Author: Wei Liu

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Preprints

Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset

• Downloaded 34,491 times
• Download rankings, all-time:
  • Site-wide: 309
  • In infectious diseases: 111
• Year to date:
  • Site-wide: 19,587
• Since beginning of last month:
  • Site-wide: 20,506

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

• Downloaded 13,492 times
• Download rankings, all-time:
  • Site-wide: 940
  • In infectious diseases: 312
• Year to date:
  • Site-wide: 24,066
• Since beginning of last month:
  • Site-wide: 15,982

The impact of temperature and absolute humidity on the coronavirus disease 2019 (COVID-19) outbreak - evidence from China

• Downloaded 6,741 times
• Download rankings, all-time:
  • Site-wide: 2,330
  • In occupational and environmental health: 13
• Year to date:
  • Site-wide: 17,158
• Since beginning of last month:
  • Site-wide: 39,653

Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension

• Downloaded 6,705 times
• Download rankings, all-time:
  • Site-wide: 2,346
  • In pathology: 20
• Year to date:
  • Site-wide: 24,314
• Since beginning of last month:
  • Site-wide: 54,104

Structural basis for Nirmatrelvir in vitro efficacy against SARS-CoV-2 variants

• Downloaded 3,440 times
• Download rankings, all-time:
  • Site-wide: 5,988
  • In biochemistry: 113
• Year to date:
  • Site-wide: 4,050
• Since beginning of last month:
  • Site-wide: 9,501

Estimating prevalence for limb-girdle muscular dystrophy based on public sequencing databases

• Downloaded 2,422 times
• Download rankings, all-time:
  • Site-wide: 10,049
  • In epidemiology: 806
• Year to date:
  • Site-wide: 62,090
• Since beginning of last month:
  • Site-wide: 74,952

Protein Classifier for Thyroid Nodules Learned from Rapidly Acquired Proteotypes

• Downloaded 2,377 times
• Download rankings, all-time:
  • Site-wide: 10,349
  • In oncology: 11
• Year to date:
  • Site-wide: 63,734
• Since beginning of last month:
  • Site-wide: 34,344

Multi-organ Proteomic Landscape of COVID-19 Autopsies

• Downloaded 2,360 times
• Download rankings, all-time:
  • Site-wide: 10,474
  • In infectious diseases: 1,622
• Year to date:
  • Site-wide: 89,106
• Since beginning of last month:
  • Site-wide: 63,627

Neutralizing and binding antibody kinetics of COVID-19 patients during hospital and convalescent phases

• Downloaded 2,319 times
• Download rankings, all-time:
  • Site-wide: 10,710
  • In infectious diseases: 1,652
• Year to date:
  • Site-wide: 19,544
• Since beginning of last month:
  • Site-wide: 52,886

Ccube: A fast and robust method for estimating cancer cell fractions

• Downloaded 1,934 times
• Download rankings, all-time:
  • Site-wide: 14,145
  • In bioinformatics: 1,533
• Year to date:
  • Site-wide: 62,789
• Since beginning of last month:
  • Site-wide: 38,110

Parallel loss of symbiosis genes in relatives of nitrogen-fixing non-legume Parasponia

• Downloaded 1,769 times
• Download rankings, all-time:
  • Site-wide: 16,231
  • In plant biology: 173
• Year to date:
  • Site-wide: 94,411
• Since beginning of last month:
  • Site-wide: 76,021

Nursing students' attitudes, knowledge, and willingness to receive the COVID-19 vaccine: A cross-sectional study

• Downloaded 1,681 times
• Download rankings, all-time:
  • Site-wide: 17,585
  • In nursing: 13
• Year to date:
  • Site-wide: 19,077
• Since beginning of last month:
  • Site-wide: 17,057

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course

• Downloaded 1,642 times
• Download rankings, all-time:
  • Site-wide: 18,263
  • In respiratory medicine: 59
• Year to date:
  • Site-wide: 84,676
• Since beginning of last month:
  • Site-wide: 45,505

