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Author: Alexander Gusev

Rankings

  • All-time downloads: 84,922 (rank: 1,865 )
  • Categories:
    • bioinformatics: 961 (rank: 16,656 (tie) )
    • cancer biology: 3,922 (rank: 1,127 )
    • epidemiology: 1,884 (rank: 6,786 (tie) )
    • evolutionary biology: 1,518 (rank: 4,447 (tie) )
    • genetic and genomic medicine: 488 (rank: 6,523 (tie) )
    • genetics: 51,130 (rank: 80 )
    • genomics: 25,019 (rank: 485 )

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Preprints

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

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An Atlas of Genetic Correlations across Human Diseases and Traits

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    • Site-wide: 583
    • In genomics: 31
  • Year to date:
    • Site-wide: 15,173
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Partitioning heritability by functional category using GWAS summary statistics

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  • Downloaded 8,100 times
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    • Site-wide: 1,267
    • In genetics: 33
  • Year to date:
    • Site-wide: 13,361
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    • Site-wide: 105,700

Regulatory variants explain much more heritability than coding variants across 11 common diseases

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    • Site-wide: 2,796
    • In genetics: 91
  • Year to date:
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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

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    • Site-wide: 2,891
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Tumor mutational landscape is a record of the pre-malignant state

genomics more details view paper
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    • Site-wide: 3,679
    • In genomics: 377
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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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  • Downloaded 3,209 times
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    • Site-wide: 4,509
    • In genetics: 173
  • Year to date:
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Haplotypes of common SNPs can explain missing heritability of complex diseases

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    • Site-wide: 4,612
    • In genetics: 180
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Predicting master transcription factors from pan-cancer expression data

cancer biology more details view paper
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Integrative approaches for large-scale transcriptome-wide association studies

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  • Downloaded 2,950 times
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    • Site-wide: 5,061
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  • Year to date:
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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

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    • Site-wide: 5,301
    • In genetics: 215
  • Year to date:
    • Site-wide: 74,846
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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  • Downloaded 2,611 times
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    • Site-wide: 6,023
    • In genomics: 626
  • Year to date:
    • Site-wide: 108,057
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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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    • Site-wide: 6,030
    • In genetics: 253
  • Year to date:
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Estimating the proportion of disease heritability mediated by gene expression levels

genetics more details view paper
  • Downloaded 2,272 times
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    • Site-wide: 7,419
    • In genetics: 327
  • Year to date:
    • Site-wide: 73,768
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Probabilistic fine-mapping of transcriptome-wide association studies

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  • Downloaded 1,924 times
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    • Site-wide: 9,451
    • In genetics: 402
  • Year to date:
    • Site-wide: 92,962
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Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

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  • Downloaded 1,899 times
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    • Site-wide: 9,642
    • In genetics: 417
  • Year to date:
    • Site-wide: 121,809
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Quantifying genetic effects on disease mediated by assayed gene expression levels

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  • Downloaded 1,814 times
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    • Site-wide: 10,308
    • In genetics: 452
  • Year to date:
    • Site-wide: 36,440
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Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

genetics more details view paper
  • Downloaded 1,718 times
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    • Site-wide: 11,166
    • In genetics: 491
  • Year to date:
    • Site-wide: 124,409
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    • Site-wide: 58,908

Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations

genetics more details view paper
  • Downloaded 1,556 times
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    • Site-wide: 12,858
    • In genetics: 585
  • Year to date:
    • Site-wide: 40,913
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    • Site-wide: 132,586

An evolutionary compass for detecting signals of polygenic selection and mutational bias

evolutionary biology more details view paper
  • Downloaded 1,518 times
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    • Site-wide: 13,329
    • In evolutionary biology: 429
  • Year to date:
    • Site-wide: 102,400
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Transcriptome-wide association studies accounting for colocalization using Egger regression

epidemiology more details view paper
  • Downloaded 1,434 times
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    • Site-wide: 14,605
    • In epidemiology: 1,004
  • Year to date:
    • Site-wide: 97,953
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    • Site-wide: 23,161

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

genetics more details view paper
  • Downloaded 1,432 times
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    • Site-wide: 14,636
    • In genetics: 667
  • Year to date:
    • Site-wide: 139,337
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Subtle stratification confounds estimates of heritability from rare variants

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  • Downloaded 1,212 times
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    • Site-wide: 18,789
    • In genetics: 863
  • Year to date:
    • Site-wide: 80,466
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    • Site-wide: 37,158

