Author: Ian J Deary

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,392 times
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  • Site-wide: 875
  • In genetics: 26
• Year to date:
  • Site-wide: 32,750
• Since beginning of last month:
  • Site-wide: 37,308

The genetic architecture of the human cerebral cortex

• Downloaded 8,006 times
• Download rankings, all-time:
  • Site-wide: 1,074
  • In genetics: 31
• Year to date:
  • Site-wide: 14,130
• Since beginning of last month:
  • Site-wide: 26,233

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,083 times
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  • Site-wide: 4,004
  • In genetics: 168
• Year to date:
  • Site-wide: 55,878
• Since beginning of last month:
  • Site-wide: 75,377

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,710 times
• Download rankings, all-time:
  • Site-wide: 4,820
  • In genetics: 213
• Year to date:
  • Site-wide: 100,288
• Since beginning of last month:
  • Site-wide: 108,484

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,567 times
• Download rankings, all-time:
  • Site-wide: 5,193
  • In genetics: 237
• Year to date:
  • Site-wide: 23,664
• Since beginning of last month:
  • Site-wide: 29,943

Molecular genetic contributions to self-rated health

• Downloaded 2,234 times
• Download rankings, all-time:
  • Site-wide: 6,392
  • In genetics: 307
• Year to date:
  • Site-wide: 57,896
• Since beginning of last month:
  • Site-wide: 48,144

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 2,172 times
• Download rankings, all-time:
  • Site-wide: 6,650
  • In genetics: 320
• Year to date:
  • Site-wide: 14,644
• Since beginning of last month:
  • Site-wide: 21,821

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,039 times
• Download rankings, all-time:
  • Site-wide: 7,289
  • In genetics: 344
• Year to date:
  • Site-wide: 114,816
• Since beginning of last month:
  • Site-wide: 116,277

GWAS on family history of Alzheimer's disease

• Downloaded 1,990 times
• Download rankings, all-time:
  • Site-wide: 7,580
  • In genetics: 353
• Year to date:
  • Site-wide: 65,170
• Since beginning of last month:
  • Site-wide: 54,106

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,792 times
• Download rankings, all-time:
  • Site-wide: 8,864
  • In genetics: 415
• Year to date:
  • Site-wide: 64,390
• Since beginning of last month:
  • Site-wide: 85,875

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,717 times
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  • Site-wide: 9,478
  • In genetics: 450
• Year to date:
  • Site-wide: 85,161
• Since beginning of last month:
  • Site-wide: 94,471

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,640 times
• Download rankings, all-time:
  • Site-wide: 10,115
  • In neuroscience: 1,099
• Year to date:
  • Site-wide: 81,393
• Since beginning of last month:
  • Site-wide: 88,840

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,586 times
• Download rankings, all-time:
  • Site-wide: 10,622
  • In genomics: 1,147
• Year to date:
  • Site-wide: 66,241
• Since beginning of last month:
  • Site-wide: 66,738

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,472 times
• Download rankings, all-time:
  • Site-wide: 11,810
  • In neuroscience: 1,322
• Year to date:
  • Site-wide: 79,627
• Since beginning of last month:
  • Site-wide: 85,019

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,457 times
• Download rankings, all-time:
  • Site-wide: 11,999
  • In genetics: 582
• Year to date:
  • Site-wide: 27,568
• Since beginning of last month:
  • Site-wide: 21,549

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,206 times
• Download rankings, all-time:
  • Site-wide: 16,014
  • In genetics: 790
• Year to date:
  • Site-wide: 5,625
• Since beginning of last month:
  • Site-wide: 5,004

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,114 times
• Download rankings, all-time:
  • Site-wide: 18,032
  • In bioinformatics: 2,156
• Year to date:
  • Site-wide: 110,306
• Since beginning of last month:
  • Site-wide: 115,572

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 1,077 times
• Download rankings, all-time:
  • Site-wide: 18,957
  • In neuroscience: 2,372
• Year to date:
  • Site-wide: 114,119
• Since beginning of last month:
  • Site-wide: 114,922

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,047 times
• Download rankings, all-time:
  • Site-wide: 19,750
  • In genomics: 1,984
• Year to date:
  • Site-wide: 87,249
• Since beginning of last month:
  • Site-wide: 87,098

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 1,033 times
• Download rankings, all-time:
  • Site-wide: 20,124
  • In genetics: 966
• Year to date:
  • Site-wide: 17,260
• Since beginning of last month:
  • Site-wide: 42,123

