Author: Wei Wang

Downloads per author, site-wide

Preprints

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 24,945 times
• Download rankings, all-time:
  • Site-wide: 298
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 5,501
• Since beginning of last month:
  • Site-wide: 10,109

Age profile of susceptibility, mixing, and social distancing shape the dynamics of the novel coronavirus disease 2019 outbreak in China

• Downloaded 10,613 times
• Download rankings, all-time:
  • Site-wide: 868
  • In epidemiology: 120
• Year to date:
  • Site-wide: 11,284
• Since beginning of last month:
  • Site-wide: 8,172

COVID-19 in Wuhan: Immediate Psychological Impact on 5062 Health Workers

• Downloaded 9,782 times
• Download rankings, all-time:
  • Site-wide: 964
  • In psychiatry and clinical psychology: 5
• Year to date:
  • Site-wide: 1,152
• Since beginning of last month:
  • Site-wide: 1,619

Modified TCA/acetone precipitation of plant proteins for proteomic analysis

• Downloaded 8,260 times
• Download rankings, all-time:
  • Site-wide: 1,196
  • In biochemistry: 14
• Year to date:
  • Site-wide: 786
• Since beginning of last month:
  • Site-wide: 1,183

Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers

• Downloaded 7,938 times
• Download rankings, all-time:
  • Site-wide: 1,257
  • In infectious diseases: 363
• Year to date:
  • Site-wide: 10,002
• Since beginning of last month:
  • Site-wide: 10,005

Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

• Downloaded 6,307 times
• Download rankings, all-time:
  • Site-wide: 1,684
  • In infectious diseases: 442
• Year to date:
  • Site-wide: 7,890
• Since beginning of last month:
  • Site-wide: 9,513

Is Oculudentavis a bird or even archosaur?

• Downloaded 5,166 times
• Download rankings, all-time:
  • Site-wide: 2,212
  • In evolutionary biology: 29
• Year to date:
  • Site-wide: 15,396
• Since beginning of last month:
  • Site-wide: 6,844

Systematic mapping of chromatin state landscapes during mouse development

• Downloaded 4,782 times
• Download rankings, all-time:
  • Site-wide: 2,470
  • In genomics: 245
• Year to date:
  • Site-wide: 19,871
• Since beginning of last month:
  • Site-wide: 22,156

CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

• Downloaded 4,522 times
• Download rankings, all-time:
  • Site-wide: 2,672
  • In developmental biology: 19
• Year to date:
  • Site-wide: 4,485
• Since beginning of last month:
  • Site-wide: 10,822

Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients

• Downloaded 4,461 times
• Download rankings, all-time:
  • Site-wide: 2,717
  • In infectious diseases: 605
• Year to date:
  • Site-wide: 14,598
• Since beginning of last month:
  • Site-wide: None

Evolving epidemiology of novel coronavirus diseases 2019 and possible interruption of local transmission outside Hubei Province in China: a descriptive and modeling study

• Downloaded 3,847 times
• Download rankings, all-time:
  • Site-wide: 3,381
  • In infectious diseases: 695
• Year to date:
  • Site-wide: 22,880
• Since beginning of last month:
  • Site-wide: 22,289

The Use of Adjuvant Therapy in Preventing Progression to Severe Pneumonia in Patients with Coronavirus Disease 2019: A Multicenter Data Analysis

• Downloaded 2,937 times
• Download rankings, all-time:
  • Site-wide: 4,916
  • In infectious diseases: 889
• Year to date:
  • Site-wide: 47,214
• Since beginning of last month:
  • Site-wide: 31,429

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

• Downloaded 2,893 times
• Download rankings, all-time:
  • Site-wide: 5,028
  • In infectious diseases: 903
• Year to date:
  • Site-wide: 6,260
• Since beginning of last month:
  • Site-wide: 9,536

A single cell transcriptional roadmap for cardiopharyngeal fate diversification

• Downloaded 2,771 times
• Download rankings, all-time:
  • Site-wide: 5,345
  • In developmental biology: 60
• Year to date:
  • Site-wide: 50,957
• Since beginning of last month:
  • Site-wide: 51,382

Early Prediction of Disease Progression in 2019 Novel Coronavirus Pneumonia Patients Outside Wuhan with CT and Clinical Characteristics

• Downloaded 2,661 times
• Download rankings, all-time:
  • Site-wide: 5,671
  • In infectious diseases: 967
• Year to date:
  • Site-wide: 31,933
• Since beginning of last month:
  • Site-wide: 38,181

Assessment of single cell RNA-seq normalization methods

• Downloaded 2,268 times
• Download rankings, all-time:
  • Site-wide: 7,185
  • In bioinformatics: 810
• Year to date:
  • Site-wide: 105,256
• Since beginning of last month:
  • Site-wide: 94,680

In-Vivo Toxicity Studies and In-Vitro Inactivation of SARS-CoV-2 by Povidone-iodine In-situ Gel Forming Formulations

