Author: Ian J Deary

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,323 times
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  • Site-wide: 754
  • In genetics: 24
• Year to date:
  • Site-wide: 21,710
• Since beginning of last month:
  • Site-wide: 23,223

The genetic architecture of the human cerebral cortex

• Downloaded 7,858 times
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  • Site-wide: 948
  • In genetics: 30
• Year to date:
  • Site-wide: 10,588
• Since beginning of last month:
  • Site-wide: 14,037

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,052 times
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  • Site-wide: 3,553
  • In genetics: 163
• Year to date:
  • Site-wide: 19,361
• Since beginning of last month:
  • Site-wide: 42,060

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,689 times
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  • Site-wide: 4,212
  • In genetics: 202
• Year to date:
  • Site-wide: 121,930
• Since beginning of last month:
  • Site-wide: 24,519

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,476 times
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  • Site-wide: 4,778
  • In genetics: 233
• Year to date:
  • Site-wide: 12,450
• Since beginning of last month:
  • Site-wide: 15,667

Molecular genetic contributions to self-rated health

• Downloaded 2,191 times
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  • Site-wide: 5,740
  • In genetics: 286
• Year to date:
  • Site-wide: 101,630
• Since beginning of last month:
  • Site-wide: 42,290

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 2,032 times
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  • Site-wide: 6,388
  • In genetics: 324
• Year to date:
  • Site-wide: 9,370
• Since beginning of last month:
  • Site-wide: 25,473

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,024 times
• Download rankings, all-time:
  • Site-wide: 6,431
  • In genetics: 327
• Year to date:
  • Site-wide: 115,994
• Since beginning of last month:
  • Site-wide: 80,687

GWAS on family history of Alzheimer's disease

• Downloaded 1,953 times
• Download rankings, all-time:
  • Site-wide: 6,776
  • In genetics: 339
• Year to date:
  • Site-wide: 99,821
• Since beginning of last month:
  • Site-wide: 109,675

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,758 times
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  • Site-wide: 7,903
  • In genetics: 396
• Year to date:
  • Site-wide: 57,302
• Since beginning of last month:
  • Site-wide: 80,879

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,693 times
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  • Site-wide: 8,390
  • In genetics: 425
• Year to date:
  • Site-wide: 88,417
• Since beginning of last month:
  • Site-wide: 59,669

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,617 times
• Download rankings, all-time:
  • Site-wide: 9,036
  • In neuroscience: 998
• Year to date:
  • Site-wide: 56,166
• Since beginning of last month:
  • Site-wide: 59,717

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,556 times
• Download rankings, all-time:
  • Site-wide: 9,570
  • In genomics: 1,084
• Year to date:
  • Site-wide: 41,621
• Since beginning of last month:
  • Site-wide: 45,847

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,452 times
• Download rankings, all-time:
  • Site-wide: 10,556
  • In neuroscience: 1,222
• Year to date:
  • Site-wide: 34,966
• Since beginning of last month:
  • Site-wide: 39,648

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,369 times
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  • Site-wide: 11,572
  • In genetics: 596
• Year to date:
  • Site-wide: 30,828
• Since beginning of last month:
  • Site-wide: 46,615

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,102 times
• Download rankings, all-time:
  • Site-wide: 16,036
  • In bioinformatics: 1,999
• Year to date:
  • Site-wide: 64,124
• Since beginning of last month:
  • Site-wide: 101,152

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 1,063 times
• Download rankings, all-time:
  • Site-wide: 16,922
  • In neuroscience: 2,166
• Year to date:
  • Site-wide: 102,991
• Since beginning of last month:
  • Site-wide: 78,132

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,029 times
• Download rankings, all-time:
  • Site-wide: 17,748
  • In genomics: 1,867
• Year to date:
  • Site-wide: 46,771
• Since beginning of last month:
  • Site-wide: 103,020

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 965 times
• Download rankings, all-time:
  • Site-wide: 19,527
  • In genetics: 990
• Year to date:
  • Site-wide: 42,760
• Since beginning of last month:
  • Site-wide: 117,701

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 944 times
• Download rankings, all-time:
  • Site-wide: 20,118
  • In genetics: 1,011
• Year to date:
  • Site-wide: 3,503
• Since beginning of last month:
  • Site-wide: 19,139

