Author: Kent Taylor

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Preprints

An open resource of structural variation for medical and population genetics

• Downloaded 11,229 times
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  • Site-wide: 832
  • In genomics: 57
• Year to date:
  • Site-wide: 9,984
• Since beginning of last month:
  • Site-wide: 8,599

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 8,465 times
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  • Site-wide: 1,202
  • In genomics: 97
• Year to date:
  • Site-wide: 3,936
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  • Site-wide: 57,857

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,352 times
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  • Site-wide: 4,200
  • In genetics: 154
• Year to date:
  • Site-wide: 44,104
• Since beginning of last month:
  • Site-wide: 19,358

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,277 times
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  • Site-wide: 4,344
  • In genomics: 443
• Year to date:
  • Site-wide: 89,795
• Since beginning of last month:
  • Site-wide: 99,214

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,216 times
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  • Site-wide: 4,477
  • In genetics: 171
• Year to date:
  • Site-wide: 37,030
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  • Site-wide: 103,743

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 3,094 times
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  • Site-wide: 4,719
  • In genomics: 488
• Year to date:
  • Site-wide: 10,255
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  • Site-wide: 88,996

Genotyping common, large structural variations in 5,202 genomes using pangenomes, the Giraffe mapper, and the vg toolkit

• Downloaded 1,941 times
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  • Site-wide: 9,291
  • In bioinformatics: 1,057
• Year to date:
  • Site-wide: 2,687
• Since beginning of last month:
  • Site-wide: 52,624

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,896 times
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  • Site-wide: 9,641
  • In genetics: 418
• Year to date:
  • Site-wide: 92,091
• Since beginning of last month:
  • Site-wide: 31,941

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,750 times
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  • Site-wide: 10,834
  • In genetics: 478
• Year to date:
  • Site-wide: 54,153
• Since beginning of last month:
  • Site-wide: 19,849

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 1,578 times
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  • Site-wide: 12,594
  • In hiv aids: 7
• Year to date:
  • Site-wide: 5,549
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  • Site-wide: 24,492

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,496 times
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  • Site-wide: 13,614
  • In genetics: 620
• Year to date:
  • Site-wide: 114,206
• Since beginning of last month:
  • Site-wide: 100,386

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,478 times
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  • Site-wide: 13,875
  • In genetic and genomic medicine: 62
• Year to date:
  • Site-wide: 6,261
• Since beginning of last month:
  • Site-wide: 9,564

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 1,138 times
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  • Site-wide: 20,578
  • In genetics: 943
• Year to date:
  • Site-wide: 9,021
• Since beginning of last month:
  • Site-wide: 5,996

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 993 times
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  • Site-wide: 25,110
  • In genetics: 1,140
• Year to date:
  • Site-wide: 25,488
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  • Site-wide: 119,416

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 908 times
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  • Site-wide: 28,581
  • In gastroenterology: 26
• Year to date:
  • Site-wide: 33,959
• Since beginning of last month:
  • Site-wide: 21,987

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

• Downloaded 896 times
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  • Site-wide: 29,094
  • In genomics: 2,582
• Year to date:
  • Site-wide: 53,525
• Since beginning of last month:
  • Site-wide: 13,584

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 861 times
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  • Site-wide: 30,806
  • In genetics: 1,416
• Year to date:
  • Site-wide: 86,936
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  • Site-wide: 87,471

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 799 times
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  • Site-wide: 34,147
  • In genomics: 2,910
• Year to date:
  • Site-wide: 79,007
• Since beginning of last month:
  • Site-wide: 38,987

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 776 times
• Download rankings, all-time:
  • Site-wide: 35,625
  • In genomics: 2,997
• Year to date:
  • Site-wide: 117,854
• Since beginning of last month:
  • Site-wide: 104,866

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 39,214
  • In genetics: 1,765
• Year to date:
  • Site-wide: 147,731
• Since beginning of last month:
  • Site-wide: 113,206

