Author: Wei Liu

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Preprints

Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset

• Downloaded 33,886 times
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  • Site-wide: 251
  • In infectious diseases: 95
• Year to date:
  • Site-wide: 4,530
• Since beginning of last month:
  • Site-wide: 21,245

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

• Downloaded 13,188 times
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  • Site-wide: 753
  • In infectious diseases: 262
• Year to date:
  • Site-wide: 12,789
• Since beginning of last month:
  • Site-wide: 36,467

Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension

• Downloaded 6,407 times
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  • Site-wide: 1,905
  • In pathology: 16
• Year to date:
  • Site-wide: 9,479
• Since beginning of last month:
  • Site-wide: 20,786

The impact of temperature and absolute humidity on the coronavirus disease 2019 (COVID-19) outbreak - evidence from China

• Downloaded 6,338 times
• Download rankings, all-time:
  • Site-wide: 1,934
  • In occupational and environmental health: 10
• Year to date:
  • Site-wide: 8,998
• Since beginning of last month:
  • Site-wide: 15,141

Estimating prevalence for limb-girdle muscular dystrophy based on public sequencing databases

• Downloaded 2,179 times
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  • Site-wide: 8,773
  • In epidemiology: 709
• Year to date:
  • Site-wide: 14,673
• Since beginning of last month:
  • Site-wide: 67,090

Multi-organ Proteomic Landscape of COVID-19 Autopsies

• Downloaded 2,174 times
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  • Site-wide: 8,814
  • In infectious diseases: 1,354
• Year to date:
  • Site-wide: 7,674
• Since beginning of last month:
  • Site-wide: 20,720

Neutralizing and binding antibody kinetics of COVID-19 patients during hospital and convalescent phases

• Downloaded 2,118 times
• Download rankings, all-time:
  • Site-wide: 9,136
  • In infectious diseases: 1,389
• Year to date:
  • Site-wide: 8,937
• Since beginning of last month:
  • Site-wide: 19,691

Protein Classifier for Thyroid Nodules Learned from Rapidly Acquired Proteotypes

• Downloaded 1,832 times
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  • Site-wide: 11,373
  • In oncology: 13
• Year to date:
  • Site-wide: 8,348
• Since beginning of last month:
  • Site-wide: 7,559

Ccube: A fast and robust method for estimating cancer cell fractions

• Downloaded 1,721 times
• Download rankings, all-time:
  • Site-wide: 12,478
  • In bioinformatics: 1,401
• Year to date:
  • Site-wide: 17,197
• Since beginning of last month:
  • Site-wide: 86,369

Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-legume Parasponia

• Downloaded 1,640 times
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  • Site-wide: 13,399
  • In plant biology: 135
• Year to date:
  • Site-wide: 59,801
• Since beginning of last month:
  • Site-wide: 97,084

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course

• Downloaded 1,416 times
• Download rankings, all-time:
  • Site-wide: 16,868
  • In respiratory medicine: 59
• Year to date:
  • Site-wide: 24,064
• Since beginning of last month:
  • Site-wide: 27,530

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

• Downloaded 1,346 times
• Download rankings, all-time:
  • Site-wide: 18,206
  • In genetics: 811
• Year to date:
  • Site-wide: 151,810
• Since beginning of last month:
  • Site-wide: 142,246

Non-specific Primers Reveal False-negative Risk in Detection of COVID-19 Infections

• Downloaded 1,324 times
• Download rankings, all-time:
  • Site-wide: 18,668
  • In public and global health: 386
• Year to date:
  • Site-wide: 37,965
• Since beginning of last month:
  • Site-wide: 44,075

Structural and functional MRI from a cross-sectional Southwest University Adult lifespan Dataset (SALD)

• Downloaded 1,322 times
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  • Site-wide: 18,707
  • In neuroscience: 2,215
• Year to date:
  • Site-wide: 48,462
• Since beginning of last month:
  • Site-wide: 86,299

Single-cell regulatory landscape and disease vulnerability map of adult Macaque cortex

• Downloaded 1,293 times
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  • Site-wide: 19,317
  • In neuroscience: 2,303
• Year to date:
  • Site-wide: 19,328
• Since beginning of last month:
  • Site-wide: 22,526

Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

• Downloaded 1,185 times
• Download rankings, all-time:
  • Site-wide: 22,060
  • In biophysics: 567
• Year to date:
  • Site-wide: 126,535
• Since beginning of last month:
  • Site-wide: 101,900

Nursing students' attitudes, knowledge, and willingness to receive the COVID-19 vaccine: A cross-sectional study

• Downloaded 1,122 times
• Download rankings, all-time:
  • Site-wide: 24,004
  • In nursing: 16
• Year to date:
  • Site-wide: 4,501
• Since beginning of last month:
  • Site-wide: 3,627

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

• Downloaded 1,095 times
• Download rankings, all-time:
  • Site-wide: 24,878
  • In biochemistry: 553
• Year to date:
  • Site-wide: 59,249
• Since beginning of last month:
  • Site-wide: 34,020