• Downloaded 2,125 times
• Download rankings, all-time:
  • Site-wide: 7,896
  • In microbiology: 464
• Year to date:
  • Site-wide: 4,909
• Since beginning of last month:
  • Site-wide: 17,066

Case fatality risk of novel coronavirus diseases 2019 in China

• Downloaded 2,065 times
• Download rankings, all-time:
  • Site-wide: 8,215
  • In infectious diseases: 1,195
• Year to date:
  • Site-wide: 42,318
• Since beginning of last month:
  • Site-wide: 33,829

GSKB: A gene set database for pathway analysis in mouse

• Downloaded 1,854 times
• Download rankings, all-time:
  • Site-wide: 9,670
  • In bioinformatics: 1,130
• Year to date:
  • Site-wide: 11,588
• Since beginning of last month:
  • Site-wide: 15,107

Establishment In Culture Of Expanded Potential Stem Cells

• Downloaded 1,765 times
• Download rankings, all-time:
  • Site-wide: 10,405
  • In developmental biology: 137
• Year to date:
  • Site-wide: 68,655
• Since beginning of last month:
  • Site-wide: 74,636

Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients

• Downloaded 1,752 times
• Download rankings, all-time:
  • Site-wide: 10,503
  • In infectious diseases: 1,386
• Year to date:
  • Site-wide: 43,892
• Since beginning of last month:
  • Site-wide: 53,182

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1

• Downloaded 1,724 times
• Download rankings, all-time:
  • Site-wide: 10,759
  • In genomics: 1,118
• Year to date:
  • Site-wide: 93,577
• Since beginning of last month:
  • Site-wide: 110,323

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

• Downloaded 1,702 times
• Download rankings, all-time:
  • Site-wide: 10,976
  • In cancer biology: 208
• Year to date:
  • Site-wide: 7,353
• Since beginning of last month:
  • Site-wide: 6,183

The Effectiveness of China’s National Forest Protection Program and National-level Nature Reserves, 2000 to 2010

• Downloaded 1,570 times
• Download rankings, all-time:
  • Site-wide: 12,316
  • In ecology: 165
• Year to date:
  • Site-wide: 78,651
• Since beginning of last month:
  • Site-wide: 95,166

Identification of DNA motifs that regulate DNA methylation

• Downloaded 1,412 times
• Download rankings, all-time:
  • Site-wide: 14,464
  • In bioinformatics: 1,685
• Year to date:
  • Site-wide: 49,172
• Since beginning of last month:
  • Site-wide: 95,307

Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and mice

• Downloaded 1,333 times
• Download rankings, all-time:
  • Site-wide: 15,782
  • In neuroscience: 1,833
• Year to date:
  • Site-wide: 9,310
• Since beginning of last month:
  • Site-wide: 20,816

Single-cell transcriptome profiling of the Ciona larval brain

• Downloaded 1,320 times
• Download rankings, all-time:
  • Site-wide: 16,011
  • In developmental biology: 249
• Year to date:
  • Site-wide: 54,908
• Since beginning of last month:
  • Site-wide: 109,604

Assessing the measurement transfer function of single-cell RNA sequencing

• Downloaded 1,120 times
• Download rankings, all-time:
  • Site-wide: 20,447
  • In genomics: 1,970
• Year to date:
  • Site-wide: 133,699
• Since beginning of last month:
  • Site-wide: 129,239

Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris

• Downloaded 1,116 times
• Download rankings, all-time:
  • Site-wide: 20,563
  • In evolutionary biology: 790
• Year to date:
  • Site-wide: 91,799
• Since beginning of last month:
  • Site-wide: 134,822

Finding de novo methylated DNA motifs

• Downloaded 1,085 times
• Download rankings, all-time:
  • Site-wide: 21,407
  • In bioinformatics: 2,468
• Year to date:
  • Site-wide: 82,210
• Since beginning of last month:
  • Site-wide: 97,605

TahcoRoll: An Efficient Approach for Signature Profiling in Genomic Data through Variable-Length k-mers

• Downloaded 1,076 times
• Download rankings, all-time:
  • Site-wide: 21,668
  • In bioinformatics: 2,493
• Year to date:
  • Site-wide: 74,815
• Since beginning of last month:
  • Site-wide: 76,525

Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study

• Downloaded 1,031 times
• Download rankings, all-time:
  • Site-wide: 23,090
  • In cardiovascular medicine: 32
• Year to date:
  • Site-wide: 14,596
• Since beginning of last month:
  • Site-wide: 24,429

Association of Personal Protective Equipment Use with Successful Protection Against COVID-19 Infection Among Health Care Workers

• Downloaded 1,014 times
• Download rankings, all-time:
  • Site-wide: 23,646
  • In epidemiology: 1,377
• Year to date:
  • Site-wide: 22,152
• Since beginning of last month:
  • Site-wide: 22,437

Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

• Downloaded 988 times
• Download rankings, all-time:
  • Site-wide: 24,579
  • In biophysics: 673
• Year to date:
  • Site-wide: 58,739
• Since beginning of last month:
  • Site-wide: 64,445

The RNA-binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

• Downloaded 985 times
• Download rankings, all-time:
  • Site-wide: 24,673
  • In genetics: 1,136
• Year to date:
  • Site-wide: 96,753
• Since beginning of last month:
  • Site-wide: 125,438

Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons

• Downloaded 947 times
• Download rankings, all-time:
  • Site-wide: 26,147
  • In neuroscience: 3,335
• Year to date:
  • Site-wide: 78,862
• Since beginning of last month:
  • Site-wide: 147,855

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

• Downloaded 943 times
• Download rankings, all-time:
  • Site-wide: 26,323
  • In microbiology: 1,537
• Year to date:
  • Site-wide: 41,107
• Since beginning of last month:
  • Site-wide: 103,335

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

• Downloaded 880 times
• Download rankings, all-time:
  • Site-wide: 28,978
  • In microbiology: 1,715
• Year to date:
  • Site-wide: 3,544
• Since beginning of last month:
  • Site-wide: 10,249

Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

• Downloaded 872 times
• Download rankings, all-time:
  • Site-wide: 29,363
  • In genetics: 1,357
• Year to date:
  • Site-wide: 128,309
• Since beginning of last month:
  • Site-wide: 117,817

Association of 25 hydroxyvitamin D concentration with risk of COVID-19: a Mendelian randomization study

• Downloaded 866 times
• Download rankings, all-time:
  • Site-wide: 29,655
  • In infectious diseases: 2,308
• Year to date:
  • Site-wide: 51,881
• Since beginning of last month:
  • Site-wide: 23,751

Full-genome evolutionary histories of selfing, splitting and selection in Caenorhabditis

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 30,614
  • In genomics: 2,711
• Year to date:
  • Site-wide: 135,124
• Since beginning of last month:
  • Site-wide: 129,177

A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs

• Downloaded 840 times
• Download rankings, all-time:
  • Site-wide: 30,907
  • In developmental biology: 598
• Year to date:
  • Site-wide: 96,669
• Since beginning of last month:
  • Site-wide: 50,755

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

• Downloaded 830 times
• Download rankings, all-time:
  • Site-wide: 31,449
  • In infectious diseases: 2,378
• Year to date:
  • Site-wide: 52,035
• Since beginning of last month:
  • Site-wide: 20,847

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 809 times
• Download rankings, all-time:
  • Site-wide: 32,595
  • In genetic and genomic medicine: 128
• Year to date:
  • Site-wide: 26,367
• Since beginning of last month:
  • Site-wide: 54,026

Molecular evolution across developmental time reveals rapid divergence in early embryogenesis

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 34,379
  • In evolutionary biology: 1,595
• Year to date:
  • Site-wide: 96,462
• Since beginning of last month:
  • Site-wide: 110,944

Contemporary circulating enterovirus D68 strains show differential viral entry and replication in human neuronal cells

• Downloaded 764 times
• Download rankings, all-time:
  • Site-wide: 35,306
  • In microbiology: 2,116
• Year to date:
  • Site-wide: 70,685
• Since beginning of last month:
  • Site-wide: 66,281

An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

• Downloaded 756 times
• Download rankings, all-time:
  • Site-wide: 35,818
  • In developmental biology: 741
• Year to date:
  • Site-wide: 107,725
• Since beginning of last month:
  • Site-wide: 126,085

Computational Study of Ions and Water Permeation and Transportation Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel

• Downloaded 752 times
• Download rankings, all-time:
  • Site-wide: 36,053
  • In biophysics: 1,110
• Year to date:
  • Site-wide: 89,558
• Since beginning of last month:
  • Site-wide: 132,676

Paralogues of the PXY and ER receptor kinases enforce radial patterning in plant vascular tissue.

• Downloaded 727 times
• Download rankings, all-time:
  • Site-wide: 37,826
  • In plant biology: 764
• Year to date:
  • Site-wide: 77,731
• Since beginning of last month:
  • Site-wide: 77,070

Global, regional, and national estimates of target population sizes for COVID-19 vaccination

• Downloaded 725 times
• Download rankings, all-time:
  • Site-wide: 38,017
  • In infectious diseases: 2,609
• Year to date:
  • Site-wide: 20,400
• Since beginning of last month:
  • Site-wide: 39,863

Systems-level identification of transcription factors critical for mouse embryonic development

• Downloaded 716 times
• Download rankings, all-time:
  • Site-wide: 38,653
  • In bioinformatics: 4,178
• Year to date:
  • Site-wide: 147,056
• Since beginning of last month:
  • Site-wide: None

