Author: Wei Wang

Downloads per author, site-wide

Preprints

Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

• Downloaded 25,331 times
• Download rankings, all-time:
  • Site-wide: 350
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 5,093
• Since beginning of last month:
  • Site-wide: 6,874

Age profile of susceptibility, mixing, and social distancing shape the dynamics of the novel coronavirus disease 2019 outbreak in China

• Downloaded 10,769 times
• Download rankings, all-time:
  • Site-wide: 996
  • In epidemiology: 137
• Year to date:
  • Site-wide: 13,647
• Since beginning of last month:
  • Site-wide: 32,082

COVID-19 in Wuhan: Immediate Psychological Impact on 5062 Health Workers

• Downloaded 10,703 times
• Download rankings, all-time:
  • Site-wide: 1,005
  • In psychiatry and clinical psychology: 6
• Year to date:
  • Site-wide: 1,214
• Since beginning of last month:
  • Site-wide: 1,608

Modified TCA/acetone precipitation of plant proteins for proteomic analysis

• Downloaded 8,836 times
• Download rankings, all-time:
  • Site-wide: 1,254
  • In biochemistry: 14
• Year to date:
  • Site-wide: 1,035
• Since beginning of last month:
  • Site-wide: 3,888

Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers

• Downloaded 8,106 times
• Download rankings, all-time:
  • Site-wide: 1,406
  • In infectious diseases: 412
• Year to date:
  • Site-wide: 11,971
• Since beginning of last month:
  • Site-wide: 43,894

Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

• Downloaded 6,500 times
• Download rankings, all-time:
  • Site-wide: 1,869
  • In infectious diseases: 514
• Year to date:
  • Site-wide: 9,401
• Since beginning of last month:
  • Site-wide: 34,815

Is Oculudentavis a bird or even archosaur?

• Downloaded 5,288 times
• Download rankings, all-time:
  • Site-wide: 2,466
  • In evolutionary biology: 34
• Year to date:
  • Site-wide: 19,355
• Since beginning of last month:
  • Site-wide: 35,145

Systematic mapping of chromatin state landscapes during mouse development

• Downloaded 4,903 times
• Download rankings, all-time:
  • Site-wide: 2,756
  • In genomics: 259
• Year to date:
  • Site-wide: 23,845
• Since beginning of last month:
  • Site-wide: 60,822

CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

• Downloaded 4,700 times
• Download rankings, all-time:
  • Site-wide: 2,905
  • In developmental biology: 19
• Year to date:
  • Site-wide: 6,076
• Since beginning of last month:
  • Site-wide: 40,077

Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients

• Downloaded 4,669 times
• Download rankings, all-time:
  • Site-wide: 2,932
  • In infectious diseases: 686
• Year to date:
  • Site-wide: 14,130
• Since beginning of last month:
  • Site-wide: 19,721

Evolving epidemiology of novel coronavirus diseases 2019 and possible interruption of local transmission outside Hubei Province in China: a descriptive and modeling study

• Downloaded 3,967 times
• Download rankings, all-time:
  • Site-wide: 3,693
  • In infectious diseases: 791
• Year to date:
  • Site-wide: 26,540
• Since beginning of last month:
  • Site-wide: 48,384

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

• Downloaded 3,111 times
• Download rankings, all-time:
  • Site-wide: 5,211
  • In infectious diseases: 995
• Year to date:
  • Site-wide: 7,487
• Since beginning of last month:
  • Site-wide: 20,215

The Use of Adjuvant Therapy in Preventing Progression to Severe Pneumonia in Patients with Coronavirus Disease 2019: A Multicenter Data Analysis

• Downloaded 3,048 times
• Download rankings, all-time:
  • Site-wide: 5,353
  • In infectious diseases: 1,013
• Year to date:
  • Site-wide: 46,196
• Since beginning of last month:
  • Site-wide: 53,371

A single cell transcriptional roadmap for cardiopharyngeal fate diversification

• Downloaded 2,859 times
• Download rankings, all-time:
  • Site-wide: 5,884
  • In developmental biology: 65
• Year to date:
  • Site-wide: 55,343
• Since beginning of last month:
  • Site-wide: 37,729

Early Prediction of Disease Progression in 2019 Novel Coronavirus Pneumonia Patients Outside Wuhan with CT and Clinical Characteristics

• Downloaded 2,772 times
• Download rankings, all-time:
  • Site-wide: 6,164
  • In infectious diseases: 1,100
• Year to date:
  • Site-wide: 35,240
• Since beginning of last month:
  • Site-wide: 56,133

In-Vivo Toxicity Studies and In-Vitro Inactivation of SARS-CoV-2 by Povidone-iodine In-situ Gel Forming Formulations

• Downloaded 2,357 times
• Download rankings, all-time:
  • Site-wide: 7,826
  • In microbiology: 471
• Year to date:
  • Site-wide: 5,966
• Since beginning of last month:
  • Site-wide: 22,037

Assessment of single cell RNA-seq normalization methods

• Downloaded 2,305 times
• Download rankings, all-time:
  • Site-wide: 8,099
  • In bioinformatics: 891
• Year to date:
  • Site-wide: 127,450
• Since beginning of last month:
  • Site-wide: 125,338