Correcting subtle stratification in summary association statistics

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  • Downloaded 1,038 times
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    • Site-wide: 23,620
    • In genetics: 1,083
  • Year to date:
    • Site-wide: 89,129
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    • Site-wide: 31,030

Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

genomics more details view paper
  • Downloaded 960 times
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    • Site-wide: 26,453
    • In genomics: 2,425
  • Year to date:
    • Site-wide: 110,300
  • Since beginning of last month:
    • Site-wide: 116,088

Germline features associated with immune infiltration in solid tumors

genetics more details view paper
  • Downloaded 936 times
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    • Site-wide: 27,449
    • In genetics: 1,256
  • Year to date:
    • Site-wide: 94,836
  • Since beginning of last month:
    • Site-wide: 33,990

Functional partitioning of local and distal gene expression regulation in multiple human tissues

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  • Downloaded 872 times
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    • Site-wide: 30,321
    • In genomics: 2,665
  • Year to date:
    • Site-wide: 148,044
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    • Site-wide: 120,649

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

cancer biology more details view paper
  • Downloaded 836 times
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    • Site-wide: 32,197
    • In cancer biology: 859
  • Year to date:
    • Site-wide: 108,458
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    • Site-wide: 69,954

Somatic mutational profiles and germline polygenic risk scores in human cancer

genomics more details view paper
  • Downloaded 807 times
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    • Site-wide: 33,811
    • In genomics: 2,890
  • Year to date:
    • Site-wide: 4,652
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    • Site-wide: 12,458

Leveraging distant relatedness to quantify human mutation and gene conversion rates

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  • Downloaded 792 times
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    • Site-wide: 34,720
    • In genetics: 1,577
  • Year to date:
    • Site-wide: 128,422
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    • Site-wide: 41,253

Allele-Specific QTL Fine-Mapping with PLASMA

bioinformatics more details view paper
  • Downloaded 779 times
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    • Site-wide: 35,571
    • In bioinformatics: 3,872
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    • Site-wide: 133,251
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    • Site-wide: 110,260

DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

genomics more details view paper
  • Downloaded 726 times
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    • Site-wide: 39,182
    • In genomics: 3,222
  • Year to date:
    • Site-wide: 32,453
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    • Site-wide: 39,616

Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

genetics more details view paper
  • Downloaded 669 times
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    • Site-wide: 43,622
    • In genetics: 1,953
  • Year to date:
    • Site-wide: 90,466
  • Since beginning of last month:
    • Site-wide: 71,094

Allelic imbalance reveals widespread germline-somatic regulatory differences and prioritizes risk loci in Renal Cell Carcinoma

genetics more details view paper
  • Downloaded 599 times
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    • Site-wide: 50,325
    • In genetics: 2,223
  • Year to date:
    • Site-wide: 61,290
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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

genetics more details view paper
  • Downloaded 574 times
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    • Site-wide: 53,109
    • In genetics: 2,341
  • Year to date:
    • Site-wide: 136,420
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    • Site-wide: 120,477

H3k27ac-HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility

genomics more details view paper
  • Downloaded 521 times
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    • Site-wide: 59,599
    • In genomics: 4,377
  • Year to date:
    • Site-wide: 31,365
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    • Site-wide: 127,153

Mixed Model Association with Family-Biased Case-Control Ascertainment

genetics more details view paper
  • Downloaded 503 times
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    • Site-wide: 62,076
    • In genetics: 2,745
  • Year to date:
    • Site-wide: 152,187
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    • Site-wide: 120,101

Constructing germline research cohorts from the discarded reads of clinical tumor sequences

genetic and genomic medicine more details view paper
  • Downloaded 488 times
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    • Site-wide: 64,188
    • In genetic and genomic medicine: 267
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    • Site-wide: 9,735
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    • Site-wide: 10,000

Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations

epidemiology more details view paper
  • Downloaded 450 times
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    • Site-wide: 70,055
    • In epidemiology: 3,076
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    • Site-wide: 50,206
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    • Site-wide: 128,209

Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

genetics more details view paper
  • Downloaded 436 times
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    • Site-wide: 72,328
    • In genetics: 3,175
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    • Site-wide: 31,358
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Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencing

bioinformatics more details view paper
  • Downloaded 182 times
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    • Site-wide: 128,826
    • In bioinformatics: 10,248
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Seeing beyond the target: Leveraging off-target reads in targeted clinical tumor sequencing to identify prognostic biomarkers

genomics more details view paper
  • Downloaded 155 times
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    • Site-wide: 135,154
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Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms

cancer biology more details view paper
  • Downloaded 86 times
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    • Site-wide: 148,465
    • In cancer biology: 4,587
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