Author: Charles Kooperberg

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

• Downloaded 10,431 times
• Download rankings, all-time:
  • Site-wide: 265 out of 100,957
  • In genetics: 18 out of 5,023
• Year to date:
  • Site-wide: 889 out of 100,957
• Since beginning of last month:
  • Site-wide: 1,045 out of 100,957

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

• Downloaded 7,032 times
• Download rankings, all-time:
  • Site-wide: 501 out of 100,957
  • In genomics: 100 out of 6,258
• Year to date:
  • Site-wide: 583 out of 100,957
• Since beginning of last month:
  • Site-wide: 649 out of 100,957

A reference panel of 64,976 haplotypes for genotype imputation

• Downloaded 4,539 times
• Download rankings, all-time:
  • Site-wide: 1,044 out of 100,957
  • In genetics: 72 out of 5,023
• Year to date:
  • Site-wide: 73,410 out of 100,957
• Since beginning of last month:
  • Site-wide: 68,396 out of 100,957

The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex Traits

• Downloaded 3,045 times
• Download rankings, all-time:
  • Site-wide: 2,117 out of 100,957
  • In genetics: 153 out of 5,023
• Year to date:
  • Site-wide: 13,918 out of 100,957
• Since beginning of last month:
  • Site-wide: 13,693 out of 100,957

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

• Downloaded 2,423 times
• Download rankings, all-time:
  • Site-wide: 3,075 out of 100,957
  • In genomics: 559 out of 6,258
• Year to date:
  • Site-wide: 1,532 out of 100,957
• Since beginning of last month:
  • Site-wide: 1,362 out of 100,957

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

• Downloaded 1,070 times
• Download rankings, all-time:
  • Site-wide: 12,024 out of 100,957
  • In genetics: 793 out of 5,023
• Year to date:
  • Site-wide: 46,349 out of 100,957
• Since beginning of last month:
  • Site-wide: 53,070 out of 100,957

Novel genetic determinants of telomere length from a multi-ethnic analysis of 75,000 whole genome sequences in TOPMed

• Downloaded 935 times
• Download rankings, all-time:
  • Site-wide: 14,975 out of 100,957
  • In genetics: 957 out of 5,023
• Year to date:
  • Site-wide: 7,968 out of 100,957
• Since beginning of last month:
  • Site-wide: 10,542 out of 100,957

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

• Downloaded 802 times
• Download rankings, all-time:
  • Site-wide: 19,037 out of 100,957
  • In genetics: 1,182 out of 5,023
• Year to date:
  • Site-wide: 44,810 out of 100,957
• Since beginning of last month:
  • Site-wide: 70,607 out of 100,957

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

• Downloaded 768 times
• Download rankings, all-time:
  • Site-wide: 20,293 out of 100,957
  • In genetics: 1,261 out of 5,023
• Year to date:
  • Site-wide: 47,399 out of 100,957
• Since beginning of last month:
  • Site-wide: 43,641 out of 100,957

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

• Downloaded 685 times
• Download rankings, all-time:
  • Site-wide: 24,074 out of 100,957
  • In genetics: 1,469 out of 5,023
• Year to date:
  • Site-wide: 83,144 out of 100,957
• Since beginning of last month:
  • Site-wide: 63,832 out of 100,957

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

• Downloaded 676 times
• Download rankings, all-time:
  • Site-wide: 24,506 out of 100,957
  • In genomics: 2,694 out of 6,258
• Year to date:
  • Site-wide: 31,147 out of 100,957
• Since beginning of last month:
  • Site-wide: 51,242 out of 100,957

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

• Downloaded 609 times
• Download rankings, all-time:
  • Site-wide: 28,331 out of 100,957
  • In genomics: 2,955 out of 6,258
• Year to date:
  • Site-wide: 38,404 out of 100,957
• Since beginning of last month:
  • Site-wide: 54,364 out of 100,957

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

• Downloaded 556 times
• Download rankings, all-time:
  • Site-wide: 31,881 out of 100,957
  • In genetics: 1,858 out of 5,023
• Year to date:
  • Site-wide: 28,267 out of 100,957
• Since beginning of last month:
  • Site-wide: 63,838 out of 100,957

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

• Downloaded 552 times
• Download rankings, all-time:
  • Site-wide: 32,118 out of 100,957
  • In genetics: 1,870 out of 5,023
• Year to date:
  • Site-wide: 90,578 out of 100,957
• Since beginning of last month:
  • Site-wide: 91,766 out of 100,957

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 475 times
• Download rankings, all-time:
  • Site-wide: 38,867 out of 100,957
  • In genomics: 3,662 out of 6,258
• Year to date:
  • Site-wide: 80,599 out of 100,957
• Since beginning of last month:
  • Site-wide: 72,636 out of 100,957

Threshold trait architecture of Hsp90-buffered variation

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 47,773 out of 100,957
  • In genetics: 2,695 out of 5,023
• Year to date:
  • Site-wide: 91,355 out of 100,957
• Since beginning of last month:
  • Site-wide: 68,514 out of 100,957

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

• Downloaded 343 times
• Download rankings, all-time:
  • Site-wide: 54,754 out of 100,957
  • In genetics: 3,015 out of 5,023
• Year to date:
  • Site-wide: 61,722 out of 100,957
• Since beginning of last month:
  • Site-wide: 62,895 out of 100,957

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

• Downloaded 326 times
• Download rankings, all-time:
  • Site-wide: 57,285 out of 100,957
  • In epidemiology: 867 out of 1,556
• Year to date:
  • Site-wide: 55,910 out of 100,957
• Since beginning of last month:
  • Site-wide: 41,284 out of 100,957

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

• Downloaded 257 times
• Download rankings, all-time:
  • Site-wide: 68,455 out of 100,957
  • In epidemiology: 1,096 out of 1,556
• Year to date:
  • Site-wide: 59,781 out of 100,957
• Since beginning of last month:
  • Site-wide: 72,681 out of 100,957

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

• Downloaded 243 times
• Download rankings, all-time:
  • Site-wide: 70,904 out of 100,957
  • In genetics: 3,784 out of 5,023
• Year to date:
  • Site-wide: 91,795 out of 100,957
• Since beginning of last month:
  • Site-wide: 87,353 out of 100,957

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

• Downloaded 227 times
• Download rankings, all-time:
  • Site-wide: 73,932 out of 100,957
  • In bioinformatics: 7,514 out of 9,269
• Year to date:
  • Site-wide: 24,803 out of 100,957
• Since beginning of last month:
  • Site-wide: 26,828 out of 100,957

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 82,180 out of 100,957
  • In genetics: 4,324 out of 5,023
• Year to date:
  • Site-wide: 33,247 out of 100,957
• Since beginning of last month:
  • Site-wide: 21,629 out of 100,957

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 164 times
• Download rankings, all-time:
  • Site-wide: 84,968 out of 100,957
  • In genomics: 5,713 out of 6,258
• Year to date:
  • Site-wide: 37,580 out of 100,957
• Since beginning of last month:
  • Site-wide: 37,210 out of 100,957