Author: Ian J Deary

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,146
  • In genetics: 26
• Year to date:
  • Site-wide: 44,855
• Since beginning of last month:
  • Site-wide: 36,720

The genetic architecture of the human cerebral cortex

• Downloaded 8,225 times
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  • Site-wide: 1,381
  • In genetics: 35
• Year to date:
  • Site-wide: 23,144
• Since beginning of last month:
  • Site-wide: 46,537

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,289 times
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  • Site-wide: 4,804
  • In genetics: 181
• Year to date:
  • Site-wide: 42,864
• Since beginning of last month:
  • Site-wide: 60,287

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,795 times
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  • Site-wide: 6,087
  • In genetics: 247
• Year to date:
  • Site-wide: 108,782
• Since beginning of last month:
  • Site-wide: 120,636

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,761 times
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  • Site-wide: 6,177
  • In genetics: 251
• Year to date:
  • Site-wide: 32,852
• Since beginning of last month:
  • Site-wide: 67,388

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 2,542 times
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  • Site-wide: 6,999
  • In genetics: 288
• Year to date:
  • Site-wide: 14,119
• Since beginning of last month:
  • Site-wide: 35,675

Molecular genetic contributions to self-rated health

• Downloaded 2,288 times
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  • Site-wide: 8,172
  • In genetics: 347
• Year to date:
  • Site-wide: 114,559
• Since beginning of last month:
  • Site-wide: 135,185

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,082 times
• Download rankings, all-time:
  • Site-wide: 9,352
  • In genetics: 386
• Year to date:
  • Site-wide: 149,203
• Since beginning of last month:
  • Site-wide: 153,727

GWAS on family history of Alzheimer's disease

• Downloaded 2,054 times
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  • Site-wide: 9,548
  • In genetics: 392
• Year to date:
  • Site-wide: 111,069
• Since beginning of last month:
  • Site-wide: 111,849

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,904 times
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  • Site-wide: 10,722
  • In genetics: 456
• Year to date:
  • Site-wide: 78,754
• Since beginning of last month:
  • Site-wide: 124,005

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,822 times
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  • Site-wide: 11,450
  • In genetics: 482
• Year to date:
  • Site-wide: 90,249
• Since beginning of last month:
  • Site-wide: 81,814

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,686 times
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  • Site-wide: 12,843
  • In neuroscience: 1,360
• Year to date:
  • Site-wide: 135,753
• Since beginning of last month:
  • Site-wide: 142,382

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,682 times
• Download rankings, all-time:
  • Site-wide: 12,901
  • In genomics: 1,289
• Year to date:
  • Site-wide: 89,076
• Since beginning of last month:
  • Site-wide: 85,958

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,590 times
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  • Site-wide: 13,992
  • In genetics: 611
• Year to date:
  • Site-wide: 47,912
• Since beginning of last month:
  • Site-wide: 57,095

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,546 times
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  • Site-wide: 14,649
  • In genetics: 641
• Year to date:
  • Site-wide: 9,833
• Since beginning of last month:
  • Site-wide: 35,451

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,518 times
• Download rankings, all-time:
  • Site-wide: 15,111
  • In neuroscience: 1,673
• Year to date:
  • Site-wide: 134,928
• Since beginning of last month:
  • Site-wide: 146,012

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 1,252 times
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  • Site-wide: 20,275
  • In genetics: 900
• Year to date:
  • Site-wide: 25,494
• Since beginning of last month:
  • Site-wide: 31,541

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 1,250 times
• Download rankings, all-time:
  • Site-wide: 20,312
  • In genetic and genomic medicine: 95
• Year to date:
  • Site-wide: 7,874
• Since beginning of last month:
  • Site-wide: 16,386

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,156 times
• Download rankings, all-time:
  • Site-wide: 22,873
  • In bioinformatics: 2,573
• Year to date:
  • Site-wide: 148,913
• Since beginning of last month:
  • Site-wide: 145,345

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 1,114 times
• Download rankings, all-time:
  • Site-wide: 24,210
  • In neuroscience: 2,976
• Year to date:
  • Site-wide: 152,955
• Since beginning of last month:
  • Site-wide: 158,480

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,092 times
• Download rankings, all-time:
  • Site-wide: 24,966
  • In genomics: 2,278
• Year to date:
  • Site-wide: 139,592
• Since beginning of last month:
  • Site-wide: 146,027

