Author: Guy A Rutter

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Preprints

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

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β-cell dedifferentiation is associated with epithelial-mesenchymal transition triggered by miR-7-mediated repression of mSwi/Snf complex

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Agonist binding affinity determines palmitoylation of the glucagon-like peptide-1 receptor and its functional interaction with plasma membrane nanodomains in pancreatic beta cells

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Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve mitochondrial architecture and insulin secretion

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Differences in signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

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DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation.

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The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

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Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

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Signal bias at glucagon family receptors: rationale and downstream impacts

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Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse

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The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists

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The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

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Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

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Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

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Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice

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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

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Bariatric surgery normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

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Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

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Replication and cross-validation of T2D subtypes based on clinical variables: an IMI-RHAPSODY study

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The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic β-cell identity and function.

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