Structural and functional MRI from a cross-sectional Southwest University Adult lifespan Dataset (SALD)

• Downloaded 1,539 times
• Download rankings, all-time:
  • Site-wide: 20,197
  • In neuroscience: 2,328
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 43,203

Non-specific Primers Reveal False-negative Risk in Detection of COVID-19 Infections

• Downloaded 1,480 times
• Download rankings, all-time:
  • Site-wide: 21,524
  • In public and global health: 473
• Year to date:
  • Site-wide: 48,717
• Since beginning of last month:
  • Site-wide: 101,324

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease

• Downloaded 1,409 times
• Download rankings, all-time:
  • Site-wide: 23,303
  • In genetics: 923
• Year to date:
  • Site-wide: 132,635
• Since beginning of last month:
  • Site-wide: 175,222

Cryo-EM structure of the receptor-activated TRPC5 ion channel at 2.9 angstrom resolution

• Downloaded 1,252 times
• Download rankings, all-time:
  • Site-wide: 28,141
  • In biophysics: 770
• Year to date:
  • Site-wide: 136,578
• Since beginning of last month:
  • Site-wide: 147,308

Hippocampal-medial prefrontal event segmentation and integration contribute to episodic memory formation

• Downloaded 1,213 times
• Download rankings, all-time:
  • Site-wide: 29,560
  • In neuroscience: 3,935
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 34,178

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

• Downloaded 1,157 times
• Download rankings, all-time:
  • Site-wide: 31,877
  • In biochemistry: 717
• Year to date:
  • Site-wide: 139,749
• Since beginning of last month:
  • Site-wide: 206,039

Application of high-resolution landmark-free morphometrics to a mouse model of Down Syndrome reveals a tightly localised cranial phenotype

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 35,080
  • In genetics: 1,411
• Year to date:
  • Site-wide: 139,559
• Since beginning of last month:
  • Site-wide: 21,504

Leveraging functional annotation to identify genes associated with complex diseases

• Downloaded 1,086 times
• Download rankings, all-time:
  • Site-wide: 35,077
  • In genetics: 1,377
• Year to date:
  • Site-wide: 188,861
• Since beginning of last month:
  • Site-wide: 154,106

DPHL: A pan-human protein mass spectrometry library for robust biomarker discovery using Data-Independent Acquisition and Parallel Reaction Monitoring

• Downloaded 956 times
• Download rankings, all-time:
  • Site-wide: 42,753
  • In bioinformatics: 4,505
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 162,917

A Registration and Deep Learning Approach to Automated Landmark Detection for Geometric Morphometrics

• Downloaded 943 times
• Download rankings, all-time:
  • Site-wide: 43,640
  • In evolutionary biology: 1,724
• Year to date:
  • Site-wide: 113,430
• Since beginning of last month:
  • Site-wide: 130,784

A New Method for Primary Culture of Mouse Dorsal Root Ganglion Neurons

• Downloaded 863 times
• Download rankings, all-time:
  • Site-wide: 50,019
  • In neuroscience: 6,736
• Year to date:
  • Site-wide: 50,011
• Since beginning of last month:
  • Site-wide: 59,589

Shapes and Genescapes: Mapping Multivariate Phenotype-Biological Process Associations for Craniofacial Shape

• Downloaded 761 times
• Download rankings, all-time:
  • Site-wide: 60,396
  • In genomics: 4,273
• Year to date:
  • Site-wide: 37,107
• Since beginning of last month:
  • Site-wide: 52,622

tFold-Ab: Fast and Accurate Antibody Structure Prediction without Sequence Homologs

• Downloaded 756 times
• Download rankings, all-time:
  • Site-wide: 60,923
  • In bioinformatics: 7,082
• Year to date:
  • Site-wide: 3,067
• Since beginning of last month:
  • Site-wide: 1,184