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 1,049 times
• Download rankings, all-time:
  • Site-wide: 26,595
  • In genetics: 1,171
• Year to date:
  • Site-wide: 121,206
• Since beginning of last month:
  • Site-wide: 123,967

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 919 times
• Download rankings, all-time:
  • Site-wide: 32,256
  • In genetics: 1,417
• Year to date:
  • Site-wide: 139,962
• Since beginning of last month:
  • Site-wide: 131,866

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 33,594
  • In genomics: 2,825
• Year to date:
  • Site-wide: 107,277
• Since beginning of last month:
  • Site-wide: 131,613

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 873 times
• Download rankings, all-time:
  • Site-wide: 34,752
  • In genetics: 1,519
• Year to date:
  • Site-wide: 142,987
• Since beginning of last month:
  • Site-wide: 112,657

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 848 times
• Download rankings, all-time:
  • Site-wide: 36,200
  • In genomics: 2,993
• Year to date:
  • Site-wide: 57,131
• Since beginning of last month:
  • Site-wide: 92,018

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 840 times
• Download rankings, all-time:
  • Site-wide: 36,714
  • In genetics: 1,608
• Year to date:
  • Site-wide: 144,783
• Since beginning of last month:
  • Site-wide: 151,399

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 804 times
• Download rankings, all-time:
  • Site-wide: 39,183
  • In bioinformatics: 4,186
• Year to date:
  • Site-wide: 118,227
• Since beginning of last month:
  • Site-wide: 86,845

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 798 times
• Download rankings, all-time:
  • Site-wide: 39,584
  • In genetics: 1,713
• Year to date:
  • Site-wide: 150,936
• Since beginning of last month:
  • Site-wide: 148,541

Factors associated with sharing email information and mental health survey participation in large population cohorts

• Downloaded 796 times
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  • Site-wide: 39,695
  • In genetics: 1,720
• Year to date:
  • Site-wide: 141,164
• Since beginning of last month:
  • Site-wide: 142,446

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 737 times
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  • Site-wide: 44,373
  • In genomics: 3,489
• Year to date:
  • Site-wide: 158,519
• Since beginning of last month:
  • Site-wide: 148,297

Genetic contributions to self-reported tiredness

• Downloaded 735 times
• Download rankings, all-time:
  • Site-wide: 44,528
  • In genetics: 1,922
• Year to date:
  • Site-wide: 145,274
• Since beginning of last month:
  • Site-wide: 163,851

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 658 times
• Download rankings, all-time:
  • Site-wide: 51,800
  • In genomics: 3,902
• Year to date:
  • Site-wide: 80,682
• Since beginning of last month:
  • Site-wide: 63,086

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 656 times
• Download rankings, all-time:
  • Site-wide: 52,011
  • In neuroscience: 7,326
• Year to date:
  • Site-wide: 89,574
• Since beginning of last month:
  • Site-wide: 83,325

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 621 times
• Download rankings, all-time:
  • Site-wide: 56,049
  • In genetics: 2,380
• Year to date:
  • Site-wide: 149,714
• Since beginning of last month:
  • Site-wide: 156,729

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 56,650
  • In neuroscience: 8,052
• Year to date:
  • Site-wide: 93,228
• Since beginning of last month:
  • Site-wide: 86,317

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 603 times
• Download rankings, all-time:
  • Site-wide: 58,244
  • In genetics: 2,465
• Year to date:
  • Site-wide: 153,978
• Since beginning of last month:
  • Site-wide: 142,659

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 58,568
  • In genomics: 4,277
• Year to date:
  • Site-wide: 155,653
• Since beginning of last month:
  • Site-wide: 148,025

Age-related clonal haemopoiesis is associated with increased epigenetic age

• Downloaded 557 times
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  • Site-wide: 64,286
  • In bioinformatics: 6,180
• Year to date:
  • Site-wide: 162,712
• Since beginning of last month:
  • Site-wide: 162,817

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 546 times
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  • Site-wide: 65,807
  • In genomics: 4,639
• Year to date:
  • Site-wide: 159,032
• Since beginning of last month:
  • Site-wide: 154,126

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 540 times
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  • Site-wide: 66,687
  • In epidemiology: 3,000
• Year to date:
  • Site-wide: 147,312
• Since beginning of last month:
  • Site-wide: 146,497

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 534 times
• Download rankings, all-time:
  • Site-wide: 67,683
  • In genomics: 4,708
• Year to date:
  • Site-wide: 115,192
• Since beginning of last month:
  • Site-wide: 113,967

