Author: Wei Wu

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Preprints

Clinical diagnosis of 8274 samples with 2019-novel coronavirus in Wuhan

• Downloaded 21,085 times
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  • Site-wide: 326
  • In infectious diseases: 123
• Year to date:
  • Site-wide: 6,382
• Since beginning of last month:
  • Site-wide: 9,548

Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population

• Downloaded 2,522 times
• Download rankings, all-time:
  • Site-wide: 5,456
  • In infectious diseases: 878
• Year to date:
  • Site-wide: 46,713
• Since beginning of last month:
  • Site-wide: 51,810

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

• Downloaded 2,364 times
• Download rankings, all-time:
  • Site-wide: 6,044
  • In cancer biology: 92
• Year to date:
  • Site-wide: 12,297
• Since beginning of last month:
  • Site-wide: 21,617

Clinical Characteristics of SARS-CoV-2 Pneumonia Compared to Controls in Chinese Han Population

• Downloaded 1,755 times
• Download rankings, all-time:
  • Site-wide: 9,362
  • In infectious diseases: 1,198
• Year to date:
  • Site-wide: 35,031
• Since beginning of last month:
  • Site-wide: 21,726

The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

• Downloaded 1,593 times
• Download rankings, all-time:
  • Site-wide: 10,788
  • In infectious diseases: 1,283
• Year to date:
  • Site-wide: 34,995
• Since beginning of last month:
  • Site-wide: 42,882

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

• Downloaded 1,480 times
• Download rankings, all-time:
  • Site-wide: 12,002
  • In neuroscience: 1,336
• Year to date:
  • Site-wide: 1,488
• Since beginning of last month:
  • Site-wide: 1,586

Evolution and clinical impact of genetic epistasis within EGFR-mutant lung cancers

• Downloaded 1,402 times
• Download rankings, all-time:
  • Site-wide: 13,039
  • In cancer biology: 278
• Year to date:
  • Site-wide: 94,190
• Since beginning of last month:
  • Site-wide: 93,832

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

• Downloaded 1,318 times
• Download rankings, all-time:
  • Site-wide: 14,319
  • In cancer biology: 312
• Year to date:
  • Site-wide: 34,761
• Since beginning of last month:
  • Site-wide: 37,762

Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation positive lung cancer

• Downloaded 1,312 times
• Download rankings, all-time:
  • Site-wide: 14,430
  • In cancer biology: 316
• Year to date:
  • Site-wide: 29,717
• Since beginning of last month:
  • Site-wide: 22,254

Clinical and Imaging Findings in COVID-19 Patients Complicated by Pulmonary Embolism

• Downloaded 1,209 times
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  • Site-wide: 16,318
  • In radiology and imaging: 36
• Year to date:
  • Site-wide: 34,095
• Since beginning of last month:
  • Site-wide: 19,241

Distinct mutations and lineages of SARS-CoV-2 virus in the early phase of COVID-19 pandemic and subsequent global expansion

• Downloaded 1,152 times
• Download rankings, all-time:
  • Site-wide: 17,530
  • In genomics: 1,791
• Year to date:
  • Site-wide: 1,170
• Since beginning of last month:
  • Site-wide: 7,312

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

• Downloaded 1,117 times
• Download rankings, all-time:
  • Site-wide: 18,327
  • In cancer biology: 427
• Year to date:
  • Site-wide: 2,464
• Since beginning of last month:
  • Site-wide: 2,587

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

• Downloaded 1,057 times
• Download rankings, all-time:
  • Site-wide: 19,885
  • In biophysics: 524
• Year to date:
  • Site-wide: 25,737
• Since beginning of last month:
  • Site-wide: 16,147

The CIC-DUX4 fusion oncoprotein drives metastasis and tumor growth via distinct downstream regulatory programs and therapeutic targets in sarcoma

• Downloaded 964 times
• Download rankings, all-time:
  • Site-wide: 22,722
  • In cancer biology: 558
• Year to date:
  • Site-wide: 95,077
• Since beginning of last month:
  • Site-wide: 67,550

Sex-specific differences in COVID-19 testing, cases and outcomes: a population-wide study in Ontario, Canada