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 996 times
• Download rankings, all-time:
  • Site-wide: 21,219
  • In genetics: 1,018
• Year to date:
  • Site-wide: 64,906
• Since beginning of last month:
  • Site-wide: 67,173

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 871 times
• Download rankings, all-time:
  • Site-wide: 25,762
  • In genetics: 1,236
• Year to date:
  • Site-wide: 95,072
• Since beginning of last month:
  • Site-wide: 101,709

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 825 times
• Download rankings, all-time:
  • Site-wide: 27,759
  • In genomics: 2,564
• Year to date:
  • Site-wide: 64,790
• Since beginning of last month:
  • Site-wide: 62,425

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 817 times
• Download rankings, all-time:
  • Site-wide: 28,166
  • In genetics: 1,364
• Year to date:
  • Site-wide: 127,140
• Since beginning of last month:
  • Site-wide: 129,061

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 29,145
  • In genetics: 1,411
• Year to date:
  • Site-wide: 98,307
• Since beginning of last month:
  • Site-wide: 85,526

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 757 times
• Download rankings, all-time:
  • Site-wide: 31,350
  • In genetics: 1,506
• Year to date:
  • Site-wide: 115,908
• Since beginning of last month:
  • Site-wide: 127,170

Factors associated with sharing email information and mental health survey participation in large population cohorts

• Downloaded 749 times
• Download rankings, all-time:
  • Site-wide: 31,811
  • In genetics: 1,534
• Year to date:
  • Site-wide: 98,611
• Since beginning of last month:
  • Site-wide: 114,932

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 32,149
  • In genomics: 2,850
• Year to date:
  • Site-wide: 28,188
• Since beginning of last month:
  • Site-wide: 44,394

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 725 times
• Download rankings, all-time:
  • Site-wide: 33,304
  • In bioinformatics: 3,726
• Year to date:
  • Site-wide: 114,316
• Since beginning of last month:
  • Site-wide: 116,342

Genetic contributions to self-reported tiredness

• Downloaded 714 times
• Download rankings, all-time:
  • Site-wide: 33,917
  • In genetics: 1,634
• Year to date:
  • Site-wide: 60,682
• Since beginning of last month:
  • Site-wide: 128,833

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 704 times
• Download rankings, all-time:
  • Site-wide: 34,620
  • In genomics: 3,011
• Year to date:
  • Site-wide: 130,619
• Since beginning of last month:
  • Site-wide: 125,189

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 689 times
• Download rankings, all-time:
  • Site-wide: 35,606
  • In genetic and genomic medicine: 112
• Year to date:
  • Site-wide: 10,387
• Since beginning of last month:
  • Site-wide: 12,296

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 44,301
  • In genetics: 2,074
• Year to date:
  • Site-wide: 108,487
• Since beginning of last month:
  • Site-wide: 108,747

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 44,744
  • In neuroscience: 6,462
• Year to date:
  • Site-wide: 50,733
• Since beginning of last month:
  • Site-wide: 52,224

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 571 times
• Download rankings, all-time:
  • Site-wide: 45,245
  • In genetics: 2,129
• Year to date:
  • Site-wide: 106,117
• Since beginning of last month:
  • Site-wide: 101,764

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 45,822
  • In genomics: 3,668
• Year to date:
  • Site-wide: 120,221
• Since beginning of last month:
  • Site-wide: 101,500

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 554 times
• Download rankings, all-time:
  • Site-wide: 46,980
  • In genomics: 3,736
• Year to date:
  • Site-wide: 58,907
• Since beginning of last month:
  • Site-wide: 35,979

Age-related clonal haemopoiesis is associated with increased epigenetic age

• Downloaded 531 times
• Download rankings, all-time:
  • Site-wide: 49,446
  • In bioinformatics: 5,131
• Year to date:
  • Site-wide: 133,307
• Since beginning of last month:
  • Site-wide: 128,689

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 519 times
• Download rankings, all-time:
  • Site-wide: 50,812
  • In genomics: 3,963
• Year to date:
  • Site-wide: 116,163
• Since beginning of last month:
  • Site-wide: 101,157

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

• Downloaded 514 times
• Download rankings, all-time:
  • Site-wide: 51,365
  • In neuroscience: 7,574
• Year to date:
  • Site-wide: 91,306
• Since beginning of last month:
  • Site-wide: 79,399

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 54,373
  • In epidemiology: 2,392
• Year to date:
  • Site-wide: 126,405
• Since beginning of last month:
  • Site-wide: 131,543

