings, all-time:
  • Site-wide: 10,691
  • In neuroscience: 1,117
• Year to date:
  • Site-wide: 36,812
• Since beginning of last month:
  • Site-wide: 23,828

Critical timing for triggering public health interventions to prevent COVID-19 resurgence: a mathematical modelling study

• Downloaded 1,712 times
• Download rankings, all-time:
  • Site-wide: 10,726
  • In infectious diseases: 1,393
• Year to date:
  • Site-wide: 1,333
• Since beginning of last month:
  • Site-wide: 208

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

• Downloaded 1,625 times
• Download rankings, all-time:
  • Site-wide: 11,612
  • In genomics: 1,207
• Year to date:
  • Site-wide: 21,238
• Since beginning of last month:
  • Site-wide: 24,869

A brain network supporting social influences in human decision-making

• Downloaded 1,448 times
• Download rankings, all-time:
  • Site-wide: 13,751
  • In neuroscience: 1,539
• Year to date:
  • Site-wide: 55,650
• Since beginning of last month:
  • Site-wide: 45,291

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

• Downloaded 1,275 times
• Download rankings, all-time:
  • Site-wide: 16,644
  • In microbiology: 964
• Year to date:
  • Site-wide: 5,469
• Since beginning of last month:
  • Site-wide: 3,836

DeepHINT: Understanding HIV-1 integration via deep learning with attention

• Downloaded 1,084 times
• Download rankings, all-time:
  • Site-wide: 21,141
  • In bioinformatics: 2,444
• Year to date:
  • Site-wide: 51,453
• Since beginning of last month:
  • Site-wide: 26,634

Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

• Downloaded 981 times
• Download rankings, all-time:
  • Site-wide: 24,514
  • In infectious diseases: 2,050
• Year to date:
  • Site-wide: 11,983
• Since beginning of last month:
  • Site-wide: 13,893

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 25,144
  • In genomics: 2,351
• Year to date:
  • Site-wide: 24,920
• Since beginning of last month:
  • Site-wide: 21,904

Generating Templates and Growth Charts for School-Aged Brain Development

• Downloaded 881 times
• Download rankings, all-time:
  • Site-wide: 28,549
  • In neuroscience: 3,724
• Year to date:
  • Site-wide: 65,048
• Since beginning of last month:
  • Site-wide: 54,847

SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 811 times
• Download rankings, all-time:
  • Site-wide: 32,045
  • In bioinformatics: 3,566
• Year to date:
  • Site-wide: 125,375
• Since beginning of last month:
  • Site-wide: 117,960

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 807 times
• Download rankings, all-time:
  • Site-wide: 32,236
  • In biochemistry: 765
• Year to date:
  • Site-wide: 43,992
• Since beginning of last month:
  • Site-wide: 60,978

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

• Downloaded 792 times
• Download rankings, all-time:
  • Site-wide: 33,094
  • In bioinformatics: 3,670
• Year to date:
  • Site-wide: 38,575
• Since beginning of last month:
  • Site-wide: 64,402

Development and clinical application of a rapid and sensitive loop-mediated isothermalamplification test for SARS-CoV-2 infection

• Downloaded 780 times
• Download rankings, all-time:
  • Site-wide: 33,781
  • In infectious diseases: 2,446
• Year to date:
  • Site-wide: 57,575
• Since beginning of last month:
  • Site-wide: 43,018

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 39,927
  • In systems biology: 874
• Year to date:
  • Site-wide: 82,632
• Since beginning of last month:
  • Site-wide: 111,992

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 40,327
  • In neuroscience: 5,576
• Year to date:
  • Site-wide: 46,152
• Since beginning of last month:
  • Site-wide: 48,584

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 45,348
  • In immunology: 1,360
• Year to date:
  • Site-wide: 91,427
• Since beginning of last month:
  • Site-wide: 100,655

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 619 times
• Download rankings, all-time:
  • Site-wide: 46,027
  • In bioinformatics: 4,812
• Year to date:
  • Site-wide: 29,779
• Since beginning of last month:
  • Site-wide: 26,723

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 614 times
• Download rankings, all-time:
  • Site-wide: 46,458
  • In genomics: 3,678
• Year to date:
  • Site-wide: 92,150
• Since beginning of last month:
  • Site-wide: 98,921

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 47,515
  • In genomics: 3,724
• Year to date:
  • Site-wide: 137,694
• Since beginning of last month:
  • Site-wide: 124,361

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 47,892
  • In genomics: 3,742
• Year to date:
  • Site-wide: 34,978
• Since beginning of last month:
  • Site-wide: 19,645

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 49,740
  • In biophysics: 1,652
• Year to date:
  • Site-wide: 53,764
• Since beginning of last month:
  • Site-wide: 43,437

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 51,464
  • In genomics: 3,956
• Year to date:
  • Site-wide: 98,493
• Since beginning of last month:
  • Site-wide: 100,852

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

• Downloaded 555 times
• Download rankings, all-time:
  • Site-wide: 52,695
  • In cell biology: 2,292
• Year to date:
  • Site-wide: 62,363
• Since beginning of last month:
  • Site-wide: 62,938

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

• Downloaded 547 times
• Download rankings, all-time:
  • Site-wide: 53,567
  • In plant biology: 1,267
• Year to date:
  • Site-wide: 103,744
• Since beginning of last month:
  • Site-wide: 81,282

Characterization of fluorescent proteins with intramolecular photostabilization

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 55,293
  • In biophysics: 1,865
• Year to date:
  • Site-wide: 40,949
• Since beginning of last month:
  • Site-wide: 34,806

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 56,415
  • In cancer biology: 1,587
• Year to date:
  • Site-wide: 22,978
• Since beginning of last month:
  • Site-wide: 20,505