Motto: Representing motifs in consensus sequences with minimum information loss

• Downloaded 695 times
• Download rankings, all-time:
  • Site-wide: 40,152
  • In bioinformatics: 4,308
• Year to date:
  • Site-wide: 47,345
• Since beginning of last month:
  • Site-wide: 73,756

Systematic identification of cooperation between DNA binding proteins in 3D space

• Downloaded 691 times
• Download rankings, all-time:
  • Site-wide: 40,468
  • In bioinformatics: 4,338
• Year to date:
  • Site-wide: 135,457
• Since beginning of last month:
  • Site-wide: 64,302

MiniScrub: de novo long read scrubbing using approximate alignment and deep learning

• Downloaded 686 times
• Download rankings, all-time:
  • Site-wide: 40,900
  • In bioinformatics: 4,379
• Year to date:
  • Site-wide: 107,848
• Since beginning of last month:
  • Site-wide: 124,825

Lasagna: Multifaceted Protein-Protein Interaction Prediction Based on Siamese Residual RCNN

• Downloaded 672 times
• Download rankings, all-time:
  • Site-wide: 41,989
  • In bioinformatics: 4,484
• Year to date:
  • Site-wide: 88,232
• Since beginning of last month:
  • Site-wide: 84,265

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

• Downloaded 669 times
• Download rankings, all-time:
  • Site-wide: 42,276
  • In cancer biology: 1,154
• Year to date:
  • Site-wide: 12,959
• Since beginning of last month:
  • Site-wide: 23,858

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

• Downloaded 664 times
• Download rankings, all-time:
  • Site-wide: 42,604
  • In genomics: 3,451
• Year to date:
  • Site-wide: 5,338
• Since beginning of last month:
  • Site-wide: 25,223

Prophase removal of chromosome-associated RNAs facilitates anaphase chromosome segregation

• Downloaded 616 times
• Download rankings, all-time:
  • Site-wide: 46,898
  • In cell biology: 1,981
• Year to date:
  • Site-wide: 71,293
• Since beginning of last month:
  • Site-wide: 87,928

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

• Downloaded 597 times
• Download rankings, all-time:
  • Site-wide: 48,730
  • In genetics: 2,181
• Year to date:
  • Site-wide: 98,209
• Since beginning of last month:
  • Site-wide: 74,418

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 594 times
• Download rankings, all-time:
  • Site-wide: 49,107
  • In genetics: 2,200
• Year to date:
  • Site-wide: 77,088
• Since beginning of last month:
  • Site-wide: 88,256

Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with self-reported medical data

• Downloaded 584 times
• Download rankings, all-time:
  • Site-wide: 50,228
  • In genetic and genomic medicine: 197
• Year to date:
  • Site-wide: 6,440
• Since beginning of last month:
  • Site-wide: 5,977

Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

• Downloaded 582 times
• Download rankings, all-time:
  • Site-wide: 50,386
  • In biophysics: 1,662
• Year to date:
  • Site-wide: 113,953
• Since beginning of last month:
  • Site-wide: 108,412

JEDI: Circular RNA Prediction based on Junction Encoders and Deep Interaction among Splice Sites

• Downloaded 574 times
• Download rankings, all-time:
  • Site-wide: 51,301
  • In bioinformatics: 5,236
• Year to date:
  • Site-wide: 48,419
• Since beginning of last month:
  • Site-wide: 47,465

Mechanisms of integrin αVβ5 clustering in flat clathrin lattices

• Downloaded 572 times
• Download rankings, all-time:
  • Site-wide: 51,542
  • In cell biology: 2,234
• Year to date:
  • Site-wide: 80,133
• Since beginning of last month:
  • Site-wide: 58,906

Global variability of the human IgG glycome

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 51,724
  • In biochemistry: 1,340
• Year to date:
  • Site-wide: 105,598
• Since beginning of last month:
  • Site-wide: 86,223

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm

• Downloaded 566 times
• Download rankings, all-time:
  • Site-wide: 52,278
  • In developmental biology: 1,210
• Year to date:
  • Site-wide: 11,819
• Since beginning of last month:
  • Site-wide: 12,486

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 53,067
  • In developmental biology: 1,238
• Year to date:
  • Site-wide: 111,909
• Since beginning of last month:
  • Site-wide: 99,076

Genome structure predicts modular transcriptome responses to genetic and environmental conditions

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 54,150
  • In genomics: 4,102
• Year to date:
  • Site-wide: 82,878
• Since beginning of last month:
  • Site-wide: 20,394

Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization

• Downloaded 549 times
• Download rankings, all-time:
  • Site-wide: 54,221
  • In genetic and genomic medicine: 213
• Year to date:
  • Site-wide: 55,472
• Since beginning of last month:
  • Site-wide: 51,657

Neurogenin regulates effectors of migratory neuron cell behaviors in Ciona

• Downloaded 538 times
• Download rankings, all-time:
  • Site-wide: 55,454
  • In developmental biology: 1,300
• Year to date:
  • Site-wide: 75,275
• Since beginning of last month:
  • Site-wide: 95,696