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 517 times
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  • Site-wide: 70,227
  • In genomics: 4,842
• Year to date:
  • Site-wide: 112,149
• Since beginning of last month:
  • Site-wide: 77,537

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 516 times
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  • Site-wide: 70,404
  • In genomics: 4,849
• Year to date:
  • Site-wide: 158,096
• Since beginning of last month:
  • Site-wide: 150,215

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 516 times
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  • Site-wide: 70,419
  • In genomics: 4,852
• Year to date:
  • Site-wide: 157,707
• Since beginning of last month:
  • Site-wide: 161,011

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 71,119
  • In genetics: 3,027
• Year to date:
  • Site-wide: 145,884
• Since beginning of last month:
  • Site-wide: 157,326

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 74,640
  • In neuroscience: 10,917
• Year to date:
  • Site-wide: 143,870
• Since beginning of last month:
  • Site-wide: 111,856

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 75,836
  • In genetics: 3,220
• Year to date:
  • Site-wide: 136,061
• Since beginning of last month:
  • Site-wide: 91,942

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

• Downloaded 457 times
• Download rankings, all-time:
  • Site-wide: 80,526
  • In genomics: 5,282
• Year to date:
  • Site-wide: 149,412
• Since beginning of last month:
  • Site-wide: 129,140

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 456 times
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  • Site-wide: 80,720
  • In neuroscience: 11,881
• Year to date:
  • Site-wide: 131,558
• Since beginning of last month:
  • Site-wide: 97,973

Genetic correlations between pain phenotypes and depression and neuroticism

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 83,107
  • In genetics: 3,493
• Year to date:
  • Site-wide: 154,951
• Since beginning of last month:
  • Site-wide: 153,791

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 439 times
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  • Site-wide: 84,126
  • In genetics: 3,536
• Year to date:
  • Site-wide: 97,705
• Since beginning of last month:
  • Site-wide: 109,516

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

• Downloaded 409 times
• Download rankings, all-time:
  • Site-wide: 90,137
  • In neuroscience: 13,395
• Year to date:
  • Site-wide: 131,118
• Since beginning of last month:
  • Site-wide: 103,070

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 92,115
  • In genetic and genomic medicine: 476
• Year to date:
  • Site-wide: 54,568
• Since beginning of last month:
  • Site-wide: 45,704

Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

• Downloaded 386 times
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  • Site-wide: 95,307
  • In genetics: 3,958
• Year to date:
  • Site-wide: 108,597
• Since beginning of last month:
  • Site-wide: 102,412

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 97,020
  • In genetics: 4,022
• Year to date:
  • Site-wide: 159,092
• Since beginning of last month:
  • Site-wide: 146,209

Genetic contributions to health literacy

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 97,331
  • In epidemiology: 4,158
• Year to date:
  • Site-wide: 153,936
• Since beginning of last month:
  • Site-wide: 143,841

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 98,193
  • In neuroscience: 14,588
• Year to date:
  • Site-wide: 160,315
• Since beginning of last month:
  • Site-wide: 164,145

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 99,431
  • In genetics: 4,123
• Year to date:
  • Site-wide: 162,640
• Since beginning of last month:
  • Site-wide: 162,321

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 344 times
• Download rankings, all-time:
  • Site-wide: 105,190
  • In epidemiology: 4,464
• Year to date:
  • Site-wide: 142,052
• Since beginning of last month:
  • Site-wide: 112,337

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 329 times
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  • Site-wide: 108,786
  • In cell biology: 5,065
• Year to date:
  • Site-wide: 133,917
• Since beginning of last month:
  • Site-wide: 132,206

Epigenetic signatures of starting and stopping smoking

• Downloaded 314 times
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  • Site-wide: 112,802
  • In genomics: 6,485
• Year to date:
  • Site-wide: 162,444
• Since beginning of last month:
  • Site-wide: 145,406

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 289 times
• Download rankings, all-time:
  • Site-wide: 119,086
  • In neuroscience: 17,863
• Year to date:
  • Site-wide: 138,580
• Since beginning of last month:
  • Site-wide: 106,542

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 237 times
• Download rankings, all-time:
  • Site-wide: 132,953
  • In neuroscience: 19,949
• Year to date:
  • Site-wide: 88,479
• Since beginning of last month:
  • Site-wide: 119,709