Author: Leslie A Lange

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Preprints

Recovery of trait heritability from whole genome sequence data

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  • Site-wide: 724
  • In genetics: 14
• Year to date:
  • Site-wide: 1,374
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  • Site-wide: 1,709

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 8,701 times
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  • Site-wide: 1,292
  • In genomics: 96
• Year to date:
  • Site-wide: 4,476
• Since beginning of last month:
  • Site-wide: 14,899

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

• Downloaded 3,048 times
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  • Site-wide: 5,361
  • In genetics: 212
• Year to date:
  • Site-wide: 5,476
• Since beginning of last month:
  • Site-wide: 27,254

The Polygenic and Monogenic Basis of Blood Traits and Diseases

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  • Site-wide: 8,992
  • In genetic and genomic medicine: 44
• Year to date:
  • Site-wide: 43,706
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  • Site-wide: 118,703

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

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  • Site-wide: 10,728
  • In genetics: 454
• Year to date:
  • Site-wide: 131,255
• Since beginning of last month:
  • Site-wide: 157,640

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

• Downloaded 1,784 times
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  • Site-wide: 11,866
  • In genetic and genomic medicine: 54
• Year to date:
  • Site-wide: 5,808
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  • Site-wide: 5,648

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

• Downloaded 1,774 times
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  • Site-wide: 11,952
  • In genetics: 509
• Year to date:
  • Site-wide: 79,471
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  • Site-wide: 132,666

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 19,742
  • In genetics: 879
• Year to date:
  • Site-wide: 5,385
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  • Site-wide: 12,836

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

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  • Site-wide: 21,874
  • In genetics: 956
• Year to date:
  • Site-wide: 13,306
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  • Site-wide: 79,637

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

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  • Site-wide: 25,548
  • In genetics: 1,122
• Year to date:
  • Site-wide: 30,164
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  • Site-wide: 64,062

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

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  • Site-wide: 36,851
  • In hematology: 33
• Year to date:
  • Site-wide: 10,421
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  • Site-wide: 21,830

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

• Downloaded 614 times
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  • Site-wide: 57,112
  • In genetics: 2,417
• Year to date:
  • Site-wide: 138,157
• Since beginning of last month:
  • Site-wide: 157,590

Meta-analysis of exome array data identifies six novel genetic loci for lung function

• Downloaded 529 times
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  • Site-wide: 68,633
  • In genetics: 2,917
• Year to date:
  • Site-wide: 144,016
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  • Site-wide: 94,252

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

• Downloaded 291 times
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  • Site-wide: 119,097
  • In genetics: 4,843
• Year to date:
  • Site-wide: 36,041
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  • Site-wide: 3,084

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequences

• Downloaded 266 times
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  • Site-wide: 125,728
  • In genomics: 6,906
• Year to date:
  • Site-wide: 77,264
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  • Site-wide: 87,844

Presence and Transmission of Mitochondrial Heteroplasmic Mutations in Human Populations of European and African Ancestry

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  • Site-wide: 136,344
  • In genetics: 5,418
• Year to date:
  • Site-wide: 98,318
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  • Site-wide: 117,768

Genetic Underpinnings of Regional Adiposity Distribution in African Americans: Assessments from the Jackson Heart Study

• Downloaded 193 times
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  • Site-wide: 144,132
  • In genetic and genomic medicine: 870
• Year to date:
  • Site-wide: 87,682
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  • Site-wide: 82,167

HBA Copy Number and Kidney Disease Risk among Black Americans: a Longitudinal Cohort Study

• Downloaded 176 times
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  • Site-wide: 148,108
  • In genetic and genomic medicine: 913
• Year to date:
  • Site-wide: 67,747
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  • Site-wide: 81,452

Evaluation of height as a disease risk factor through a phenome-wide association study of genetically-predicted height

• Downloaded 120 times
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  • Site-wide: 157,990
  • In epidemiology: 6,516
• Year to date:
  • Site-wide: 99,672
• Since beginning of last month:
  • Site-wide: 38,007