• Downloaded 822 times
• Download rankings, all-time:
  • Site-wide: 28,473
  • In public and global health: 455
• Year to date:
  • Site-wide: 37,805
• Since beginning of last month:
  • Site-wide: 35,102

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 30,778
  • In cancer biology: 812
• Year to date:
  • Site-wide: 95,128
• Since beginning of last month:
  • Site-wide: 90,995

SMARCA4 supports the oncogenic landscape of KRAS-driven lung tumors

• Downloaded 700 times
• Download rankings, all-time:
  • Site-wide: 35,673
  • In cancer biology: 959
• Year to date:
  • Site-wide: 14,626
• Since beginning of last month:
  • Site-wide: 16,406

Dual Histone Methyl Reader ZCWPW1 Facilitates Repair of Meiotic Double Strand Breaks

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 36,584
  • In genetics: 1,729
• Year to date:
  • Site-wide: 75,011
• Since beginning of last month:
  • Site-wide: 85,744

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

• Downloaded 657 times
• Download rankings, all-time:
  • Site-wide: 38,758
  • In cancer biology: 1,046
• Year to date:
  • Site-wide: 85,899
• Since beginning of last month:
  • Site-wide: 61,473

CTCF is a Barrier for Totipotent-like Reprogramming

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 45,192
  • In developmental biology: 1,035
• Year to date:
  • Site-wide: 7,041
• Since beginning of last month:
  • Site-wide: 14,312

Coupled Mixed Model for Joint Genetic Analysis of Complex Disorders with Two Independently Collected Data Sets

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 45,862
  • In genetics: 2,139
• Year to date:
  • Site-wide: 69,451
• Since beginning of last month:
  • Site-wide: 95,964

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

• Downloaded 567 times
• Download rankings, all-time:
  • Site-wide: 46,736
  • In immunology: 1,317
• Year to date:
  • Site-wide: 3,211
• Since beginning of last month:
  • Site-wide: 2,251

Social Media Study of Public Opinions on Potential COVID-19 Vaccines: Informing Dissent, Disparities, and Dissemination

• Downloaded 550 times
• Download rankings, all-time:
  • Site-wide: 48,486
  • In epidemiology: 2,215
• Year to date:
  • Site-wide: 7,303
• Since beginning of last month:
  • Site-wide: 7,864

The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 48,540
  • In molecular biology: 1,369
• Year to date:
  • Site-wide: 25,000
• Since beginning of last month:
  • Site-wide: 21,316

Ennet: construction of potential cancer-driving networks based on somatic enhancer mutations only

• Downloaded 542 times
• Download rankings, all-time:
  • Site-wide: 49,257
  • In bioinformatics: 5,108
• Year to date:
  • Site-wide: 86,231
• Since beginning of last month:
  • Site-wide: 118,128

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 51,617
  • In cell biology: 2,245
• Year to date:
  • Site-wide: 83,896
• Since beginning of last month:
  • Site-wide: 67,638

ATM and PRDM9 Regulate SPO11-bound Recombination Intermediates During Meiosis

• Downloaded 494 times
• Download rankings, all-time:
  • Site-wide: 54,931
  • In molecular biology: 1,568
• Year to date:
  • Site-wide: 125,708
• Since beginning of last month:
  • Site-wide: 127,506

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 55,937
  • In developmental biology: 1,366
• Year to date:
  • Site-wide: 58,303
• Since beginning of last month:
  • Site-wide: 83,119

Loneliness among older adults in the community during COVID-19

• Downloaded 358 times
• Download rankings, all-time:
  • Site-wide: 75,861
  • In geriatric medicine: 44
• Year to date:
  • Site-wide: 12,164
• Since beginning of last month:
  • Site-wide: 10,163

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

• Downloaded 317 times
• Download rankings, all-time:
  • Site-wide: 83,640
  • In cancer biology: 2,491
• Year to date:
  • Site-wide: 25,960
• Since beginning of last month:
  • Site-wide: 36,318

