Author: Rosie M Walker

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Preprints

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

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Improved prediction of chronological age from DNA methylation limits it as a biomarker of ageing

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  • Site-wide: 15,594
  • In bioinformatics: 1,808
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  • Site-wide: 102,692

Bayesian reassessment of the epigenetic architecture of complex traits

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Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer

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  • Site-wide: 21,750
  • In epidemiology: 1,320
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Epigenetic prediction of complex traits and death

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  • Site-wide: 23,859
  • In genomics: 2,237
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  • Site-wide: 101,474
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Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

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  • Site-wide: 34,832
  • In genomics: 2,943
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Epigenetic scores for the circulating proteome as tools for disease prediction

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  • In genomics: 3,507
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A meta-analysis of genome-wide association studies of epigenetic age acceleration

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  • Site-wide: 50,598
  • In genetics: 2,240
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Accelerated Epigenetic Ageing in Major Depressive Disorder

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  • In genomics: 3,942
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DNA methylation age acceleration and risk factors for Alzheimer's disease

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  • In genomics: 3,969
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  • Site-wide: 143,666
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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

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  • In epidemiology: 2,651
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Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

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  • In genomics: 4,820
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  • Site-wide: 127,804
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A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

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  • Site-wide: 70,313
  • In bioinformatics: 6,644
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  • Site-wide: 10,902
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  • Site-wide: 84,264

Epigenetic prediction of major depressive disorder

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  • Site-wide: 70,939
  • In psychiatry and clinical psychology: 251
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  • Site-wide: 118,786
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  • Site-wide: 71,951

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

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  • In genomics: 5,135
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Epigenome-wide analyses identify DNA methylation signatures of dementia risk

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  • Site-wide: 80,501
  • In genetic and genomic medicine: 347
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Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2

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  • Site-wide: 81,863
  • In genetics: 3,559
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  • Site-wide: 95,875
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Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip

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  • Site-wide: 84,089
  • In genomics: 5,458
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  • Site-wide: 134,157
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An epigenome-wide association study of sex-specific chronological ageing

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  • Site-wide: 91,310
  • In genomics: 5,729
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  • Site-wide: 152,375
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Creating and validating a DNA methylation-based proxy for Interleukin-6

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  • Site-wide: 98,555
  • In genetic and genomic medicine: 465
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  • Site-wide: 60,769
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  • Site-wide: 47,531

Epigenetic signatures of starting and stopping smoking

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  • Site-wide: 99,329
  • In genomics: 6,024
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  • Site-wide: 149,527
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  • Site-wide: 73,013

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

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  • Site-wide: 105,299
  • In genetics: 4,472
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  • Site-wide: 99,442
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DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

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  • Site-wide: 106,034
  • In genetic and genomic medicine: 519
• Year to date:
  • Site-wide: 107,572
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  • Site-wide: 68,040

Assessment of Dried Blood Spots for DNA Methylation Profiling

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  • Site-wide: 106,177
  • In genomics: 6,231
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  • Site-wide: 150,972
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DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorder

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  • Site-wide: 107,719
  • In psychiatry and clinical psychology: 466
• Year to date:
  • Site-wide: 66,434
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  • Site-wide: 55,032

Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

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  • Site-wide: 108,764
  • In genomics: 6,337
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  • Site-wide: 140,076
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  • Site-wide: 44,367

Associations between alcohol use and accelerated biological ageing

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  • Site-wide: 113,097
  • In psychiatry and clinical psychology: 493
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  • Site-wide: 57,948
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  • Site-wide: 42,467

DNA methylation in the APOE gene: its link with Alzheimer's and cardiovascular health

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  • Site-wide: 117,697
  • In neuroscience: 17,774
• Year to date:
  • Site-wide: 149,237
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  • Site-wide: 120,208

Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

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  • Site-wide: 122,650
  • In genomics: 6,782
• Year to date:
  • Site-wide: 50,312
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  • Site-wide: 77,458

Blood-based epigenome-wide analyses of cognitive abilities

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  • Site-wide: 124,305
  • In genetic and genomic medicine: 666
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  • Site-wide: 91,618

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

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  • Site-wide: 130,091
  • In genetic and genomic medicine: 706
• Year to date:
  • Site-wide: 38,355
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  • Site-wide: 12,659

Epigenome-wide association study of self-reported antidepressant use in Generation Scotland implicates the innate immune system

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  • Site-wide: 132,114
  • In psychiatry and clinical psychology: 658
• Year to date:
  • Site-wide: 83,149
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  • Site-wide: 60,197

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

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  • Site-wide: 133,591
  • In genetic and genomic medicine: 734
• Year to date:
  • Site-wide: 42,552
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  • Site-wide: 132,948

Local CpG density affects the trajectory of age-associated epigenetic changes

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  • Site-wide: 134,878
  • In genetics: 5,453
• Year to date:
  • Site-wide: 44,328
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  • Site-wide: 76,797

DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

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  • Site-wide: 143,396
  • In psychiatry and clinical psychology: 826
• Year to date:
  • Site-wide: 60,672
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  • Site-wide: 9,822

Loss of SORCS2 is associated with neuronal DNA double-strand breaks

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  • Site-wide: 147,420
  • In neuroscience: 22,053
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  • Site-wide: 74,124
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  • Site-wide: 77,066

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

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  • Site-wide: 150,563
  • In genetics: 5,886
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Epigenome and phenome study reveals circulating markers pertinent to brain health

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  • Site-wide: 152,869
  • In genetic and genomic medicine: 922
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  • Site-wide: 130,619
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  • Site-wide: 11,661