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

• Downloaded 530 times
• Download rankings, all-time:
  • Site-wide: 56,487
  • In microbiology: 3,595
• Year to date:
  • Site-wide: 85,326
• Since beginning of last month:
  • Site-wide: 97,453

Identification of 67 pleiotropic genes for seven autoimmune diseases using multivariate statistical analysis

• Downloaded 527 times
• Download rankings, all-time:
  • Site-wide: 56,868
  • In genetics: 2,526
• Year to date:
  • Site-wide: 107,671
• Since beginning of last month:
  • Site-wide: 127,569

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 514 times
• Download rankings, all-time:
  • Site-wide: 58,546
  • In genetics: 2,606
• Year to date:
  • Site-wide: 43,029
• Since beginning of last month:
  • Site-wide: 69,753

Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 60,887
  • In cancer biology: 1,734
• Year to date:
  • Site-wide: 134,424
• Since beginning of last month:
  • Site-wide: 147,598

Non-parametric and semi-parametric support estimation using SEquential RESampling random walks on biomolecular sequences

• Downloaded 497 times
• Download rankings, all-time:
  • Site-wide: 60,909
  • In bioinformatics: 6,004
• Year to date:
  • Site-wide: 127,880
• Since beginning of last month:
  • Site-wide: 58,217

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 60,968
  • In molecular biology: 1,741
• Year to date:
  • Site-wide: 26,765
• Since beginning of last month:
  • Site-wide: 10,033

Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 63,125
  • In microbiology: 4,097
• Year to date:
  • Site-wide: 81,175
• Since beginning of last month:
  • Site-wide: 108,048

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

• Downloaded 466 times
• Download rankings, all-time:
  • Site-wide: 65,229
  • In cancer biology: 1,894
• Year to date:
  • Site-wide: 55,417
• Since beginning of last month:
  • Site-wide: 89,221

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

• Downloaded 447 times
• Download rankings, all-time:
  • Site-wide: 68,175
  • In microbiology: 4,519
• Year to date:
  • Site-wide: 136,754
• Since beginning of last month:
  • Site-wide: 128,285

Bacterial Glycogen as a Durable Energy Reserve Contributing to Persistence: An Updated Bibliography and Mathematical Model

• Downloaded 444 times
• Download rankings, all-time:
  • Site-wide: 68,583
  • In microbiology: 4,561
• Year to date:
  • Site-wide: 88,789
• Since beginning of last month:
  • Site-wide: 100,391

Build a Better Bootstrap and the RAWR Shall Beat a Random Path to Your Door: Phylogenetic Support Estimation Revisited

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 68,926
  • In bioinformatics: 6,576
• Year to date:
  • Site-wide: 60,944
• Since beginning of last month:
  • Site-wide: 33,854

Targeted mutations on 3D hub loci alter spatial interaction environment

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 70,524
  • In biophysics: 2,522
• Year to date:
  • Site-wide: 138,018
• Since beginning of last month:
  • Site-wide: 130,502

Mutation effect estimation on protein-protein interactions using deep contextualized representation learning

• Downloaded 431 times
• Download rankings, all-time:
  • Site-wide: 70,753
  • In bioinformatics: 6,693
• Year to date:
  • Site-wide: 130,302
• Since beginning of last month:
  • Site-wide: 142,683

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

• Downloaded 430 times
• Download rankings, all-time:
  • Site-wide: 71,016
  • In pharmacology and toxicology: 451
• Year to date:
  • Site-wide: 102,545
• Since beginning of last month:
  • Site-wide: 64,705

Cell cycle-gated feedback control mediates desensitization to interferon stimulation

• Downloaded 426 times
• Download rankings, all-time:
  • Site-wide: 71,696
  • In systems biology: 1,662
• Year to date:
  • Site-wide: 112,943
• Since beginning of last month:
  • Site-wide: 131,644

Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male Mice

• Downloaded 424 times
• Download rankings, all-time:
  • Site-wide: 71,961
  • In neuroscience: 10,688
• Year to date:
  • Site-wide: 27,334
• Since beginning of last month:
  • Site-wide: 28,440

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 74,199
  • In neuroscience: 11,047
• Year to date:
  • Site-wide: 110,767
• Since beginning of last month:
  • Site-wide: 69,311

Bio-JOIE: Joint Representation Learning of Biological Knowledge Bases

• Downloaded 410 times
• Download rankings, all-time:
  • Site-wide: 74,266
  • In bioinformatics: 6,958
• Year to date:
  • Site-wide: 67,314
• Since beginning of last month:
  • Site-wide: 141,593

Uncovering Medical Insights from Vast Amounts of Biomedical Data in Clinical Case Reports

• Downloaded 400 times
• Download rankings, all-time:
  • Site-wide: 76,225
  • In bioinformatics: 7,080
• Year to date:
  • Site-wide: 116,253
• Since beginning of last month:
  • Site-wide: 64,444