Structural basis for receptor selectivity and inverse agonism in S1P5 receptors

• Downloaded 754 times
• Download rankings, all-time:
  • Site-wide: 61,263
  • In biophysics: 2,129
• Year to date:
  • Site-wide: 15,654
• Since beginning of last month:
  • Site-wide: 22,359

An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 66,025
  • In immunology: 2,195
• Year to date:
  • Site-wide: 81,383
• Since beginning of last month:
  • Site-wide: 102,046

hTFtarget: a comprehensive database for regulations of human transcription factors and their targets

• Downloaded 668 times
• Download rankings, all-time:
  • Site-wide: 72,743
  • In bioinformatics: 6,669
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Variation of the vaginal microbiome during and after pregnancy in Chinese women

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 73,185
  • In genetic and genomic medicine: 475
• Year to date:
  • Site-wide: 29,755
• Since beginning of last month:
  • Site-wide: 80,942

Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs and mRNAs in live bacterial cells

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 75,300
  • In biophysics: 2,602
• Year to date:
  • Site-wide: 119,768
• Since beginning of last month:
  • Site-wide: 186,223

Decoys provide a scalable platform for the genetic analysis of plant E3 ubiquitin ligases that regulate circadian clock function

• Downloaded 645 times
• Download rankings, all-time:
  • Site-wide: 76,317
  • In plant biology: 1,825
• Year to date:
  • Site-wide: 111,981
• Since beginning of last month:
  • Site-wide: 205,939

GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex

• Downloaded 612 times
• Download rankings, all-time:
  • Site-wide: 81,599
  • In plant biology: 1,970
• Year to date:
  • Site-wide: 168,946
• Since beginning of last month:
  • Site-wide: 209,346

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes

• Downloaded 611 times
• Download rankings, all-time:
  • Site-wide: 81,683
  • In cancer biology: 2,399
• Year to date:
  • Site-wide: 191,279
• Since beginning of last month:
  • Site-wide: 140,737

Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation

• Downloaded 593 times
• Download rankings, all-time:
  • Site-wide: 84,940
  • In biophysics: 3,036
• Year to date:
  • Site-wide: 181,982
• Since beginning of last month:
  • Site-wide: 57,332

Two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and its regulation by T-box structural elements

• Downloaded 562 times
• Download rankings, all-time:
  • Site-wide: 90,891
  • In biophysics: 3,235
• Year to date:
  • Site-wide: 187,683
• Since beginning of last month:
  • Site-wide: 145,508

Common neural and transcriptional correlates of inhibitory control underlie emotion regulation and memory control

• Downloaded 562 times
• Download rankings, all-time:
  • Site-wide: 90,913
  • In neuroscience: 13,082
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 144,446

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

• Downloaded 553 times
• Download rankings, all-time:
  • Site-wide: 92,734
  • In immunology: 3,010
• Year to date:
  • Site-wide: 72,048
• Since beginning of last month:
  • Site-wide: 176,938

Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 97,002
  • In genetics: 3,677
• Year to date:
  • Site-wide: 161,971
• Since beginning of last month:
  • Site-wide: 213,456

Probing the neural dynamics of mnemonic representations after the initial consolidation

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 98,335
  • In neuroscience: 14,166
• Year to date:
  • Site-wide: 165,881
• Since beginning of last month:
  • Site-wide: 187,396

A Decoy Library Uncovers U-box E3 Ubiquitin Ligases that Regulate Flowering Time in Arabidopsis

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 101,181
  • In plant biology: 2,631
• Year to date:
  • Site-wide: 120,422
• Since beginning of last month:
  • Site-wide: 184,565

A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection

• Downloaded 510 times
• Download rankings, all-time:
  • Site-wide: 101,864
  • In microbiology: 6,647
• Year to date:
  • Site-wide: 121,009
• Since beginning of last month:
  • Site-wide: 131,336

Evaluation of Ultrafast Wave-CAIPI 3D FLAIR in the Visualization and Volumetric Estimation of Cerebral White Matter Lesions

