Author: Yang Li

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Preprints

Induction of trained immunity by influenza vaccination - impact on COVID-19

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The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

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  • Site-wide: 38
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  • Site-wide: 76

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

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  • Site-wide: 395
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  • Site-wide: 16,693
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SnapATAC: A Comprehensive Analysis Package for Single Cell ATAC-seq

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  • Site-wide: 1,002
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  • Site-wide: 2,063
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Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

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  • Site-wide: 1,706
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A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

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  • Site-wide: 2,636
  • In neuroscience: 165
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  • Site-wide: 3,635
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  • Site-wide: 3,985

Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

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  • Site-wide: 3,109
  • In infectious diseases: 664
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  • Site-wide: 15,285
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Suppressive myeloid cells are a hallmark of severe COVID-19

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  • Site-wide: 3,203
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  • Site-wide: 8,534
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Binary and analog variation of synapses between cortical pyramidal neurons

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  • Site-wide: 4,110
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  • Site-wide: 7,364
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The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

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  • Site-wide: 4,404
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  • Site-wide: 108,358

A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention

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  • Site-wide: 4,637
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  • Site-wide: 27,275
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  • Site-wide: 40,882

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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  • Site-wide: 4,958
  • In bioengineering: 55
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  • Site-wide: 15,378
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  • Site-wide: 23,478

Multiscale and multimodal reconstruction of cortical structure and function

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  • Site-wide: 5,623
  • In neuroscience: 496
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  • Site-wide: 3,820
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  • Site-wide: 416

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients

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  • Site-wide: 7,997
  • In infectious diseases: 1,191
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  • Site-wide: 23,231
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  • Site-wide: 57,276

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 8,628
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

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  • Site-wide: 9,933
  • In biophysics: 206
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  • Site-wide: 1,384
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  • Site-wide: 8,116

GeNets: A unified web platform for network-based analyses of genomic data

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  • Site-wide: 10,842
  • In genomics: 1,113
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  • Site-wide: 63,697
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  • Site-wide: 72,449

Allele-Specific Quantification of Structural Variations in Cancer Genomes

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  • Site-wide: 12,124
  • In bioinformatics: 1,410
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  • Site-wide: 130,580
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Chandelier cell anatomy and function reveal a variably distributed but common signal

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  • Site-wide: 12,925
  • In neuroscience: 1,426
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Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 14,312
  • In genomics: 1,458
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  • Site-wide: 26,385
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  • Site-wide: 61,559

An epigenetic landscape governs early fate decision in cellular aging

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  • Site-wide: 16,156
  • In systems biology: 300
• Year to date:
  • Site-wide: 94,954
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  • Site-wide: 38,749

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

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  • Site-wide: 23,210
  • In plant biology: 357
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  • Site-wide: 83,119
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  • Site-wide: 79,188

Preliminary evaluation of the safety and efficacy of oral human antimicrobial peptide LL-37 in the treatment of patients of COVID-19, a small-scale, single-arm, exploratory safety study

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  • Site-wide: 24,225
  • In infectious diseases: 2,074
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  • Site-wide: 19,774
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  • Site-wide: 19,761

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

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  • Site-wide: 26,518
  • In biochemistry: 594
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  • Site-wide: 21,334
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  • Site-wide: 24,594

Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run

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  • Site-wide: 27,808
  • In immunology: 890
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  • Site-wide: 18,234
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  • Site-wide: 67,013

The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics.

• Downloaded 862 times
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  • Site-wide: 30,210
  • In cell biology: 1,133
• Year to date:
  • Site-wide: 84,229
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  • Site-wide: 77,249

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

• Downloaded 859 times
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  • Site-wide: 30,324
  • In infectious diseases: 2,360
• Year to date:
  • Site-wide: 31,111
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  • Site-wide: 101,268

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

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  • Site-wide: 31,416
  • In infectious diseases: 2,398
• Year to date:
  • Site-wide: 51,489
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  • Site-wide: 108,758

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

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  • Site-wide: 32,705
  • In neuroscience: 4,337
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  • Site-wide: 98,404
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  • Site-wide: 80,614

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

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  • Site-wide: 34,409
  • In systems biology: 728
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  • Site-wide: 109,459
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Multi-generational silencing dynamics control cell aging

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  • Site-wide: 35,015
  • In systems biology: 743
• Year to date:
  • Site-wide: 138,764
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Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

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  • Site-wide: 35,074
  • In genomics: 2,966
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  • Site-wide: 133,547
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RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

• Downloaded 772 times
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  • Site-wide: 35,183
  • In immunology: 1,098
• Year to date:
  • Site-wide: 17,680
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  • Site-wide: 67,677