Dual functions of Discoidin domain receptor coordinate cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 79,325
  • In developmental biology: 2,039
• Year to date:
  • Site-wide: 115,914
• Since beginning of last month:
  • Site-wide: 75,871

Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation

• Downloaded 377 times
• Download rankings, all-time:
  • Site-wide: 80,413
  • In genomics: 5,304
• Year to date:
  • Site-wide: 118,445
• Since beginning of last month:
  • Site-wide: 123,855

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 373 times
• Download rankings, all-time:
  • Site-wide: 81,035
  • In epidemiology: 3,436
• Year to date:
  • Site-wide: 49,380
• Since beginning of last month:
  • Site-wide: 62,401

Recovery of Consciousness and Cognition after General Anesthesia in Humans

• Downloaded 366 times
• Download rankings, all-time:
  • Site-wide: 82,592
  • In neuroscience: 12,405
• Year to date:
  • Site-wide: 54,035
• Since beginning of last month:
  • Site-wide: 131,905

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

• Downloaded 359 times
• Download rankings, all-time:
  • Site-wide: 83,929
  • In microbiology: 5,770
• Year to date:
  • Site-wide: 145,829
• Since beginning of last month:
  • Site-wide: 145,793

DTI-CDF: a CDF model towards the prediction of DTIs based on hybrid features

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 85,083
  • In bioinformatics: 7,655
• Year to date:
  • Site-wide: 122,507
• Since beginning of last month:
  • Site-wide: 95,912

Contextual Regression: An Accurate and Conveniently Interpretable Nonlinear Model for Mining Discovery from Scientific Data

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 85,348
  • In bioinformatics: 7,667
• Year to date:
  • Site-wide: 117,464
• Since beginning of last month:
  • Site-wide: 37,093

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

• Downloaded 347 times
• Download rankings, all-time:
  • Site-wide: 86,416
  • In evolutionary biology: 4,527
• Year to date:
  • Site-wide: 13,665
• Since beginning of last month:
  • Site-wide: 29,341

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 86,859
  • In microbiology: 6,023
• Year to date:
  • Site-wide: 79,366
• Since beginning of last month:
  • Site-wide: 87,202

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 87,578
  • In plant biology: 2,306
• Year to date:
  • Site-wide: 89,590
• Since beginning of last month:
  • Site-wide: 69,957

A multiethnic GWAS meta-analysis of 585,243 individuals identifies new risk loci associated with cataract and reveals sex-specific effects

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 88,315
  • In genetic and genomic medicine: 378
• Year to date:
  • Site-wide: 38,345
• Since beginning of last month:
  • Site-wide: 50,029

Surfaceome CRISPR Screen Identifies OLFML3 as a Rhinovirus-inducible IFN Antagonist

• Downloaded 337 times
• Download rankings, all-time:
  • Site-wide: 88,395
  • In molecular biology: 2,599
• Year to date:
  • Site-wide: 27,081
• Since beginning of last month:
  • Site-wide: 30,793

Role of Water Mediated Interactions in Calcium-Coupled Allostery of Calmodulin Domains

• Downloaded 336 times
• Download rankings, all-time:
  • Site-wide: 88,640
  • In biochemistry: 2,539
• Year to date:
  • Site-wide: 85,073
• Since beginning of last month:
  • Site-wide: 45,969

Structural basis for transfer RNA mimicry by a bacterial Y RNA

• Downloaded 332 times
• Download rankings, all-time:
  • Site-wide: 89,534
  • In biochemistry: 2,566
• Year to date:
  • Site-wide: 134,940
• Since beginning of last month:
  • Site-wide: 96,846

Comparative Transcriptomes Analysis of Taenia pisiformis at Different Development Stages

• Downloaded 318 times
• Download rankings, all-time:
  • Site-wide: 92,512
  • In molecular biology: 2,720
• Year to date:
  • Site-wide: 109,958
• Since beginning of last month:
  • Site-wide: 119,795

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

• Downloaded 315 times
• Download rankings, all-time:
  • Site-wide: 93,216
  • In pharmacology and toxicology: 654
• Year to date:
  • Site-wide: 137,889
• Since beginning of last month:
  • Site-wide: 146,826

Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq

• Downloaded 301 times
• Download rankings, all-time:
  • Site-wide: 96,449
  • In genomics: 5,927
• Year to date:
  • Site-wide: 125,908
• Since beginning of last month:
  • Site-wide: 102,138

Testosterone Changes in Female Pandas in Estrus

• Downloaded 298 times
• Download rankings, all-time:
  • Site-wide: 97,159
  • In zoology: 382
• Year to date:
  • Site-wide: 73,591
• Since beginning of last month:
  • Site-wide: 103,074

An Analysis of Outbreak Dynamics and Intervention Effects for COVID-19 Transmission in Europe

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 97,754
  • In infectious diseases: 4,213
• Year to date:
  • Site-wide: 119,347
• Since beginning of last month:
  • Site-wide: 103,301

