Author: Inti Pedroso

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 1,395
  • In genetics: 27
• Year to date:
  • Site-wide: 26,127
• Since beginning of last month:
  • Site-wide: 21,650

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

• Downloaded 9,281 times
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  • Site-wide: 1,516
  • In genetic and genomic medicine: 8
• Year to date:
  • Site-wide: 2,721
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  • Site-wide: 1,210

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

• Downloaded 5,827 times
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  • Site-wide: 2,830
  • In genetics: 79
• Year to date:
  • Site-wide: 7,032
• Since beginning of last month:
  • Site-wide: 30,024

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 5,261 times
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  • Site-wide: 3,280
  • In genomics: 280
• Year to date:
  • Site-wide: 19,169
• Since beginning of last month:
  • Site-wide: 33,218

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

• Downloaded 4,791 times
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  • Site-wide: 3,713
  • In genomics: 330
• Year to date:
  • Site-wide: 17,211
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  • Site-wide: 60,171

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,741 times
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  • Site-wide: 3,766
  • In genetics: 105
• Year to date:
  • Site-wide: 38,168
• Since beginning of last month:
  • Site-wide: 149,031

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

• Downloaded 3,730 times
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  • Site-wide: 5,313
  • In genomics: 491
• Year to date:
  • Site-wide: 163,165
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  • Site-wide: 117,031

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

• Downloaded 3,707 times
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  • Site-wide: 5,354
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 12,539
• Since beginning of last month:
  • Site-wide: 19,090

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

• Downloaded 3,261 times
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  • Site-wide: 6,498
  • In genetics: 232
• Year to date:
  • Site-wide: 15,194
• Since beginning of last month:
  • Site-wide: 9,701

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

• Downloaded 2,300 times
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  • Site-wide: 10,877
  • In genomics: 992
• Year to date:
  • Site-wide: 102,310
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  • Site-wide: 90,932

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

• Downloaded 2,273 times
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  • Site-wide: 11,082
  • In genetics: 420
• Year to date:
  • Site-wide: 7,554
• Since beginning of last month:
  • Site-wide: 13,146

Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity

• Downloaded 2,181 times
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  • Site-wide: 11,822
  • In neurology: 36
• Year to date:
  • Site-wide: 13,341
• Since beginning of last month:
  • Site-wide: 70,978

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

• Downloaded 1,941 times
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  • Site-wide: 14,086
  • In genetics: 556
• Year to date:
  • Site-wide: 144,662
• Since beginning of last month:
  • Site-wide: 92,900

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,624 times
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  • Site-wide: 18,601
  • In genomics: 1,676
• Year to date:
  • Site-wide: 139,225
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  • Site-wide: 51,703

Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

• Downloaded 1,442 times
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  • Site-wide: 22,488
  • In genomics: 1,941
• Year to date:
  • Site-wide: 156,976
• Since beginning of last month:
  • Site-wide: 189,231

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,277 times
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  • Site-wide: 27,350
  • In genetics: 1,093
• Year to date:
  • Site-wide: 47,590
• Since beginning of last month:
  • Site-wide: 178,066

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 1,166 times
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  • Site-wide: 31,539
  • In genetics: 1,278
• Year to date:
  • Site-wide: 31,697
• Since beginning of last month:
  • Site-wide: 43,274

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

• Downloaded 1,156 times
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  • Site-wide: 31,982
  • In genomics: 2,649
• Year to date:
  • Site-wide: 100,553
• Since beginning of last month:
  • Site-wide: 178,940

Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)

• Downloaded 1,137 times
• Download rankings, all-time:
  • Site-wide: 32,797
  • In infectious diseases: 2,980
• Year to date:
  • Site-wide: 128,755
• Since beginning of last month:
  • Site-wide: 104,110

FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations

• Downloaded 1,116 times
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  • Site-wide: 33,790
  • In genetics: 1,344
• Year to date:
  • Site-wide: 80,770
• Since beginning of last month:
  • Site-wide: 207,503