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

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  • Site-wide: 43,533
  • In immunology: 1,325
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  • Site-wide: 74,493
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Cycloserine for Treatment of Multidrug-Resistant Tuberculosis in China: A Retrospective Observational Study

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  • Site-wide: 46,532
  • In microbiology: 2,896
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  • Site-wide: 95,176
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  • Site-wide: 13,566

Electrospun Ag-doped SnO2 hollow nanofibers with high antibacterial activity

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  • Site-wide: 49,308
  • In biochemistry: 1,262
• Year to date:
  • Site-wide: 66,277
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  • Site-wide: 67,678

Gender differences in attitudes toward death among Chinese university students: A survey in hunan and Heilongjiang province

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  • Site-wide: 50,242
  • In scientific communication and education: 301
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  • Site-wide: 62,013
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  • Site-wide: 62,531

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

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  • Site-wide: 50,304
  • In cancer biology: 1,404
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  • Site-wide: 130,077
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From Community Acquired Pneumonia to COVID-19: A Deep Learning Based Method for Quantitative Analysis of COVID-19 on thick-section CT Scans

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  • Site-wide: 50,409
  • In radiology and imaging: 83
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  • Site-wide: 105,157

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

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  • Site-wide: 53,537
  • In neuroscience: 7,722
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Vinculin anchors contractile actin to the cardiomyocyte adherens junction

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  • Site-wide: 58,847
  • In cell biology: 2,549
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  • Site-wide: 116,747
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  • Site-wide: 85,008

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

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  • Site-wide: 61,398
  • In biophysics: 2,112
• Year to date:
  • Site-wide: 149,983
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  • Site-wide: 83,768

Ultra-fast and accurate motif finding in large ChIP-seq datasets reveals transcription factor binding patterns

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  • Site-wide: 62,932
  • In bioinformatics: 6,207
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  • Site-wide: 112,726
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  • Site-wide: 71,858

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity

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  • Site-wide: 67,408
  • In bioinformatics: 6,514
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  • Site-wide: 32,412
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  • Site-wide: 39,453

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

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  • Site-wide: 73,058
  • In bioinformatics: 6,899
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  • Site-wide: 40,317

The genetic risk for COVID-19 severity is associated with defective innate immune responses

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  • Site-wide: 73,999
  • In genetic and genomic medicine: 306
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  • Site-wide: 25,695
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  • Site-wide: 30,206

A label-free approach to detect ligand binding to cell surface proteins in real time

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  • Site-wide: 77,388
  • In biophysics: 2,808
• Year to date:
  • Site-wide: 131,272
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  • Site-wide: 34,364

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 380 times
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  • Site-wide: 80,784
  • In epidemiology: 3,421
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  • Site-wide: 49,278
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  • Site-wide: 29,981

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

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  • Site-wide: 81,274
  • In molecular biology: 2,367
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  • Site-wide: 129,892
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bHLH11 negatively regulates Fe homeostasis by its EAR motifs recruiting corepressors in Arabidopsis

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  • Site-wide: 82,404
  • In plant biology: 2,145
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  • Site-wide: 90,258
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Variable sensitivity to DNA damaging chemotherapeutic modulated by cell type-dependent bimodal p53 dynamics

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  • Site-wide: 83,891
  • In systems biology: 1,920
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  • Site-wide: 147,585
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Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

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  • Site-wide: 87,856
  • In bioinformatics: 7,891
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  • Site-wide: 39,591
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  • Site-wide: 53,036

Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients

• Downloaded 329 times
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  • Site-wide: 91,261
  • In public and global health: 1,152
• Year to date:
  • Site-wide: 46,542
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  • Site-wide: 104,217

Structural and mechanistic basis for protein glutamylation by the kinase fold

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  • Site-wide: 91,244
  • In biochemistry: 2,609
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  • Site-wide: 15,605
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Microplate Assay for Denatured Collagen using Collagen Hybridizing Peptides

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  • Site-wide: 94,913
  • In bioengineering: 1,784
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  • Site-wide: 145,364
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  • Site-wide: 81,480

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

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  • Site-wide: 99,826
  • In genetics: 4,265
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  • Site-wide: 113,934
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FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

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  • Site-wide: 100,584
  • In plant biology: 2,679
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  • Site-wide: 122,248
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  • Site-wide: 59,338

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

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  • Site-wide: 101,289
  • In neuroscience: 15,523
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  • Site-wide: 127,833
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  • Site-wide: 92,170

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as regulator of cell adhesion and actin dynamics in Drosophila

• Downloaded 277 times
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  • Site-wide: 103,084
  • In genetics: 4,389
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  • Site-wide: 138,289
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Reconstructing species evolutionary trees using the numerical features of microRNA