Case fatality risk of novel coronavirus diseases 2019 in China

• Downloaded 2,175 times
• Download rankings, all-time:
  • Site-wide: 8,810
  • In infectious diseases: 1,354
• Year to date:
  • Site-wide: 43,358
• Since beginning of last month:
  • Site-wide: 51,009

GSKB: A gene set database for pathway analysis in mouse

• Downloaded 2,050 times
• Download rankings, all-time:
  • Site-wide: 9,604
  • In bioinformatics: 1,069
• Year to date:
  • Site-wide: 12,469
• Since beginning of last month:
  • Site-wide: 20,138

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

• Downloaded 1,955 times
• Download rankings, all-time:
  • Site-wide: 10,327
  • In cancer biology: 186
• Year to date:
  • Site-wide: 7,806
• Since beginning of last month:
  • Site-wide: 16,321

Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients

• Downloaded 1,864 times
• Download rankings, all-time:
  • Site-wide: 11,096
  • In infectious diseases: 1,537
• Year to date:
  • Site-wide: 43,980
• Since beginning of last month:
  • Site-wide: 44,162

Establishment In Culture Of Expanded Potential Stem Cells

• Downloaded 1,855 times
• Download rankings, all-time:
  • Site-wide: 11,177
  • In developmental biology: 141
• Year to date:
  • Site-wide: 67,720
• Since beginning of last month:
  • Site-wide: 55,170

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1

• Downloaded 1,753 times
• Download rankings, all-time:
  • Site-wide: 12,142
  • In genomics: 1,208
• Year to date:
  • Site-wide: 125,590
• Since beginning of last month:
  • Site-wide: 133,731

The Effectiveness of China’s National Forest Protection Program and National-level Nature Reserves, 2000 to 2010

• Downloaded 1,583 times
• Download rankings, all-time:
  • Site-wide: 14,134
  • In ecology: 190
• Year to date:
  • Site-wide: 126,989
• Since beginning of last month:
  • Site-wide: 162,355

Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and mice

• Downloaded 1,493 times
• Download rankings, all-time:
  • Site-wide: 15,540
  • In neuroscience: 1,744
• Year to date:
  • Site-wide: 11,603
• Since beginning of last month:
  • Site-wide: 33,816

Identification of DNA motifs that regulate DNA methylation

• Downloaded 1,459 times
• Download rankings, all-time:
  • Site-wide: 16,131
  • In bioinformatics: 1,823
• Year to date:
  • Site-wide: 69,770
• Since beginning of last month:
  • Site-wide: 147,132

Single-cell transcriptome profiling of the Ciona larval brain

• Downloaded 1,394 times
• Download rankings, all-time:
  • Site-wide: 17,308
  • In developmental biology: 263
• Year to date:
  • Site-wide: 63,903
• Since beginning of last month:
  • Site-wide: 49,962

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

• Downloaded 1,381 times
• Download rankings, all-time:
  • Site-wide: 17,555
  • In cell biology: 533
• Year to date:
  • Site-wide: 6,775
• Since beginning of last month:
  • Site-wide: 4,462

Assessing the measurement transfer function of single-cell RNA sequencing

• Downloaded 1,166 times
• Download rankings, all-time:
  • Site-wide: 22,642
  • In genomics: 2,094
• Year to date:
  • Site-wide: 137,704
• Since beginning of last month:
  • Site-wide: 124,560

Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study

• Downloaded 1,157 times
• Download rankings, all-time:
  • Site-wide: 22,915
  • In cardiovascular medicine: 34
• Year to date:
  • Site-wide: 18,268
• Since beginning of last month:
  • Site-wide: 27,706

TahcoRoll: An Efficient Approach for Signature Profiling in Genomic Data through Variable-Length k-mers

• Downloaded 1,145 times
• Download rankings, all-time:
  • Site-wide: 23,243
  • In bioinformatics: 2,615
• Year to date:
  • Site-wide: 81,887
• Since beginning of last month:
  • Site-wide: 101,868

Finding de novo methylated DNA motifs

• Downloaded 1,143 times
• Download rankings, all-time:
  • Site-wide: 23,309
  • In bioinformatics: 2,618
• Year to date:
  • Site-wide: 93,843
• Since beginning of last month:
  • Site-wide: 64,491

Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris

• Downloaded 1,136 times
• Download rankings, all-time:
  • Site-wide: 23,523
  • In evolutionary biology: 898
• Year to date:
  • Site-wide: 133,016
• Since beginning of last month:
  • Site-wide: 146,863

Association of Personal Protective Equipment Use with Successful Protection Against COVID-19 Infection Among Health Care Workers

• Downloaded 1,124 times
• Download rankings, all-time:
  • Site-wide: 23,948
  • In epidemiology: 1,441
• Year to date:
  • Site-wide: 26,935
• Since beginning of last month:
  • Site-wide: 26,923

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

• Downloaded 1,106 times
• Download rankings, all-time:
  • Site-wide: 24,525
  • In microbiology: 1,427
• Year to date:
  • Site-wide: 4,613
• Since beginning of last month:
  • Site-wide: 9,824

Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons

• Downloaded 1,038 times
• Download rankings, all-time:
  • Site-wide: 27,020
  • In neuroscience: 3,374
• Year to date:
  • Site-wide: 73,228
• Since beginning of last month:
  • Site-wide: 45,331

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

• Downloaded 1,030 times
• Download rankings, all-time:
  • Site-wide: 27,336
  • In microbiology: 1,590
• Year to date:
  • Site-wide: 47,718
• Since beginning of last month:
  • Site-wide: 80,242

The RNA-binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

• Downloaded 1,017 times
• Download rankings, all-time:
  • Site-wide: 27,850
  • In genetics: 1,223
• Year to date:
  • Site-wide: 125,821
• Since beginning of last month:
  • Site-wide: 137,959

Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

• Downloaded 1,012 times
• Download rankings, all-time:
  • Site-wide: 28,064
  • In biophysics: 792
• Year to date:
  • Site-wide: 93,921
• Since beginning of last month:
  • Site-wide: 154,363

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

• Downloaded 992 times
• Download rankings, all-time:
  • Site-wide: 28,873
  • In genetic and genomic medicine: 134
• Year to date:
  • Site-wide: 22,807
• Since beginning of last month:
  • Site-wide: 15,273

Association of 25 hydroxyvitamin D concentration with risk of COVID-19: a Mendelian randomization study

• Downloaded 961 times
• Download rankings, all-time:
  • Site-wide: 30,226
  • In infectious diseases: 2,552
• Year to date:
  • Site-wide: 54,073
• Since beginning of last month:
  • Site-wide: 62,758

Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

• Downloaded 926 times
• Download rankings, all-time:
  • Site-wide: 31,993
  • In genetics: 1,397
• Year to date:
  • Site-wide: 126,351
• Since beginning of last month:
  • Site-wide: 72,931

A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs

• Downloaded 916 times
• Download rankings, all-time:
  • Site-wide: 32,488
  • In developmental biology: 632
• Year to date:
  • Site-wide: 91,574
• Since beginning of last month:
  • Site-wide: 68,096

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

• Downloaded 911 times
• Download rankings, all-time:
  • Site-wide: 32,714
  • In genomics: 2,759
• Year to date:
  • Site-wide: 6,225
• Since beginning of last month:
  • Site-wide: 18,975

Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with self-reported medical data

• Downloaded 910 times
• Download rankings, all-time:
  • Site-wide: 32,795
  • In genetic and genomic medicine: 154
• Year to date:
  • Site-wide: 6,236
• Since beginning of last month:
  • Site-wide: 4,524

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

• Downloaded 894 times
• Download rankings, all-time:
  • Site-wide: 33,693
  • In infectious diseases: 2,707
• Year to date:
  • Site-wide: 65,573
• Since beginning of last month:
  • Site-wide: 93,964

Full-genome evolutionary histories of selfing, splitting and selection in Caenorhabditis

• Downloaded 861 times
• Download rankings, all-time:
  • Site-wide: 35,488
  • In genomics: 2,946
• Year to date:
  • Site-wide: 159,453
• Since beginning of last month:
  • Site-wide: 163,022

Global, regional, and national estimates of target population sizes for COVID-19 vaccination

• Downloaded 846 times
• Download rankings, all-time:
  • Site-wide: 36,442
  • In infectious diseases: 2,828
• Year to date:
  • Site-wide: 24,300
• Since beginning of last month:
  • Site-wide: 35,535

Computational Study of Ions and Water Permeation and Transportation Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel

• Downloaded 832 times
• Download rankings, all-time:
  • Site-wide: 37,342
  • In biophysics: 1,146
• Year to date:
  • Site-wide: 85,022
• Since beginning of last month:
  • Site-wide: 39,869

An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

• Downloaded 832 times
• Download rankings, all-time:
  • Site-wide: 37,386
  • In developmental biology: 760
• Year to date:
  • Site-wide: 97,834
• Since beginning of last month:
  • Site-wide: 41,010

Contemporary circulating enterovirus D68 strains show differential viral entry and replication in human neuronal cells

• Downloaded 829 times
• Download rankings, all-time:
  • Site-wide: 37,553
  • In microbiology: 2,241
• Year to date:
  • Site-wide: 81,004
• Since beginning of last month:
  • Site-wide: 101,187

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm

• Downloaded 808 times
• Download rankings, all-time:
  • Site-wide: 38,968
  • In developmental biology: 813
• Year to date:
  • Site-wide: 11,279
• Since beginning of last month:
  • Site-wide: 19,298

Molecular evolution across developmental time reveals rapid divergence in early embryogenesis

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 39,447
  • In evolutionary biology: 1,758
• Year to date:
  • Site-wide: 134,954
• Since beginning of last month:
  • Site-wide: 148,930

Paralogues of the PXY and ER receptor kinases enforce radial patterning in plant vascular tissue.

