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Author: Darrell J Irvine

  • ORCiD: http://orcid.org/0000-0002-8637-1405
  • Most recently observed institution: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

Rankings

  • All-time downloads: 8,337 (rank: 25,457 (tie) )
  • Categories:
    • bioengineering: 679 (rank: 5,737 (tie) )
    • cancer biology: 542 (rank: 17,050 (tie) )
    • cell biology: 1,508 (rank: 5,041 (tie) )
    • immunology: 4,754 (rank: 1,770 )
    • molecular biology: 854 (rank: 7,278 (tie) )

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Preprints

Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

immunology more details view paper

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Cytoskeletal tension actively sustains the migratory T cell synaptic contact

cell biology more details view paper
  • Downloaded 1,508 times
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    • Site-wide: 12,327
    • In cell biology: 338
  • Year to date:
    • Site-wide: 64,576
  • Since beginning of last month:
    • Site-wide: 83,780

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

immunology more details view paper
  • Downloaded 1,233 times
  • Download rankings, all-time:
    • Site-wide: 16,754
    • In immunology: 520
  • Year to date:
    • Site-wide: 54,072
  • Since beginning of last month:
    • Site-wide: 66,646

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

immunology more details view paper
  • Downloaded 1,224 times
  • Download rankings, all-time:
    • Site-wide: 16,928
    • In immunology: 522
  • Year to date:
    • Site-wide: 120,684
  • Since beginning of last month:
    • Site-wide: 128,015

Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters

molecular biology more details view paper
  • Downloaded 854 times
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    • Site-wide: 28,605
    • In molecular biology: 788
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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

immunology more details view paper
  • Downloaded 674 times
  • Download rankings, all-time:
    • Site-wide: 39,583
    • In immunology: 1,190
  • Year to date:
    • Site-wide: 102,257
  • Since beginning of last month:
    • Site-wide: 105,849

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

immunology more details view paper
  • Downloaded 582 times
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    • Site-wide: 47,636
    • In immunology: 1,386
  • Year to date:
    • Site-wide: 77,266
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    • Site-wide: 69,729

The Injury Response to DNA Damage Promotes Anti-Tumor Immunity

cancer biology more details view paper
  • Downloaded 542 times
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    • Site-wide: 51,967
    • In cancer biology: 1,466
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    • Site-wide: 29,711
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    • Site-wide: 40,115

Controlling wireframe DNA origami nuclease degradation with minor groove binders

bioengineering more details view paper
  • Downloaded 463 times
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    • Site-wide: 62,103
    • In bioengineering: 1,153
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    • Site-wide: 38,208
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DOCK2 sets the threshold for entry into the virtual memory CD8+ T cell compartment by negatively regulating tonic TCR triggering

immunology more details view paper
  • Downloaded 409 times
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    • Site-wide: 70,604
    • In immunology: 2,031
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    • Site-wide: 87,641
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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

immunology more details view paper
  • Downloaded 342 times
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    • Site-wide: 82,896
    • In immunology: 2,399
  • Year to date:
    • Site-wide: 10,032
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    • Site-wide: 28,555

An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes

immunology more details view paper
  • Downloaded 290 times
  • Download rankings, all-time:
    • Site-wide: 93,764
    • In immunology: 2,718
  • Year to date:
    • Site-wide: 23,011
  • Since beginning of last month:
    • Site-wide: 27,418

Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

bioengineering more details view paper
  • Downloaded 216 times
  • Download rankings, all-time:
    • Site-wide: 111,010
    • In bioengineering: 2,147
  • Year to date:
    • Site-wide: 55,693
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    • Site-wide: 43,298

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