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 54,774
  • In genomics: 4,181
• Year to date:
  • Site-wide: 113,448
• Since beginning of last month:
  • Site-wide: 121,188

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 484 times
• Download rankings, all-time:
  • Site-wide: 55,077
  • In genomics: 4,191
• Year to date:
  • Site-wide: 124,607
• Since beginning of last month:
  • Site-wide: 123,452

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 468 times
• Download rankings, all-time:
  • Site-wide: 57,175
  • In genetics: 2,664
• Year to date:
  • Site-wide: 102,847
• Since beginning of last month:
  • Site-wide: 72,111

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 58,325
  • In genomics: 4,345
• Year to date:
  • Site-wide: 95,371
• Since beginning of last month:
  • Site-wide: 80,209

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 437 times
• Download rankings, all-time:
  • Site-wide: 61,391
  • In neuroscience: 9,218
• Year to date:
  • Site-wide: 123,901
• Since beginning of last month:
  • Site-wide: 114,813

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 62,169
  • In genomics: 4,511
• Year to date:
  • Site-wide: 111,371
• Since beginning of last month:
  • Site-wide: 93,896

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 421 times
• Download rankings, all-time:
  • Site-wide: 63,782
  • In genetics: 2,962
• Year to date:
  • Site-wide: 123,060
• Since beginning of last month:
  • Site-wide: 108,899

Genetic correlations between pain phenotypes and depression and neuroticism

• Downloaded 413 times
• Download rankings, all-time:
  • Site-wide: 65,020
  • In genetics: 2,999
• Year to date:
  • Site-wide: 107,921
• Since beginning of last month:
  • Site-wide: 108,594

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

• Downloaded 407 times
• Download rankings, all-time:
  • Site-wide: 65,993
  • In genomics: 4,694
• Year to date:
  • Site-wide: 132,591
• Since beginning of last month:
  • Site-wide: 132,764

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 69,287
  • In neuroscience: 10,526
• Year to date:
  • Site-wide: 126,561
• Since beginning of last month:
  • Site-wide: 114,364

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

• Downloaded 355 times
• Download rankings, all-time:
  • Site-wide: 74,878
  • In neuroscience: 11,428
• Year to date:
  • Site-wide: 96,577
• Since beginning of last month:
  • Site-wide: 117,828

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 75,773
  • In genetics: 3,458
• Year to date:
  • Site-wide: 76,821
• Since beginning of last month:
  • Site-wide: 64,608

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 349 times
• Download rankings, all-time:
  • Site-wide: 75,888
  • In genetics: 3,461
• Year to date:
  • Site-wide: 122,820
• Since beginning of last month:
  • Site-wide: 113,602

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 76,791
  • In genetics: 3,493
• Year to date:
  • Site-wide: 127,175
• Since beginning of last month:
  • Site-wide: 113,864

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 76,674
  • In neuroscience: 11,724
• Year to date:
  • Site-wide: 113,216
• Since beginning of last month:
  • Site-wide: 111,747

Genetic contributions to health literacy

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 78,273
  • In epidemiology: 3,262
• Year to date:
  • Site-wide: 126,899
• Since beginning of last month:
  • Site-wide: 132,276

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 88,320
  • In epidemiology: 3,638
• Year to date:
  • Site-wide: 124,631
• Since beginning of last month:
  • Site-wide: 132,989

Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

• Downloaded 288 times
• Download rankings, all-time:
  • Site-wide: 88,274
  • In genetics: 3,976
• Year to date:
  • Site-wide: 132,786
• Since beginning of last month:
  • Site-wide: 133,180

Epigenetic signatures of starting and stopping smoking

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 88,615
  • In genomics: 5,586
• Year to date:
  • Site-wide: 133,823
• Since beginning of last month:
  • Site-wide: 134,754

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 279 times
• Download rankings, all-time:
  • Site-wide: 90,165
  • In cell biology: 4,175
• Year to date:
  • Site-wide: 86,247
• Since beginning of last month:
  • Site-wide: 80,709

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 97,216
  • In genetic and genomic medicine: 388
• Year to date:
  • Site-wide: 47,497
• Since beginning of last month:
  • Site-wide: 51,631

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 101,511
  • In neuroscience: 15,753
• Year to date:
  • Site-wide: 130,266
• Since beginning of last month:
  • Site-wide: 108,882

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 122,572
  • In neuroscience: 18,857
• Year to date:
  • Site-wide: 86,790
• Since beginning of last month:
  • Site-wide: 56,667