Author: Mark R. Cookson

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Preprints

A reference induced pluripotent stem cell line for large-scale collaborative studies

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  • Site-wide: 3,708
  • In neuroscience: 241
• Year to date:
  • Site-wide: 4,487
• Since beginning of last month:
  • Site-wide: 907

LRRK2 mediates tubulation and vesicle sorting from membrane damaged lysosomes

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  • Site-wide: 11,598
  • In cell biology: 279
• Year to date:
  • Site-wide: 62,169
• Since beginning of last month:
  • Site-wide: 161,955

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele

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  • Site-wide: 14,403
  • In neuroscience: 1,516
• Year to date:
  • Site-wide: 132,163
• Since beginning of last month:
  • Site-wide: 27,619

The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

• Downloaded 1,838 times
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  • Site-wide: 15,328
  • In genomics: 1,386
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 35,015

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson disease

• Downloaded 1,699 times
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  • Site-wide: 17,300
  • In genetics: 694
• Year to date:
  • Site-wide: 91,487
• Since beginning of last month:
  • Site-wide: 120,978

Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse

• Downloaded 1,675 times
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  • Site-wide: 17,717
  • In neuroscience: 1,983
• Year to date:
  • Site-wide: 59,235
• Since beginning of last month:
  • Site-wide: 22,564

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

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  • Site-wide: 20,138
  • In neuroscience: 2,306
• Year to date:
  • Site-wide: 98,819
• Since beginning of last month:
  • Site-wide: 43,834

Controlling homology-directed repair outcomes in human stem cells with dCas9

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  • Site-wide: 22,654
  • In genetics: 970
• Year to date:
  • Site-wide: 3,605
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  • Site-wide: 11,336

Association of a common genetic variant with Parkinson's disease is propagated through microglia

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  • Site-wide: 24,288
  • In neuroscience: 3,051
• Year to date:
  • Site-wide: 20,258
• Since beginning of last month:
  • Site-wide: 8,125

A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons

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  • Site-wide: 25,437
  • In neuroscience: 3,259
• Year to date:
  • Site-wide: 32,180
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  • Site-wide: 6,765

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

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  • Site-wide: 29,796
  • In neuroscience: 3,673
• Year to date:
  • Site-wide: 33,486
• Since beginning of last month:
  • Site-wide: 67,168

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2-positive lysosomes

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  • Site-wide: 34,033
  • In cell biology: 1,262
• Year to date:
  • Site-wide: 155,396
• Since beginning of last month:
  • Site-wide: 168,779

Common variation at the LRRK2 locus is associated with survival in the primary tauopathy progressive supranuclear palsy

• Downloaded 993 times
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  • Site-wide: 40,385
  • In genetics: 1,604
• Year to date:
  • Site-wide: 61,811
• Since beginning of last month:
  • Site-wide: 187,128

Pathogenic mutations in LRRK2 sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

• Downloaded 846 times
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  • Site-wide: 51,790
  • In cell biology: 2,117
• Year to date:
  • Site-wide: 133,197
• Since beginning of last month:
  • Site-wide: 121,893

CoExp Web, a web tool for the exploitation of co-expression networks

• Downloaded 811 times
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  • Site-wide: 55,041
  • In bioinformatics: 5,430
• Year to date:
  • Site-wide: 183,253
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  • Site-wide: 54,568

Quality Control Metrics for Whole Blood Transcriptome Analysis in the Parkinson's Progression Markers Initiative (PPMI)

• Downloaded 743 times
• Download rankings, all-time:
  • Site-wide: 62,719
  • In genetic and genomic medicine: 398
• Year to date:
  • Site-wide: 30,101
• Since beginning of last month:
  • Site-wide: 59,387

A revised 1.6 A structure of the GTPase domain of the Parkinson's disease-associated protein LRRK2 provides insights into mechanisms

• Downloaded 662 times
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  • Site-wide: 73,736
  • In biochemistry: 2,000
• Year to date:
  • Site-wide: 76,718
• Since beginning of last month:
  • Site-wide: 197,938

The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 77,127
  • In neuroscience: 11,712
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 12,661

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

• Downloaded 637 times
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  • Site-wide: 77,612
  • In molecular biology: 2,214
• Year to date:
  • Site-wide: 110,249
• Since beginning of last month:
  • Site-wide: 159,399

Specific Detection of Endogenous S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay

• Downloaded 590 times
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  • Site-wide: 85,699
  • In neuroscience: 12,695
• Year to date:
  • Site-wide: 86,627
• Since beginning of last month:
  • Site-wide: 32,048

Genome-wide analysis of Structural Variants in Parkinson's Disease using Short-Read Sequencing data

• Downloaded 585 times
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  • Site-wide: 86,635
  • In genetics: 3,599
• Year to date:
  • Site-wide: 6,383
• Since beginning of last month:
  • Site-wide: 7,272

LRRK2 coding variants and the risk of Parkinson's disease

• Downloaded 529 times
• Download rankings, all-time:
  • Site-wide: 98,011
  • In neurology: 429
• Year to date:
  • Site-wide: 85,859
• Since beginning of last month:
  • Site-wide: 47,657

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.

• Downloaded 493 times
• Download rankings, all-time:
  • Site-wide: 106,078
  • In genetics: 4,025
• Year to date:
  • Site-wide: 133,036
• Since beginning of last month:
  • Site-wide: 184,297

Evidence for GRN as part of a neuroinflammatory mechanism connecting common neurodegenerative diseases.

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 124,485
  • In neurology: 616
• Year to date:
  • Site-wide: 132,678
• Since beginning of last month:
  • Site-wide: 168,433

Combined knockout of Lrrk2 and Rab29 does not result in behavioral abnormalities in vivo

• Downloaded 417 times
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  • Site-wide: 125,537
  • In animal behavior and cognition: 1,348
• Year to date:
  • Site-wide: 128,416
• Since beginning of last month:
  • Site-wide: 128,821

DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons

• Downloaded 384 times
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  • Site-wide: 135,111
  • In biochemistry: 4,195
• Year to date:
  • Site-wide: 17,368
• Since beginning of last month:
  • Site-wide: 31,118

THAP1 Modulates Oligodendrocyte Maturation by Regulating ECM Degradation in Lysosomes

• Downloaded 296 times
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  • Site-wide: 161,660
  • In neuroscience: 23,752
• Year to date:
  • Site-wide: 152,691
• Since beginning of last month:
  • Site-wide: 80,353

Leucine-Rich Repeat Kinase 2 limits dopamine D1 receptor signaling in the striatum and biases against heavy persistent alcohol drinking

• Downloaded 132 times
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  • Site-wide: 202,016
  • In neuroscience: 29,253
• Year to date:
  • Site-wide: 191,049
• Since beginning of last month:
  • Site-wide: 115,299

Application of Aligned-UMAP to longitudinal biomedical studies

• Downloaded 122 times
• Download rankings, all-time:
  • Site-wide: 203,891
  • In bioinformatics: None
• Year to date:
  • Site-wide: 8,963
• Since beginning of last month:
  • Site-wide: 2,605