Author: Wei Wu

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Preprints

Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

• Downloaded 21,330 times
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  • Site-wide: 357
  • In infectious diseases: 132
• Year to date:
  • Site-wide: 5,701
• Since beginning of last month:
  • Site-wide: 4,231

Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population

• Downloaded 2,566 times
• Download rankings, all-time:
  • Site-wide: 5,904
  • In infectious diseases: 984
• Year to date:
  • Site-wide: 50,127
• Since beginning of last month:
  • Site-wide: 38,264

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

• Downloaded 2,484 times
• Download rankings, all-time:
  • Site-wide: 6,212
  • In cancer biology: 94
• Year to date:
  • Site-wide: 12,848
• Since beginning of last month:
  • Site-wide: 15,359

Clinical Characteristics of SARS-CoV-2 Pneumonia Compared to Controls in Chinese Han Population

• Downloaded 1,921 times
• Download rankings, all-time:
  • Site-wide: 9,029
  • In infectious diseases: 1,254
• Year to date:
  • Site-wide: 18,977
• Since beginning of last month:
  • Site-wide: 11,676

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

• Downloaded 1,807 times
• Download rankings, all-time:
  • Site-wide: 9,898
  • In neuroscience: 1,027
• Year to date:
  • Site-wide: 1,934
• Since beginning of last month:
  • Site-wide: 5,252

The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

• Downloaded 1,641 times
• Download rankings, all-time:
  • Site-wide: 11,432
  • In infectious diseases: 1,428
• Year to date:
  • Site-wide: 39,763
• Since beginning of last month:
  • Site-wide: 33,856

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

• Downloaded 1,467 times
• Download rankings, all-time:
  • Site-wide: 13,428
  • In cancer biology: 286
• Year to date:
  • Site-wide: 2,600
• Since beginning of last month:
  • Site-wide: 2,775

Evolution and clinical impact of genetic epistasis within EGFR-mutant lung cancers

• Downloaded 1,416 times
• Download rankings, all-time:
  • Site-wide: 14,199
  • In cancer biology: 301
• Year to date:
  • Site-wide: 107,252
• Since beginning of last month:
  • Site-wide: 124,467

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

• Downloaded 1,372 times
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  • Site-wide: 14,890
  • In cancer biology: 320
• Year to date:
  • Site-wide: 38,232
• Since beginning of last month:
  • Site-wide: 41,106

Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer

• Downloaded 1,364 times
• Download rankings, all-time:
  • Site-wide: 15,018
  • In cancer biology: 326
• Year to date:
  • Site-wide: 34,319
• Since beginning of last month:
  • Site-wide: 46,290

Distinct mutations and lineages of SARS-CoV-2 virus in the early phase of COVID-19 pandemic and subsequent global expansion

• Downloaded 1,340 times
• Download rankings, all-time:
  • Site-wide: 15,422
  • In genomics: 1,554
• Year to date:
  • Site-wide: 1,824
• Since beginning of last month:
  • Site-wide: 9,325

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

• Downloaded 1,262 times
• Download rankings, all-time:
  • Site-wide: 16,885
  • In radiology and imaging: 37
• Year to date:
  • Site-wide: 37,868
• Since beginning of last month:
  • Site-wide: 30,669

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

• Downloaded 1,103 times
• Download rankings, all-time:
  • Site-wide: 20,600
  • In biophysics: 539
• Year to date:
  • Site-wide: 32,232
• Since beginning of last month:
  • Site-wide: 55,286

The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma

• Downloaded 986 times
• Download rankings, all-time:
  • Site-wide: 24,270
  • In cancer biology: 594
• Year to date:
  • Site-wide: 97,235
• Since beginning of last month:
  • Site-wide: 65,925

Sex-specific differences in COVID-19 testing, cases and outcomes: a population-wide study in Ontario, Canada

• Downloaded 882 times
• Download rankings, all-time:
  • Site-wide: 28,472
  • In public and global health: 493
• Year to date:
  • Site-wide: 38,300
• Since beginning of last month:
  • Site-wide: 27,281

