Author: Yang Chen

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Preprints

High-performance GFP-based calcium indicators for imaging activity in neuronal populations and microcompartments

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  • Site-wide: 685
  • In neuroscience: 19
• Year to date:
  • Site-wide: 2,368
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  • Site-wide: 4,511

Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance

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  • Site-wide: 2,185
  • In immunology: 75
• Year to date:
  • Site-wide: 1,932
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  • Site-wide: 4,578

Systems-level immunomonitoring from acute to recovery phase of severe COVID-19

• Downloaded 4,793 times
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  • Site-wide: 2,832
  • In allergy and immunology: 21
• Year to date:
  • Site-wide: 28,497
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  • Site-wide: 53,728

Analysis of the epidemic growth of the early 2019-nCoV outbreak using internationally confirmed cases

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  • Site-wide: 4,374
  • In epidemiology: 430
• Year to date:
  • Site-wide: 33,636
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  • Site-wide: 59,578

Systems-level immunomonitoring using self-sampled capillary blood

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  • Site-wide: 8,587
  • In immunology: 308
• Year to date:
  • Site-wide: 69,887
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  • Site-wide: 94,272

Human immune system variation during one year

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  • Site-wide: 11,272
  • In immunology: 391
• Year to date:
  • Site-wide: 68,360
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  • Site-wide: 92,377

Single-cell classification using learned cell phenotypes

• Downloaded 1,736 times
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  • Site-wide: 12,279
  • In immunology: 419
• Year to date:
  • Site-wide: 37,742
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  • Site-wide: 59,588

Bifidobacteria-mediated immune system imprinting early in life

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  • Site-wide: 14,197
  • In immunology: 492
• Year to date:
  • Site-wide: 7,215
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  • Site-wide: 37,631

Predicting cellular position in the Drosophila embryo from Single-Cell Transcriptomics data

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  • Site-wide: 18,959
  • In systems biology: 348
• Year to date:
  • Site-wide: 61,945
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  • Site-wide: 103,267

Deep-learning enables proteome-scale identification of phase-separated protein candidates from immunofluorescence images

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  • Site-wide: 22,314
  • In bioinformatics: 2,519
• Year to date:
  • Site-wide: 29,862
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  • Site-wide: 14,153

Feature Design for Protein Interface hotspots using KFC2 and Rosetta

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  • Site-wide: 26,133
  • In bioinformatics: 2,913
• Year to date:
  • Site-wide: 47,266
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  • Site-wide: 54,646

Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics

• Downloaded 1,032 times
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  • Site-wide: 27,182
  • In bioinformatics: 3,011
• Year to date:
  • Site-wide: 115,385
• Since beginning of last month:
  • Site-wide: 154,922

N-Acetyl Cysteine Alleviates Coxsackievirus B-Induced Myocarditis by Suppressing caspase-1

• Downloaded 1,014 times
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  • Site-wide: 27,853
  • In microbiology: 1,626
• Year to date:
  • Site-wide: 27,583
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  • Site-wide: 12,316

SIP: An Interchangeable Pipeline for scRNA-seq Data Processing

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  • Site-wide: 28,434
  • In bioinformatics: 3,162
• Year to date:
  • Site-wide: 85,490
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  • Site-wide: 110,583

Genome-wide circadian rhythm detection methods: systematic evaluations and practical guidelines

• Downloaded 958 times
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  • Site-wide: 30,255
  • In bioinformatics: 3,353
• Year to date:
  • Site-wide: 18,812
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  • Site-wide: 35,773

3D Genome Analysis Identifies Enhancer Hijacking Mechanism for High-Risk Factors in Human T-Lineage Acute Lymphoblastic Leukemia

• Downloaded 927 times
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  • Site-wide: 31,796
  • In genomics: 2,710
• Year to date:
  • Site-wide: 40,657
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  • Site-wide: 34,243

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

• Downloaded 895 times
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  • Site-wide: 33,458
  • In genomics: 2,818
• Year to date:
  • Site-wide: 11,682
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  • Site-wide: 2,730

Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index

• Downloaded 871 times
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  • Site-wide: 34,764
  • In cell biology: 1,337
• Year to date:
  • Site-wide: 16,322
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  • Site-wide: 49,990

Identification of novel risk loci with shared effects on alcoholism, heroin and methamphetamine dependence

• Downloaded 870 times
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  • Site-wide: 34,852
  • In genomics: 2,916
• Year to date:
  • Site-wide: 33,944
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  • Site-wide: 12,912

The landscape of somatic mutation in sporadic Chinese colorectal cancer

• Downloaded 838 times
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  • Site-wide: 36,807
  • In genomics: 3,030
• Year to date:
  • Site-wide: 134,852
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  • Site-wide: 134,009

