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Author: Alexander Gusev

Rankings

  • All-time downloads: 98,195 (rank: 2,233 )
  • Categories:
    • bioinformatics: 1,237 (rank: 17,298 (tie) )
    • cancer biology: 4,805 (rank: 1,322 )
    • epidemiology: 2,086 (rank: 8,905 )
    • evolutionary biology: 1,592 (rank: 5,903 (tie) )
    • genetic and genomic medicine: 2,055 (rank: 3,208 )
    • genetics: 56,329 (rank: 79 )
    • genomics: 27,737 (rank: 507 )

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Preprints

Polygenic Prediction of Molecular Traits using Large-Scale Meta-analysis Summary Statistics

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Germline determinants of the prostate tumor genome

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An Atlas of Genetic Correlations across Human Diseases and Traits

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    • Site-wide: 773
    • In genomics: 33
  • Year to date:
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Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 8,900 times
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    • Site-wide: 1,562
    • In genetics: 34
  • Year to date:
    • Site-wide: 9,160
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Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
  • Downloaded 4,634 times
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    • Site-wide: 3,778
    • In genetics: 103
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

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    • Site-wide: 3,918
    • In genetics: 109
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Tumor mutational landscape is a record of the pre-malignant state

genomics more details view paper
  • Downloaded 4,251 times
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    • Site-wide: 4,259
    • In genomics: 392
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Predicting master transcription factors from pan-cancer expression data

cancer biology more details view paper
  • Downloaded 3,657 times
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    • Site-wide: 5,309
    • In cancer biology: 68
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Downloaded 3,356 times
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    • Site-wide: 6,038
    • In genetics: 201
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Haplotypes of common SNPs can explain missing heritability of complex diseases

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  • Downloaded 3,267 times
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    • In genetics: 208
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Integrative approaches for large-scale transcriptome-wide association studies

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  • Downloaded 3,088 times
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    • Site-wide: 6,827
    • In genetics: 240
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

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  • Downloaded 3,027 times
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    • Site-wide: 7,008
    • In genetics: 253
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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  • Downloaded 2,756 times
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    • Site-wide: 8,023
    • In genetics: 296
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • Downloaded 2,684 times
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    • Site-wide: 8,339
    • In genomics: 770
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Estimating the proportion of disease heritability mediated by gene expression levels

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  • Downloaded 2,409 times
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    • Site-wide: 9,803
    • In genetics: 370
  • Year to date:
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Probabilistic fine-mapping of transcriptome-wide association studies

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  • Downloaded 2,068 times
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    • Site-wide: 12,362
    • In genetics: 450
  • Year to date:
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Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

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  • Downloaded 2,002 times
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    • Site-wide: 12,971
    • In genetics: 486
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Quantifying genetic effects on disease mediated by assayed gene expression levels

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  • Downloaded 1,982 times
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    • Site-wide: 13,168
    • In genetics: 498
  • Year to date:
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Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,824 times
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    • Site-wide: 14,938
    • In genetics: 589
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    • Site-wide: 162,818
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Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations

genetics more details view paper
  • Downloaded 1,724 times
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    • Site-wide: 16,278
    • In genetics: 647
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An evolutionary compass for detecting signals of polygenic selection and mutational bias

evolutionary biology more details view paper
  • Downloaded 1,612 times
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    • Site-wide: 18,094
    • In evolutionary biology: 512
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Transcriptome-wide association studies accounting for colocalization using Egger regression

epidemiology more details view paper
  • Downloaded 1,550 times
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    • Site-wide: 19,225
    • In epidemiology: 1,252
  • Year to date:
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    • Site-wide: 120,795

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,485 times
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    • Site-wide: 20,601
    • In genetics: 814
  • Year to date:
    • Site-wide: 201,319
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    • Site-wide: 163,982

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,316 times
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    • Site-wide: 24,982
    • In genetics: 982
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    • Site-wide: 145,872

Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 1,129 times
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    • Site-wide: 31,798
    • In genetics: 1,261
  • Year to date:
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    • Site-wide: 106,072

Somatic mutational profiles and germline polygenic risk scores in human cancer

genomics more details view paper
  • Downloaded 1,103 times
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    • Site-wide: 32,966
    • In genomics: 2,656
  • Year to date:
    • Site-wide: 68,923
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    • Site-wide: 180,264

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

genomics more details view paper
  • Downloaded 1,077 times
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    • Site-wide: 34,160
    • In genomics: 2,734
  • Year to date:
    • Site-wide: 139,205
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    • Site-wide: 78,117

Germline features associated with immune infiltration in solid tumors

genetics more details view paper
  • Downloaded 1,026 times
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    • Site-wide: 36,801
    • In genetics: 1,440
  • Year to date:
    • Site-wide: 171,308
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Functional partitioning of local and distal gene expression regulation in multiple human tissues

genomics more details view paper
  • Downloaded 978 times
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    • Site-wide: 39,579
    • In genomics: 3,026
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    • Site-wide: 196,509
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    • Site-wide: 167,162