Leveraging functional annotation to identify genes associated with complex diseases

• Downloaded 1,020 times
• Download rankings, all-time:
  • Site-wide: 27,707
  • In genetics: 1,218
• Year to date:
  • Site-wide: 119,173
• Since beginning of last month:
  • Site-wide: 137,053

Application of high-resolution landmark-free morphometrics to a mouse model of Down Syndrome reveals a tightly localised cranial phenotype

• Downloaded 950 times
• Download rankings, all-time:
  • Site-wide: 30,715
  • In genetics: 1,351
• Year to date:
  • Site-wide: 47,275
• Since beginning of last month:
  • Site-wide: 57,201

Hippocampal-medial prefrontal event segmentation and integration contribute to episodic memory formation

• Downloaded 925 times
• Download rankings, all-time:
  • Site-wide: 31,992
  • In neuroscience: 4,148
• Year to date:
  • Site-wide: 17,036
• Since beginning of last month:
  • Site-wide: 38,493

DPHL: A pan-human protein mass spectrometry library for robust biomarker discovery using Data-Independent Acquisition and Parallel Reaction Monitoring

• Downloaded 910 times
• Download rankings, all-time:
  • Site-wide: 32,752
  • In bioinformatics: 3,578
• Year to date:
  • Site-wide: 77,827
• Since beginning of last month:
  • Site-wide: 33,572

A Registration and Deep Learning Approach to Automated Landmark Detection for Geometric Morphometrics

• Downloaded 786 times
• Download rankings, all-time:
  • Site-wide: 40,479
  • In evolutionary biology: 1,821
• Year to date:
  • Site-wide: 28,450
• Since beginning of last month:
  • Site-wide: 32,148

A New Method for Primary Culture of Mouse Dorsal Root Ganglion Neurons

• Downloaded 727 times
• Download rankings, all-time:
  • Site-wide: 45,310
  • In neuroscience: 6,243
• Year to date:
  • Site-wide: 61,442
• Since beginning of last month:
  • Site-wide: 87,137

An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

• Downloaded 631 times
• Download rankings, all-time:
  • Site-wide: 54,917
  • In immunology: 1,701
• Year to date:
  • Site-wide: 59,873
• Since beginning of last month:
  • Site-wide: 69,604

Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs and mRNAs in live bacterial cells

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 58,679
  • In biophysics: 1,974
• Year to date:
  • Site-wide: 115,833
• Since beginning of last month:
  • Site-wide: 118,911

Decoys provide a scalable platform for the genetic analysis of plant E3 ubiquitin ligases that regulate circadian clock function

• Downloaded 600 times
• Download rankings, all-time:
  • Site-wide: 58,608
  • In plant biology: 1,371
• Year to date:
  • Site-wide: 129,928
• Since beginning of last month:
  • Site-wide: 91,495

hTFtarget: a comprehensive database for regulations of human transcription factors and their targets

• Downloaded 597 times
• Download rankings, all-time:
  • Site-wide: 59,040
  • In bioinformatics: 5,801
• Year to date:
  • Site-wide: 46,908
• Since beginning of last month:
  • Site-wide: 46,502

GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex

• Downloaded 569 times
• Download rankings, all-time:
  • Site-wide: 62,621
  • In plant biology: 1,505
• Year to date:
  • Site-wide: 135,013
• Since beginning of last month:
  • Site-wide: 149,492

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 63,016
  • In cancer biology: 1,823
• Year to date:
  • Site-wide: 143,316
• Since beginning of last month:
  • Site-wide: 145,214

Variation of the vaginal microbiome during and after pregnancy in Chinese women

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 71,653
  • In genetic and genomic medicine: 346
• Year to date:
  • Site-wide: 45,135
• Since beginning of last month:
  • Site-wide: 65,706

Common neural and transcriptional correlates of inhibitory control underlie emotion regulation and memory control

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 73,883
  • In neuroscience: 10,788
• Year to date:
  • Site-wide: 136,581
• Since beginning of last month:
  • Site-wide: 135,757

Two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and its regulation by T-box structural elements

• Downloaded 490 times
• Download rankings, all-time:
  • Site-wide: 74,807
  • In biophysics: 2,675
• Year to date:
  • Site-wide: 124,023
• Since beginning of last month:
  • Site-wide: 57,150

Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade

• Downloaded 482 times
• Download rankings, all-time:
  • Site-wide: 76,218
  • In genetics: 3,237
• Year to date:
  • Site-wide: 120,713
• Since beginning of last month:
  • Site-wide: 143,757

Shapes and Genescapes: Mapping Multivariate Phenotype-Biological Process Associations for Craniofacial Shape

• Downloaded 477 times
• Download rankings, all-time:
  • Site-wide: 77,059
  • In genomics: 5,129
• Year to date:
  • Site-wide: 26,978
• Since beginning of last month:
  • Site-wide: 18,627

Probing the neural dynamics of mnemonic representations after the initial consolidation