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 692 times
• Download rankings, all-time:
  • Site-wide: 41,605
  • In genomics: 3,358
• Year to date:
  • Site-wide: 107,152
• Since beginning of last month:
  • Site-wide: 57,718

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 651 times
• Download rankings, all-time:
  • Site-wide: 45,078
  • In genetics: 2,017
• Year to date:
  • Site-wide: 93,603
• Since beginning of last month:
  • Site-wide: 35,854

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 631 times
• Download rankings, all-time:
  • Site-wide: 46,921
  • In genetics: 2,093
• Year to date:
  • Site-wide: 125,881
• Since beginning of last month:
  • Site-wide: 64,907

Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality

• Downloaded 586 times
• Download rankings, all-time:
  • Site-wide: 51,468
  • In genetics: 2,273
• Year to date:
  • Site-wide: 7,303
• Since beginning of last month:
  • Site-wide: 76,682

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 518 times
• Download rankings, all-time:
  • Site-wide: 59,883
  • In genomics: 4,377
• Year to date:
  • Site-wide: 146,771
• Since beginning of last month:
  • Site-wide: None

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 499 times
• Download rankings, all-time:
  • Site-wide: 62,408
  • In genetics: 2,758
• Year to date:
  • Site-wide: 23,513
• Since beginning of last month:
  • Site-wide: 43,323

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 483 times
• Download rankings, all-time:
  • Site-wide: 64,639
  • In genetics: 2,851
• Year to date:
  • Site-wide: 150,090
• Since beginning of last month:
  • Site-wide: None

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 460 times
• Download rankings, all-time:
  • Site-wide: 68,186
  • In genetic and genomic medicine: 281
• Year to date:
  • Site-wide: 24,951
• Since beginning of last month:
  • Site-wide: 42,238

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 77,466
  • In epidemiology: 3,332
• Year to date:
  • Site-wide: 98,528
• Since beginning of last month:
  • Site-wide: 41,179

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 91,832
  • In epidemiology: 3,876
• Year to date:
  • Site-wide: 64,303
• Since beginning of last month:
  • Site-wide: 126,684

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 93,652
  • In genetics: 4,037
• Year to date:
  • Site-wide: 17,198
• Since beginning of last month:
  • Site-wide: 10,173

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 96,434
  • In epidemiology: 4,079
• Year to date:
  • Site-wide: 18,154
• Since beginning of last month:
  • Site-wide: 95,515

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

• Downloaded 310 times
• Download rankings, all-time:
  • Site-wide: 97,205
  • In genetics: 4,168
• Year to date:
  • Site-wide: 113,833
• Since beginning of last month:
  • Site-wide: 23,879

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 290 times
• Download rankings, all-time:
  • Site-wide: 101,910
  • In genetic and genomic medicine: 488
• Year to date:
  • Site-wide: 20,205
• Since beginning of last month:
  • Site-wide: 52,507

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 275 times
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  • Site-wide: 105,487
  • In genetics: 4,475
• Year to date:
  • Site-wide: 151,606
• Since beginning of last month:
  • Site-wide: None

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 267 times
• Download rankings, all-time:
  • Site-wide: 107,308
  • In genetics: 4,545
• Year to date:
  • Site-wide: 152,602
• Since beginning of last month:
  • Site-wide: 106,189

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 117,508
  • In genetic and genomic medicine: 620
• Year to date:
  • Site-wide: 28,144
• Since beginning of last month:
  • Site-wide: 59,903

Protein prediction for trait mapping in diverse populations

• Downloaded 152 times
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  • Site-wide: 135,498
  • In genomics: 7,163
• Year to date:
  • Site-wide: 45,321
• Since beginning of last month:
  • Site-wide: 1,802

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

• Downloaded 118 times
• Download rankings, all-time:
  • Site-wide: 142,678
  • In genetic and genomic medicine: 815
• Year to date:
  • Site-wide: 58,620
• Since beginning of last month:
  • Site-wide: None