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Author: Tuomas P.J. Knowles

Rankings

  • All-time downloads: 51,465 (rank: 4,182 )
  • Categories:
    • allergy and immunology: 1,541 (rank: 1,238 (tie) )
    • biochemistry: 1,335 (rank: 5,006 (tie) )
    • biophysics: 39,773 (rank: 3 )
    • molecular biology: 516 (rank: 16,706 (tie) )
    • neurology: 7,301 (rank: 146 (tie) )
    • neuroscience: 999 (rank: 31,176 (tie) )

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Preprints

Kinetic fingerprints differentiate anti-Aβ therapies

biophysics more details view paper
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    • Site-wide: 366
    • In biophysics: 1
  • Year to date:
    • Site-wide: 49,341
  • Since beginning of last month:
    • Site-wide: 85,192

Autoantibodies against the prion protein in individuals with PRNP mutations

neurology more details view paper
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    • Site-wide: 1,694
    • In neurology: 5
  • Year to date:
    • Site-wide: 35,087
  • Since beginning of last month:
    • Site-wide: 2,943

Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics

biophysics more details view paper
  • Downloaded 1,949 times
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    • Site-wide: 10,857
    • In biophysics: 222
  • Year to date:
    • Site-wide: 12,459
  • Since beginning of last month:
    • Site-wide: 8,800

Surface electrostatics govern the emulsion stability of biomolecular condensates

biophysics more details view paper
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    • Site-wide: 11,890
    • In biophysics: 258
  • Year to date:
    • Site-wide: 5,199
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Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

biophysics more details view paper
  • Downloaded 1,802 times
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    • Site-wide: 12,206
    • In biophysics: 267
  • Year to date:
    • Site-wide: 104,876
  • Since beginning of last month:
    • Site-wide: 35,146

Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors

allergy and immunology more details view paper
  • Downloaded 1,541 times
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    • Site-wide: 15,460
    • In allergy and immunology: 67
  • Year to date:
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    • Site-wide: 19,884

Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease

biophysics more details view paper
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    • Site-wide: 17,840
    • In biophysics: 433
  • Year to date:
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    • Site-wide: 68,630

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

biophysics more details view paper
  • Downloaded 1,311 times
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    • Site-wide: 19,742
    • In biophysics: 489
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LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

neuroscience more details view paper
  • Downloaded 999 times
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    • Site-wide: 29,773
    • In neuroscience: 3,741
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    • Site-wide: None
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Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum

biophysics more details view paper
  • Downloaded 934 times
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    • Site-wide: 32,900
    • In biophysics: 984
  • Year to date:
    • Site-wide: 7,870
  • Since beginning of last month:
    • Site-wide: 14,330

Direct digital sensing of proteins in solution through single-molecule optofluidics

biophysics more details view paper
  • Downloaded 830 times
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    • Site-wide: 39,078
    • In biophysics: 1,209
  • Year to date:
    • Site-wide: 73,001
  • Since beginning of last month:
    • Site-wide: 58,408

In vitro measurements of protein-protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum

biochemistry more details view paper
  • Downloaded 765 times
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    • Site-wide: 43,938
    • In biochemistry: 1,106
  • Year to date:
    • Site-wide: 58,592
  • Since beginning of last month:
    • Site-wide: 77,372

The chromatin regulator HMGA1a undergoes phase separation in the nucleus

biophysics more details view paper
  • Downloaded 633 times
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    • Site-wide: 56,954
    • In biophysics: 1,899
  • Year to date:
    • Site-wide: 11,322
  • Since beginning of last month:
    • Site-wide: 6,268

Intermolecular reorganisation of single-componentcondensates during ageing promotes multiphasearchitectures.

biophysics more details view paper
  • Downloaded 625 times
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    • Site-wide: 57,901
    • In biophysics: 1,942
  • Year to date:
    • Site-wide: 12,236
  • Since beginning of last month:
    • Site-wide: 14,030

Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape

biochemistry more details view paper
  • Downloaded 570 times
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    • Site-wide: 65,144
    • In biochemistry: 1,734
  • Year to date:
    • Site-wide: 14,592
  • Since beginning of last month:
    • Site-wide: 34,218

Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism

biophysics more details view paper
  • Downloaded 540 times
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    • Site-wide: 69,455
    • In biophysics: 2,450
  • Year to date:
    • Site-wide: 53,701
  • Since beginning of last month:
    • Site-wide: 88,192

A conformational switch controlling the toxicity of the prion protein

molecular biology more details view paper
  • Downloaded 516 times
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    • Site-wide: 73,404
    • In molecular biology: 2,099
  • Year to date:
    • Site-wide: 19,970
  • Since beginning of last month:
    • Site-wide: 29,205

Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer's disease

biophysics more details view paper
  • Downloaded 468 times
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    • Site-wide: 81,875
    • In biophysics: 2,971
  • Year to date:
    • Site-wide: 103,244
  • Since beginning of last month:
    • Site-wide: 40,568

Machine learning aided top-down protein identification on a microfluidic platform

biophysics more details view paper
  • Downloaded 431 times
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    • Site-wide: 89,297
    • In biophysics: 3,295
  • Year to date:
    • Site-wide: 57,198
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Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2

biophysics more details view paper
  • Downloaded 311 times
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    • Site-wide: 117,953
    • In biophysics: 4,510
  • Year to date:
    • Site-wide: 15,898
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    • Site-wide: 19,184

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

biophysics more details view paper
  • Downloaded 221 times
  • Download rankings, all-time:
    • Site-wide: 142,387
    • In biophysics: 5,461
  • Year to date:
    • Site-wide: 145,003
  • Since beginning of last month:
    • Site-wide: 169,046

2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution

biophysics more details view paper
  • Downloaded 198 times
  • Download rankings, all-time:
    • Site-wide: 148,138
    • In biophysics: 5,661
  • Year to date:
    • Site-wide: 15,777
  • Since beginning of last month:
    • Site-wide: 12,509

Single-molecule sizing through nano-cavity confinement

biophysics more details view paper
  • Downloaded 156 times
  • Download rankings, all-time:
    • Site-wide: 157,414
    • In biophysics: 6,035
  • Year to date:
    • Site-wide: 4,547
  • Since beginning of last month:
    • Site-wide: 4,143

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