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 908 times
• Download rankings, all-time:
  • Site-wide: 21,323
  • In genetics: 1,069
• Year to date:
  • Site-wide: 5,935
• Since beginning of last month:
  • Site-wide: 12,530

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 851 times
• Download rankings, all-time:
  • Site-wide: 23,412
  • In genetics: 1,180
• Year to date:
  • Site-wide: 85,321
• Since beginning of last month:
  • Site-wide: 104,692

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 810 times
• Download rankings, all-time:
  • Site-wide: 25,103
  • In genetics: 1,269
• Year to date:
  • Site-wide: 80,392
• Since beginning of last month:
  • Site-wide: 82,634

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 789 times
• Download rankings, all-time:
  • Site-wide: 26,020
  • In genomics: 2,486
• Year to date:
  • Site-wide: 92,635
• Since beginning of last month:
  • Site-wide: 46,207

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 777 times
• Download rankings, all-time:
  • Site-wide: 26,615
  • In genetics: 1,346
• Year to date:
  • Site-wide: 98,388
• Since beginning of last month:
  • Site-wide: 101,405

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 28,218
  • In genetics: 1,428
• Year to date:
  • Site-wide: 91,872
• Since beginning of last month:
  • Site-wide: 90,031

Factors associated with sharing email information and mental health survey participation in large population cohorts

• Downloaded 732 times
• Download rankings, all-time:
  • Site-wide: 28,896
  • In genetics: 1,454
• Year to date:
  • Site-wide: 65,264
• Since beginning of last month:
  • Site-wide: 92,556

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 29,998
  • In bioinformatics: 3,485
• Year to date:
  • Site-wide: 76,516
• Since beginning of last month:
  • Site-wide: 70,482

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 30,951
  • In genomics: 2,813
• Year to date:
  • Site-wide: 102,590
• Since beginning of last month:
  • Site-wide: 121,060

Genetic contributions to self-reported tiredness

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 31,631
  • In genetics: 1,594
• Year to date:
  • Site-wide: 23,765
• Since beginning of last month:
  • Site-wide: 64,698

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 662 times
• Download rankings, all-time:
  • Site-wide: 33,086
  • In genomics: 2,951
• Year to date:
  • Site-wide: 19,309
• Since beginning of last month:
  • Site-wide: 29,225

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 40,575
  • In genetics: 1,976
• Year to date:
  • Site-wide: 99,748
• Since beginning of last month:
  • Site-wide: 98,558

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 557 times
• Download rankings, all-time:
  • Site-wide: 41,296
  • In genetics: 2,024
• Year to date:
  • Site-wide: 67,397
• Since beginning of last month:
  • Site-wide: 111,468

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 554 times
• Download rankings, all-time:
  • Site-wide: 41,577
  • In genomics: 3,451
• Year to date:
  • Site-wide: 100,185
• Since beginning of last month:
  • Site-wide: 93,582

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 535 times
• Download rankings, all-time:
  • Site-wide: 43,389
  • In neuroscience: 6,423
• Year to date:
  • Site-wide: 27,656
• Since beginning of last month:
  • Site-wide: 22,834

Age-related clonal haemopoiesis is associated with increased epigenetic age

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 44,284
  • In bioinformatics: 4,758
• Year to date:
  • Site-wide: 91,697
• Since beginning of last month:
  • Site-wide: 116,589

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 517 times
• Download rankings, all-time:
  • Site-wide: 45,245
  • In genomics: 3,681
• Year to date:
  • Site-wide: 53,808
• Since beginning of last month:
  • Site-wide: 106,326

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 46,074
  • In genomics: 3,738
• Year to date:
  • Site-wide: 79,579
• Since beginning of last month:
  • Site-wide: 98,504

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 46,173
  • In genetic and genomic medicine: 114
• Year to date:
  • Site-wide: 6,499
• Since beginning of last month:
  • Site-wide: 9,490

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 47,577
  • In neuroscience: 7,141
• Year to date:
  • Site-wide: 57,821
• Since beginning of last month:
  • Site-wide: 64,538

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 481 times
• Download rankings, all-time:
  • Site-wide: 49,204
  • In epidemiology: 2,123
• Year to date:
  • Site-wide: 100,420
• Since beginning of last month:
  • Site-wide: 90,382