The impact of containment measures and air temperature on mitigating the transmission of COVID-19: a novel data-based comprehensive modeling analysis

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 57,591
  • In public and global health: 815
• Year to date:
  • Site-wide: 74,295
• Since beginning of last month:
  • Site-wide: 55,013

Rational design of hepatitis C virus E2 core nanoparticle vaccines

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 60,858
  • In microbiology: 3,937
• Year to date:
  • Site-wide: 104,442
• Since beginning of last month:
  • Site-wide: 137,491

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 61,367
  • In genomics: 4,455
• Year to date:
  • Site-wide: 41,009
• Since beginning of last month:
  • Site-wide: 40,808

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 478 times
• Download rankings, all-time:
  • Site-wide: 62,461
  • In genomics: 4,498
• Year to date:
  • Site-wide: 131,455
• Since beginning of last month:
  • Site-wide: 105,606

Genome-wide association study of appendicular lean mass in UK Biobank cohort

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 64,100
  • In genetics: 2,855
• Year to date:
  • Site-wide: 104,319
• Since beginning of last month:
  • Site-wide: 68,236

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 443 times
• Download rankings, all-time:
  • Site-wide: 67,921
  • In oncology: 99
• Year to date:
  • Site-wide: 64,829
• Since beginning of last month:
  • Site-wide: 101,917

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 67,977
  • In biochemistry: 1,842
• Year to date:
  • Site-wide: 85,610
• Since beginning of last month:
  • Site-wide: 47,610

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

• Downloaded 428 times
• Download rankings, all-time:
  • Site-wide: 70,222
  • In genomics: 4,864
• Year to date:
  • Site-wide: 131,939
• Since beginning of last month:
  • Site-wide: 98,224

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 70,466
  • In systems biology: 1,635
• Year to date:
  • Site-wide: 67,390
• Since beginning of last month:
  • Site-wide: 66,387

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 74,425
  • In molecular biology: 2,174
• Year to date:
  • Site-wide: 111,714
• Since beginning of last month:
  • Site-wide: 125,806

Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 75,746
  • In infectious diseases: 3,615
• Year to date:
  • Site-wide: 66,986
• Since beginning of last month:
  • Site-wide: 85,454

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 371 times
• Download rankings, all-time:
  • Site-wide: 80,459
  • In neuroscience: 12,080
• Year to date:
  • Site-wide: 27,727
• Since beginning of last month:
  • Site-wide: 24,997

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 80,989
  • In molecular biology: 2,379
• Year to date:
  • Site-wide: 54,013
• Since beginning of last month:
  • Site-wide: 74,987

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 83,861
  • In genetics: 3,708
• Year to date:
  • Site-wide: 93,119
• Since beginning of last month:
  • Site-wide: 80,274

Modeling of histone modifications reveals formation mechanism and function of bivalent chromatin

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 89,615
  • In systems biology: 2,072
• Year to date:
  • Site-wide: 13,956
• Since beginning of last month:
  • Site-wide: 23,693

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 92,482
  • In genomics: 5,756
• Year to date:
  • Site-wide: 65,487
• Since beginning of last month:
  • Site-wide: 61,025

Performance of bitumen coating sheet using biomass pyrolysis oil

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 94,760
  • In bioengineering: 1,792
• Year to date:
  • Site-wide: 117,057
• Since beginning of last month:
  • Site-wide: 103,740

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 299 times
• Download rankings, all-time:
  • Site-wide: 95,534
  • In bioinformatics: 8,325
• Year to date:
  • Site-wide: 60,932
• Since beginning of last month:
  • Site-wide: 33,287

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 96,324
  • In infectious diseases: 4,127
• Year to date:
  • Site-wide: 39,569
• Since beginning of last month:
  • Site-wide: 35,926

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 98,437
  • In bioengineering: 1,875
• Year to date:
  • Site-wide: 140,166
• Since beginning of last month:
  • Site-wide: 123,897

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 99,332
  • In microbiology: 7,138
• Year to date:
  • Site-wide: 59,182
• Since beginning of last month:
  • Site-wide: 64,523

CNSA: a data repository for archiving omics data

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 103,567
  • In genomics: 6,152
• Year to date:
  • Site-wide: 73,202
• Since beginning of last month:
  • Site-wide: 77,510

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 107,894
  • In systems biology: 2,429
• Year to date:
  • Site-wide: 110,471
• Since beginning of last month:
  • Site-wide: 52,136

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 110,477
  • In microbiology: 8,066
• Year to date:
  • Site-wide: 46,382
• Since beginning of last month:
  • Site-wide: 39,595

VirusDIP: Virus Data Integration Platform

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 114,315
  • In bioinformatics: 9,469
• Year to date:
  • Site-wide: 95,049
• Since beginning of last month:
  • Site-wide: 90,960

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 116,567
  • In developmental biology: 3,153
• Year to date:
  • Site-wide: 111,141
• Since beginning of last month:
  • Site-wide: 101,148

Membrane Env liposomes for immunization with HIV spikes

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 135,266
  • In immunology: 3,995
• Year to date:
  • Site-wide: 88,659
• Since beginning of last month:
  • Site-wide: 78,472

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 125 times
• Download rankings, all-time:
  • Site-wide: 136,109
  • In physiology: 1,584
• Year to date:
  • Site-wide: 110,656
• Since beginning of last month:
  • Site-wide: 140,289

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 137,497
  • In plant biology: 3,880
• Year to date:
  • Site-wide: 93,442
• Since beginning of last month:
  • Site-wide: 84,679

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 140,382
  • In genetics: 5,624
• Year to date:
  • Site-wide: 119,772
• Since beginning of last month:
  • Site-wide: 109,552