Author: Kent D. Taylor

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Preprints

An open resource of structural variation for medical and population genetics

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  • Site-wide: 712
  • In genomics: 53
• Year to date:
  • Site-wide: 8,335
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  • Site-wide: 11,058

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 1,043
  • In genomics: 94
• Year to date:
  • Site-wide: 2,209
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  • Site-wide: 4,938

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

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  • Site-wide: 3,681
  • In genetics: 152
• Year to date:
  • Site-wide: 40,888
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  • Site-wide: 87,175

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,247 times
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  • Site-wide: 3,700
  • In genomics: 417
• Year to date:
  • Site-wide: 59,351
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  • Site-wide: 43,131

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,082 times
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  • Site-wide: 3,980
  • In genetics: 168
• Year to date:
  • Site-wide: 54,748
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  • Site-wide: 75,074

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

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  • Site-wide: 4,296
  • In genomics: 478
• Year to date:
  • Site-wide: 6,528
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  • Site-wide: 6,387

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,851 times
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  • Site-wide: 8,394
  • In genetics: 393
• Year to date:
  • Site-wide: 88,409
• Since beginning of last month:
  • Site-wide: 89,295

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,660 times
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  • Site-wide: 9,876
  • In genetics: 469
• Year to date:
  • Site-wide: 64,920
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  • Site-wide: 46,031

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 11,714
  • In genetics: 569
• Year to date:
  • Site-wide: 80,258
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  • Site-wide: 79,422

Genotyping common, large structural variations in 5,202 genomes using pangenomes, the Giraffe mapper, and the vg toolkit

• Downloaded 1,446 times
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  • Site-wide: 12,079
  • In bioinformatics: 1,479
• Year to date:
  • Site-wide: 1,943
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  • Site-wide: 3,530

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 1,121 times
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  • Site-wide: 17,766
  • In hiv aids: 8
• Year to date:
  • Site-wide: 8,038
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  • Site-wide: 5,591

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,083 times
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  • Site-wide: 18,690
  • In genetic and genomic medicine: 64
• Year to date:
  • Site-wide: 7,845
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  • Site-wide: 9,541

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,365
  • In genetics: 1,226
• Year to date:
  • Site-wide: 19,450
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  • Site-wide: 11,141

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

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  • Site-wide: 27,610
  • In genetics: 1,338
• Year to date:
  • Site-wide: 62,860
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  • Site-wide: 71,870

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

• Downloaded 814 times
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  • Site-wide: 28,153
  • In genomics: 2,601
• Year to date:
  • Site-wide: 53,082
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  • Site-wide: 43,533

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 797 times
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  • Site-wide: 28,963
  • In gastroenterology: 22
• Year to date:
  • Site-wide: 31,682
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  • Site-wide: 42,006

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 794 times
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  • Site-wide: 29,108
  • In genetics: 1,412
• Year to date:
  • Site-wide: 14,171
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  • Site-wide: 10,831

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 751 times
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  • Site-wide: 31,480
  • In genomics: 2,815
• Year to date:
  • Site-wide: 95,331
• Since beginning of last month:
  • Site-wide: 112,443

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 747 times
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  • Site-wide: 31,760
  • In genomics: 2,826
• Year to date:
  • Site-wide: 72,336
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  • Site-wide: 86,374

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 713 times
• Download rankings, all-time:
  • Site-wide: 33,770
  • In genetics: 1,634
• Year to date:
  • Site-wide: 120,987
• Since beginning of last month:
  • Site-wide: 110,876

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 667 times
• Download rankings, all-time:
  • Site-wide: 37,041
  • In genomics: 3,150
• Year to date:
  • Site-wide: 75,782
• Since beginning of last month:
  • Site-wide: 108,325

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 617 times
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  • Site-wide: 40,924
  • In genetics: 1,943
• Year to date:
  • Site-wide: 5,053
• Since beginning of last month:
  • Site-wide: 15,877

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 613 times
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  • Site-wide: 41,249
  • In genetics: 1,953
• Year to date:
  • Site-wide: 77,774
• Since beginning of last month:
  • Site-wide: 71,584

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 607 times
• Download rankings, all-time:
  • Site-wide: 41,777
  • In genetics: 1,980
• Year to date:
  • Site-wide: 110,894
• Since beginning of last month:
  • Site-wide: 89,308

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 506 times
• Download rankings, all-time:
  • Site-wide: 52,124
  • In genomics: 4,040
• Year to date:
  • Site-wide: 121,832
• Since beginning of last month:
  • Site-wide: 121,776

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 476 times
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  • Site-wide: 55,873
  • In genetics: 2,589
• Year to date:
  • Site-wide: 118,483
• Since beginning of last month:
  • Site-wide: 130,956

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 368 times
• Download rankings, all-time:
  • Site-wide: 72,184
  • In epidemiology: 3,031
• Year to date:
  • Site-wide: 87,302
• Since beginning of last month:
  • Site-wide: 71,900

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 320 times
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  • Site-wide: 81,180
  • In genetic and genomic medicine: 285
• Year to date:
  • Site-wide: 23,874
• Since beginning of last month:
  • Site-wide: 21,430

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 293 times
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  • Site-wide: 86,663
  • In epidemiology: 3,557
• Year to date:
  • Site-wide: 39,976
• Since beginning of last month:
  • Site-wide: 54,051

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 292 times
• Download rankings, all-time:
  • Site-wide: 86,850
  • In genetics: 3,932
• Year to date:
  • Site-wide: 49,920
• Since beginning of last month:
  • Site-wide: None

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

• Downloaded 274 times
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  • Site-wide: 90,693
  • In genetics: 4,096
• Year to date:
  • Site-wide: 117,923
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  • Site-wide: 102,703

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 269 times
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  • Site-wide: 91,971
  • In genetics: 4,133
• Year to date:
  • Site-wide: 121,192
• Since beginning of last month:
  • Site-wide: 104,841

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 259 times
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  • Site-wide: 94,202
  • In genetics: 4,223
• Year to date:
  • Site-wide: 129,914
• Since beginning of last month:
  • Site-wide: 127,784

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 178 times
• Download rankings, all-time:
  • Site-wide: 111,875
  • In genetic and genomic medicine: 498
• Year to date:
  • Site-wide: 12,821
• Since beginning of last month:
  • Site-wide: 37,999

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 171 times
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  • Site-wide: 113,419
  • In genetic and genomic medicine: 513
• Year to date:
  • Site-wide: 13,477
• Since beginning of last month:
  • Site-wide: 42,391

The Socioeconomic Gradient in Epigenetic Aging Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study

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  • Site-wide: 114,682
  • In epidemiology: 4,721
• Year to date:
  • Site-wide: 14,086
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  • Site-wide: 4,085

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL Study

• Downloaded 81 times
• Download rankings, all-time:
  • Site-wide: 130,262
  • In genetic and genomic medicine: 639
• Year to date:
  • Site-wide: 32,395
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  • Site-wide: 24,535