Author: Yang Li

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Preprints

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

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  • Site-wide: 348
  • In infectious diseases: 129
• Year to date:
  • Site-wide: 56
• Since beginning of last month:
  • Site-wide: 7

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

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  • Site-wide: 370
  • In infectious diseases: 138
• Year to date:
  • Site-wide: 17,770
• Since beginning of last month:
  • Site-wide: 15,399

SnapATAC: A Comprehensive Analysis Package for Single Cell ATAC-seq

• Downloaded 9,387 times
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  • Site-wide: 951
  • In bioinformatics: 48
• Year to date:
  • Site-wide: 1,707
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  • Site-wide: 3,793

Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

• Downloaded 6,198 times
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  • Site-wide: 1,623
  • In infectious diseases: 423
• Year to date:
  • Site-wide: 8,304
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  • Site-wide: 11,712

A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

• Downloaded 4,476 times
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  • Site-wide: 2,563
  • In neuroscience: 161
• Year to date:
  • Site-wide: 3,233
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  • Site-wide: 6,744

Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

• Downloaded 4,054 times
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  • Site-wide: 2,945
  • In infectious diseases: 615
• Year to date:
  • Site-wide: 14,333
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  • Site-wide: 24,592

Suppressive myeloid cells are a hallmark of severe COVID-19

• Downloaded 3,941 times
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  • Site-wide: 3,076
  • In infectious diseases: 633
• Year to date:
  • Site-wide: 8,027
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  • Site-wide: 8,328

Binary and analog variation of synapses between cortical pyramidal neurons

• Downloaded 3,239 times
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  • Site-wide: 4,063
  • In neuroscience: 329
• Year to date:
  • Site-wide: 7,468
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  • Site-wide: 10,674

The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

• Downloaded 3,176 times
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  • Site-wide: 4,187
  • In infectious diseases: 774
• Year to date:
  • Site-wide: 30,942
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  • Site-wide: 54,211

A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention

• Downloaded 3,042 times
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  • Site-wide: 4,441
  • In infectious diseases: 808
• Year to date:
  • Site-wide: 27,014
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  • Site-wide: 19,947

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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  • Site-wide: 4,775
  • In bioengineering: 55
• Year to date:
  • Site-wide: 13,906
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  • Site-wide: 16,380

Multiscale and multimodal reconstruction of cortical structure and function

• Downloaded 2,464 times
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  • Site-wide: 6,051
  • In neuroscience: 555
• Year to date:
  • Site-wide: 4,229
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  • Site-wide: 6,511

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients

• Downloaded 2,078 times
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  • Site-wide: 7,751
  • In infectious diseases: 1,133
• Year to date:
  • Site-wide: 21,662
• Since beginning of last month:
  • Site-wide: 26,534

Cell specific eQTL analysis without sorting cells

• Downloaded 2,011 times
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  • Site-wide: 8,106
  • In genetics: 362
• Year to date:
  • Site-wide: 121,062
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  • Site-wide: 118,504

GeNets: A unified web platform for network-based analyses of genomic data

• Downloaded 1,710 times
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  • Site-wide: 10,334
  • In genomics: 1,096
• Year to date:
  • Site-wide: 58,402
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  • Site-wide: 75,570

Allele-Specific Quantification of Structural Variations in Cancer Genomes

• Downloaded 1,594 times
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  • Site-wide: 11,456
  • In bioinformatics: 1,362
• Year to date:
  • Site-wide: 124,698
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  • Site-wide: 108,348

Chandelier cell anatomy and function reveal a variably distributed but common signal

• Downloaded 1,415 times
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  • Site-wide: 13,686
  • In neuroscience: 1,546
• Year to date:
  • Site-wide: 10,105
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  • Site-wide: 13,712

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

• Downloaded 1,415 times
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  • Site-wide: 13,685
  • In genomics: 1,426
• Year to date:
  • Site-wide: 20,901
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  • Site-wide: 19,254

An epigenetic landscape governs early fate decision in cellular aging

• Downloaded 1,307 times
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  • Site-wide: 15,424
  • In systems biology: 289
• Year to date:
  • Site-wide: 91,149
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  • Site-wide: 80,466

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

• Downloaded 1,276 times
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  • Site-wide: 16,006
  • In biophysics: 394
• Year to date:
  • Site-wide: 1,567
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  • Site-wide: 283