• Downloaded 779 times
• Download rankings, all-time:
  • Site-wide: 41,020
  • In plant biology: 829
• Year to date:
  • Site-wide: 94,737
• Since beginning of last month:
  • Site-wide: 87,120

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 41,533
  • In cancer biology: 1,133
• Year to date:
  • Site-wide: 17,891
• Since beginning of last month:
  • Site-wide: 58,502

Motto: Representing motifs in consensus sequences with minimum information loss

• Downloaded 759 times
• Download rankings, all-time:
  • Site-wide: 42,610
  • In bioinformatics: 4,471
• Year to date:
  • Site-wide: 60,497
• Since beginning of last month:
  • Site-wide: 130,346

MiniScrub: de novo long read scrubbing using approximate alignment and deep learning

• Downloaded 751 times
• Download rankings, all-time:
  • Site-wide: 43,306
  • In bioinformatics: 4,537
• Year to date:
  • Site-wide: 105,815
• Since beginning of last month:
  • Site-wide: 58,042

Systematic identification of cooperation between DNA binding proteins in 3D space

• Downloaded 750 times
• Download rankings, all-time:
  • Site-wide: 43,358
  • In bioinformatics: 4,546
• Year to date:
  • Site-wide: 126,739
• Since beginning of last month:
  • Site-wide: 83,641

Systems-level identification of transcription factors critical for mouse embryonic development

• Downloaded 734 times
• Download rankings, all-time:
  • Site-wide: 44,718
  • In bioinformatics: 4,660
• Year to date:
  • Site-wide: 162,677
• Since beginning of last month:
  • Site-wide: 153,233

Lasagna: Multifaceted Protein-Protein Interaction Prediction Based on Siamese Residual RCNN

• Downloaded 721 times
• Download rankings, all-time:
  • Site-wide: 45,883
  • In bioinformatics: 4,757
• Year to date:
  • Site-wide: 104,827
• Since beginning of last month:
  • Site-wide: 133,700

Prophase removal of chromosome-associated RNAs facilitates anaphase chromosome segregation

• Downloaded 671 times
• Download rankings, all-time:
  • Site-wide: 50,676
  • In cell biology: 2,146
• Year to date:
  • Site-wide: 86,779
• Since beginning of last month:
  • Site-wide: 118,501

Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

• Downloaded 658 times
• Download rankings, all-time:
  • Site-wide: 51,971
  • In biophysics: 1,698
• Year to date:
  • Site-wide: 101,333
• Since beginning of last month:
  • Site-wide: 43,141

JEDI: Circular RNA Prediction based on Junction Encoders and Deep Interaction among Splice Sites

• Downloaded 656 times
• Download rankings, all-time:
  • Site-wide: 52,215
  • In bioinformatics: 5,224
• Year to date:
  • Site-wide: 55,508
• Since beginning of last month:
  • Site-wide: 108,608

Global variability of the human IgG glycome

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 52,694
  • In biochemistry: 1,359
• Year to date:
  • Site-wide: 92,781
• Since beginning of last month:
  • Site-wide: 43,214

Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization

• Downloaded 641 times
• Download rankings, all-time:
  • Site-wide: 53,877
  • In genetic and genomic medicine: 253
• Year to date:
  • Site-wide: 57,802
• Since beginning of last month:
  • Site-wide: 59,215

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

• Downloaded 640 times
• Download rankings, all-time:
  • Site-wide: 53,968
  • In genetics: 2,300
• Year to date:
  • Site-wide: 98,550
• Since beginning of last month:
  • Site-wide: 138,530

Genome structure predicts modular transcriptome responses to genetic and environmental conditions

• Downloaded 637 times
• Download rankings, all-time:
  • Site-wide: 54,359
  • In genomics: 4,046
• Year to date:
  • Site-wide: 77,022
• Since beginning of last month:
  • Site-wide: 31,659

Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

• Downloaded 625 times
• Download rankings, all-time:
  • Site-wide: 55,733
  • In genetics: 2,362
• Year to date:
  • Site-wide: 130,183
• Since beginning of last month:
  • Site-wide: 154,113

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

• Downloaded 620 times
• Download rankings, all-time:
  • Site-wide: 56,316
  • In molecular biology: 1,595
• Year to date:
  • Site-wide: 29,170
• Since beginning of last month:
  • Site-wide: 32,090

Mechanisms of integrin αVβ5 clustering in flat clathrin lattices

• Downloaded 619 times
• Download rankings, all-time:
  • Site-wide: 56,422
  • In cell biology: 2,462
• Year to date:
  • Site-wide: 100,133
• Since beginning of last month:
  • Site-wide: 125,452

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

• Downloaded 611 times
• Download rankings, all-time:
  • Site-wide: 57,463
  • In genetics: 2,432
• Year to date:
  • Site-wide: 46,869
• Since beginning of last month:
  • Site-wide: 62,132

Neurogenin regulates effectors of migratory neuron cell behaviors in Ciona

• Downloaded 598 times
• Download rankings, all-time:
  • Site-wide: 58,973
  • In developmental biology: 1,410
• Year to date:
  • Site-wide: 87,886
• Since beginning of last month:
  • Site-wide: 75,061

Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

• Downloaded 581 times
• Download rankings, all-time:
  • Site-wide: 61,150
  • In developmental biology: 1,463
• Year to date:
  • Site-wide: 145,180
• Since beginning of last month:
  • Site-wide: 154,656

Identification of 67 pleiotropic genes for seven autoimmune diseases using multivariate statistical analysis

• Downloaded 570 times
• Download rankings, all-time:
  • Site-wide: 62,488
  • In genetics: 2,663
• Year to date:
  • Site-wide: 124,232
• Since beginning of last month:
  • Site-wide: 120,825

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

• Downloaded 563 times
• Download rankings, all-time:
  • Site-wide: 63,474
  • In microbiology: 4,000
• Year to date:
  • Site-wide: 115,319
• Since beginning of last month:
  • Site-wide: 129,827

Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 64,048
  • In cancer biology: 1,852
• Year to date:
  • Site-wide: 123,362
• Since beginning of last month:
  • Site-wide: 55,230

Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 65,914
  • In microbiology: 4,191
• Year to date:
  • Site-wide: 88,030
• Since beginning of last month:
  • Site-wide: 83,581

Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male Mice

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 68,040
  • In neuroscience: 9,875
• Year to date:
  • Site-wide: 31,943
• Since beginning of last month:
  • Site-wide: 48,026

Non-parametric and semi-parametric support estimation using SEquential RESampling random walks on biomolecular sequences

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 70,699
  • In bioinformatics: 6,659
• Year to date:
  • Site-wide: 155,308
• Since beginning of last month:
  • Site-wide: 153,318

Build a Better Bootstrap and the RAWR Shall Beat a Random Path to Your Door: Phylogenetic Support Estimation Revisited

• Downloaded 511 times
• Download rankings, all-time:
  • Site-wide: 71,271
  • In bioinformatics: 6,707
• Year to date:
  • Site-wide: 71,003
• Since beginning of last month:
  • Site-wide: 105,219

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

• Downloaded 507 times
• Download rankings, all-time:
  • Site-wide: 71,928
  • In cancer biology: 2,090
• Year to date:
  • Site-wide: 79,728
• Since beginning of last month:
  • Site-wide: 150,995

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 72,533
  • In evolutionary biology: 3,655
• Year to date:
  • Site-wide: 15,779
• Since beginning of last month:
  • Site-wide: 27,994

Bacterial Glycogen as a Durable Energy Reserve Contributing to Persistence: An Updated Bibliography and Mathematical Model

• Downloaded 502 times
• Download rankings, all-time:
  • Site-wide: 72,818
  • In microbiology: 4,772
• Year to date:
  • Site-wide: 98,892
• Since beginning of last month:
  • Site-wide: 83,026

Cell cycle-gated feedback control mediates desensitization to interferon stimulation

• Downloaded 496 times
• Download rankings, all-time:
  • Site-wide: 73,751
  • In systems biology: 1,640
• Year to date:
  • Site-wide: 105,238
• Since beginning of last month:
  • Site-wide: 48,592

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 75,960
  • In pharmacology and toxicology: 497
• Year to date:
  • Site-wide: 111,663
• Since beginning of last month:
  • Site-wide: 103,375

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

• Downloaded 480 times
• Download rankings, all-time:
  • Site-wide: 76,548
  • In microbiology: 5,060
• Year to date:
  • Site-wide: 149,508
• Since beginning of last month:
  • Site-wide: 139,569

Targeted mutations on 3D hub loci alter spatial interaction environment

• Downloaded 477 times
• Download rankings, all-time:
  • Site-wide: 77,066
  • In biophysics: 2,775
• Year to date:
  • Site-wide: 142,072
• Since beginning of last month:
  • Site-wide: 107,669

Mutation effect estimation on protein-protein interactions using deep contextualized representation learning

• Downloaded 477 times
• Download rankings, all-time:
  • Site-wide: 77,144
  • In bioinformatics: 7,069
• Year to date:
  • Site-wide: 136,049
• Since beginning of last month:
  • Site-wide: 104,255

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 77,453
  • In epidemiology: 3,404
• Year to date:
  • Site-wide: 50,360
• Since beginning of last month:
  • Site-wide: 51,928

Bio-JOIE: Joint Representation Learning of Biological Knowledge Bases

• Downloaded 472 times
• Download rankings, all-time:
  • Site-wide: 77,919
  • In bioinformatics: 7,129
• Year to date:
  • Site-wide: 79,911
• Since beginning of last month:
  • Site-wide: 80,574

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 80,920
  • In neuroscience: 11,928
• Year to date:
  • Site-wide: 123,763
• Since beginning of last month:
  • Site-wide: 123,215

Uncovering Medical Insights from Vast Amounts of Biomedical Data in Clinical Case Reports

• Downloaded 442 times
• Download rankings, all-time:
  • Site-wide: 83,732
  • In bioinformatics: 7,523
• Year to date:
  • Site-wide: 130,256
• Since beginning of last month:
  • Site-wide: 124,719

Surfaceome CRISPR Screen Identifies OLFML3 as a Rhinovirus-inducible IFN Antagonist