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 97,795
  • In psychiatry and clinical psychology: 386
• Year to date:
  • Site-wide: 72,305
• Since beginning of last month:
  • Site-wide: 89,120

Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study

• Downloaded 294 times
• Download rankings, all-time:
  • Site-wide: 98,018
  • In genetic and genomic medicine: 448
• Year to date:
  • Site-wide: 69,865
• Since beginning of last month:
  • Site-wide: 86,635

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 98,566
  • In pharmacology and toxicology: 698
• Year to date:
  • Site-wide: 149,068
• Since beginning of last month:
  • Site-wide: 128,075

Screening of Botanical Drugs against SARS-CoV-2 Entry

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 98,703
  • In microbiology: 7,044
• Year to date:
  • Site-wide: 17,497
• Since beginning of last month:
  • Site-wide: 62,881

Sulforaphane modulates microRNA expression in colon cancer cells to implicate the regulation of oncogenes CDC25A, HMGA2 and MYC

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 98,943
  • In cancer biology: 2,981
• Year to date:
  • Site-wide: 140,197
• Since beginning of last month:
  • Site-wide: 110,492

The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli

• Downloaded 284 times
• Download rankings, all-time:
  • Site-wide: 100,190
  • In molecular biology: 2,974
• Year to date:
  • Site-wide: 69,216
• Since beginning of last month:
  • Site-wide: 60,939

Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

• Downloaded 281 times
• Download rankings, all-time:
  • Site-wide: 100,942
  • In pathology: 540
• Year to date:
  • Site-wide: 79,291
• Since beginning of last month:
  • Site-wide: 41,217

Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 102,746
  • In developmental biology: 2,759
• Year to date:
  • Site-wide: 138,447
• Since beginning of last month:
  • Site-wide: 119,324

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 105,276
  • In cell biology: 4,850
• Year to date:
  • Site-wide: 144,276
• Since beginning of last month:
  • Site-wide: 126,421

Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation

• Downloaded 246 times
• Download rankings, all-time:
  • Site-wide: 109,486
  • In biophysics: 4,201
• Year to date:
  • Site-wide: 80,938
• Since beginning of last month:
  • Site-wide: 80,447

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis

• Downloaded 245 times
• Download rankings, all-time:
  • Site-wide: 109,560
  • In developmental biology: 2,949
• Year to date:
  • Site-wide: 145,888
• Since beginning of last month:
  • Site-wide: 141,518

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 111,852
  • In neuroscience: 17,017
• Year to date:
  • Site-wide: 35,938
• Since beginning of last month:
  • Site-wide: 32,297

Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis

• Downloaded 235 times
• Download rankings, all-time:
  • Site-wide: 112,130
  • In neuroscience: 17,060
• Year to date:
  • Site-wide: 131,189
• Since beginning of last month:
  • Site-wide: 134,943

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 113,670
  • In neuroscience: 17,274
• Year to date:
  • Site-wide: 136,604
• Since beginning of last month:
  • Site-wide: 75,057

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary protein trafficking, Hedgehog signaling and embryogenesis

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 114,713
  • In genetics: 4,824
• Year to date:
  • Site-wide: 147,327
• Since beginning of last month:
  • Site-wide: 141,908

Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers

• Downloaded 220 times
• Download rankings, all-time:
  • Site-wide: 115,975
  • In bioinformatics: 9,542
• Year to date:
  • Site-wide: 149,060
• Since beginning of last month:
  • Site-wide: 134,975

Impact of Retinopathy and Systemic Vascular Comorbidities on All-Cause Mortality

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 116,465
  • In ophthalmology: 123
• Year to date:
  • Site-wide: 25,815
• Since beginning of last month:
  • Site-wide: 63,045

Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities

• Downloaded 215 times
• Download rankings, all-time:
  • Site-wide: 117,138
  • In cell biology: 5,400
• Year to date:
  • Site-wide: 121,329
• Since beginning of last month:
  • Site-wide: 92,227

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

• Downloaded 206 times
• Download rankings, all-time:
  • Site-wide: 119,421
  • In infectious diseases: 4,780
• Year to date:
  • Site-wide: 27,706
• Since beginning of last month:
  • Site-wide: 56,161

Prediction of LncRNA Encoded Small Peptides in Glioma and The Oligomer Channel Functional Analysis Using in Silico Approaches

• Downloaded 198 times
• Download rankings, all-time:
  • Site-wide: 121,263
  • In biophysics: 4,655
• Year to date:
  • Site-wide: 96,181
• Since beginning of last month:
  • Site-wide: 60,483

Oncogenic Activation of AKT by MAPK6

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 122,153
  • In cancer biology: 3,719
• Year to date:
  • Site-wide: 95,616
• Since beginning of last month:
  • Site-wide: 78,867

NEIL1 and NEIL2 DNA glycosylases regulate anxiety and learning in a cooperative manner

