Author: Mark R. Cookson

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Preprints

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

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  • Site-wide: 8,412
  • In cell biology: 183
• Year to date:
  • Site-wide: 49,681
• Since beginning of last month:
  • Site-wide: 18,359

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson disease

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  • Site-wide: 13,895
  • In genetics: 635
• Year to date:
  • Site-wide: 12,647
• Since beginning of last month:
  • Site-wide: 83,335

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

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  • Site-wide: 16,985
  • In neuroscience: 2,027
• Year to date:
  • Site-wide: 19,013
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  • Site-wide: 34,133

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele

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  • Site-wide: 21,866
  • In neuroscience: 2,725
• Year to date:
  • Site-wide: 21,829
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  • Site-wide: 19,232

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

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  • Site-wide: 26,807
  • In neuroscience: 3,469
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  • Site-wide: 40,885
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  • Site-wide: None

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

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  • Site-wide: 31,101
  • In genetics: 1,430
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  • Site-wide: 61,551
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  • Site-wide: 88,164

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

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  • Site-wide: 31,686
  • In neuroscience: 4,195
• Year to date:
  • Site-wide: 4,047
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  • Site-wide: 1,594

The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

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  • Site-wide: 36,343
  • In genomics: 3,053
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  • Site-wide: 13,361

Association of a common genetic variant with Parkinson's disease is propagated through microglia

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  • Site-wide: 39,981
  • In neuroscience: 5,547
• Year to date:
  • Site-wide: 5,186
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  • Site-wide: 44,393

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

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  • Site-wide: 49,504
  • In cell biology: 2,107
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  • Site-wide: 27,754
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  • Site-wide: 16,796

A revised 1.6 A structure of the GTPase domain of the Parkinson's disease-associated protein LRRK2 provides insights into mechanisms

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  • Site-wide: 55,160
  • In biochemistry: 1,417
• Year to date:
  • Site-wide: 78,998
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  • Site-wide: 73,463

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

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  • Site-wide: 58,175
  • In molecular biology: 1,641
• Year to date:
  • Site-wide: 126,366
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  • Site-wide: 79,616

CoExp Web, a web tool for the exploitation of co-expression networks

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  • Site-wide: 62,593
  • In bioinformatics: 6,167
• Year to date:
  • Site-wide: 24,237
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  • Site-wide: 30,547

Membrane targeting activates Leucine-rich repeat kinase 2 with differential effects on downstream Rab activation

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  • Site-wide: 73,488
  • In cell biology: 3,305
• Year to date:
  • Site-wide: 38,149
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  • Site-wide: 43,784

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.

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  • Site-wide: 80,762
  • In genetics: 3,524
• Year to date:
  • Site-wide: 84,624
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  • Site-wide: None

Quality Control Metrics for Whole Blood Transcriptome Analysis in the Parkinson's Progression Markers Initiative (PPMI)

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  • Site-wide: 82,565
  • In genetic and genomic medicine: 353
• Year to date:
  • Site-wide: 13,179
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  • Site-wide: 32,905

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

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  • Site-wide: 97,541
  • In animal behavior and cognition: 1,126
• Year to date:
  • Site-wide: 82,090
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  • Site-wide: 88,767

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

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  • Site-wide: 101,492
  • In neurology: 321
• Year to date:
  • Site-wide: 76,453
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  • Site-wide: 104,265

THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

• Downloaded 189 times
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  • Site-wide: 124,629
  • In neuroscience: 19,065
• Year to date:
  • Site-wide: 100,584
• Since beginning of last month:
  • Site-wide: None

LRRK2 coding variants and the risk of Parkinson's disease

• Downloaded 139 times
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  • Site-wide: 136,062
  • In neurology: 648
• Year to date:
  • Site-wide: 46,122
• Since beginning of last month:
  • Site-wide: 21,711