Author: Ian J Deary

Downloads per author, site-wide

Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,147 times
• Download rankings, all-time:
  • Site-wide: 296 out of 94,912
  • In genetics: 22 out of 4,824
• Year to date:
  • Site-wide: 13,191 out of 94,912
• Since beginning of last month:
  • Site-wide: 11,019 out of 94,912

The genetic architecture of the human cerebral cortex

• Downloaded 7,580 times
• Download rankings, all-time:
  • Site-wide: 403 out of 94,912
  • In genetics: 28 out of 4,824
• Year to date:
  • Site-wide: 1,669 out of 94,912
• Since beginning of last month:
  • Site-wide: 5,860 out of 94,912

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 2,958 times
• Download rankings, all-time:
  • Site-wide: 2,031 out of 94,912
  • In genetics: 155 out of 4,824
• Year to date:
  • Site-wide: 26,029 out of 94,912
• Since beginning of last month:
  • Site-wide: 18,506 out of 94,912

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,617 times
• Download rankings, all-time:
  • Site-wide: 2,491 out of 94,912
  • In genetics: 189 out of 4,824
• Year to date:
  • Site-wide: 32,028 out of 94,912
• Since beginning of last month:
  • Site-wide: 61,738 out of 94,912

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,087 times
• Download rankings, all-time:
  • Site-wide: 3,636 out of 94,912
  • In genetics: 274 out of 4,824
• Year to date:
  • Site-wide: 8,622 out of 94,912
• Since beginning of last month:
  • Site-wide: 10,747 out of 94,912

Molecular genetic contributions to self-rated health

• Downloaded 2,063 times
• Download rankings, all-time:
  • Site-wide: 3,697 out of 94,912
  • In genetics: 279 out of 4,824
• Year to date:
  • Site-wide: 61,731 out of 94,912
• Since beginning of last month:
  • Site-wide: 41,329 out of 94,912

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,000 times
• Download rankings, all-time:
  • Site-wide: 3,878 out of 94,912
  • In genetics: 289 out of 4,824
• Year to date:
  • Site-wide: 40,387 out of 94,912
• Since beginning of last month:
  • Site-wide: 37,215 out of 94,912

GWAS on family history of Alzheimer's disease

• Downloaded 1,911 times
• Download rankings, all-time:
  • Site-wide: 4,176 out of 94,912
  • In genetics: 307 out of 4,824
• Year to date:
  • Site-wide: 35,482 out of 94,912
• Since beginning of last month:
  • Site-wide: 35,353 out of 94,912

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 1,838 times
• Download rankings, all-time:
  • Site-wide: 4,474 out of 94,912
  • In genetics: 323 out of 4,824
• Year to date:
  • Site-wide: 7,264 out of 94,912
• Since beginning of last month:
  • Site-wide: 6,529 out of 94,912

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,713 times
• Download rankings, all-time:
  • Site-wide: 5,009 out of 94,912
  • In genetics: 364 out of 4,824
• Year to date:
  • Site-wide: 47,384 out of 94,912
• Since beginning of last month:
  • Site-wide: 48,401 out of 94,912

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,644 times
• Download rankings, all-time:
  • Site-wide: 5,356 out of 94,912
  • In genetics: 388 out of 4,824
• Year to date:
  • Site-wide: 44,242 out of 94,912
• Since beginning of last month:
  • Site-wide: 48,193 out of 94,912

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,573 times
• Download rankings, all-time:
  • Site-wide: 5,800 out of 94,912
  • In neuroscience: 849 out of 16,862
• Year to date:
  • Site-wide: 78,645 out of 94,912
• Since beginning of last month:
  • Site-wide: 63,680 out of 94,912

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,470 times
• Download rankings, all-time:
  • Site-wide: 6,486 out of 94,912
  • In genomics: 1,017 out of 5,955
• Year to date:
  • Site-wide: 26,665 out of 94,912
• Since beginning of last month:
  • Site-wide: 39,729 out of 94,912

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,384 times
• Download rankings, all-time:
  • Site-wide: 7,159 out of 94,912
  • In neuroscience: 1,076 out of 16,862
• Year to date:
  • Site-wide: 53,839 out of 94,912
• Since beginning of last month:
  • Site-wide: 38,251 out of 94,912

