Author: Gerome Breen

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 754
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• Year to date:
  • Site-wide: 22,103
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  • Site-wide: 23,410

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 1,676
  • In genetics: 67
• Year to date:
  • Site-wide: 10,932
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  • Site-wide: 19,032

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 1,914
  • In genomics: 216
• Year to date:
  • Site-wide: 5,552
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  • Site-wide: 13,306

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 1,971
  • In genetics: 80
• Year to date:
  • Site-wide: 86,170
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  • Site-wide: 59,796

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

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  • Site-wide: 2,371
  • In genomics: 288
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  • Site-wide: 8,120
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  • Site-wide: 26,595

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • Site-wide: 2,808
  • In genomics: 344
• Year to date:
  • Site-wide: 50,422
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  • Site-wide: 71,384

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 5,081
  • In genetic and genomic medicine: 12
• Year to date:
  • Site-wide: 1,096
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  • Site-wide: 1,396

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • Site-wide: 6,216
  • In genetics: 314
• Year to date:
  • Site-wide: 4,713
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  • Site-wide: 9,258

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

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  • Site-wide: 6,601
  • In genomics: 763
• Year to date:
  • Site-wide: 20,755
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  • Site-wide: 31,513

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

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  • Site-wide: 8,155
  • In genetics: 409
• Year to date:
  • Site-wide: 35,809
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  • Site-wide: 51,607

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,087
  • In genetics: 464
• Year to date:
  • Site-wide: 11,839
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  • Site-wide: 25,774

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 10,808
  • In genomics: 1,227
• Year to date:
  • Site-wide: 72,512
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  • Site-wide: 103,094

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

• Downloaded 1,319 times
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  • Site-wide: 12,215
  • In psychiatry and clinical psychology: 35
• Year to date:
  • Site-wide: 3,973
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  • Site-wide: 2,533

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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  • Site-wide: 15,796
  • In genetics: 818
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  • Site-wide: 60,381
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  • Site-wide: 69,991

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • Site-wide: 18,484
  • In genomics: 1,931
• Year to date:
  • Site-wide: 78,207
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  • Site-wide: 92,064

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

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  • Site-wide: 20,397
  • In genetics: 1,023
• Year to date:
  • Site-wide: 121,435
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  • Site-wide: 77,872

FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations

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  • Site-wide: 24,766
  • In genetics: 1,245
• Year to date:
  • Site-wide: 45,371
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  • Site-wide: 37,592

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 24,810
  • In genetics: 1,252
• Year to date:
  • Site-wide: 81,687
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  • Site-wide: 64,638

Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders

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  • Site-wide: 32,308
  • In genetics: 1,621
• Year to date:
  • Site-wide: 9,520
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  • Site-wide: 9,982

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,614
  • In genetics: 1,677
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  • Site-wide: 6,362
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  • Site-wide: 15,414

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

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  • Site-wide: 38,030
  • In genomics: 3,243
• Year to date:
  • Site-wide: 16,336
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  • Site-wide: 34,364

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

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  • Site-wide: 39,109
  • In genomics: 3,308
• Year to date:
  • Site-wide: 71,965
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  • Site-wide: 105,120

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • Site-wide: 41,025
  • In genetics: 2,005
• Year to date:
  • Site-wide: 36,579
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  • Site-wide: 81,859

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 513 times
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  • Site-wide: 45,578
  • In genetics: 2,219
• Year to date:
  • Site-wide: 58,279
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  • Site-wide: 108,046

Genetic effects on educational attainment in Hungary

• Downloaded 438 times
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  • Site-wide: 54,558
  • In genetics: 2,621
• Year to date:
  • Site-wide: 39,890
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  • Site-wide: 57,137

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

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  • Site-wide: 55,490
  • In genetics: 2,668
• Year to date:
  • Site-wide: 62,223
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  • Site-wide: 71,014

Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

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  • Site-wide: 63,352
  • In genomics: 4,572
• Year to date:
  • Site-wide: 7,935
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  • Site-wide: 20,856

Genomic Influences on Self-Reported Childhood Maltreatment

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  • Site-wide: 65,454
  • In genomics: 4,673
• Year to date:
  • Site-wide: 121,403
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  • Site-wide: 69,154

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 331 times
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  • Site-wide: 71,010
  • In genetic and genomic medicine: 196
• Year to date:
  • Site-wide: 10,060
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  • Site-wide: 1,164

Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

• Downloaded 279 times
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  • Site-wide: 80,863
  • In psychiatry and clinical psychology: 236
• Year to date:
  • Site-wide: 64,895
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  • Site-wide: 78,013

Genes associated with neuropsychiatric disease increase vulnerability to abnormal deep grey matter development

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  • Site-wide: 83,757
  • In neuroscience: 13,163
• Year to date:
  • Site-wide: 100,272
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  • Site-wide: 93,104

Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk

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  • Site-wide: 93,417
  • In genomics: 5,727
• Year to date:
  • Site-wide: 10,570
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  • Site-wide: 2,238