Author: Yang Li

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Preprints

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

• Downloaded 19,547 times
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  • Site-wide: 340
  • In infectious diseases: 129
• Year to date:
  • Site-wide: 17,627
• Since beginning of last month:
  • Site-wide: 21,326

SnapATAC: A Comprehensive Analysis Package for Single Cell ATAC-seq

• Downloaded 9,082 times
• Download rankings, all-time:
  • Site-wide: 899
  • In bioinformatics: 49
• Year to date:
  • Site-wide: 1,223
• Since beginning of last month:
  • Site-wide: 1,804

Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

• Downloaded 6,011 times
• Download rankings, all-time:
  • Site-wide: 1,528
  • In infectious diseases: 388
• Year to date:
  • Site-wide: 9,428
• Since beginning of last month:
  • Site-wide: 10,189

A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

• Downloaded 4,289 times
• Download rankings, all-time:
  • Site-wide: 2,460
  • In neuroscience: 163
• Year to date:
  • Site-wide: 2,270
• Since beginning of last month:
  • Site-wide: 3,051

Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

• Downloaded 3,967 times
• Download rankings, all-time:
  • Site-wide: 2,748
  • In infectious diseases: 556
• Year to date:
  • Site-wide: 11,398
• Since beginning of last month:
  • Site-wide: 12,757

Suppressive myeloid cells are a hallmark of severe COVID-19

• Downloaded 3,788 times
• Download rankings, all-time:
  • Site-wide: 2,941
  • In infectious diseases: 577
• Year to date:
  • Site-wide: 7,221
• Since beginning of last month:
  • Site-wide: 7,004

The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

• Downloaded 3,127 times
• Download rankings, all-time:
  • Site-wide: 3,874
  • In infectious diseases: 680
• Year to date:
  • Site-wide: 24,863
• Since beginning of last month:
  • Site-wide: 18,979

Binary and analog variation of synapses between cortical pyramidal neurons

• Downloaded 3,101 times
• Download rankings, all-time:
  • Site-wide: 3,908
  • In neuroscience: 327
• Year to date:
  • Site-wide: 5,977
• Since beginning of last month:
  • Site-wide: 6,442

A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention

• Downloaded 2,958 times
• Download rankings, all-time:
  • Site-wide: 4,170
  • In infectious diseases: 717
• Year to date:
  • Site-wide: 29,995
• Since beginning of last month:
  • Site-wide: 20,690

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

• Downloaded 2,768 times
• Download rankings, all-time:
  • Site-wide: 4,595
  • In bioengineering: 55
• Year to date:
  • Site-wide: 13,831
• Since beginning of last month:
  • Site-wide: 23,151

Multiscale and multimodal reconstruction of cortical structure and function

• Downloaded 2,216 times
• Download rankings, all-time:
  • Site-wide: 6,392
  • In neuroscience: 628
• Year to date:
  • Site-wide: 3,942
• Since beginning of last month:
  • Site-wide: 6,228

Cell specific eQTL analysis without sorting cells

• Downloaded 2,001 times
• Download rankings, all-time:
  • Site-wide: 7,406
  • In genetics: 351
• Year to date:
  • Site-wide: 111,328
• Since beginning of last month:
  • Site-wide: 98,469

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients

• Downloaded 1,997 times
• Download rankings, all-time:
  • Site-wide: 7,426
  • In infectious diseases: 1,013
• Year to date:
  • Site-wide: 20,144
• Since beginning of last month:
  • Site-wide: 20,522

GeNets: A unified web platform for network-based analyses of genomic data

• Downloaded 1,684 times
• Download rankings, all-time:
  • Site-wide: 9,627
  • In genomics: 1,058
• Year to date:
  • Site-wide: 46,107
• Since beginning of last month:
  • Site-wide: 96,481

Allele-Specific Quantification of Structural Variations in Cancer Genomes

• Downloaded 1,584 times
• Download rankings, all-time:
  • Site-wide: 10,506
  • In bioinformatics: 1,283
• Year to date:
  • Site-wide: 115,055
• Since beginning of last month:
  • Site-wide: 110,847

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,322 times
• Download rankings, all-time:
  • Site-wide: 13,787
  • In genomics: 1,463
• Year to date:
  • Site-wide: 21,471
• Since beginning of last month:
  • Site-wide: 24,229

An epigenetic landscape governs early fate decision in cellular aging

• Downloaded 1,286 times
• Download rankings, all-time:
  • Site-wide: 14,359
  • In systems biology: 282
• Year to date:
  • Site-wide: 90,300
• Since beginning of last month:
  • Site-wide: 69,893