• Downloaded 462 times
• Download rankings, all-time:
  • Site-wide: 79,723
  • In neuroscience: 11,759
• Year to date:
  • Site-wide: 118,178
• Since beginning of last month:
  • Site-wide: 94,613

A Decoy Library Uncovers U-box E3 Ubiquitin Ligases that Regulate Flowering Time in Arabidopsis

• Downloaded 455 times
• Download rankings, all-time:
  • Site-wide: 81,136
  • In plant biology: 2,085
• Year to date:
  • Site-wide: 123,082
• Since beginning of last month:
  • Site-wide: 136,439

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

• Downloaded 452 times
• Download rankings, all-time:
  • Site-wide: 81,661
  • In immunology: 2,467
• Year to date:
  • Site-wide: 128,119
• Since beginning of last month:
  • Site-wide: 140,725

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 85,962
  • In microbiology: 5,770
• Year to date:
  • Site-wide: 62,787
• Since beginning of last month:
  • Site-wide: 51,639

Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

• Downloaded 395 times
• Download rankings, all-time:
  • Site-wide: 93,258
  • In biophysics: 3,474
• Year to date:
  • Site-wide: 22,904
• Since beginning of last month:
  • Site-wide: 40,944

Specific Eph Receptor-Cytoplasmic Effector Signaling Mediated by SAM-SAM Domain Interactions

• Downloaded 387 times
• Download rankings, all-time:
  • Site-wide: 95,030
  • In biophysics: 3,551
• Year to date:
  • Site-wide: 140,091
• Since beginning of last month:
  • Site-wide: 127,849

Transmission dynamics and control measures of COVID-19 outbreak in China: a modelling study

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 101,045
  • In infectious diseases: 4,723
• Year to date:
  • Site-wide: 134,413
• Since beginning of last month:
  • Site-wide: 136,982

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 101,005
  • In microbiology: 6,980
• Year to date:
  • Site-wide: 124,770
• Since beginning of last month:
  • Site-wide: 109,458

Dynamic Analysis on Simultaneous iEEG-MEG Data via Hidden Markov Model

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 103,166
  • In neurology: 362
• Year to date:
  • Site-wide: 74,013
• Since beginning of last month:
  • Site-wide: 134,304

Real-time monitoring epidemic trends and key mutations in SARS-CoV-2 evolution by an automated tool

• Downloaded 350 times
• Download rankings, all-time:
  • Site-wide: 103,667
  • In genomics: 6,176
• Year to date:
  • Site-wide: 50,437
• Since beginning of last month:
  • Site-wide: 103,067

Evaluation of Ultrafast Wave-CAIPI 3D FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 105,810
  • In radiology and imaging: 202
• Year to date:
  • Site-wide: 28,371
• Since beginning of last month:
  • Site-wide: 41,418

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 109,216
  • In genomics: 6,378
• Year to date:
  • Site-wide: 89,932
• Since beginning of last month:
  • Site-wide: 122,968

Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

• Downloaded 306 times
• Download rankings, all-time:
  • Site-wide: 114,896
  • In genomics: 6,544
• Year to date:
  • Site-wide: 33,274
• Since beginning of last month:
  • Site-wide: 7,938

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes

• Downloaded 296 times
• Download rankings, all-time:
  • Site-wide: 117,536
  • In genetics: 4,790
• Year to date:
  • Site-wide: 152,810
• Since beginning of last month:
  • Site-wide: 136,981

NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 118,675
  • In cell biology: 5,535
• Year to date:
  • Site-wide: 158,171
• Since beginning of last month:
  • Site-wide: 149,230

Emodin Attenuates Renal Interstitial Fibrosis via Regulation of TIMP1/MM9 Pathway in Rats

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 125,455
  • In molecular biology: 3,725
• Year to date:
  • Site-wide: 135,299
• Since beginning of last month:
  • Site-wide: 122,238

A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq

• Downloaded 258 times
• Download rankings, all-time:
  • Site-wide: 127,574
  • In microbiology: 9,265
• Year to date:
  • Site-wide: 41,922
• Since beginning of last month:
  • Site-wide: 52,569

The right time and place: time- and age-dependent vaccine-enhanced mucosal immunity to parasite infection

• Downloaded 222 times
• Download rankings, all-time:
  • Site-wide: 136,931
  • In immunology: 4,099
• Year to date:
  • Site-wide: 50,927
• Since beginning of last month:
  • Site-wide: 30,269

Unique intramolecular oxidative rearrangement N-nitrosation mechanism of non-heam iron-containing enzyme SznF

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 150,111
  • In biochemistry: 4,575
• Year to date:
  • Site-wide: 94,112
• Since beginning of last month:
  • Site-wide: 97,562

Estimation of in-scanner head pose changes during structural MRI using a convolutional neural network trained on eye tracker video

• Downloaded 108 times
• Download rankings, all-time:
  • Site-wide: 159,070
  • In neuroscience: 23,661
• Year to date:
  • Site-wide: 107,448
• Since beginning of last month:
  • Site-wide: 98,621