Author: Shane Crotty

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Preprints

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

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Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

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  • In immunology: 19
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  • Site-wide: 96
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  • Site-wide: 383

Low dose mRNA-1273 COVID-19 vaccine generates durable T cell memory and antibodies enhanced by pre-existing crossreactive T cell memory

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  • Site-wide: 1,548
  • In infectious diseases: 447
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  • Site-wide: 408
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Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

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  • Site-wide: 5,832
  • In immunology: 215
• Year to date:
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CD4+ follicular helper-like T cells are key players in anti-tumor immunity

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Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

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  • Site-wide: 20,148
  • In immunology: 705
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AI-guided discovery of the invariant host response to viral pandemics

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  • Site-wide: 21,149
  • In bioinformatics: 2,393
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  • Site-wide: 12,241
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Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny

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Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

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Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers

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  • In infectious diseases: 2,507
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Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations

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  • In immunology: 1,064
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Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients

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  • In allergy and immunology: 90
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  • Site-wide: 107,062

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

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  • In immunology: 1,172
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

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B cells expressing authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple independent mouse models

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Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

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  • In immunology: 1,501
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Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

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  • In immunology: 2,175
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Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naive human B cells

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  • Site-wide: 107,597
  • In immunology: 3,238
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Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19

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  • Site-wide: 112,905
  • In genomics: 6,494
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