Chandelier cell anatomy and function reveal a variably distributed but common signal

• Downloaded 1,277 times
• Download rankings, all-time:
  • Site-wide: 14,515
  • In neuroscience: 1,726
• Year to date:
  • Site-wide: 9,602
• Since beginning of last month:
  • Site-wide: 11,254

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

• Downloaded 995 times
• Download rankings, all-time:
  • Site-wide: 21,002
  • In plant biology: 335
• Year to date:
  • Site-wide: 71,149
• Since beginning of last month:
  • Site-wide: 53,550

Preliminary evaluation of the safety and efficacy of oral human antimicrobial peptide LL-37 in the treatment of patients of COVID-19, a small-scale, single-arm, exploratory safety study

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 26,478
  • In infectious diseases: 1,916
• Year to date:
  • Site-wide: 20,180
• Since beginning of last month:
  • Site-wide: 30,404

The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics.

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 28,030
  • In cell biology: 1,042
• Year to date:
  • Site-wide: 92,576
• Since beginning of last month:
  • Site-wide: 88,257

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 28,561
  • In biochemistry: 666
• Year to date:
  • Site-wide: 20,137
• Since beginning of last month:
  • Site-wide: 21,248

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

• Downloaded 788 times
• Download rankings, all-time:
  • Site-wide: 29,223
  • In neuroscience: 3,950
• Year to date:
  • Site-wide: 73,260
• Since beginning of last month:
  • Site-wide: 57,560

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

• Downloaded 783 times
• Download rankings, all-time:
  • Site-wide: 29,493
  • In infectious diseases: 2,041
• Year to date:
  • Site-wide: 20,097
• Since beginning of last month:
  • Site-wide: 24,461

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

• Downloaded 768 times
• Download rankings, all-time:
  • Site-wide: 30,346
  • In infectious diseases: 2,079
• Year to date:
  • Site-wide: 44,714
• Since beginning of last month:
  • Site-wide: 34,209

Multi-generational silencing dynamics control cell aging

• Downloaded 765 times
• Download rankings, all-time:
  • Site-wide: 30,528
  • In systems biology: 680
• Year to date:
  • Site-wide: 106,753
• Since beginning of last month:
  • Site-wide: 114,918

Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run

• Downloaded 763 times
• Download rankings, all-time:
  • Site-wide: 30,626
  • In immunology: 881
• Year to date:
  • Site-wide: 15,679
• Since beginning of last month:
  • Site-wide: 15,787

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 762 times
• Download rankings, all-time:
  • Site-wide: 30,715
  • In genomics: 2,760
• Year to date:
  • Site-wide: 101,764
• Since beginning of last month:
  • Site-wide: 92,078

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

• Downloaded 759 times
• Download rankings, all-time:
  • Site-wide: 30,875
  • In systems biology: 686
• Year to date:
  • Site-wide: 93,718
• Since beginning of last month:
  • Site-wide: 87,840

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

• Downloaded 634 times
• Download rankings, all-time:
  • Site-wide: 39,312
  • In immunology: 1,109
• Year to date:
  • Site-wide: 43,366
• Since beginning of last month:
  • Site-wide: 68,375

Cycloserine for Treatment of Multidrug-Resistant Tuberculosis in China: A Retrospective Observational Study

• Downloaded 589 times
• Download rankings, all-time:
  • Site-wide: 43,112
  • In microbiology: 2,650
• Year to date:
  • Site-wide: 89,079
• Since beginning of last month:
  • Site-wide: 107,569

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

• Downloaded 580 times
• Download rankings, all-time:
  • Site-wide: 43,922
  • In immunology: 1,230
• Year to date:
  • Site-wide: 22,157
• Since beginning of last month:
  • Site-wide: 16,669

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

• Downloaded 568 times
• Download rankings, all-time:
  • Site-wide: 45,125
  • In cancer biology: 1,265
• Year to date:
  • Site-wide: 119,568
• Since beginning of last month:
  • Site-wide: 123,198

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 46,734
  • In neuroscience: 6,802
• Year to date:
  • Site-wide: 118,822
• Since beginning of last month:
  • Site-wide: 114,567

Electrospun Ag-doped SnO2 hollow nanofibers with high antibacterial activity

• Downloaded 542 times
• Download rankings, all-time:
  • Site-wide: 47,780
  • In biochemistry: 1,232
• Year to date:
  • Site-wide: 59,496
• Since beginning of last month:
  • Site-wide: 62,968

