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Author: Charles Kooperberg

Rankings

  • All-time downloads: 48,139 (rank: 2,939 )
  • Categories:
    • bioinformatics: 321 (rank: 31,161 (tie) )
    • epidemiology: 669 (rank: 12,204 (tie) )
    • genetic and genomic medicine: 5,064 (rank: 127 )
    • genetics: 27,748 (rank: 225 )
    • genomics: 13,232 (rank: 1,232 )
    • hematology: 518 (rank: 431 (tie) )
    • sexual and reproductive health: 587 (rank: 188 (tie) )

Downloads per author, site-wide

Preprints

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

infectious diseases more details view paper

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Recovery of trait heritability from whole genome sequence data

genetics more details view paper
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    • Site-wide: 661
    • In genetics: 17
  • Year to date:
    • Site-wide: 2,411
  • Since beginning of last month:
    • Site-wide: 2,728

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

genomics more details view paper
  • Downloaded 8,181 times
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    • Site-wide: 1,049
    • In genomics: 95
  • Year to date:
    • Site-wide: 2,341
  • Since beginning of last month:
    • Site-wide: 5,676

A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
  • Downloaded 4,588 times
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    • Site-wide: 2,260
    • In genetics: 82
  • Year to date:
    • Site-wide: 81,660
  • Since beginning of last month:
    • Site-wide: 104,328

The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex Traits

genetics more details view paper
  • Downloaded 3,186 times
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    • Site-wide: 3,833
    • In genetics: 161
  • Year to date:
    • Site-wide: 33,651
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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
  • Downloaded 2,917 times
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    • Site-wide: 4,318
    • In genomics: 478
  • Year to date:
    • Site-wide: 6,926
  • Since beginning of last month:
    • Site-wide: 7,421

Improving reporting standards for polygenic scores in risk prediction studies

genetic and genomic medicine more details view paper
  • Downloaded 2,168 times
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    • Site-wide: 6,666
    • In genetic and genomic medicine: 23
  • Year to date:
    • Site-wide: 2,178
  • Since beginning of last month:
    • Site-wide: 1,614

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

genetics more details view paper
  • Downloaded 1,455 times
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    • Site-wide: 12,030
    • In genetics: 585
  • Year to date:
    • Site-wide: 7,505
  • Since beginning of last month:
    • Site-wide: 6,279

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,138 times
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    • Site-wide: 17,420
    • In genetics: 849
  • Year to date:
    • Site-wide: 76,167
  • Since beginning of last month:
    • Site-wide: 71,182

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,083 times
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    • Site-wide: 18,761
    • In genetic and genomic medicine: 66
  • Year to date:
    • Site-wide: 8,274
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    • Site-wide: 10,855

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 840 times
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    • Site-wide: 27,025
    • In genetics: 1,304
  • Year to date:
    • Site-wide: 95,777
  • Since beginning of last month:
    • Site-wide: 101,091

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

genetics more details view paper
  • Downloaded 828 times
  • Download rankings, all-time:
    • Site-wide: 27,575
    • In genetics: 1,337
  • Year to date:
    • Site-wide: 61,016
  • Since beginning of last month:
    • Site-wide: 62,700

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

genomics more details view paper
  • Downloaded 747 times
  • Download rankings, all-time:
    • Site-wide: 31,883
    • In genomics: 2,829
  • Year to date:
    • Site-wide: 73,959
  • Since beginning of last month:
    • Site-wide: 88,720

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

genetics more details view paper
  • Downloaded 713 times
  • Download rankings, all-time:
    • Site-wide: 33,904
    • In genetics: 1,638
  • Year to date:
    • Site-wide: 122,218
  • Since beginning of last month:
    • Site-wide: 115,099

Integration of rare large-effect expression variants improves polygenic risk prediction

genetic and genomic medicine more details view paper
  • Downloaded 685 times
  • Download rankings, all-time:
    • Site-wide: 35,907
    • In genetic and genomic medicine: 113
  • Year to date:
    • Site-wide: 7,891
  • Since beginning of last month:
    • Site-wide: 17,894

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

genomics more details view paper
  • Downloaded 667 times
  • Download rankings, all-time:
    • Site-wide: 37,169
    • In genomics: 3,160
  • Year to date:
    • Site-wide: 78,307
  • Since beginning of last month:
    • Site-wide: 108,702

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 617 times
  • Download rankings, all-time:
    • Site-wide: 41,049
    • In genetics: 1,947
  • Year to date:
    • Site-wide: 5,375
  • Since beginning of last month:
    • Site-wide: 17,873

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

genetics more details view paper
  • Downloaded 613 times
  • Download rankings, all-time:
    • Site-wide: 41,423
    • In genetics: 1,957
  • Year to date:
    • Site-wide: 79,453
  • Since beginning of last month:
    • Site-wide: 73,210

