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Author: Alexander Gusev

Rankings

  • All-time downloads: 82,313 (rank: 1,736 )
  • Categories:
    • bioinformatics: 763 (rank: 18,682 (tie) )
    • cancer biology: 3,571 (rank: 1,095 (tie) )
    • epidemiology: 1,817 (rank: 5,736 )
    • evolutionary biology: 1,492 (rank: 3,999 (tie) )
    • genetic and genomic medicine: 314 (rank: 6,179 (tie) )
    • genetics: 50,136 (rank: 78 )
    • genomics: 24,220 (rank: 414 )

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Preprints

Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencing

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An Atlas of Genetic Correlations across Human Diseases and Traits

genomics more details view paper
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    • Site-wide: 497
    • In genomics: 28
  • Year to date:
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Partitioning heritability by functional category using GWAS summary statistics

genetics more details view paper
  • Downloaded 7,955 times
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    • Site-wide: 1,115
    • In genetics: 33
  • Year to date:
    • Site-wide: 11,714
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    • Site-wide: 11,009

Regulatory variants explain much more heritability than coding variants across 11 common diseases

genetics more details view paper
  • Downloaded 4,471 times
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    • Site-wide: 2,430
    • In genetics: 88
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

genetics more details view paper
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    • Site-wide: 2,533
    • In genetics: 94
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Tumor mutational landscape is a record of the pre-malignant state

genomics more details view paper
  • Downloaded 3,562 times
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    • Site-wide: 3,377
    • In genomics: 373
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

genetics more details view paper
  • Downloaded 3,186 times
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    • Site-wide: 3,957
    • In genetics: 163
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Haplotypes of common SNPs can explain missing heritability of complex diseases

genetics more details view paper
  • Downloaded 3,094 times
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    • Site-wide: 4,122
    • In genetics: 170
  • Year to date:
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Integrative approaches for large-scale transcriptome-wide association studies

genetics more details view paper
  • Downloaded 2,912 times
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    • Site-wide: 4,468
    • In genetics: 192
  • Year to date:
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

genetics more details view paper
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    • Site-wide: 4,677
    • In genetics: 200
  • Year to date:
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Predicting master transcription factors from pan-cancer expression data

cancer biology more details view paper
  • Downloaded 2,757 times
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    • Site-wide: 4,848
    • In cancer biology: 69
  • Year to date:
    • Site-wide: 4,006
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    • Site-wide: 4,022

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

genomics more details view paper
  • Downloaded 2,573 times
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    • Site-wide: 5,342
    • In genomics: 588
  • Year to date:
    • Site-wide: 122,552
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

genetics more details view paper
  • Downloaded 2,564 times
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    • Site-wide: 5,370
    • In genetics: 243
  • Year to date:
    • Site-wide: 66,575
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    • Site-wide: 50,272

Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
  • Downloaded 2,215 times
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    • Site-wide: 6,688
    • In genetics: 316
  • Year to date:
    • Site-wide: 84,357
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Probabilistic fine-mapping of transcriptome-wide association studies

genetics more details view paper
  • Downloaded 1,902 times
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    • Site-wide: 8,395
    • In genetics: 379
  • Year to date:
    • Site-wide: 68,482
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    • Site-wide: 58,396

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

genetics more details view paper
  • Downloaded 1,872 times
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    • Site-wide: 8,588
    • In genetics: 398
  • Year to date:
    • Site-wide: 121,449
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    • Site-wide: 118,564

Quantifying genetic effects on disease mediated by assayed gene expression levels

genetics more details view paper
  • Downloaded 1,733 times
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    • Site-wide: 9,665
    • In genetics: 455
  • Year to date:
    • Site-wide: 33,640
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    • Site-wide: 37,806

Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,694 times
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    • Site-wide: 9,991
    • In genetics: 470
  • Year to date:
    • Site-wide: 118,731
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    • Site-wide: 76,349

Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations

genetics more details view paper
  • Downloaded 1,521 times
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    • Site-wide: 11,639
    • In genetics: 558
  • Year to date:
    • Site-wide: 25,935
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    • Site-wide: 25,024

An evolutionary compass for detecting signals of polygenic selection and mutational bias

evolutionary biology more details view paper
  • Downloaded 1,492 times
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    • Site-wide: 11,972
    • In evolutionary biology: 402
  • Year to date:
    • Site-wide: 85,780
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    • Site-wide: 117,811

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,422 times
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    • Site-wide: 12,925
    • In genetics: 625
  • Year to date:
    • Site-wide: 111,590
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    • Site-wide: 113,063