From Community Acquired Pneumonia to COVID-19: A Deep Learning Based Method for Quantitative Analysis of COVID-19 on thick-section CT Scans

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 48,747
  • In radiology and imaging: 77
• Year to date:
  • Site-wide: 71,581
• Since beginning of last month:
  • Site-wide: 66,955

Gender differences in attitudes toward death among Chinese university students: A survey in hunan and Heilongjiang province

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 50,220
  • In scientific communication and education: 305
• Year to date:
  • Site-wide: 70,591
• Since beginning of last month:
  • Site-wide: 58,237

Vinculin anchors contractile actin to the cardiomyocyte adherens junction

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 53,375
  • In cell biology: 2,309
• Year to date:
  • Site-wide: 102,126
• Since beginning of last month:
  • Site-wide: 88,038

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 54,161
  • In biophysics: 1,870
• Year to date:
  • Site-wide: 132,703
• Since beginning of last month:
  • Site-wide: 125,403

Ultra-fast and accurate motif finding in large ChIP-seq datasets reveals transcription factor binding patterns

• Downloaded 461 times
• Download rankings, all-time:
  • Site-wide: 57,507
  • In bioinformatics: 5,768
• Year to date:
  • Site-wide: 98,344
• Since beginning of last month:
  • Site-wide: 71,118

SARS-CoV-2 antibody signatures for predicting the outcome of COVID-19

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 61,699
  • In infectious diseases: 2,910
• Year to date:
  • Site-wide: 10,914
• Since beginning of last month:
  • Site-wide: 11,106

A label-free approach to detect ligand binding to cell surface proteins in real time

• Downloaded 382 times
• Download rankings, all-time:
  • Site-wide: 69,400
  • In biophysics: 2,538
• Year to date:
  • Site-wide: 110,540
• Since beginning of last month:
  • Site-wide: 114,138

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 70,859
  • In bioinformatics: 6,746
• Year to date:
  • Site-wide: 41,382
• Since beginning of last month:
  • Site-wide: 31,784

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 73,507
  • In molecular biology: 2,156
• Year to date:
  • Site-wide: 115,789
• Since beginning of last month:
  • Site-wide: 87,733

Variable sensitivity to DNA damaging chemotherapeutic modulated by cell type-dependent bimodal p53 dynamics

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 74,624
  • In systems biology: 1,799
• Year to date:
  • Site-wide: 131,144
• Since beginning of last month:
  • Site-wide: 123,614

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 76,821
  • In bioinformatics: 7,123
• Year to date:
  • Site-wide: 34,592
• Since beginning of last month:
  • Site-wide: 33,857

bHLH11 negatively regulates Fe homeostasis by its EAR motifs recruiting corepressors in Arabidopsis

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 77,692
  • In plant biology: 2,072
• Year to date:
  • Site-wide: 76,931
• Since beginning of last month:
  • Site-wide: 73,576

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 79,578
  • In epidemiology: 3,302
• Year to date:
  • Site-wide: 32,787
• Since beginning of last month:
  • Site-wide: 29,561

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 84,333
  • In bioinformatics: 7,607
• Year to date:
  • Site-wide: 20,438
• Since beginning of last month:
  • Site-wide: 18,455

Microplate Assay for Denatured Collagen using Collagen Hybridizing Peptides

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 84,602
  • In bioengineering: 1,583
• Year to date:
  • Site-wide: 124,727
• Since beginning of last month:
  • Site-wide: 115,708

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 89,870
  • In genetics: 4,058
• Year to date:
  • Site-wide: 75,187
• Since beginning of last month:
  • Site-wide: 127,747

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 91,628
  • In plant biology: 2,458
• Year to date:
  • Site-wide: 99,887
• Since beginning of last month:
  • Site-wide: 128,045

Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients

• Downloaded 262 times
• Download rankings, all-time:
  • Site-wide: 92,890
  • In public and global health: 1,025
• Year to date:
  • Site-wide: 35,679
• Since beginning of last month:
  • Site-wide: 23,465

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 93,870
  • In neuroscience: 14,550
• Year to date:
  • Site-wide: 130,142
• Since beginning of last month:
  • Site-wide: 105,225

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as regulator of cell adhesion and actin dynamics in Drosophila

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 94,136
  • In genetics: 4,222
• Year to date:
  • Site-wide: 130,339
• Since beginning of last month:
  • Site-wide: 130,423