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 102,348
  • In radiology and imaging: 208
• Year to date:
  • Site-wide: 152,484
• Since beginning of last month:
  • Site-wide: 43,941

Specific Eph Receptor-Cytoplasmic Effector Signaling Mediated by SAM-SAM Domain Interactions

• Downloaded 453 times
• Download rankings, all-time:
  • Site-wide: 115,650
  • In biophysics: 4,218
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

A novel antiviral lncRNA EDAL shields a T309 O-GlcNAcylation site to promote EZH2 degradation

• Downloaded 448 times
• Download rankings, all-time:
  • Site-wide: 116,883
  • In microbiology: 7,952
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 76,803

Dynamic Analysis on Simultaneous iEEG-MEG Data via Hidden Markov Model

• Downloaded 439 times
• Download rankings, all-time:
  • Site-wide: 119,270
  • In neurology: 580
• Year to date:
  • Site-wide: 89,877
• Since beginning of last month:
  • Site-wide: 185,364

Transmission dynamics and control measures of COVID-19 outbreak in China: a modelling study

• Downloaded 423 times
• Download rankings, all-time:
  • Site-wide: 123,431
  • In infectious diseases: 6,123
• Year to date:
  • Site-wide: 184,898
• Since beginning of last month:
  • Site-wide: 131,616

Real-time monitoring epidemic trends and key mutations in SARS-CoV-2 evolution by an automated tool

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 124,321
  • In genomics: 6,987
• Year to date:
  • Site-wide: 64,859
• Since beginning of last month:
  • Site-wide: 136,646

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 127,585
  • In genomics: 7,144
• Year to date:
  • Site-wide: 44,240
• Since beginning of last month:
  • Site-wide: 121,522

Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 136,870
  • In genomics: 7,376
• Year to date:
  • Site-wide: 144,630
• Since beginning of last month:
  • Site-wide: 97,059

A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 137,842
  • In microbiology: 9,495
• Year to date:
  • Site-wide: 181,457
• Since beginning of last month:
  • Site-wide: 96,701

NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 149,876
  • In cell biology: 6,954
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 177,353

Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 150,328
  • In genetics: 5,570
• Year to date:
  • Site-wide: 165,219
• Since beginning of last month:
  • Site-wide: 212,037

Emodin Attenuates Renal Interstitial Fibrosis via Regulation of TIMP1/MM9 Pathway in Rats

• Downloaded 323 times
• Download rankings, all-time:
  • Site-wide: 152,935
  • In molecular biology: 4,498
• Year to date:
  • Site-wide: 139,895
• Since beginning of last month:
  • Site-wide: 148,128

The right time and place: time- and age-dependent vaccine-enhanced mucosal immunity to parasite infection

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 156,812
  • In immunology: 4,911
• Year to date:
  • Site-wide: 144,564
• Since beginning of last month:
  • Site-wide: 112,640

Estimation of in-scanner head pose changes during structural MRI using a convolutional neural network trained on eye tracker video

• Downloaded 297 times
• Download rankings, all-time:
  • Site-wide: 161,007
  • In neuroscience: 23,790
• Year to date:
  • Site-wide: 52,483
• Since beginning of last month:
  • Site-wide: 84,295

The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 163,029
  • In molecular biology: 4,843
• Year to date:
  • Site-wide: 145,016
• Since beginning of last month:
  • Site-wide: 87,277

Unique intramolecular oxidative rearrangement N-nitrosation mechanism of non-heam iron-containing enzyme SznF

• Downloaded 219 times
• Download rankings, all-time:
  • Site-wide: 182,928
  • In biochemistry: 5,676
• Year to date:
  • Site-wide: 161,938
• Since beginning of last month:
  • Site-wide: 158,441

The circ_0002538/miR-138-5p/PLLP axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy

• Downloaded 177 times
• Download rankings, all-time:
  • Site-wide: 192,657
  • In neuroscience: 28,280
• Year to date:
  • Site-wide: 31,966
• Since beginning of last month:
  • Site-wide: 48,674