Author: Matthew C. Keller

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Preprints

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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Haplotypes of common SNPs can explain missing heritability of complex diseases

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Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.

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Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

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A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

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Genome-Wide Association Study of Over 427,000 Individuals Establishes Executive Functioning as a Neurocognitive Basis of Psychiatric Disorders Influenced by GABAergic Processes

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Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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Within-sibship GWAS improve estimates of direct genetic effects

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Imprint of Assortative Mating on the Human Genome

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Subtle stratification confounds estimates of heritability from rare variants

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Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data

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Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

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Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

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Testing the moderation of quantitative gene by environment interactions in unrelated individuals

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Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

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No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: a reappraisal of Domingue et al (2018)

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Relationships between estimated autozygosity and complex traits in the UK Biobank

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Estimation of parental effects using polygenic scores

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Imputation of Behavioral Candidate Gene Repeat Polymorphisms in 486,551 Publicly-Available UK Biobank Individuals.

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  • In genetics: 3,696
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Assortative Mating Biases Marker-based Heritability Estimators

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The role of a priori-identified addiction and smoking gene sets in smoking behaviors.

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Genetic architecture of four smoking behaviors using partitioned h2SNP.

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Novel Approach for Parallelizing Pairwise Comparison Problems as Applied to Detecting Segments Identical By Decent in Whole-Genome Data

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  • Site-wide: 118,712
  • In bioinformatics: 9,700
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Bias and precision of parameter estimates from models using polygenic scores to estimate environmental and genetic parental influences

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