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

• Downloaded 1,016 times
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  • Site-wide: 22,398
  • In plant biology: 353
• Year to date:
  • Site-wide: 79,780
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  • Site-wide: 63,886

Preliminary evaluation of the safety and efficacy of oral human antimicrobial peptide LL-37 in the treatment of patients of COVID-19, a small-scale, single-arm, exploratory safety study

• Downloaded 912 times
• Download rankings, all-time:
  • Site-wide: 26,220
  • In infectious diseases: 2,067
• Year to date:
  • Site-wide: 23,962
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  • Site-wide: 24,435

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

• Downloaded 890 times
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  • Site-wide: 27,074
  • In biochemistry: 627
• Year to date:
  • Site-wide: 20,592
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  • Site-wide: 24,604

Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run

• Downloaded 872 times
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  • Site-wide: 27,903
  • In immunology: 862
• Year to date:
  • Site-wide: 15,811
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  • Site-wide: 14,308

The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics.

• Downloaded 833 times
• Download rankings, all-time:
  • Site-wide: 29,773
  • In cell biology: 1,125
• Year to date:
  • Site-wide: 93,657
• Since beginning of last month:
  • Site-wide: 59,577

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

• Downloaded 828 times
• Download rankings, all-time:
  • Site-wide: 29,998
  • In infectious diseases: 2,238
• Year to date:
  • Site-wide: 27,520
• Since beginning of last month:
  • Site-wide: 39,756

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

• Downloaded 803 times
• Download rankings, all-time:
  • Site-wide: 31,301
  • In neuroscience: 4,160
• Year to date:
  • Site-wide: 89,063
• Since beginning of last month:
  • Site-wide: 119,002

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 31,656
  • In infectious diseases: 2,302
• Year to date:
  • Site-wide: 55,107
• Since beginning of last month:
  • Site-wide: 53,833

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 771 times
• Download rankings, all-time:
  • Site-wide: 33,078
  • In genomics: 2,885
• Year to date:
  • Site-wide: 117,365
• Since beginning of last month:
  • Site-wide: 129,208

Multi-generational silencing dynamics control cell aging

• Downloaded 770 times
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  • Site-wide: 33,161
  • In systems biology: 713
• Year to date:
  • Site-wide: 129,081
• Since beginning of last month:
  • Site-wide: 134,020

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

• Downloaded 768 times
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  • Site-wide: 33,236
  • In systems biology: 719
• Year to date:
  • Site-wide: 112,086
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  • Site-wide: 120,114

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

• Downloaded 704 times
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  • Site-wide: 37,546
  • In immunology: 1,126
• Year to date:
  • Site-wide: 17,614
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  • Site-wide: 9,278

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

• Downloaded 645 times
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  • Site-wide: 42,095
  • In immunology: 1,252
• Year to date:
  • Site-wide: 66,085
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  • Site-wide: 103,616

Cycloserine for Treatment of Multidrug-Resistant Tuberculosis in China: A Retrospective Observational Study

• Downloaded 609 times
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  • Site-wide: 45,236
  • In microbiology: 2,799
• Year to date:
  • Site-wide: 93,413
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  • Site-wide: 75,022

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

• Downloaded 583 times
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  • Site-wide: 47,800
  • In cancer biology: 1,341
• Year to date:
  • Site-wide: 117,872
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  • Site-wide: 75,480

From Community Acquired Pneumonia to COVID-19: A Deep Learning Based Method for Quantitative Analysis of COVID-19 on thick-section CT Scans

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 48,659
  • In radiology and imaging: 77
• Year to date:
  • Site-wide: 61,634
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  • Site-wide: 42,471

Electrospun Ag-doped SnO2 hollow nanofibers with high antibacterial activity

• Downloaded 573 times
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  • Site-wide: 48,752
  • In biochemistry: 1,260
• Year to date:
  • Site-wide: 63,604
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  • Site-wide: 63,867

Gender differences in attitudes toward death among Chinese university students: A survey in hunan and Heilongjiang province

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  • Site-wide: 49,233
  • In scientific communication and education: 299
• Year to date:
  • Site-wide: 56,493
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  • Site-wide: 34,676