SMARCA4 supports the oncogenic landscape of KRAS-driven lung tumors

• Downloaded 805 times
• Download rankings, all-time:
  • Site-wide: 32,347
  • In cancer biology: 861
• Year to date:
  • Site-wide: 15,543
• Since beginning of last month:
  • Site-wide: 18,577

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

• Downloaded 788 times
• Download rankings, all-time:
  • Site-wide: 33,267
  • In cancer biology: 888
• Year to date:
  • Site-wide: 116,345
• Since beginning of last month:
  • Site-wide: 103,092

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

• Downloaded 749 times
• Download rankings, all-time:
  • Site-wide: 35,708
  • In immunology: 1,100
• Year to date:
  • Site-wide: 4,146
• Since beginning of last month:
  • Site-wide: 8,768

Dual Histone Methyl Reader ZCWPW1 Facilitates Repair of Meiotic Double Strand Breaks

• Downloaded 696 times
• Download rankings, all-time:
  • Site-wide: 39,468
  • In genetics: 1,793
• Year to date:
  • Site-wide: 97,845
• Since beginning of last month:
  • Site-wide: 119,805

CTCF is a Barrier for Totipotent-like Reprogramming

• Downloaded 677 times
• Download rankings, all-time:
  • Site-wide: 40,929
  • In developmental biology: 887
• Year to date:
  • Site-wide: 9,423
• Since beginning of last month:
  • Site-wide: 13,941

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 41,738
  • In cancer biology: 1,141
• Year to date:
  • Site-wide: 106,753
• Since beginning of last month:
  • Site-wide: 102,460

The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice

• Downloaded 605 times
• Download rankings, all-time:
  • Site-wide: 47,205
  • In molecular biology: 1,346
• Year to date:
  • Site-wide: 29,548
• Since beginning of last month:
  • Site-wide: 51,064

Coupled Mixed Model for Joint Genetic Analysis of Complex Disorders with Two Independently Collected Data Sets

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 47,736
  • In genetics: 2,144
• Year to date:
  • Site-wide: 77,160
• Since beginning of last month:
  • Site-wide: 67,090

Social Media Study of Public Opinions on Potential COVID-19 Vaccines: Informing Dissent, Disparities, and Dissemination

• Downloaded 599 times
• Download rankings, all-time:
  • Site-wide: 47,756
  • In epidemiology: 2,236
• Year to date:
  • Site-wide: 11,445
• Since beginning of last month:
  • Site-wide: 59,662

Ennet: construction of potential cancer-driving networks based on somatic enhancer mutations only

• Downloaded 561 times
• Download rankings, all-time:
  • Site-wide: 52,001
  • In bioinformatics: 5,295
• Year to date:
  • Site-wide: 95,645
• Since beginning of last month:
  • Site-wide: 94,354

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

• Downloaded 537 times
• Download rankings, all-time:
  • Site-wide: 54,709
  • In cell biology: 2,389
• Year to date:
  • Site-wide: 97,297
• Since beginning of last month:
  • Site-wide: 117,801

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 55,716
  • In developmental biology: 1,314
• Year to date:
  • Site-wide: 58,197
• Since beginning of last month:
  • Site-wide: 37,500

ATM and PRDM9 Regulate SPO11-bound Recombination Intermediates During Meiosis

• Downloaded 502 times
• Download rankings, all-time:
  • Site-wide: 59,217
  • In molecular biology: 1,680
• Year to date:
  • Site-wide: 138,407
• Since beginning of last month:
  • Site-wide: 139,820

Loneliness among older adults in the community during COVID-19

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 67,968
  • In geriatric medicine: 34
• Year to date:
  • Site-wide: 14,963
• Since beginning of last month:
  • Site-wide: 26,141

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

• Downloaded 403 times
• Download rankings, all-time:
  • Site-wide: 74,471
  • In cancer biology: 2,172
• Year to date:
  • Site-wide: 25,219
• Since beginning of last month:
  • Site-wide: 16,838

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 81,904
  • In immunology: 2,390
• Year to date:
  • Site-wide: 11,888
• Since beginning of last month:
  • Site-wide: 29,868