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 587 times
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    • Site-wide: 43,717
    • In sexual and reproductive health: 19
  • Year to date:
    • Site-wide: 2,503
  • Since beginning of last month:
    • Site-wide: 8,396

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

genetics more details view paper
  • Downloaded 577 times
  • Download rankings, all-time:
    • Site-wide: 44,589
    • In genetics: 2,093
  • Year to date:
    • Site-wide: 117,285
  • Since beginning of last month:
    • Site-wide: 100,548

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

hematology more details view paper
  • Downloaded 518 times
  • Download rankings, all-time:
    • Site-wide: 50,808
    • In hematology: 33
  • Year to date:
    • Site-wide: 5,520
  • Since beginning of last month:
    • Site-wide: 7,004

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 508 times
  • Download rankings, all-time:
    • Site-wide: 52,032
    • In genomics: 4,036
  • Year to date:
    • Site-wide: 116,272
  • Since beginning of last month:
    • Site-wide: 107,542

Threshold trait architecture of Hsp90-buffered variation

genetics more details view paper
  • Downloaded 418 times
  • Download rankings, all-time:
    • Site-wide: 64,219
    • In genetics: 2,975
  • Year to date:
    • Site-wide: 129,281
  • Since beginning of last month:
    • Site-wide: 134,432

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

genetics more details view paper
  • Downloaded 398 times
  • Download rankings, all-time:
    • Site-wide: 67,485
    • In genetics: 3,101
  • Year to date:
    • Site-wide: 60,642
  • Since beginning of last month:
    • Site-wide: 67,599

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

epidemiology more details view paper
  • Downloaded 368 times
  • Download rankings, all-time:
    • Site-wide: 72,510
    • In epidemiology: 3,042
  • Year to date:
    • Site-wide: 90,848
  • Since beginning of last month:
    • Site-wide: 73,963

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

genetic and genomic medicine more details view paper
  • Downloaded 337 times
  • Download rankings, all-time:
    • Site-wide: 78,207
    • In genetic and genomic medicine: 275
  • Year to date:
    • Site-wide: 21,269
  • Since beginning of last month:
    • Site-wide: 16,985

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 321 times
  • Download rankings, all-time:
    • Site-wide: 81,309
    • In bioinformatics: 7,423
  • Year to date:
    • Site-wide: 58,094
  • Since beginning of last month:
    • Site-wide: 43,624

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 301 times
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    • Site-wide: 85,302
    • In epidemiology: 3,516
  • Year to date:
    • Site-wide: 78,769
  • Since beginning of last month:
    • Site-wide: 84,184

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

genetics more details view paper
  • Downloaded 292 times
  • Download rankings, all-time:
    • Site-wide: 87,331
    • In genetics: 3,941
  • Year to date:
    • Site-wide: 51,013
  • Since beginning of last month:
    • Site-wide: None

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

genetics more details view paper
  • Downloaded 259 times
  • Download rankings, all-time:
    • Site-wide: 94,459
    • In genetics: 4,233
  • Year to date:
    • Site-wide: 131,110
  • Since beginning of last month:
    • Site-wide: 129,371

Genetic architectures of proximal and distal colorectal cancer are partly distinct

genetic and genomic medicine more details view paper
  • Downloaded 242 times
  • Download rankings, all-time:
    • Site-wide: 98,173
    • In genetic and genomic medicine: 393
  • Year to date:
    • Site-wide: 61,907
  • Since beginning of last month:
    • Site-wide: 65,953

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 212 times
  • Download rankings, all-time:
    • Site-wide: 104,969
    • In genomics: 6,124
  • Year to date:
    • Site-wide: 93,826
  • Since beginning of last month:
    • Site-wide: 69,386

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

genetic and genomic medicine more details view paper
  • Downloaded 198 times
  • Download rankings, all-time:
    • Site-wide: 108,132
    • In genetic and genomic medicine: 469
  • Year to date:
    • Site-wide: 11,732
  • Since beginning of last month:
    • Site-wide: 3,656

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

genetics more details view paper
  • Downloaded 197 times
  • Download rankings, all-time:
    • Site-wide: 108,168
    • In genetics: 4,731
  • Year to date:
    • Site-wide: 11,839
  • Since beginning of last month:
    • Site-wide: 11,199

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

genetic and genomic medicine more details view paper
  • Downloaded 178 times
  • Download rankings, all-time:
    • Site-wide: 112,370
    • In genetic and genomic medicine: 504
  • Year to date:
    • Site-wide: 13,510
  • Since beginning of last month:
    • Site-wide: 41,034

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 173 times
  • Download rankings, all-time:
    • Site-wide: 113,426
    • In genetic and genomic medicine: 517
  • Year to date:
    • Site-wide: 14,031
  • Since beginning of last month:
    • Site-wide: 41,462

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