Genome-wide association study identifies new locus associated with OCD

• Downloaded 1,096 times
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  • Site-wide: 34,698
  • In psychiatry and clinical psychology: 149
• Year to date:
  • Site-wide: 16,599
• Since beginning of last month:
  • Site-wide: 11,230

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

• Downloaded 1,029 times
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  • Site-wide: 38,259
  • In genetics: 1,504
• Year to date:
  • Site-wide: 163,419
• Since beginning of last month:
  • Site-wide: 209,418

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 979 times
• Download rankings, all-time:
  • Site-wide: 41,311
  • In genetics: 1,628
• Year to date:
  • Site-wide: 166,743
• Since beginning of last month:
  • Site-wide: 202,327

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 938 times
• Download rankings, all-time:
  • Site-wide: 44,143
  • In genetic and genomic medicine: 273
• Year to date:
  • Site-wide: 92,473
• Since beginning of last month:
  • Site-wide: 110,454

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

• Downloaded 934 times
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  • Site-wide: 44,401
  • In genomics: 3,434
• Year to date:
  • Site-wide: 39,175
• Since beginning of last month:
  • Site-wide: 34,464

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

• Downloaded 838 times
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  • Site-wide: 52,440
  • In genetics: 2,055
• Year to date:
  • Site-wide: 53,321
• Since beginning of last month:
  • Site-wide: 214,073

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

• Downloaded 766 times
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  • Site-wide: 59,940
  • In genetics: 2,365
• Year to date:
  • Site-wide: 26,705
• Since beginning of last month:
  • Site-wide: 79,615

Genetic effects on educational attainment in Hungary

• Downloaded 715 times
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  • Site-wide: 66,255
  • In genetics: 2,599
• Year to date:
  • Site-wide: 45,892
• Since beginning of last month:
  • Site-wide: 39,505

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 66,741
  • In genomics: 4,554
• Year to date:
  • Site-wide: 197,683
• Since beginning of last month:
  • Site-wide: 151,822

Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

• Downloaded 665 times
• Download rankings, all-time:
  • Site-wide: 73,428
  • In psychiatry and clinical psychology: 348
• Year to date:
  • Site-wide: 26,717
• Since beginning of last month:
  • Site-wide: 39,917

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 647 times
• Download rankings, all-time:
  • Site-wide: 76,118
  • In genetics: 2,922
• Year to date:
  • Site-wide: 163,400
• Since beginning of last month:
  • Site-wide: 150,890

Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk

• Downloaded 512 times
• Download rankings, all-time:
  • Site-wide: 101,728
  • In genomics: 6,088
• Year to date:
  • Site-wide: 113,009
• Since beginning of last month:
  • Site-wide: 170,898

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 453 times
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  • Site-wide: 115,874
  • In genomics: 6,665
• Year to date:
  • Site-wide: 143,515
• Since beginning of last month:
  • Site-wide: 197,986

Reliability of multi-modal MRI-derived brain phenotypes for multi-site assessment of neuropsychiatric complications of SARS-CoV-2 infection

• Downloaded 428 times
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  • Site-wide: 122,480
  • In neurology: 636
• Year to date:
  • Site-wide: 25,101
• Since beginning of last month:
  • Site-wide: 41,561

Genes associated with neuropsychiatric disease increase vulnerability to abnormal deep grey matter development

• Downloaded 374 times
• Download rankings, all-time:
  • Site-wide: 137,898
  • In neuroscience: 20,220
• Year to date:
  • Site-wide: 174,146
• Since beginning of last month:
  • Site-wide: 153,759

Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures

• Downloaded 174 times
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  • Site-wide: 193,701
  • In health informatics: 924
• Year to date:
  • Site-wide: 150,159
• Since beginning of last month:
  • Site-wide: 56,689

Longitudinal gut microbial signals are associated with weight loss: insights from a digital therapeutics program

• Downloaded 84 times
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  • Site-wide: 210,828
  • In nutrition: None
• Year to date:
  • Site-wide: 1,693
• Since beginning of last month:
  • Site-wide: None