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,264 times
• Download rankings, all-time:
  • Site-wide: 8,361 out of 94,912
  • In genetics: 578 out of 4,824
• Year to date:
  • Site-wide: 12,697 out of 94,912
• Since beginning of last month:
  • Site-wide: 18,343 out of 94,912

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,060 times
• Download rankings, all-time:
  • Site-wide: 11,190 out of 94,912
  • In bioinformatics: 1,801 out of 8,837
• Year to date:
  • Site-wide: 57,081 out of 94,912
• Since beginning of last month:
  • Site-wide: 53,668 out of 94,912

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 1,027 times
• Download rankings, all-time:
  • Site-wide: 11,807 out of 94,912
  • In neuroscience: 1,858 out of 16,862
• Year to date:
  • Site-wide: 64,216 out of 94,912
• Since beginning of last month:
  • Site-wide: 59,706 out of 94,912

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 982 times
• Download rankings, all-time:
  • Site-wide: 12,627 out of 94,912
  • In genomics: 1,722 out of 5,955
• Year to date:
  • Site-wide: 58,404 out of 94,912
• Since beginning of last month:
  • Site-wide: 63,237 out of 94,912

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 936 times
• Download rankings, all-time:
  • Site-wide: 13,606 out of 94,912
  • In genetics: 888 out of 4,824
• Year to date:
  • Site-wide: 64,481 out of 94,912
• Since beginning of last month:
  • Site-wide: 51,126 out of 94,912

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 813 times
• Download rankings, all-time:
  • Site-wide: 16,982 out of 94,912
  • In genetics: 1,076 out of 4,824
• Year to date:
  • Site-wide: 52,529 out of 94,912
• Since beginning of last month:
  • Site-wide: 48,304 out of 94,912

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 782 times
• Download rankings, all-time:
  • Site-wide: 18,032 out of 94,912
  • In genetics: 1,141 out of 4,824
• Year to date:
  • Site-wide: 72,995 out of 94,912
• Since beginning of last month:
  • Site-wide: 54,090 out of 94,912

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 747 times
• Download rankings, all-time:
  • Site-wide: 19,294 out of 94,912
  • In genetics: 1,217 out of 4,824
• Year to date:
  • Site-wide: 77,030 out of 94,912
• Since beginning of last month:
  • Site-wide: 81,326 out of 94,912

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 718 times
• Download rankings, all-time:
  • Site-wide: 20,451 out of 94,912
  • In genomics: 2,388 out of 5,955
• Year to date:
  • Site-wide: 30,189 out of 94,912
• Since beginning of last month:
  • Site-wide: 33,708 out of 94,912

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 20,534 out of 94,912
  • In genetics: 1,289 out of 4,824
• Year to date:
  • Site-wide: 56,640 out of 94,912
• Since beginning of last month:
  • Site-wide: 73,495 out of 94,912

Factors associated with sharing email information and mental health survey participation in large population cohorts

• Downloaded 693 times
• Download rankings, all-time:
  • Site-wide: 21,557 out of 94,912
  • In genetics: 1,352 out of 4,824
• Year to date:
  • Site-wide: 36,458 out of 94,912
• Since beginning of last month:
  • Site-wide: 50,914 out of 94,912

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 21,761 out of 94,912
  • In bioinformatics: 3,113 out of 8,837
• Year to date:
  • Site-wide: 68,222 out of 94,912
• Since beginning of last month:
  • Site-wide: 51,200 out of 94,912

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 655 times
• Download rankings, all-time:
  • Site-wide: 23,457 out of 94,912
  • In genomics: 2,610 out of 5,955
• Year to date:
  • Site-wide: 67,093 out of 94,912
• Since beginning of last month:
  • Site-wide: 28,273 out of 94,912

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 596 times
• Download rankings, all-time:
  • Site-wide: 26,728 out of 94,912
  • In genetics: 1,633 out of 4,824
• Year to date:
  • Site-wide: 4,164 out of 94,912
• Since beginning of last month:
  • Site-wide: 628 out of 94,912

Genetic contributions to self-reported tiredness

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 27,749 out of 94,912
  • In genetics: 1,691 out of 4,824
• Year to date:
  • Site-wide: 87,035 out of 94,912
• Since beginning of last month:
  • Site-wide: 89,461 out of 94,912

