Author: Alanna C. Morrison

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • In genomics: 94
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  • Site-wide: 2,193
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  • Site-wide: 4,808

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,975
  • In genetics: 168
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  • Site-wide: 54,308
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  • Site-wide: 72,291

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 9,928
  • In genetics: 475
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  • Site-wide: 69,906
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 11,693
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• Year to date:
  • Site-wide: 80,284
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 16,076
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Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • Site-wide: 26,897
  • In genetics: 1,302
• Year to date:
  • Site-wide: 93,077
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Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure

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  • In genetics: 1,340
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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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  • Site-wide: 28,248
  • In genetic and genomic medicine: 89
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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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  • Site-wide: 31,472
  • In genomics: 2,814
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  • Site-wide: 108,316

ACAT: A Fast and Powerful P-value Combination Method for Rare-variant Analysis in Sequencing Studies

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  • In genetics: 1,553
• Year to date:
  • Site-wide: 54,095
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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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  • Site-wide: 36,971
  • In genomics: 3,149
• Year to date:
  • Site-wide: 75,090
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  • Site-wide: 107,864

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 40,892
  • In genetics: 1,943
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  • Site-wide: 5,002
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  • Site-wide: 15,504

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

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  • Site-wide: 41,736
  • In genetics: 1,980
• Year to date:
  • Site-wide: 110,040
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  • Site-wide: 88,710

GEM: Scalable and flexible gene-environment interaction analysis in millions of samples

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  • In bioinformatics: 5,126
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  • Site-wide: 20,443
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Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 506 times
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  • Site-wide: 52,036
  • In genomics: 4,036
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  • Site-wide: 120,060
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  • Site-wide: 116,900

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 55,735
  • In genetics: 2,588
• Year to date:
  • Site-wide: 118,304
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  • Site-wide: 130,812

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

• Downloaded 467 times
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  • Site-wide: 57,006
  • In hematology: 34
• Year to date:
  • Site-wide: 6,538
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  • Site-wide: 12,182

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 396 times
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  • Site-wide: 67,467
  • In genetics: 3,098
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  • Site-wide: 61,364
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  • Site-wide: 70,581

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies

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  • Site-wide: 71,445
  • In genetics: 3,264
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  • Site-wide: 130,540
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  • Site-wide: 126,165

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 81,123
  • In genetic and genomic medicine: 285
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  • Site-wide: 23,642
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  • Site-wide: 20,822

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 84,910
  • In epidemiology: 3,494
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  • Site-wide: 77,391
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  • Site-wide: 79,547

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 292 times
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  • Site-wide: 86,914
  • In genetics: 3,933
• Year to date:
  • Site-wide: 49,549
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  • Site-wide: None

Efficient gene-environment interaction tests for large biobank-scale sequencing studies

• Downloaded 281 times
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  • Site-wide: 89,187
  • In genetics: 4,022
• Year to date:
  • Site-wide: 70,557
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  • Site-wide: 68,034

Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • Site-wide: 92,035
  • In genetics: 4,141
• Year to date:
  • Site-wide: 123,272
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  • Site-wide: 112,705

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 210 times
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  • Site-wide: 104,866
  • In genomics: 6,130
• Year to date:
  • Site-wide: 98,746
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  • Site-wide: 75,307

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

• Downloaded 187 times
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  • Site-wide: 109,872
  • In genetics: 4,792
• Year to date:
  • Site-wide: 11,909
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Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

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  • Site-wide: 110,865
  • In genetic and genomic medicine: 484
• Year to date:
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  • Site-wide: 3,437

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 111,777
  • In genetic and genomic medicine: 497
• Year to date:
  • Site-wide: 12,724
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  • Site-wide: 37,309

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

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  • Site-wide: 113,402
  • In genetic and genomic medicine: 512
• Year to date:
  • Site-wide: 13,305
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  • Site-wide: 41,735

Lifestyle Risk Score for aggregating multiple lifestyle factors: Handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

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  • Site-wide: 125,776
  • In genetics: 5,292
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  • Site-wide: 132,829