Transcriptome-wide association studies accounting for colocalization using Egger regression

epidemiology more details view paper
  • Downloaded 1,395 times
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    • Site-wide: 13,308
    • In epidemiology: 899
  • Year to date:
    • Site-wide: 102,329
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    • Site-wide: 94,494

Subtle stratification confounds estimates of heritability from rare variants

genetics more details view paper
  • Downloaded 1,167 times
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    • Site-wide: 17,403
    • In genetics: 839
  • Year to date:
    • Site-wide: 80,077
  • Since beginning of last month:
    • Site-wide: 76,401

Correcting subtle stratification in summary association statistics

genetics more details view paper
  • Downloaded 992 times
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    • Site-wide: 22,040
    • In genetics: 1,044
  • Year to date:
    • Site-wide: 97,917
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    • Site-wide: 70,619

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

genomics more details view paper
  • Downloaded 937 times
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    • Site-wide: 24,001
    • In genomics: 2,302
  • Year to date:
    • Site-wide: 92,190
  • Since beginning of last month:
    • Site-wide: 69,999

Germline features associated with immune infiltration in solid tumors

genetics more details view paper
  • Downloaded 896 times
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    • Site-wide: 25,580
    • In genetics: 1,223
  • Year to date:
    • Site-wide: 98,978
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    • Site-wide: 132,334

Functional partitioning of local and distal gene expression regulation in multiple human tissues

genomics more details view paper
  • Downloaded 856 times
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    • Site-wide: 27,272
    • In genomics: 2,525
  • Year to date:
    • Site-wide: 138,026
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    • Site-wide: 135,911

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

cancer biology more details view paper
  • Downloaded 814 times
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    • Site-wide: 29,260
    • In cancer biology: 759
  • Year to date:
    • Site-wide: 87,368
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    • Site-wide: 71,601

Leveraging distant relatedness to quantify human mutation and gene conversion rates

genetics more details view paper
  • Downloaded 768 times
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    • Site-wide: 31,761
    • In genetics: 1,513
  • Year to date:
    • Site-wide: 126,629
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    • Site-wide: 104,254

Allele-Specific QTL Fine-Mapping with PLASMA

bioinformatics more details view paper
  • Downloaded 763 times
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    • Site-wide: 32,045
    • In bioinformatics: 3,590
  • Year to date:
    • Site-wide: 117,028
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    • Site-wide: 96,674

Somatic mutational profiles and germline polygenic risk scores in human cancer

genomics more details view paper
  • Downloaded 674 times
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    • Site-wide: 37,987
    • In genomics: 3,184
  • Year to date:
    • Site-wide: 2,738
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DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

genomics more details view paper
  • Downloaded 645 times
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    • Site-wide: 40,188
    • In genomics: 3,337
  • Year to date:
    • Site-wide: 28,166
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Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
  • Downloaded 639 times
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    • Site-wide: 40,644
    • In genetics: 1,911
  • Year to date:
    • Site-wide: 73,944
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    • Site-wide: 49,881

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

genetics more details view paper
  • Downloaded 563 times
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    • Site-wide: 47,607
    • In genetics: 2,212
  • Year to date:
    • Site-wide: 108,775
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Allelic imbalance reveals widespread germline-somatic regulatory differences and prioritizes risk loci in Renal Cell Carcinoma

genetics more details view paper
  • Downloaded 530 times
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    • Site-wide: 51,142
    • In genetics: 2,357
  • Year to date:
    • Site-wide: 72,034
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    • Site-wide: 58,698

Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 495 times
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    • Site-wide: 55,426
    • In genetics: 2,552
  • Year to date:
    • Site-wide: 135,143
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    • Site-wide: 133,451

H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility

genomics more details view paper
  • Downloaded 435 times
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    • Site-wide: 63,634
    • In genomics: 4,588
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Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations

epidemiology more details view paper
  • Downloaded 422 times
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    • Site-wide: 65,740
    • In epidemiology: 2,813
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    • Site-wide: 31,673
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Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

genetics more details view paper
  • Downloaded 387 times
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    • Site-wide: 71,447
    • In genetics: 3,229
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    • Site-wide: 20,533
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    • Site-wide: 18,079

Constructing germline research cohorts from the discarded reads of clinical tumor sequences

genetic and genomic medicine more details view paper
  • Downloaded 314 times
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    • Site-wide: 85,299
    • In genetic and genomic medicine: 322
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