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

genomics more details view paper
  • Downloaded 963 times
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    • Site-wide: 40,605
    • In genomics: 3,114
  • Year to date:
    • Site-wide: 77,909
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    • Site-wide: 133,609

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

cancer biology more details view paper
  • Downloaded 942 times
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    • Site-wide: 41,978
    • In cancer biology: 1,110
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    • Site-wide: 163,889
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    • Site-wide: 105,943

Allelic imbalance reveals widespread germline-somatic regulatory differences and prioritizes risk loci in Renal Cell Carcinoma

genetics more details view paper
  • Downloaded 926 times
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    • Site-wide: 43,091
    • In genetics: 1,803
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    • Site-wide: 34,376
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Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies

genetics more details view paper
  • Downloaded 910 times
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    • Site-wide: 44,166
    • In genetics: 1,996
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    • Site-wide: 3,931
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Leveraging distant relatedness to quantify human mutation and gene conversion rates

genetics more details view paper
  • Downloaded 859 times
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    • Site-wide: 48,304
    • In genetics: 1,868
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    • Site-wide: 160,750
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Allele-Specific QTL Fine-Mapping with PLASMA

bioinformatics more details view paper
  • Downloaded 853 times
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    • Site-wide: 48,776
    • In bioinformatics: 4,701
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Constructing germline research cohorts from the discarded reads of clinical tumor sequences

genetic and genomic medicine more details view paper
  • Downloaded 836 times
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    • Site-wide: 50,360
    • In genetic and genomic medicine: 284
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    • Site-wide: 32,861
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    • Site-wide: 180,981

Germline variants associated with immunotherapy-related adverse events

genetic and genomic medicine more details view paper
  • Downloaded 833 times
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    • Site-wide: 50,689
    • In genetic and genomic medicine: 444
  • Year to date:
    • Site-wide: 4,550
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    • Site-wide: 3,285

H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility

genomics more details view paper
  • Downloaded 777 times
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    • Site-wide: 56,151
    • In genomics: 3,943
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    • Site-wide: 77,989
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The lingering effects of Neanderthal introgression on human complex traits

genetics more details view paper
  • Downloaded 769 times
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    • Site-wide: 56,951
    • In genetics: 3,650
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    • Site-wide: 5,160
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    • Site-wide: 5,813

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
  • Downloaded 738 times
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    • Site-wide: 60,459
    • In genetics: 2,299
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Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

genomics more details view paper
  • Downloaded 670 times
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    • Site-wide: 69,359
    • In genomics: 4,962
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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

genetics more details view paper
  • Downloaded 638 times
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    • Site-wide: 74,217
    • In genetics: 2,805
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Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations

epidemiology more details view paper
  • Downloaded 577 times
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    • Site-wide: 84,178
    • In epidemiology: 3,672
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Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

genetics more details view paper
  • Downloaded 576 times
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    • Site-wide: 84,314
    • In genetics: 3,197
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Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 568 times
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    • Site-wide: 85,809
    • In genetics: 3,273
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Optimized high-throughput screening of non-coding variants identified from genome-wide association studies

genetics more details view paper
  • Downloaded 513 times
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    • Site-wide: 97,082
    • In genetics: 3,808
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Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencing

bioinformatics more details view paper
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    • In bioinformatics: 9,773
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Distal gene regulation mediated by non-coding RNAs contributes to germline risk for breast and prostate cancer

genetic and genomic medicine more details view paper
  • Downloaded 388 times
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    • Site-wide: 128,155
    • In genetic and genomic medicine: 895
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A novel method to identify cell-type specific regulatory variants and their role in cancer risk

genetics more details view paper
  • Downloaded 373 times
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    • Site-wide: 132,394
    • In genetics: 5,051
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Seeing beyond the target: Leveraging off-target reads in targeted clinical tumor sequencing to identify prognostic biomarkers

genomics more details view paper
  • Downloaded 353 times
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    • Site-wide: 138,245
    • In genomics: 7,663
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Germline predisposition to pediatric Ewing sarcoma is uniquely characterized by inherited pathogenic variants in DNA damage repair genes

genetic and genomic medicine more details view paper
  • Downloaded 310 times
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    • Site-wide: 151,175
    • In genetic and genomic medicine: 1,056
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    • Site-wide: 23,202
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Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms

cancer biology more details view paper
  • Downloaded 273 times
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    • Site-wide: 162,056
    • In cancer biology: 4,856
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The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats

genetics more details view paper
  • Downloaded 219 times
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    • In genetics: 6,575
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Germline cancer gene expression quantitative trait loci influence local and global tumor mutations

genetic and genomic medicine more details view paper
  • Downloaded 111 times
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    • Site-wide: 198,788
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