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  • Site-wide: 107,281
  • In bioinformatics: 9,110
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  • Site-wide: 141,233
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  • Site-wide: None

Evolution of cytokine production capacity in ancient and modern European populations

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  • Site-wide: 110,530
  • In genomics: 6,380
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  • Site-wide: 23,270
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  • Site-wide: 19,712

Cytochrome OmcS is not essential for long-range electron transport in Geobacter sulfurreducens strain KN400

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  • Site-wide: 111,375
  • In microbiology: 8,148
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  • Site-wide: 67,661
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  • Site-wide: 55,522

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

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  • Site-wide: 111,288
  • In bioengineering: 2,137
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  • Site-wide: 84,630
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  • Site-wide: 52,009

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

• Downloaded 236 times
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  • Site-wide: 112,873
  • In molecular biology: 3,335
• Year to date:
  • Site-wide: 78,252
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  • Site-wide: None

Rapid detection of cytochrome cd1-containing nitrite reductase encoding gene nirS with loop-mediated isothermal amplification assay

• Downloaded 235 times
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  • Site-wide: 113,368
  • In microbiology: 8,329
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  • Site-wide: 121,349
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  • Site-wide: 80,283

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

• Downloaded 230 times
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  • Site-wide: 114,689
  • In immunology: 3,364
• Year to date:
  • Site-wide: 25,341
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  • Site-wide: 104,395

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

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  • Site-wide: 115,369
  • In plant biology: 3,143
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  • Site-wide: 43,483
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  • Site-wide: None

MpsLDA-ProSVM: predicting multi-label protein subcellular localization by wMLDAe dimensionality reduction and ProSVM classifier

• Downloaded 214 times
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  • Site-wide: 118,541
  • In bioinformatics: 9,741
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  • Site-wide: 70,341
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  • Site-wide: 27,413

Exploration of target spaces in the human genome for protein and peptide drugs

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  • Site-wide: 119,362
  • In bioinformatics: 9,781
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  • Site-wide: 92,032
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  • Site-wide: 97,280

A combined microphysiological-computational omics approach in dietary protein evaluation

• Downloaded 174 times
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  • Site-wide: 128,315
  • In bioengineering: 2,561
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  • Site-wide: 128,074
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  • Site-wide: 107,887

Discovery Function Labels Based On Numerical Features Of MicroRNA Found In Plant

• Downloaded 168 times
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  • Site-wide: 129,674
  • In bioinformatics: 10,359
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  • Site-wide: 147,072
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  • Site-wide: 89,487

Discovering Differences and Similarities among Species Based on Numeric Features of microRNAs

• Downloaded 166 times
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  • Site-wide: 130,174
  • In bioinformatics: 10,386
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  • Site-wide: 137,369
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  • Site-wide: None

Protein Surface Printer for Exploring Protein Domains

• Downloaded 164 times
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  • Site-wide: 130,514
  • In bioinformatics: 10,409
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  • Site-wide: 86,071
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  • Site-wide: 55,293

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

• Downloaded 127 times
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  • Site-wide: 138,651
  • In plant biology: 3,883
• Year to date:
  • Site-wide: 151,973
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  • Site-wide: 89,368

Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

• Downloaded 119 times
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  • Site-wide: 140,193
  • In molecular biology: 4,173
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  • Site-wide: 109,740
• Since beginning of last month:
  • Site-wide: 31,108

Collagen induced inflammations

• Downloaded 118 times
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  • Site-wide: 140,581
  • In immunology: 4,161
• Year to date:
  • Site-wide: 93,910
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  • Site-wide: 113,074

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

• Downloaded 91 times
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  • Site-wide: 145,400
  • In microbiology: 11,229
• Year to date:
  • Site-wide: 68,979
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  • Site-wide: 46,452

HAMdetector: A Bayesian regression model that integrates information to detect HLA-associated mutations

• Downloaded 65 times
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  • Site-wide: 148,765
  • In bioinformatics: 11,374
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  • Site-wide: 89,506
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  • Site-wide: None

Molecular mechanism of the anti-lung cancer effect of Jin Ning Fang based on network pharmacology and experimental verification

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  • Site-wide: 149,902
  • In cancer biology: 4,620
• Year to date:
  • Site-wide: 102,537
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  • Site-wide: 116,599

A universal approach for integrating super large-scale single-cell transcriptomes by exploring gene rankings

• Downloaded 7 times
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  • Site-wide: 153,065
  • In bioinformatics: 11,561
• Year to date:
  • Site-wide: 152,971
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  • Site-wide: 13,259

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

• Downloaded 1 times
• Download rankings, all-time:
  • Site-wide: 154,515
  • In infectious diseases: 6,057
• Year to date:
  • Site-wide: 154,326
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  • Site-wide: 47,701