MarkovHC: Markov hierarchical clustering for the topological structure of high-dimensional single-cell omics data

• Downloaded 818 times
• Download rankings, all-time:
  • Site-wide: 38,127
  • In bioinformatics: 4,088
• Year to date:
  • Site-wide: 26,523
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  • Site-wide: 32,587

MyoD is a structure organizer of 3D genome architecture in muscle cells

• Downloaded 809 times
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  • Site-wide: 38,735
  • In genomics: 3,142
• Year to date:
  • Site-wide: 28,226
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  • Site-wide: 17,358

Gigapixel behavioral and neural activity imaging with a novel multi-camera array microscope

• Downloaded 714 times
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  • Site-wide: 46,310
  • In bioengineering: 874
• Year to date:
  • Site-wide: 8,997
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  • Site-wide: 616

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L.

• Downloaded 706 times
• Download rankings, all-time:
  • Site-wide: 47,018
  • In neuroscience: 6,505
• Year to date:
  • Site-wide: 112,316
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  • Site-wide: 52,293

SCOAT-Net: A Novel Network for Segmenting COVID-19 Lung Opacification from CT Images

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 56,131
  • In radiology and imaging: 98
• Year to date:
  • Site-wide: 33,094
• Since beginning of last month:
  • Site-wide: 41,074

Value-based Decision Making Takes Place in the Action Domain in the Prefrontal Cortex

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 61,815
  • In neuroscience: 8,888
• Year to date:
  • Site-wide: 116,213
• Since beginning of last month:
  • Site-wide: 84,160

A Clostridia-rich microbiota contributes to increased excretion of bile acids in diarrhea-predominant irritable bowel syndrome

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 61,838
  • In microbiology: 3,877
• Year to date:
  • Site-wide: 112,029
• Since beginning of last month:
  • Site-wide: 123,402

Different obesity phenotypes correlated with the PI3K-AKT signaling pathway in tree shrews

• Downloaded 513 times
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  • Site-wide: 70,711
  • In genetics: 3,000
• Year to date:
  • Site-wide: 80,479
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  • Site-wide: 36,448

BARTweb: a web server for transcription factor association analysis

• Downloaded 410 times
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  • Site-wide: 89,713
  • In bioinformatics: 7,944
• Year to date:
  • Site-wide: 86,804
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  • Site-wide: 74,442

SYSTEMATIC REVIEW PROTOCOL:The reporting standards of Randomised Clinical Trials in leading medical journals between 2019-2020

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  • Site-wide: 106,393
  • In health systems and quality improvement: 158
• Year to date:
  • Site-wide: 72,497
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  • Site-wide: 78,317

Enrichment-Free Identification of Native Definitive (EnFIND) O-glycoproteome of antibodies in autoimmune diseases

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 113,502
  • In systems biology: 2,455
• Year to date:
  • Site-wide: 66,892
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  • Site-wide: 62,942

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

• Downloaded 300 times
• Download rankings, all-time:
  • Site-wide: 116,050
  • In infectious diseases: 5,122
• Year to date:
  • Site-wide: 33,865
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  • Site-wide: 37,194

The diagnostic certainty levels of junior clinicians: A retrospective cohort study

• Downloaded 289 times
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  • Site-wide: 118,957
  • In health systems and quality improvement: 180
• Year to date:
  • Site-wide: 86,109
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  • Site-wide: 140,655

Slc7a11 modulated by POU2F1 is involved in pigmentation in rabbit

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 134,071
  • In molecular biology: 3,997
• Year to date:
  • Site-wide: 156,502
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  • Site-wide: 158,578

Modification of T cells function after restoration of spontaneous circulation in a rat model of cardiac arrest

• Downloaded 224 times
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  • Site-wide: 135,974
  • In immunology: 4,071
• Year to date:
  • Site-wide: 147,922
• Since beginning of last month:
  • Site-wide: 98,943

Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males

• Downloaded 184 times
• Download rankings, all-time:
  • Site-wide: 145,650
  • In genetics: 5,719
• Year to date:
  • Site-wide: 63,533
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  • Site-wide: 95,519

Exosome-LncPICALM-AU1 regulates endothelial–mesenchymal transition in hepatopulmonary syndrome

• Downloaded 175 times
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  • Site-wide: 147,737
  • In pathology: 883
• Year to date:
  • Site-wide: 126,222
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  • Site-wide: 97,140

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer

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• Download rankings, all-time:
  • Site-wide: 150,308
  • In microbiology: 11,345
• Year to date:
  • Site-wide: 103,359
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  • Site-wide: 82,513

The first crested duck genome reveals clues to genetic compensation and crest cushion formation

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• Download rankings, all-time:
  • Site-wide: 155,208
  • In genomics: 7,765
• Year to date:
  • Site-wide: 88,454
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  • Site-wide: 123,785