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

• Downloaded 555 times
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  • Site-wide: 50,745
  • In neuroscience: 7,308
• Year to date:
  • Site-wide: 138,155
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  • Site-wide: 141,427

Vinculin anchors contractile actin to the cardiomyocyte adherens junction

• Downloaded 513 times
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  • Site-wide: 55,709
  • In cell biology: 2,431
• Year to date:
  • Site-wide: 98,056
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  • Site-wide: 81,346

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

• Downloaded 491 times
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  • Site-wide: 58,610
  • In biophysics: 2,028
• Year to date:
  • Site-wide: 142,934
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  • Site-wide: 135,491

Ultra-fast and accurate motif finding in large ChIP-seq datasets reveals transcription factor binding patterns

• Downloaded 480 times
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  • Site-wide: 60,025
  • In bioinformatics: 5,956
• Year to date:
  • Site-wide: 98,594
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  • Site-wide: 80,212

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

• Downloaded 397 times
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  • Site-wide: 72,916
  • In bioinformatics: 6,852
• Year to date:
  • Site-wide: 55,000
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  • Site-wide: 71,811

A label-free approach to detect ligand binding to cell surface proteins in real time

• Downloaded 388 times
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  • Site-wide: 74,550
  • In biophysics: 2,724
• Year to date:
  • Site-wide: 129,060
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  • Site-wide: 133,904

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity

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  • Site-wide: 74,911
  • In bioinformatics: 6,965
• Year to date:
  • Site-wide: 39,607
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  • Site-wide: 42,002

The genetic risk for COVID-19 severity is associated with defective innate immune responses

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  • Site-wide: 76,963
  • In genetic and genomic medicine: 298
• Year to date:
  • Site-wide: 23,802
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  • Site-wide: 10,039

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

• Downloaded 369 times
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  • Site-wide: 77,927
  • In molecular biology: 2,295
• Year to date:
  • Site-wide: 123,102
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  • Site-wide: 97,270

Variable sensitivity to DNA damaging chemotherapeutic modulated by cell type-dependent bimodal p53 dynamics

• Downloaded 360 times
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  • Site-wide: 79,643
  • In systems biology: 1,868
• Year to date:
  • Site-wide: 138,959
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  • Site-wide: 142,174

bHLH11 negatively regulates Fe homeostasis by its EAR motifs recruiting corepressors in Arabidopsis

• Downloaded 354 times
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  • Site-wide: 80,926
  • In plant biology: 2,132
• Year to date:
  • Site-wide: 86,530
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  • Site-wide: 94,669

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 351 times
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  • Site-wide: 81,501
  • In epidemiology: 3,414
• Year to date:
  • Site-wide: 46,159
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  • Site-wide: 49,590

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 332 times
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  • Site-wide: 85,232
  • In bioinformatics: 7,665
• Year to date:
  • Site-wide: 31,173
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  • Site-wide: 73,712

Microplate Assay for Denatured Collagen using Collagen Hybridizing Peptides

• Downloaded 309 times
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  • Site-wide: 90,055
  • In bioengineering: 1,701
• Year to date:
  • Site-wide: 133,994
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  • Site-wide: 129,905

Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients

• Downloaded 306 times
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  • Site-wide: 90,824
  • In public and global health: 1,084
• Year to date:
  • Site-wide: 41,265
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  • Site-wide: 38,881

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

• Downloaded 286 times
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  • Site-wide: 95,084
  • In genetics: 4,172
• Year to date:
  • Site-wide: 96,705
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  • Site-wide: 123,667

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

• Downloaded 281 times
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  • Site-wide: 96,406
  • In plant biology: 2,585
• Year to date:
  • Site-wide: 110,684
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  • Site-wide: 102,611

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as regulator of cell adhesion and actin dynamics in Drosophila

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  • Site-wide: 98,291
  • In genetics: 4,294
• Year to date:
  • Site-wide: 126,485
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  • Site-wide: 100,392

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

• Downloaded 271 times
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  • Site-wide: 98,534
  • In neuroscience: 15,085
• Year to date:
  • Site-wide: 128,021
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  • Site-wide: 104,353

Structural and mechanistic basis for protein glutamylation by the kinase fold

• Downloaded 263 times
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  • Site-wide: 100,322
  • In biochemistry: 2,934
• Year to date:
  • Site-wide: 14,979
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  • Site-wide: 15,273