• Downloaded 433 times
• Download rankings, all-time:
  • Site-wide: 85,419
  • In molecular biology: 2,528
• Year to date:
  • Site-wide: 33,326
• Since beginning of last month:
  • Site-wide: 68,847

A multiethnic GWAS meta-analysis of 585,243 individuals identifies new risk loci associated with cataract and reveals sex-specific effects

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 86,620
  • In genetic and genomic medicine: 429
• Year to date:
  • Site-wide: 44,995
• Since beginning of last month:
  • Site-wide: 62,804

Dual functions of Discoidin domain receptor coordinate cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

• Downloaded 427 times
• Download rankings, all-time:
  • Site-wide: 86,674
  • In developmental biology: 2,270
• Year to date:
  • Site-wide: 128,636
• Since beginning of last month:
  • Site-wide: 117,354

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

• Downloaded 420 times
• Download rankings, all-time:
  • Site-wide: 88,062
  • In plant biology: 2,318
• Year to date:
  • Site-wide: 85,701
• Since beginning of last month:
  • Site-wide: 53,776

Recovery of Consciousness and Cognition after General Anesthesia in Humans

• Downloaded 417 times
• Download rankings, all-time:
  • Site-wide: 88,684
  • In neuroscience: 13,162
• Year to date:
  • Site-wide: 73,092
• Since beginning of last month:
  • Site-wide: 105,350

Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation

• Downloaded 414 times
• Download rankings, all-time:
  • Site-wide: 89,224
  • In genomics: 5,659
• Year to date:
  • Site-wide: 136,670
• Since beginning of last month:
  • Site-wide: 132,395

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

• Downloaded 412 times
• Download rankings, all-time:
  • Site-wide: 89,597
  • In microbiology: 6,067
• Year to date:
  • Site-wide: 86,695
• Since beginning of last month:
  • Site-wide: 103,892

Contextual Regression: An Accurate and Conveniently Interpretable Nonlinear Model for Mining Discovery from Scientific Data

• Downloaded 399 times
• Download rankings, all-time:
  • Site-wide: 92,428
  • In bioinformatics: 8,113
• Year to date:
  • Site-wide: 126,609
• Since beginning of last month:
  • Site-wide: 112,156

DTI-CDF: a CDF model towards the prediction of DTIs based on hybrid features

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 94,131
  • In bioinformatics: 8,218
• Year to date:
  • Site-wide: 137,867
• Since beginning of last month:
  • Site-wide: 127,921

Role of Water Mediated Interactions in Calcium-Coupled Allostery of Calmodulin Domains

• Downloaded 386 times
• Download rankings, all-time:
  • Site-wide: 95,381
  • In biochemistry: 2,758
• Year to date:
  • Site-wide: 102,173
• Since beginning of last month:
  • Site-wide: 101,575

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 96,080
  • In microbiology: 6,592
• Year to date:
  • Site-wide: 158,831
• Since beginning of last month:
  • Site-wide: 154,201

Structural basis for transfer RNA mimicry by a bacterial Y RNA

• Downloaded 381 times
• Download rankings, all-time:
  • Site-wide: 96,458
  • In biochemistry: 2,795
• Year to date:
  • Site-wide: 135,870
• Since beginning of last month:
  • Site-wide: 112,834

Screening of Botanical Drugs against SARS-CoV-2 Entry

• Downloaded 378 times
• Download rankings, all-time:
  • Site-wide: 97,315
  • In microbiology: 6,684
• Year to date:
  • Site-wide: 24,594
• Since beginning of last month:
  • Site-wide: 66,538

Comparative Transcriptomes Analysis of Taenia pisiformis at Different Development Stages

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 99,530
  • In molecular biology: 2,953
• Year to date:
  • Site-wide: 119,509
• Since beginning of last month:
  • Site-wide: 93,145

NEIL1 and NEIL2 DNA glycosylases regulate anxiety and learning in a cooperative manner

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 99,811
  • In molecular biology: 2,959
• Year to date:
  • Site-wide: 25,676
• Since beginning of last month:
  • Site-wide: 7,883

Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 101,058
  • In pathology: 527
• Year to date:
  • Site-wide: 78,267
• Since beginning of last month:
  • Site-wide: 43,655

Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study

• Downloaded 362 times
• Download rankings, all-time:
  • Site-wide: 100,918
  • In genetic and genomic medicine: 542
• Year to date:
  • Site-wide: 78,759
• Since beginning of last month:
  • Site-wide: 76,954

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

• Downloaded 361 times
• Download rankings, all-time:
  • Site-wide: 101,213
  • In psychiatry and clinical psychology: 441
• Year to date:
  • Site-wide: 81,787
• Since beginning of last month:
  • Site-wide: 66,084

An Analysis of Outbreak Dynamics and Intervention Effects for COVID-19 Transmission in Europe

• Downloaded 356 times
• Download rankings, all-time:
  • Site-wide: 102,552
  • In infectious diseases: 4,770
• Year to date:
  • Site-wide: 115,080
• Since beginning of last month:
  • Site-wide: 104,632