PIWIL3 forms a complex with TDRKH in mammalian oocytes

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 89,505
  • In cell biology: 4,142
• Year to date:
  • Site-wide: 121,599
• Since beginning of last month:
  • Site-wide: 89,916

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 90,260
  • In systems biology: 2,112
• Year to date:
  • Site-wide: 129,886
• Since beginning of last month:
  • Site-wide: 134,373

A lamin A/C variant causing striated muscle disease provides insights into filament organization

• Downloaded 259 times
• Download rankings, all-time:
  • Site-wide: 96,300
  • In cell biology: 4,467
• Year to date:
  • Site-wide: 50,526
• Since beginning of last month:
  • Site-wide: 39,266

Sex-based clinical and immunological differences in COVID-19

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 96,539
  • In infectious diseases: 3,801
• Year to date:
  • Site-wide: 89,648
• Since beginning of last month:
  • Site-wide: 86,506

Sex differences and effects of estrous stage on hippocampal-prefrontal theta communications

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 96,917
  • In neuroscience: 14,942
• Year to date:
  • Site-wide: 128,371
• Since beginning of last month:
  • Site-wide: 127,590

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

• Downloaded 256 times
• Download rankings, all-time:
  • Site-wide: 96,866
  • In immunology: 2,762
• Year to date:
  • Site-wide: 10,084
• Since beginning of last month:
  • Site-wide: 1,370

Laboratory Testing Implications of Risk-Stratification and Management for Improving Clinical Outcomes of COVID-19 Patients

• Downloaded 253 times
• Download rankings, all-time:
  • Site-wide: 97,633
  • In infectious diseases: 3,827
• Year to date:
  • Site-wide: 96,641
• Since beginning of last month:
  • Site-wide: 82,676

SRSF shape analysis for sequencing data reveal new differentiating patterns

• Downloaded 248 times
• Download rankings, all-time:
  • Site-wide: 98,729
  • In bioinformatics: 8,501
• Year to date:
  • Site-wide: 136,201
• Since beginning of last month:
  • Site-wide: 121,445

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 242 times
• Download rankings, all-time:
  • Site-wide: 100,019
  • In microbiology: 7,244
• Year to date:
  • Site-wide: 56,764
• Since beginning of last month:
  • Site-wide: 57,788

Overexpressed microRNA-141-3p enhance proliferation via targeting PLAG1 in non-diabetic macrosomia

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 101,465
  • In developmental biology: 2,737
• Year to date:
  • Site-wide: 116,996
• Since beginning of last month:
  • Site-wide: 103,502

The roles of wrinkle structures in the veins of Asian Ladybird and bioinspiration

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 103,611
  • In biophysics: 3,998
• Year to date:
  • Site-wide: 104,042
• Since beginning of last month:
  • Site-wide: 127,189

Impaired early visual categorization of fear in social anxiety

• Downloaded 197 times
• Download rankings, all-time:
  • Site-wide: 110,340
  • In neuroscience: 16,983
• Year to date:
  • Site-wide: 100,647
• Since beginning of last month:
  • Site-wide: 106,843

Genetic diversity and evolution of Hantaan virus in China and its neighbors

• Downloaded 167 times
• Download rankings, all-time:
  • Site-wide: 116,854
  • In evolutionary biology: 6,013
• Year to date:
  • Site-wide: 121,336
• Since beginning of last month:
  • Site-wide: 129,313

Modeling and Analyzing Neural Signals with Phase Variability using the Fisher-Rao Registration

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 119,754
  • In neuroscience: 18,375
• Year to date:
  • Site-wide: 86,961
• Since beginning of last month:
  • Site-wide: 129,144

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

• Downloaded 91 times
• Download rankings, all-time:
  • Site-wide: 131,763
  • In cell biology: 6,028
• Year to date:
  • Site-wide: 35,584
• Since beginning of last month:
  • Site-wide: 5,606

Caspase-dependent cleavage of DDX21 suppresses host innate immunity

• Downloaded 53 times
• Download rankings, all-time:
  • Site-wide: 136,222
  • In microbiology: 10,578
• Year to date:
  • Site-wide: 58,708
• Since beginning of last month:
  • Site-wide: 11,084