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Author: Alexander Gusev

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  • All-time downloads: 74,528 (rank: 511 out of 404,161)
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    • bioinformatics: 715 (rank: 15,348 (tie) out of 34,272)
    • cancer biology: 2,458 (rank: 1,335 (tie) out of 28,183)
    • epidemiology: 1,321 (rank: 945 (tie) out of 9,545)
    • evolutionary biology: 1,417 (rank: 3,231 (tie) out of 20,691)
    • genetics: 46,713 (rank: 79 out of 36,792)
    • genomics: 21,904 (rank: 399 out of 42,763)

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Preprints

An Atlas of Genetic Correlations across Human Diseases and Traits

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Partitioning heritability by functional category using GWAS summary statistics

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Regulatory variants explain much more heritability than coding variants across 11 common diseases

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

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Tumor mutational landscape is a record of the pre-malignant state

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Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

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Haplotypes of common SNPs can explain missing heritability of complex diseases

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Integrative approaches for large-scale transcriptome-wide association studies

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Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection

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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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Estimating the proportion of disease heritability mediated by gene expression levels

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Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits

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Predicting master transcription factors from pan-cancer expression data

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Probabilistic fine-mapping of transcriptome-wide association studies

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Leveraging molecular QTL to understand the genetic architecture of diseases and complex traits

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Quantifying genetic effects on disease mediated by assayed gene expression levels

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An evolutionary compass for detecting signals of polygenic selection and mutational bias

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Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

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Transcriptome-wide association studies accounting for colocalization using Egger regression

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Subtle stratification confounds estimates of heritability from rare variants

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Correcting subtle stratification in summary association statistics

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Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations

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Multi-Tissue Transcriptome-Wide Association Studies Identify 21 Novel Candidate Susceptibility Genes for High Grade Serous Epithelial Ovarian Cancer

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Functional partitioning of local and distal gene expression regulation in multiple human tissues

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Germline features associated with immune infiltration in solid tumors

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Leveraging distant relatedness to quantify human mutation and gene conversion rates

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Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

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Allele-Specific QTL Fine-Mapping with PLASMA

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Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability

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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

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Mixed Model Association with Family-Biased Case-Control Ascertainment

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Allelic imbalance reveals widespread germline-somatic regulatory differences and prioritizes risk loci in Renal Cell Carcinoma

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DNA methylation is a key mechanism for maintaining monoallelic expression on autosomes

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Leveraging expression from multiple tissues using sparse canonical correlation analysis (sCCA) and aggregate tests improves the power of transcriptome-wide association studies (TWAS)

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