Author: Gerome Breen

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 872
  • In genetics: 26
• Year to date:
  • Site-wide: 32,644
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  • Site-wide: 35,921

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 1,874
  • In genetics: 68
• Year to date:
  • Site-wide: 19,110
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  • Site-wide: 16,788

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,137
  • In genomics: 225
• Year to date:
  • Site-wide: 15,395
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  • Site-wide: 18,257

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 2,256
  • In genetics: 82
• Year to date:
  • Site-wide: 80,267
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  • Site-wide: 104,015

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

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  • Site-wide: 2,573
  • In genomics: 287
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  • Site-wide: 11,279
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  • Site-wide: 12,605

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • Site-wide: 3,205
  • In genomics: 361
• Year to date:
  • Site-wide: 74,238
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  • Site-wide: 60,796

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 3,534
  • In genetic and genomic medicine: 11
• Year to date:
  • Site-wide: 1,013
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  • Site-wide: 1,139

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • Site-wide: 6,240
  • In genetics: 295
• Year to date:
  • Site-wide: 8,813
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  • Site-wide: 9,668

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 6,889
  • In psychiatry and clinical psychology: 23
• Year to date:
  • Site-wide: 1,444
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  • Site-wide: 851

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

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  • Site-wide: 7,369
  • In genomics: 802
• Year to date:
  • Site-wide: 49,553
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  • Site-wide: 62,594

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

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  • Site-wide: 8,929
  • In genetics: 424
• Year to date:
  • Site-wide: 40,360
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  • Site-wide: 34,499

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,401
  • In genetics: 449
• Year to date:
  • Site-wide: 18,807
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  • Site-wide: 17,216

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

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  • Site-wide: 11,966
  • In genomics: 1,299
• Year to date:
  • Site-wide: 75,279
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  • Site-wide: 76,635

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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  • Site-wide: 17,396
  • In genetics: 849
• Year to date:
  • Site-wide: 74,931
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  • Site-wide: 70,427

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • Site-wide: 20,278
  • In genomics: 2,031
• Year to date:
  • Site-wide: 82,267
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  • Site-wide: 70,387

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

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  • Site-wide: 22,554
  • In genetics: 1,088
• Year to date:
  • Site-wide: 109,678
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  • Site-wide: 132,423

FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations

• Downloaded 886 times
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  • Site-wide: 25,137
  • In genetics: 1,214
• Year to date:
  • Site-wide: 35,793
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  • Site-wide: 42,172

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

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  • Site-wide: 26,843
  • In genetics: 1,292
• Year to date:
  • Site-wide: 77,001
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  • Site-wide: 72,900

Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

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  • Site-wide: 28,443
  • In genomics: 2,625
• Year to date:
  • Site-wide: 3,429
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  • Site-wide: 3,248

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 733 times
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  • Site-wide: 32,774
  • In genetics: 1,584
• Year to date:
  • Site-wide: 12,913
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  • Site-wide: 9,460

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 34,600
  • In genetics: 1,661
• Year to date:
  • Site-wide: 32,218
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  • Site-wide: 55,319

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

• Downloaded 679 times
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  • Site-wide: 36,289
  • In genomics: 3,109
• Year to date:
  • Site-wide: 26,224
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  • Site-wide: 21,790

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 589 times
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  • Site-wide: 43,487
  • In genomics: 3,538
• Year to date:
  • Site-wide: 125,153
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  • Site-wide: 115,012

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 524 times
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  • Site-wide: 50,071
  • In genetics: 2,338
• Year to date:
  • Site-wide: 109,747
• Since beginning of last month:
  • Site-wide: 107,366

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 516 times
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  • Site-wide: 51,029
  • In genetic and genomic medicine: 162
• Year to date:
  • Site-wide: 10,634
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  • Site-wide: 9,368

Genetic effects on educational attainment in Hungary

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  • Site-wide: 55,457
  • In genetics: 2,565
• Year to date:
  • Site-wide: 51,133
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  • Site-wide: 50,035

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

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  • Site-wide: 57,614
  • In genetics: 2,687
• Year to date:
  • Site-wide: 64,153
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  • Site-wide: 42,704

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 380 times
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  • Site-wide: 70,223
  • In genomics: 4,876
• Year to date:
  • Site-wide: 114,160
• Since beginning of last month:
  • Site-wide: 101,941

Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

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  • Site-wide: 77,982
  • In psychiatry and clinical psychology: 254
• Year to date:
  • Site-wide: 42,504
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  • Site-wide: 42,981

Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk

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  • Site-wide: 79,178
  • In genomics: 5,233
• Year to date:
  • Site-wide: 18,510
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  • Site-wide: 25,933

Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)

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  • Site-wide: 80,928
  • In infectious diseases: 3,372
• Year to date:
  • Site-wide: 5,849
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  • Site-wide: 1,804

Genes associated with neuropsychiatric disease increase vulnerability to abnormal deep grey matter development

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  • Site-wide: 90,982
  • In neuroscience: 14,078
• Year to date:
  • Site-wide: 126,324
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  • Site-wide: 121,396