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 106,326
  • In neuroscience: 15,923
• Year to date:
  • Site-wide: 39,901
• Since beginning of last month:
  • Site-wide: 51,986

Testosterone Changes in Female Pandas in Estrus

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 106,232
  • In zoology: 414
• Year to date:
  • Site-wide: 98,587
• Since beginning of last month:
  • Site-wide: 126,081

The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 107,774
  • In molecular biology: 3,207
• Year to date:
  • Site-wide: 88,754
• Since beginning of last month:
  • Site-wide: 125,837

Sulforaphane modulates microRNA expression in colon cancer cells to implicate the regulation of oncogenes CDC25A, HMGA2 and MYC

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 108,703
  • In cancer biology: 3,289
• Year to date:
  • Site-wide: 145,578
• Since beginning of last month:
  • Site-wide: 122,790

Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq

• Downloaded 329 times
• Download rankings, all-time:
  • Site-wide: 109,219
  • In genomics: 6,370
• Year to date:
  • Site-wide: 148,320
• Since beginning of last month:
  • Site-wide: 147,806

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

• Downloaded 325 times
• Download rankings, all-time:
  • Site-wide: 110,178
  • In pharmacology and toxicology: 797
• Year to date:
  • Site-wide: 162,648
• Since beginning of last month:
  • Site-wide: 164,799

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

• Downloaded 307 times
• Download rankings, all-time:
  • Site-wide: 114,694
  • In pharmacology and toxicology: 846
• Year to date:
  • Site-wide: 164,532
• Since beginning of last month:
  • Site-wide: 159,458

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

• Downloaded 304 times
• Download rankings, all-time:
  • Site-wide: 115,459
  • In cell biology: 5,380
• Year to date:
  • Site-wide: 147,772
• Since beginning of last month:
  • Site-wide: 117,946

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

• Downloaded 302 times
• Download rankings, all-time:
  • Site-wide: 115,869
  • In infectious diseases: 5,129
• Year to date:
  • Site-wide: 34,014
• Since beginning of last month:
  • Site-wide: 38,634

Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 117,882
  • In developmental biology: 3,201
• Year to date:
  • Site-wide: 157,195
• Since beginning of last month:
  • Site-wide: 149,775

Impact of Retinopathy and Systemic Vascular Comorbidities on All-Cause Mortality

• Downloaded 291 times
• Download rankings, all-time:
  • Site-wide: 118,928
  • In ophthalmology: 133
• Year to date:
  • Site-wide: 35,800
• Since beginning of last month:
  • Site-wide: 86,609

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis

• Downloaded 289 times
• Download rankings, all-time:
  • Site-wide: 119,287
  • In developmental biology: 3,240
• Year to date:
  • Site-wide: 147,187
• Since beginning of last month:
  • Site-wide: 115,135

Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis

• Downloaded 285 times
• Download rankings, all-time:
  • Site-wide: 120,294
  • In neuroscience: 18,081
• Year to date:
  • Site-wide: 132,568
• Since beginning of last month:
  • Site-wide: 112,066

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary protein trafficking, Hedgehog signaling and embryogenesis

• Downloaded 277 times
• Download rankings, all-time:
  • Site-wide: 122,565
  • In genetics: 4,967
• Year to date:
  • Site-wide: 142,404
• Since beginning of last month:
  • Site-wide: 118,784

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 123,187
  • In neuroscience: 18,503
• Year to date:
  • Site-wide: 139,676
• Since beginning of last month:
  • Site-wide: 124,790

Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation

• Downloaded 274 times
• Download rankings, all-time:
  • Site-wide: 123,328
  • In biophysics: 4,709
• Year to date:
  • Site-wide: 116,194
• Since beginning of last month:
  • Site-wide: 144,288

Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 125,673
  • In cell biology: 5,830
• Year to date:
  • Site-wide: 125,508
• Since beginning of last month:
  • Site-wide: 104,591

Oncogenic Activation of AKT by MAPK6

• Downloaded 266 times
• Download rankings, all-time:
  • Site-wide: 125,610
  • In cancer biology: 3,819
• Year to date:
  • Site-wide: 93,259
• Since beginning of last month:
  • Site-wide: 59,808

Prediction of LncRNA Encoded Small Peptides in Glioma and The Oligomer Channel Functional Analysis Using in Silico Approaches

• Downloaded 236 times
• Download rankings, all-time:
  • Site-wide: 133,440
  • In biophysics: 5,105
• Year to date:
  • Site-wide: 120,357
• Since beginning of last month:
  • Site-wide: 126,448

Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers

• Downloaded 230 times
• Download rankings, all-time:
  • Site-wide: 134,936
  • In bioinformatics: 10,629
• Year to date:
  • Site-wide: 164,861
• Since beginning of last month:
  • Site-wide: 163,613

A universal approach for integrating super large-scale single-cell transcriptomes by exploring gene rankings

• Downloaded 226 times
• Download rankings, all-time:
  • Site-wide: 136,039
  • In bioinformatics: 10,684
• Year to date:
  • Site-wide: 50,060
• Since beginning of last month:
  • Site-wide: 95,810

The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 140,254
  • In physiology: 1,525
• Year to date:
  • Site-wide: 125,099
• Since beginning of last month:
  • Site-wide: 99,696

Brassinosteroids Promote Parenchyma Cell and Secondary Xylem Development in Sugar Beet (Beta vulgaris L.) Root

• Downloaded 194 times
• Download rankings, all-time:
  • Site-wide: 143,860
  • In plant biology: 4,027
• Year to date:
  • Site-wide: 100,925
• Since beginning of last month:
  • Site-wide: 100,002

RNAi screening reveals requirement for PDGFRβ in JEV infection.