PIWIL3 forms a complex with TDRKH in mammalian oocytes

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 96,235
  • In cell biology: 4,450
• Year to date:
  • Site-wide: 139,795
• Since beginning of last month:
  • Site-wide: 122,887

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 96,246
  • In systems biology: 2,202
• Year to date:
  • Site-wide: 137,398
• Since beginning of last month:
  • Site-wide: 113,959

A lamin A/C variant causing striated muscle disease provides insights into filament organization

• Downloaded 285 times
• Download rankings, all-time:
  • Site-wide: 98,510
  • In cell biology: 4,541
• Year to date:
  • Site-wide: 62,323
• Since beginning of last month:
  • Site-wide: 54,205

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 282 times
• Download rankings, all-time:
  • Site-wide: 99,246
  • In microbiology: 7,138
• Year to date:
  • Site-wide: 58,839
• Since beginning of last month:
  • Site-wide: 62,615

Sex-based clinical and immunological differences in COVID-19

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 100,815
  • In infectious diseases: 4,235
• Year to date:
  • Site-wide: 100,721
• Since beginning of last month:
  • Site-wide: 84,317

Laboratory Testing Implications of Risk-Stratification and Management for Improving Clinical Outcomes of COVID-19 Patients

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 101,821
  • In infectious diseases: 4,260
• Year to date:
  • Site-wide: 104,595
• Since beginning of last month:
  • Site-wide: 87,073

Sex differences and effects of estrous stage on hippocampal-prefrontal theta communications

• Downloaded 271 times
• Download rankings, all-time:
  • Site-wide: 101,804
  • In neuroscience: 15,524
• Year to date:
  • Site-wide: 128,755
• Since beginning of last month:
  • Site-wide: 97,860

SRSF shape analysis for sequencing data reveal new differentiating patterns

• Downloaded 261 times
• Download rankings, all-time:
  • Site-wide: 104,158
  • In bioinformatics: 8,876
• Year to date:
  • Site-wide: 139,749
• Since beginning of last month:
  • Site-wide: 113,036

The roles of wrinkle structures in the veins of Asian Ladybird and bioinspiration

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 105,491
  • In biophysics: 4,055
• Year to date:
  • Site-wide: 93,109
• Since beginning of last month:
  • Site-wide: 88,331

Overexpressed microRNA-141-3p enhance proliferation via targeting PLAG1 in non-diabetic macrosomia

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 108,860
  • In developmental biology: 2,933
• Year to date:
  • Site-wide: 135,317
• Since beginning of last month:
  • Site-wide: 133,142

Impaired early visual categorization of fear in social anxiety

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 116,336
  • In neuroscience: 17,773
• Year to date:
  • Site-wide: 111,427
• Since beginning of last month:
  • Site-wide: 95,177

Genetic diversity and evolution of Hantaan virus in China and its neighbors

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 124,109
  • In evolutionary biology: 6,223
• Year to date:
  • Site-wide: 128,978
• Since beginning of last month:
  • Site-wide: 127,377

Modeling and Analyzing Neural Signals with Phase Variability using the Fisher-Rao Registration

• Downloaded 179 times
• Download rankings, all-time:
  • Site-wide: 124,097
  • In neuroscience: 18,866
• Year to date:
  • Site-wide: 89,659
• Since beginning of last month:
  • Site-wide: 74,017

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

• Downloaded 146 times
• Download rankings, all-time:
  • Site-wide: 131,487
  • In cell biology: 6,035
• Year to date:
  • Site-wide: 38,510
• Since beginning of last month:
  • Site-wide: 27,692

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

• Downloaded 87 times
• Download rankings, all-time:
  • Site-wide: 143,055
  • In microbiology: 10,997
• Year to date:
  • Site-wide: 63,542
• Since beginning of last month:
  • Site-wide: None

Analysis of rhizosphere bacterial diversity of Angelica dahurica var. formosana based on different experimental sites and varieties (strains)

• Downloaded 35 times
• Download rankings, all-time:
  • Site-wide: 147,571
  • In microbiology: 11,490
• Year to date:
  • Site-wide: 117,959
• Since beginning of last month:
  • Site-wide: 29,792