Reconstructing species evolutionary trees using the numerical features of microRNA

• Downloaded 244 times
• Download rankings, all-time:
  • Site-wide: 96,842
  • In bioinformatics: 8,408
• Year to date:
  • Site-wide: 126,035
• Since beginning of last month:
  • Site-wide: 133,116

Rapid detection of cytochrome cd1-containing nitrite reductase encoding gene nirS with loop-mediated isothermal amplification assay

• Downloaded 214 times
• Download rankings, all-time:
  • Site-wide: 103,666
  • In microbiology: 7,616
• Year to date:
  • Site-wide: 102,703
• Since beginning of last month:
  • Site-wide: 122,909

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

• Downloaded 208 times
• Download rankings, all-time:
  • Site-wide: 104,945
  • In bioengineering: 2,031
• Year to date:
  • Site-wide: 64,935
• Since beginning of last month:
  • Site-wide: 83,099

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

• Downloaded 204 times
• Download rankings, all-time:
  • Site-wide: 105,773
  • In molecular biology: 3,142
• Year to date:
  • Site-wide: 52,204
• Since beginning of last month:
  • Site-wide: 35,988

Evolution of cytokine production capacity in ancient and modern European populations

• Downloaded 199 times
• Download rankings, all-time:
  • Site-wide: 106,788
  • In genomics: 6,196
• Year to date:
  • Site-wide: 10,326
• Since beginning of last month:
  • Site-wide: 12,509

Cytochrome OmcS is not essential for long-range electron transport in Geobacter sulfurreducens strain KN400

• Downloaded 196 times
• Download rankings, all-time:
  • Site-wide: 107,541
  • In microbiology: 7,959
• Year to date:
  • Site-wide: 52,382
• Since beginning of last month:
  • Site-wide: 54,694

Exploration of target spaces in the human genome for protein and peptide drugs

• Downloaded 175 times
• Download rankings, all-time:
  • Site-wide: 111,988
  • In bioinformatics: 9,305
• Year to date:
  • Site-wide: 81,116
• Since beginning of last month:
  • Site-wide: 82,915

A combined microphysiological-computational omics approach in dietary protein evaluation

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 115,118
  • In bioengineering: 2,263
• Year to date:
  • Site-wide: 96,435
• Since beginning of last month:
  • Site-wide: 119,117

Discovery Function Labels Based On Numerical Features Of MicroRNA Found In Plant

• Downloaded 158 times
• Download rankings, all-time:
  • Site-wide: 115,556
  • In bioinformatics: 9,488
• Year to date:
  • Site-wide: 126,036
• Since beginning of last month:
  • Site-wide: 126,756

MpsLDA-ProSVM: predicting multi-label protein subcellular localization by wMLDAe dimensionality reduction and ProSVM classifier

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 117,990
  • In bioinformatics: 9,633
• Year to date:
  • Site-wide: 96,369
• Since beginning of last month:
  • Site-wide: 101,007

Discovering Differences and Similarities among Species Based on Numeric Features of microRNAs

• Downloaded 145 times
• Download rankings, all-time:
  • Site-wide: 118,283
  • In bioinformatics: 9,645
• Year to date:
  • Site-wide: 131,780
• Since beginning of last month:
  • Site-wide: 129,120

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

• Downloaded 121 times
• Download rankings, all-time:
  • Site-wide: 122,819
  • In plant biology: 3,459
• Year to date:
  • Site-wide: 133,253
• Since beginning of last month:
  • Site-wide: 127,992

Protein Surface Printer for Exploring Protein Domains

• Downloaded 118 times
• Download rankings, all-time:
  • Site-wide: 123,462
  • In bioinformatics: 9,927
• Year to date:
  • Site-wide: 90,871
• Since beginning of last month:
  • Site-wide: 67,126

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

• Downloaded 102 times
• Download rankings, all-time:
  • Site-wide: 126,291
  • In plant biology: 3,573
• Year to date:
  • Site-wide: 96,742
• Since beginning of last month:
  • Site-wide: 120,490

Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

• Downloaded 91 times
• Download rankings, all-time:
  • Site-wide: 128,194
  • In molecular biology: 3,857
• Year to date:
  • Site-wide: 99,128
• Since beginning of last month:
  • Site-wide: 82,548

Collagen induced inflammations

• Downloaded 84 times
• Download rankings, all-time:
  • Site-wide: 129,114
  • In immunology: 3,729
• Year to date:
  • Site-wide: 81,655
• Since beginning of last month:
  • Site-wide: 84,442