Author: Andrew Owen

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Preprints

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

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  • Site-wide: 2,153
  • In microbiology: 192
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  • Site-wide: 199
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  • Site-wide: 3,234

Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate target site concentrations derived from their established human pharmacokinetics

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  • Site-wide: 3,303
  • In pharmacology and therapeutics: 9
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  • Site-wide: 29,285
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  • Site-wide: 54,926

Optimal dose and safety of molnupiravir in patients with early SARS-CoV-2: a phase 1, dose-escalating, randomised controlled study

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  • Site-wide: 3,710
  • In pharmacology and therapeutics: 11
• Year to date:
  • Site-wide: 2,170
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  • Site-wide: 6,070

Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2

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  • Site-wide: 4,537
  • In microbiology: 294
• Year to date:
  • Site-wide: 25,478
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  • Site-wide: 50,777

Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis

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  • Site-wide: 5,705
  • In infectious diseases: 1,085
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  • Site-wide: 42,055
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  • Site-wide: 38,721

The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2

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  • Site-wide: 7,615
  • In microbiology: 450
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  • Site-wide: 46,118
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Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

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  • In microbiology: 758
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  • Site-wide: 23,609
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  • Site-wide: 49,275

Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice

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  • Site-wide: 18,093
  • In immunology: 617
• Year to date:
  • Site-wide: 66,114
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  • Site-wide: 104,273

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

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  • Site-wide: 20,359
  • In pathology: 106
• Year to date:
  • Site-wide: 11,655
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Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection

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  • Site-wide: 26,948
  • In infectious diseases: 2,510
• Year to date:
  • Site-wide: 107,680
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  • Site-wide: 93,948

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.

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  • Site-wide: 34,489
  • In pharmacology and toxicology: 214
• Year to date:
  • Site-wide: 23,869
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  • Site-wide: 15,535

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

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  • Site-wide: 44,968
  • In microbiology: 2,603
• Year to date:
  • Site-wide: 91,341
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  • Site-wide: 59,600

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5'-triphosphate exposure to support posology for SARS-CoV-2

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  • Site-wide: 47,609
  • In infectious diseases: 3,503
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  • Site-wide: 38,971
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  • Site-wide: 53,133

An open label, adaptive, phase 1 trial of high-dose oral nitazoxanide in healthy volunteers: an antiviral candidate for SARS-CoV-2

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  • Site-wide: 55,953
  • In pharmacology and therapeutics: 64
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  • Site-wide: 68,909
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  • Site-wide: 63,825

TITLE: Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

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  • Site-wide: 61,212
  • In respiratory medicine: 135
• Year to date:
  • Site-wide: 35,859
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  • Site-wide: 43,709

Unlike Chloroquine, mefloquine inhibits SARS-CoV-2 infection in physiologically relevant cells and does not induce viral variants.

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  • Site-wide: 67,882
  • In microbiology: 4,036
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  • Site-wide: 109,616
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  • Site-wide: 102,372

Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

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  • Site-wide: 72,102
  • In pharmacology and toxicology: 507
• Year to date:
  • Site-wide: 32,084
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  • Site-wide: 26,306

Lack of Ronapreve (REGN-CoV; casirivimab and imdevimab) virological efficacy against the SARS-CoV 2 Omicron variant (B.1.1.529) in K18-hACE2 mice

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  • Site-wide: 74,098
  • In microbiology: 7,654
• Year to date:
  • Site-wide: 4,088
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  • Site-wide: 29,367

Optimisation and validation of a sensitive bioanalytical method for niclosamide.

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  • Site-wide: 82,743
  • In pharmacology and toxicology: 590
• Year to date:
  • Site-wide: 40,790
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N-acetyltransferase 2 genotypes amongst ulu Speaking South Africans and isoniazid / N-acetyl-isoniazid pharmacokinetics during ant-tuberculosis treatment

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  • Site-wide: 132,657
  • In genetics: 4,970
• Year to date:
  • Site-wide: 121,338
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Efficacy and safety of nitazoxanide combined with ritonavir-boosted atazanavir for the treatment of mild to moderate COVID-19

• Downloaded 275 times
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  • Site-wide: 145,969
  • In infectious diseases: 6,908
• Year to date:
  • Site-wide: 12,598
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  • Site-wide: 36,136

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.

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  • Site-wide: 146,242
  • In pharmacology and toxicology: 1,127
• Year to date:
  • Site-wide: 91,326
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  • Site-wide: 56,745

Early Treatment of Favipiravir in COVID-19 Patients Without Pneumonia: A Multicentre, Open-Labelled, Randomized Control Study

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  • Site-wide: 168,461
  • In pharmacology and therapeutics: None
• Year to date:
  • Site-wide: 21,051
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  • Site-wide: 3,104

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.

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  • Site-wide: 169,607
  • In pharmacology and toxicology: None
• Year to date:
  • Site-wide: 21,685
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  • Site-wide: 48,374