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 30,928 out of 94,912
  • In genomics: 3,103 out of 5,955
• Year to date:
  • Site-wide: 63,391 out of 94,912
• Since beginning of last month:
  • Site-wide: 83,799 out of 94,912

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 30,913 out of 94,912
  • In genetics: 1,846 out of 4,824
• Year to date:
  • Site-wide: 39,763 out of 94,912
• Since beginning of last month:
  • Site-wide: 54,973 out of 94,912

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 527 times
• Download rankings, all-time:
  • Site-wide: 31,264 out of 94,912
  • In genetics: 1,866 out of 4,824
• Year to date:
  • Site-wide: 86,341 out of 94,912
• Since beginning of last month:
  • Site-wide: 82,300 out of 94,912

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 31,384 out of 94,912
  • In genomics: 3,140 out of 5,955
• Year to date:
  • Site-wide: 5,041 out of 94,912
• Since beginning of last month:
  • Site-wide: 10,882 out of 94,912

Estimating the effect-size of gene dosage on cognitive ability across the coding genome

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 32,733 out of 94,912
  • In genetics: 1,932 out of 4,824
• Year to date:
  • Site-wide: 5,298 out of 94,912
• Since beginning of last month:
  • Site-wide: 14,008 out of 94,912

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 34,375 out of 94,912
  • In genomics: 3,342 out of 5,955
• Year to date:
  • Site-wide: 70,644 out of 94,912
• Since beginning of last month:
  • Site-wide: 58,734 out of 94,912

Age-related clonal haemopoiesis is associated with increased epigenetic age

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 34,437 out of 94,912
  • In bioinformatics: 4,354 out of 8,837
• Year to date:
  • Site-wide: 59,948 out of 94,912
• Since beginning of last month:
  • Site-wide: 70,124 out of 94,912

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 464 times
• Download rankings, all-time:
  • Site-wide: 36,606 out of 94,912
  • In genomics: 3,500 out of 5,955
• Year to date:
  • Site-wide: 61,980 out of 94,912
• Since beginning of last month:
  • Site-wide: 52,294 out of 94,912

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 454 times
• Download rankings, all-time:
  • Site-wide: 37,525 out of 94,912
  • In genomics: 3,547 out of 5,955
• Year to date:
  • Site-wide: 72,257 out of 94,912
• Since beginning of last month:
  • Site-wide: 73,424 out of 94,912

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 451 times
• Download rankings, all-time:
  • Site-wide: 37,774 out of 94,912
  • In epidemiology: 535 out of 1,556
• Year to date:
  • Site-wide: 77,832 out of 94,912
• Since beginning of last month:
  • Site-wide: 85,090 out of 94,912

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 436 times
• Download rankings, all-time:
  • Site-wide: 39,368 out of 94,912
  • In genomics: 3,669 out of 5,955
• Year to date:
  • Site-wide: 54,788 out of 94,912
• Since beginning of last month:
  • Site-wide: 43,695 out of 94,912

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 39,764 out of 94,912
  • In neuroscience: 6,834 out of 16,862
• Year to date:
  • Site-wide: 50,510 out of 94,912
• Since beginning of last month:
  • Site-wide: 70,785 out of 94,912

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 41,595 out of 94,912
  • In genetics: 2,402 out of 4,824
• Year to date:
  • Site-wide: 78,059 out of 94,912
• Since beginning of last month:
  • Site-wide: 57,446 out of 94,912

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 42,405 out of 94,912
  • In genomics: 3,832 out of 5,955
• Year to date:
  • Site-wide: 7,477 out of 94,912
• Since beginning of last month:
  • Site-wide: 30,030 out of 94,912

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 42,571 out of 94,912
  • In neuroscience: 7,359 out of 16,862
• Year to date:
  • Site-wide: 82,776 out of 94,912
• Since beginning of last month:
  • Site-wide: 67,434 out of 94,912

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 46,087 out of 94,912
  • In genetics: 2,647 out of 4,824
• Year to date:
  • Site-wide: 90,532 out of 94,912
• Since beginning of last month:
  • Site-wide: 85,715 out of 94,912

