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Author: Mark R. Cookson

  • ORCiD: http://orcid.org/0000-0002-1058-3831
  • Most recently observed institution: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

Rankings

  • All-time downloads: 31,433 (rank: 8,994 (tie) )
  • Categories:
    • animal behavior and cognition: 411 (rank: 5,966 (tie) )
    • biochemistry: 1,019 (rank: 9,772 (tie) )
    • bioinformatics: 805 (rank: 27,151 (tie) )
    • cell biology: 4,144 (rank: 1,988 (tie) )
    • genetic and genomic medicine: 727 (rank: 9,824 (tie) )
    • genetics: 5,076 (rank: 4,919 )
    • genomics: 1,832 (rank: 18,151 (tie) )
    • molecular biology: 632 (rank: 18,563 (tie) )
    • neurology: 934 (rank: 3,644 (tie) )
    • neuroscience: 15,143 (rank: 1,221 )

Downloads per author, site-wide

Preprints

A reference induced pluripotent stem cell line for large-scale collaborative studies

neuroscience more details view paper
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    • In neuroscience: 241
  • Year to date:
    • Site-wide: 4,487
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    • Site-wide: 907

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

cell biology more details view paper
  • Downloaded 2,206 times
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    • Site-wide: 11,598
    • In cell biology: 279
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    • Site-wide: 62,169
  • Since beginning of last month:
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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele

neuroscience more details view paper
  • Downloaded 1,913 times
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    • In neuroscience: 1,516
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    • Site-wide: 132,163
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    • Site-wide: 27,619

The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

genomics more details view paper
  • Downloaded 1,838 times
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    • In genomics: 1,386
  • Year to date:
    • Site-wide: None
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    • Site-wide: 35,015

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson disease

genetics more details view paper
  • Downloaded 1,699 times
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    • Site-wide: 17,300
    • In genetics: 694
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Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

neuroscience more details view paper
  • Downloaded 1,675 times
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    • In neuroscience: 1,983
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APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

neuroscience more details view paper
  • Downloaded 1,543 times
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    • In neuroscience: 2,306
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Controlling homology-directed repair outcomes in human stem cells with dCas9

genetics more details view paper
  • Downloaded 1,435 times
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    • Site-wide: 22,654
    • In genetics: 970
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Association of a common genetic variant with Parkinson's disease is propagated through microglia

neuroscience more details view paper
  • Downloaded 1,375 times
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    • Site-wide: 24,288
    • In neuroscience: 3,051
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    • Site-wide: 20,258
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A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons

neuroscience more details view paper
  • Downloaded 1,336 times
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    • Site-wide: 25,437
    • In neuroscience: 3,259
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    • Site-wide: 32,180
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LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

neuroscience more details view paper
  • Downloaded 1,209 times
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    • Site-wide: 29,796
    • In neuroscience: 3,673
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    • Site-wide: 33,486
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    • Site-wide: 67,168

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

cell biology more details view paper
  • Downloaded 1,110 times
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    • Site-wide: 34,033
    • In cell biology: 1,262
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    • Site-wide: 155,396
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    • Site-wide: 168,779

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

genetics more details view paper
  • Downloaded 993 times
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    • Site-wide: 40,385
    • In genetics: 1,604
  • Year to date:
    • Site-wide: 61,811
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    • Site-wide: 187,128

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

cell biology more details view paper
  • Downloaded 846 times
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    • Site-wide: 51,790
    • In cell biology: 2,117
  • Year to date:
    • Site-wide: 133,197
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    • Site-wide: 121,893

CoExp Web, a web tool for the exploitation of co-expression networks

bioinformatics more details view paper
  • Downloaded 811 times
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    • Site-wide: 55,041
    • In bioinformatics: 5,430
  • Year to date:
    • Site-wide: 183,253
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Quality Control Metrics for Whole Blood Transcriptome Analysis in the Parkinson's Progression Markers Initiative (PPMI)

genetic and genomic medicine more details view paper
  • Downloaded 743 times
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    • Site-wide: 62,719
    • In genetic and genomic medicine: 398
  • Year to date:
    • Site-wide: 30,101
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    • Site-wide: 59,387

A revised 1.6 A structure of the GTPase domain of the Parkinson's disease-associated protein LRRK2 provides insights into mechanisms

biochemistry more details view paper
  • Downloaded 662 times
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    • Site-wide: 73,736
    • In biochemistry: 2,000
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    • Site-wide: 76,718
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The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease

neuroscience more details view paper
  • Downloaded 641 times
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    • In neuroscience: 11,712
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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

molecular biology more details view paper
  • Downloaded 637 times
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    • Site-wide: 77,612
    • In molecular biology: 2,214
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    • Site-wide: 110,249
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    • Site-wide: 159,399

Specific Detection of Endogenous S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay

neuroscience more details view paper
  • Downloaded 590 times
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    • Site-wide: 85,699
    • In neuroscience: 12,695
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    • Site-wide: 86,627
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    • Site-wide: 32,048

Genome-wide analysis of Structural Variants in Parkinson's Disease using Short-Read Sequencing data

genetics more details view paper
  • Downloaded 585 times
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    • Site-wide: 86,635
    • In genetics: 3,599
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    • Site-wide: 6,383
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    • Site-wide: 7,272

LRRK2 coding variants and the risk of Parkinson's disease

neurology more details view paper
  • Downloaded 529 times
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    • Site-wide: 98,011
    • In neurology: 429
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Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.

genetics more details view paper
  • Downloaded 493 times
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    • Site-wide: 106,078
    • In genetics: 4,025
  • Year to date:
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    • Site-wide: 184,297

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

neurology more details view paper
  • Downloaded 420 times
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    • Site-wide: 124,485
    • In neurology: 616
  • Year to date:
    • Site-wide: 132,678
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Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

animal behavior and cognition more details view paper
  • Downloaded 417 times
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    • Site-wide: 125,537
    • In animal behavior and cognition: 1,348
  • Year to date:
    • Site-wide: 128,416
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    • Site-wide: 128,821

DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons

biochemistry more details view paper
  • Downloaded 384 times
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    • Site-wide: 135,111
    • In biochemistry: 4,195
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    • Site-wide: 17,368
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    • Site-wide: 31,118

THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

neuroscience more details view paper
  • Downloaded 296 times
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    • Site-wide: 161,660
    • In neuroscience: 23,752
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    • Site-wide: 152,691
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Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in the striatum and biases against heavy persistent alcohol drinking

neuroscience more details view paper
  • Downloaded 132 times
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    • Site-wide: 202,016
    • In neuroscience: 29,253
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Application of Aligned-UMAP to longitudinal biomedical studies

bioinformatics more details view paper
  • Downloaded 122 times
  • Download rankings, all-time:
    • Site-wide: 203,891
    • In bioinformatics: None
  • Year to date:
    • Site-wide: 8,963
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