• Downloaded 169 times
• Download rankings, all-time:
  • Site-wide: 128,100
  • In molecular biology: 3,817
• Year to date:
  • Site-wide: 35,185
• Since beginning of last month:
  • Site-wide: 35,700

The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

• Downloaded 157 times
• Download rankings, all-time:
  • Site-wide: 130,910
  • In physiology: 1,454
• Year to date:
  • Site-wide: 121,244
• Since beginning of last month:
  • Site-wide: 79,861

Genome-wide identification of long non-coding RNAs in the gravid ectoparasite Varroa destructor

• Downloaded 147 times
• Download rankings, all-time:
  • Site-wide: 132,935
  • In genomics: 7,082
• Year to date:
  • Site-wide: 142,988
• Since beginning of last month:
  • Site-wide: 142,874

Limbal Niche Cells in Three-Dimensional Matrigel Induced Dedifferentiation of Mature Corneal Epithelial Cells toward a Progenitor State

• Downloaded 122 times
• Download rankings, all-time:
  • Site-wide: 138,415
  • In bioengineering: 2,827
• Year to date:
  • Site-wide: 123,785
• Since beginning of last month:
  • Site-wide: 103,640

RNAi screening reveals requirement for PDGFRβ in JEV infection.

• Downloaded 120 times
• Download rankings, all-time:
  • Site-wide: 138,707
  • In microbiology: 10,559
• Year to date:
  • Site-wide: 50,611
• Since beginning of last month:
  • Site-wide: 71,647

Brassinosteroids Promote Parenchyma Cell and Secondary Xylem Development in Sugar Beet (Beta vulgaris L.) Root

• Downloaded 119 times
• Download rankings, all-time:
  • Site-wide: 138,865
  • In plant biology: 3,912
• Year to date:
  • Site-wide: 112,749
• Since beginning of last month:
  • Site-wide: 141,412

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

• Downloaded 115 times
• Download rankings, all-time:
  • Site-wide: 139,692
  • In genetics: 5,608
• Year to date:
  • Site-wide: 93,024
• Since beginning of last month:
  • Site-wide: 70,254

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

• Downloaded 98 times
• Download rankings, all-time:
  • Site-wide: 142,863
  • In immunology: 4,258
• Year to date:
  • Site-wide: 61,387
• Since beginning of last month:
  • Site-wide: 118,909

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

• Downloaded 95 times
• Download rankings, all-time:
  • Site-wide: 143,364
  • In microbiology: 10,984
• Year to date:
  • Site-wide: 87,410
• Since beginning of last month:
  • Site-wide: 134,196

Stand-alone lipoylated H-protein of the glycine cleavage system enables glycine cleavage and the synthesis of glycine from one-carbon compounds in vitro

• Downloaded 91 times
• Download rankings, all-time:
  • Site-wide: 143,950
  • In biochemistry: 4,351
• Year to date:
  • Site-wide: 65,906
• Since beginning of last month:
  • Site-wide: 81,215

Screening of Botanical Drugs Against Lassa Virus Entry

• Downloaded 91 times
• Download rankings, all-time:
  • Site-wide: 143,913
  • In microbiology: 11,056
• Year to date:
  • Site-wide: 128,515
• Since beginning of last month:
  • Site-wide: 132,600

Association of Visual Impairment with Risk for Future Parkinson's Disease

• Downloaded 89 times
• Download rankings, all-time:
  • Site-wide: 144,285
  • In epidemiology: 5,928
• Year to date:
  • Site-wide: 66,843
• Since beginning of last month:
  • Site-wide: 93,493

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

• Downloaded 84 times
• Download rankings, all-time:
  • Site-wide: 145,109
  • In microbiology: 11,157
• Year to date:
  • Site-wide: 144,740
• Since beginning of last month:
  • Site-wide: 115,590

Identification of biomarkers and candidate inhibitors for multiple myeloma

• Downloaded 68 times
• Download rankings, all-time:
  • Site-wide: 146,985
  • In bioinformatics: 11,205
• Year to date:
  • Site-wide: 82,981
• Since beginning of last month:
  • Site-wide: 118,498

Mechanism through which retrocyclin targets flavivirus multiplication

• Downloaded 46 times
• Download rankings, all-time:
  • Site-wide: 148,796
  • In microbiology: 11,562
• Year to date:
  • Site-wide: 134,450
• Since beginning of last month:
  • Site-wide: 133,864

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

• Downloaded 46 times
• Download rankings, all-time:
  • Site-wide: 148,833
  • In microbiology: 11,560
• Year to date:
  • Site-wide: 108,288
• Since beginning of last month:
  • Site-wide: 80,838

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

• Downloaded 43 times
• Download rankings, all-time:
  • Site-wide: 148,945
  • In microbiology: 11,574
• Year to date:
  • Site-wide: 112,436
• Since beginning of last month:
  • Site-wide: 11,691