Reconstructing species evolutionary trees using the numerical features of microRNA

• Downloaded 248 times
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  • Site-wide: 103,998
  • In bioinformatics: 8,813
• Year to date:
  • Site-wide: 139,987
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  • Site-wide: 125,822

Transmission roles of symptomatic and asymptomatic COVID-19 cases: a modeling study

• Downloaded 239 times
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  • Site-wide: 105,908
  • In infectious diseases: 4,256
• Year to date:
  • Site-wide: 16,982
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  • Site-wide: 2,487

Evolution of cytokine production capacity in ancient and modern European populations

• Downloaded 233 times
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  • Site-wide: 107,306
  • In genomics: 6,242
• Year to date:
  • Site-wide: 17,543
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  • Site-wide: 60,715

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

• Downloaded 232 times
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  • Site-wide: 107,604
  • In bioengineering: 2,078
• Year to date:
  • Site-wide: 72,909
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  • Site-wide: 57,275

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

• Downloaded 226 times
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  • Site-wide: 109,064
  • In molecular biology: 3,235
• Year to date:
  • Site-wide: 66,070
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  • Site-wide: 63,104

Rapid detection of cytochrome cd1-containing nitrite reductase encoding gene nirS with loop-mediated isothermal amplification assay

• Downloaded 222 times
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  • Site-wide: 109,948
  • In microbiology: 8,053
• Year to date:
  • Site-wide: 121,363
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  • Site-wide: 116,934

Cytochrome OmcS is not essential for long-range electron transport in Geobacter sulfurreducens strain KN400

• Downloaded 213 times
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  • Site-wide: 112,167
  • In microbiology: 8,255
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  • Site-wide: 70,217
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  • Site-wide: 78,601

Exploration of target spaces in the human genome for protein and peptide drugs

• Downloaded 195 times
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  • Site-wide: 116,472
  • In bioinformatics: 9,550
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  • Site-wide: 87,596
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  • Site-wide: 71,274

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

• Downloaded 174 times
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  • Site-wide: 121,376
  • In immunology: 3,526
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  • Site-wide: 25,744
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  • Site-wide: 23,242

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

• Downloaded 168 times
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  • Site-wide: 122,706
  • In plant biology: 3,423
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  • Site-wide: 53,497
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  • Site-wide: 16,693

A combined microphysiological-computational omics approach in dietary protein evaluation

• Downloaded 166 times
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  • Site-wide: 123,091
  • In bioengineering: 2,452
• Year to date:
  • Site-wide: 119,713
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  • Site-wide: 111,658

Discovery Function Labels Based On Numerical Features Of MicroRNA Found In Plant

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  • Site-wide: 124,295
  • In bioinformatics: 9,977
• Year to date:
  • Site-wide: 140,213
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  • Site-wide: 139,835

MpsLDA-ProSVM: predicting multi-label protein subcellular localization by wMLDAe dimensionality reduction and ProSVM classifier

• Downloaded 155 times
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  • Site-wide: 125,598
  • In bioinformatics: 10,055
• Year to date:
  • Site-wide: 114,541
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  • Site-wide: 110,859

Discovering Differences and Similarities among Species Based on Numeric Features of microRNAs

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  • Site-wide: 126,293
  • In bioinformatics: 10,088
• Year to date:
  • Site-wide: 140,225
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  • Site-wide: 140,312

Protein Surface Printer for Exploring Protein Domains

• Downloaded 144 times
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  • Site-wide: 127,806
  • In bioinformatics: 10,174
• Year to date:
  • Site-wide: 84,493
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  • Site-wide: 72,000

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

• Downloaded 125 times
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  • Site-wide: 131,798
  • In plant biology: 3,718
• Year to date:
  • Site-wide: 142,853
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  • Site-wide: 140,343

Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

• Downloaded 109 times
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  • Site-wide: 134,976
  • In molecular biology: 4,031
• Year to date:
  • Site-wide: 100,546
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  • Site-wide: 94,349

Collagen induced inflammations

• Downloaded 107 times
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  • Site-wide: 135,375
  • In immunology: 4,000
• Year to date:
  • Site-wide: 83,778
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  • Site-wide: 88,538