• Downloaded 188 times
• Download rankings, all-time:
  • Site-wide: 145,181
  • In microbiology: 10,875
• Year to date:
  • Site-wide: 62,553
• Since beginning of last month:
  • Site-wide: 115,873

Limbal Niche Cells in Three-Dimensional Matrigel Induced Dedifferentiation of Mature Corneal Epithelial Cells toward a Progenitor State

• Downloaded 176 times
• Download rankings, all-time:
  • Site-wide: 147,969
  • In bioengineering: 3,048
• Year to date:
  • Site-wide: 123,895
• Since beginning of last month:
  • Site-wide: 108,252

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

• Downloaded 170 times
• Download rankings, all-time:
  • Site-wide: 149,165
  • In genetics: 5,819
• Year to date:
  • Site-wide: 103,973
• Since beginning of last month:
  • Site-wide: 99,997

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

• Downloaded 166 times
• Download rankings, all-time:
  • Site-wide: 149,891
  • In immunology: 4,550
• Year to date:
  • Site-wide: 71,993
• Since beginning of last month:
  • Site-wide: 85,852

Genome-wide identification of long non-coding RNAs in the gravid ectoparasite Varroa destructor

• Downloaded 161 times
• Download rankings, all-time:
  • Site-wide: 150,991
  • In genomics: 7,648
• Year to date:
  • Site-wide: 162,604
• Since beginning of last month:
  • Site-wide: 155,883

Stand-alone lipoylated H-protein of the glycine cleavage system enables glycine cleavage and the synthesis of glycine from one-carbon compounds in vitro

• Downloaded 160 times
• Download rankings, all-time:
  • Site-wide: 151,166
  • In biochemistry: 4,606
• Year to date:
  • Site-wide: 74,904
• Since beginning of last month:
  • Site-wide: 70,408

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

• Downloaded 155 times
• Download rankings, all-time:
  • Site-wide: 152,093
  • In microbiology: 11,515
• Year to date:
  • Site-wide: 96,184
• Since beginning of last month:
  • Site-wide: 85,973

Association of Visual Impairment with Risk for Future Parkinson's Disease

• Downloaded 154 times
• Download rankings, all-time:
  • Site-wide: 152,171
  • In epidemiology: 6,302
• Year to date:
  • Site-wide: 77,888
• Since beginning of last month:
  • Site-wide: 90,872

Screening of Botanical Drugs Against Lassa Virus Entry

• Downloaded 129 times
• Download rankings, all-time:
  • Site-wide: 156,415
  • In microbiology: 11,940
• Year to date:
  • Site-wide: 141,529
• Since beginning of last month:
  • Site-wide: 131,106

Epidemiological and Clinical Features, Treatment Status, and Economic Burden of Traumatic Spinal Cord Injury in China

• Downloaded 127 times
• Download rankings, all-time:
  • Site-wide: 156,797
  • In epidemiology: 6,477
• Year to date:
  • Site-wide: 94,183
• Since beginning of last month:
  • Site-wide: 16,952

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

• Downloaded 123 times
• Download rankings, all-time:
  • Site-wide: 157,246
  • In microbiology: 12,021
• Year to date:
  • Site-wide: 149,199
• Since beginning of last month:
  • Site-wide: 123,159

Identification of biomarkers and candidate inhibitors for multiple myeloma

• Downloaded 117 times
• Download rankings, all-time:
  • Site-wide: 158,077
  • In bioinformatics: 11,916
• Year to date:
  • Site-wide: 101,513
• Since beginning of last month:
  • Site-wide: 106,147

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

• Downloaded 114 times
• Download rankings, all-time:
  • Site-wide: 158,535
  • In microbiology: 12,139
• Year to date:
  • Site-wide: 103,719
• Since beginning of last month:
  • Site-wide: 49,438

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

• Downloaded 84 times
• Download rankings, all-time:
  • Site-wide: 161,806
  • In microbiology: 12,461
• Year to date:
  • Site-wide: 128,814
• Since beginning of last month:
  • Site-wide: 137,015

Mechanism through which retrocyclin targets flavivirus multiplication

• Downloaded 63 times
• Download rankings, all-time:
  • Site-wide: 163,464
  • In microbiology: 12,615
• Year to date:
  • Site-wide: 158,174
• Since beginning of last month:
  • Site-wide: 162,161

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

• Downloaded 53 times
• Download rankings, all-time:
  • Site-wide: 164,051
  • In microbiology: 12,676
• Year to date:
  • Site-wide: 153,033
• Since beginning of last month:
  • Site-wide: 139,182