Genetic correlations between pain phenotypes and depression and neuroticism

• Downloaded 372 times
• Download rankings, all-time:
  • Site-wide: 46,445 out of 94,912
  • In genetics: 2,658 out of 4,824
• Year to date:
  • Site-wide: 88,130 out of 94,912
• Since beginning of last month:
  • Site-wide: 88,684 out of 94,912

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 47,281 out of 94,912
  • In genomics: 4,120 out of 5,955
• Year to date:
  • Site-wide: 82,532 out of 94,912
• Since beginning of last month:
  • Site-wide: 89,949 out of 94,912

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 365 times
• Download rankings, all-time:
  • Site-wide: 47,433 out of 94,912
  • In genomics: 4,127 out of 5,955
• Year to date:
  • Site-wide: 22,072 out of 94,912
• Since beginning of last month:
  • Site-wide: 49,561 out of 94,912

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 49,498 out of 94,912
  • In neuroscience: 8,657 out of 16,862
• Year to date:
  • Site-wide: 79,077 out of 94,912
• Since beginning of last month:
  • Site-wide: 78,441 out of 94,912

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 53,779 out of 94,912
  • In genetics: 3,003 out of 4,824
• Year to date:
  • Site-wide: 86,194 out of 94,912
• Since beginning of last month:
  • Site-wide: 85,694 out of 94,912

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 53,948 out of 94,912
  • In genetics: 3,014 out of 4,824
• Year to date:
  • Site-wide: 84,063 out of 94,912
• Since beginning of last month:
  • Site-wide: 51,612 out of 94,912

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 55,023 out of 94,912
  • In neuroscience: 9,703 out of 16,862
• Year to date:
  • Site-wide: 11,351 out of 94,912
• Since beginning of last month:
  • Site-wide: 57,352 out of 94,912

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 59,486 out of 94,912
  • In genetics: 3,282 out of 4,824
• Year to date:
  • Site-wide: 13,150 out of 94,912
• Since beginning of last month:
  • Site-wide: 61,247 out of 94,912

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

• Downloaded 280 times
• Download rankings, all-time:
  • Site-wide: 59,555 out of 94,912
  • In neuroscience: 10,476 out of 16,862
• Year to date:
  • Site-wide: 43,765 out of 94,912
• Since beginning of last month:
  • Site-wide: 64,488 out of 94,912

Genetic contributions to health literacy

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 60,187 out of 94,912
  • In epidemiology: 988 out of 1,556
• Year to date:
  • Site-wide: 65,447 out of 94,912
• Since beginning of last month:
  • Site-wide: 34,505 out of 94,912

Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 62,083 out of 94,912
  • In genetics: 3,431 out of 4,824
• Year to date:
  • Site-wide: 87,498 out of 94,912
• Since beginning of last month:
  • Site-wide: 88,665 out of 94,912

Epigenetic signatures of starting and stopping smoking

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 62,726 out of 94,912
  • In genomics: 4,793 out of 5,955
• Year to date:
  • Site-wide: 90,405 out of 94,912
• Since beginning of last month:
  • Site-wide: 80,464 out of 94,912

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 62,724 out of 94,912
  • In epidemiology: 1,036 out of 1,556
• Year to date:
  • Site-wide: 83,620 out of 94,912
• Since beginning of last month:
  • Site-wide: 84,635 out of 94,912

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 210 times
• Download rankings, all-time:
  • Site-wide: 71,510 out of 94,912
  • In cell biology: 3,687 out of 4,894
• Year to date:
  • Site-wide: 19,983 out of 94,912
• Since beginning of last month:
  • Site-wide: 52,465 out of 94,912

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 196 times
• Download rankings, all-time:
  • Site-wide: 73,967 out of 94,912
  • In neuroscience: 13,203 out of 16,862
• Year to date:
  • Site-wide: 66,902 out of 94,912
• Since beginning of last month:
  • Site-wide: 86,169 out of 94,912

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 45 times
• Download rankings, all-time:
  • Site-wide: 92,205 out of 94,912
  • In neuroscience: 16,381 out of 16,862
• Year to date:
  • Site-wide: 88,592 out of 94,912
• Since beginning of last month:
  • Site-wide: 16,119 out of 94,912