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 477 times
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  • Site-wide: 49,702
  • In genomics: 3,932
• Year to date:
  • Site-wide: 58,967
• Since beginning of last month:
  • Site-wide: 68,017

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 477 times
• Download rankings, all-time:
  • Site-wide: 49,640
  • In genomics: 3,934
• Year to date:
  • Site-wide: 70,946
• Since beginning of last month:
  • Site-wide: 120,099

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 450 times
• Download rankings, all-time:
  • Site-wide: 52,910
  • In genetics: 2,554
• Year to date:
  • Site-wide: 102,305
• Since beginning of last month:
  • Site-wide: 87,648

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 437 times
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  • Site-wide: 54,673
  • In genomics: 4,171
• Year to date:
  • Site-wide: 114,524
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  • Site-wide: 73,287

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 56,105
  • In neuroscience: 8,587
• Year to date:
  • Site-wide: 109,182
• Since beginning of last month:
  • Site-wide: 108,525

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 418 times
• Download rankings, all-time:
  • Site-wide: 57,204
  • In genomics: 4,314
• Year to date:
  • Site-wide: 94,441
• Since beginning of last month:
  • Site-wide: 78,681

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 58,589
  • In genetics: 2,815
• Year to date:
  • Site-wide: 121,343
• Since beginning of last month:
  • Site-wide: 98,637

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

• Downloaded 401 times
• Download rankings, all-time:
  • Site-wide: 59,615
  • In genomics: 4,423
• Year to date:
  • Site-wide: 109,613
• Since beginning of last month:
  • Site-wide: 86,899

Genetic correlations between pain phenotypes and depression and neuroticism

• Downloaded 397 times
• Download rankings, all-time:
  • Site-wide: 60,293
  • In genetics: 2,886
• Year to date:
  • Site-wide: 97,954
• Since beginning of last month:
  • Site-wide: 87,700

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 63,262
  • In neuroscience: 9,795
• Year to date:
  • Site-wide: 116,067
• Since beginning of last month:
  • Site-wide: 102,938

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 69,742
  • In genetics: 3,309
• Year to date:
  • Site-wide: 98,354
• Since beginning of last month:
  • Site-wide: 109,998

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 70,164
  • In neuroscience: 10,904
• Year to date:
  • Site-wide: 95,459
• Since beginning of last month:
  • Site-wide: 118,589

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 70,387
  • In neuroscience: 10,929
• Year to date:
  • Site-wide: 55,288
• Since beginning of last month:
  • Site-wide: 82,050

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 70,246
  • In genetics: 3,335
• Year to date:
  • Site-wide: 111,980
• Since beginning of last month:
  • Site-wide: 112,473

Genetic contributions to health literacy

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 71,598
  • In epidemiology: 2,932
• Year to date:
  • Site-wide: 109,587
• Since beginning of last month:
  • Site-wide: 116,955

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 322 times
• Download rankings, all-time:
  • Site-wide: 72,579
  • In genetics: 3,439
• Year to date:
  • Site-wide: 80,535
• Since beginning of last month:
  • Site-wide: 75,282

Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 80,206
  • In genetics: 3,759
• Year to date:
  • Site-wide: 104,075
• Since beginning of last month:
  • Site-wide: 105,802

Epigenetic signatures of starting and stopping smoking

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 80,356
  • In genomics: 5,276
• Year to date:
  • Site-wide: 103,400
• Since beginning of last month:
  • Site-wide: 94,080

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 81,253
  • In epidemiology: 3,288
• Year to date:
  • Site-wide: 115,205
• Since beginning of last month:
  • Site-wide: 107,772

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 254 times
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  • Site-wide: 86,078
  • In cell biology: 4,010
• Year to date:
  • Site-wide: 107,607
• Since beginning of last month:
  • Site-wide: 75,008

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 93,459
  • In neuroscience: 14,774
• Year to date:
  • Site-wide: 115,505
• Since beginning of last month:
  • Site-wide: 103,298

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 196 times
• Download rankings, all-time:
  • Site-wide: 98,207
  • In genetic and genomic medicine: 345
• Year to date:
  • Site-wide: 60,176
• Since beginning of last month:
  • Site-wide: 25,950

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 104 times
• Download rankings, all-time:
  • Site-wide: 115,449
  • In neuroscience: 18,091
• Year to date:
  • Site-wide: 98,840
• Since beginning of last month:
  • Site-wide: 71,818