Author: Kent D Taylor

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Preprints

An open resource of structural variation for medical and population genetics

• Downloaded 10,797 times
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  • Site-wide: 605
  • In genomics: 49
• Year to date:
  • Site-wide: 2,949
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  • Site-wide: 5,070

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 7,638 times
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  • Site-wide: 961
  • In genomics: 93
• Year to date:
  • Site-wide: 1,466
• Since beginning of last month:
  • Site-wide: 1,514

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

• Downloaded 3,210 times
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  • Site-wide: 3,236
  • In genetics: 144
• Year to date:
  • Site-wide: 13,294
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  • Site-wide: 32,140

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Downloaded 3,206 times
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  • Site-wide: 3,244
  • In genomics: 387
• Year to date:
  • Site-wide: 61,984
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  • Site-wide: 72,297

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,027 times
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  • Site-wide: 3,510
  • In genetics: 165
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 56,089

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,578 times
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  • Site-wide: 4,384
  • In genomics: 529
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  • Site-wide: None
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  • Site-wide: 20,787

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

• Downloaded 1,833 times
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  • Site-wide: 7,287
  • In genetics: 364
• Year to date:
  • Site-wide: 25,398
• Since beginning of last month:
  • Site-wide: 76,486

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,627 times
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  • Site-wide: 8,711
  • In genetics: 450
• Year to date:
  • Site-wide: 37,292
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  • Site-wide: 26,510

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

• Downloaded 1,455 times
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  • Site-wide: 10,284
  • In genetics: 525
• Year to date:
  • Site-wide: 18,488
• Since beginning of last month:
  • Site-wide: 50,641

A high-resolution HLA reference panel capturing global population diversity enables multi-ethnic fine-mapping in HIV host response

• Downloaded 889 times
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  • Site-wide: 21,510
  • In hiv aids: 9
• Year to date:
  • Site-wide: 8,155
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  • Site-wide: 4,391

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 853 times
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  • Site-wide: 22,839
  • In genetic and genomic medicine: 61
• Year to date:
  • Site-wide: 5,428
• Since beginning of last month:
  • Site-wide: 3,977

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 785 times
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  • Site-wide: 25,659
  • In genetics: 1,308
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 90,457

Mitochondrial DNA Copy Number (mtDNA-CN) Can Influence Mortality and Cardiovascular Disease via Methylation of Nuclear DNA CpGs

• Downloaded 774 times
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  • Site-wide: 26,131
  • In genomics: 2,508
• Year to date:
  • Site-wide: 22,066
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  • Site-wide: 43,695

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

• Downloaded 764 times
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  • Site-wide: 26,562
  • In genetics: 1,354
• Year to date:
  • Site-wide: 10,466
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  • Site-wide: 16,893

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

• Downloaded 726 times
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  • Site-wide: 28,644
  • In genomics: 2,659
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 107,381

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 723 times
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  • Site-wide: 28,779
  • In genomics: 2,675
• Year to date:
  • Site-wide: 18,574
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  • Site-wide: 30,759

rs641738C>T near MBOAT7 promotes steatosis, NASH, fibrosis and hepatocellular carcinoma in non-alcoholic fatty liver disease: a meta-analysis

• Downloaded 721 times
• Download rankings, all-time:
  • Site-wide: 28,866
  • In gastroenterology: 20
• Year to date:
  • Site-wide: 24,784
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  • Site-wide: 10,256

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 695 times
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  • Site-wide: 30,387
  • In genetics: 1,541
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 99,669

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

• Downloaded 645 times
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  • Site-wide: 33,569
  • In genetics: 1,694
• Year to date:
  • Site-wide: 10,933
• Since beginning of last month:
  • Site-wide: 7,775

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 626 times
• Download rankings, all-time:
  • Site-wide: 34,910
  • In genomics: 3,068
• Year to date:
  • Site-wide: None
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  • Site-wide: 84,364

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

• Downloaded 591 times
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  • Site-wide: 37,501
  • In genetics: 1,870
• Year to date:
  • Site-wide: 64,250
• Since beginning of last month:
  • Site-wide: 93,459

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 587 times
• Download rankings, all-time:
  • Site-wide: 37,895
  • In genetics: 1,877
• Year to date:
  • Site-wide: 41,182
• Since beginning of last month:
  • Site-wide: 46,664

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 491 times
• Download rankings, all-time:
  • Site-wide: 46,968
  • In genomics: 3,791
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 112,771

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

• Downloaded 462 times
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  • Site-wide: 50,404
  • In genetics: 2,463
• Year to date:
  • Site-wide: 358
• Since beginning of last month:
  • Site-wide: 953

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 460 times
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  • Site-wide: 50,563
  • In genetics: 2,470
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 106,922

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 345 times
• Download rankings, all-time:
  • Site-wide: 67,208
  • In epidemiology: 2,736
• Year to date:
  • Site-wide: 57,972
• Since beginning of last month:
  • Site-wide: 89,971

Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

• Downloaded 263 times
• Download rankings, all-time:
  • Site-wide: 82,590
  • In genetics: 3,860
• Year to date:
  • Site-wide: 48,105
• Since beginning of last month:
  • Site-wide: 75,285

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

• Downloaded 254 times
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  • Site-wide: 84,536
  • In genetics: 3,938
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 102,416

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 254 times
• Download rankings, all-time:
  • Site-wide: 84,502
  • In genetics: 3,937
• Year to date:
  • Site-wide: 41,349
• Since beginning of last month:
  • Site-wide: 94,830

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 225 times
• Download rankings, all-time:
  • Site-wide: 90,536
  • In genetics: 4,208
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 36,985

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 221 times
• Download rankings, all-time:
  • Site-wide: 91,348
  • In genetic and genomic medicine: 303
• Year to date:
  • Site-wide: 18,986
• Since beginning of last month:
  • Site-wide: 6,247

Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries

• Downloaded 209 times
• Download rankings, all-time:
  • Site-wide: 93,799
  • In epidemiology: 3,752
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 63,679

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

• Downloaded 80 times
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  • Site-wide: 117,547
  • In genetic and genomic medicine: 511
• Year to date:
  • Site-wide: 1,246
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  • Site-wide: None

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

• Downloaded 33 times
• Download rankings, all-time:
  • Site-wide: 122,120
  • In genetic and genomic medicine: 538
• Year to date:
  • Site-wide: 4,084
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  • Site-wide: None