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Author: Charles Kooperberg

Rankings

  • All-time downloads: 61,167 (rank: 3,107 )
  • Categories:
    • bioinformatics: 409 (rank: 33,981 (tie) )
    • epidemiology: 763 (rank: 15,094 (tie) )
    • genetic and genomic medicine: 8,642 (rank: 126 )
    • genetics: 32,942 (rank: 200 )
    • genomics: 14,504 (rank: 1,292 )
    • hematology: 840 (rank: 498 (tie) )
    • infectious diseases: 868 (rank: 32,400 (tie) )
    • sexual and reproductive health: 2,199 (rank: 123 (tie) )

Downloads per author, site-wide

Preprints

Recovery of trait heritability from whole genome sequence data

genetics more details view paper
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    • Site-wide: 725
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    • Site-wide: 1,377
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    • Site-wide: 1,744

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

genomics more details view paper
  • Downloaded 8,701 times
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    • Site-wide: 1,295
    • In genomics: 96
  • Year to date:
    • Site-wide: 4,481
  • Since beginning of last month:
    • Site-wide: 15,120

A reference panel of 64,976 haplotypes for genotype imputation

genetics more details view paper
  • Downloaded 4,655 times
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    • Site-wide: 2,953
    • In genetics: 92
  • Year to date:
    • Site-wide: 118,390
  • Since beginning of last month:
    • Site-wide: 90,058

The PAGE Study: How Genetic Diversity Improves Our Understanding of the Architecture of Complex Traits

genetics more details view paper
  • Downloaded 3,350 times
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    • Site-wide: 4,711
    • In genetics: 174
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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

genomics more details view paper
  • Downloaded 3,235 times
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    • Site-wide: 4,941
    • In genomics: 486
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    • Site-wide: 11,889
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    • Site-wide: 37,150

Improving reporting standards for polygenic scores in risk prediction studies

genetic and genomic medicine more details view paper
  • Downloaded 2,688 times
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    • Site-wide: 6,453
    • In genetic and genomic medicine: 29
  • Year to date:
    • Site-wide: 4,306
  • Since beginning of last month:
    • Site-wide: 12,189

Genetic insights into the biological mechanisms governing human ovarian ageing

sexual and reproductive health more details view paper
  • Downloaded 2,199 times
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    • Site-wide: 8,695
    • In sexual and reproductive health: 12
  • Year to date:
    • Site-wide: 1,749
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    • Site-wide: 2,820

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed

genetics more details view paper
  • Downloaded 2,133 times
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    • Site-wide: 9,080
    • In genetics: 375
  • Year to date:
    • Site-wide: 5,864
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Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

genetic and genomic medicine more details view paper
  • Downloaded 1,784 times
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    • Site-wide: 11,874
    • In genetic and genomic medicine: 54
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    • Site-wide: 5,826
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Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

genetics more details view paper
  • Downloaded 1,277 times
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    • Site-wide: 19,762
    • In genetics: 878
  • Year to date:
    • Site-wide: 5,392
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    • Site-wide: 13,090

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

genetics more details view paper
  • Downloaded 1,205 times
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    • Site-wide: 21,593
    • In genetics: 943
  • Year to date:
    • Site-wide: 115,988
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    • Site-wide: 135,052

Integration of rare large-effect expression variants improves polygenic risk prediction

genetic and genomic medicine more details view paper
  • Downloaded 1,006 times
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    • Site-wide: 28,336
    • In genetic and genomic medicine: 133
  • Year to date:
    • Site-wide: 12,611
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    • Site-wide: 18,702

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

genetics more details view paper
  • Downloaded 887 times
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    • Site-wide: 34,122
    • In genetics: 1,492
  • Year to date:
    • Site-wide: 114,165
  • Since beginning of last month:
    • Site-wide: 141,899

Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

genetics more details view paper
  • Downloaded 880 times
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    • Site-wide: 34,488
    • In genetics: 1,504
  • Year to date:
    • Site-wide: 147,264
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    • Site-wide: 151,074

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

infectious diseases more details view paper
  • Downloaded 868 times
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    • Site-wide: 35,139
    • In infectious diseases: 2,782
  • Year to date:
    • Site-wide: 6,768
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    • Site-wide: 7,668

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

hematology more details view paper
  • Downloaded 840 times
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    • Site-wide: 36,884
    • In hematology: 33
  • Year to date:
    • Site-wide: 10,444
  • Since beginning of last month:
    • Site-wide: 22,174

Loss-of-function genomic variants with impact on liver-related blood traits highlight potential therapeutic targets for cardiovascular disease

genomics more details view paper
  • Downloaded 837 times
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    • Site-wide: 37,134
    • In genomics: 3,039
  • Year to date:
    • Site-wide: 97,323
  • Since beginning of last month:
    • Site-wide: 95,226

Trans-ethnic genome-wide association study provides insight into effector genes and molecular mechanisms for kidney function and highlights a causal effect on kidney-specific disease aetiologies

genetics more details view paper
  • Downloaded 758 times
  • Download rankings, all-time:
    • Site-wide: 42,805
    • In genetics: 1,850
  • Year to date:
    • Site-wide: 150,949
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    • Site-wide: 133,102

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

genomics more details view paper
  • Downloaded 699 times
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    • Site-wide: 48,003
    • In genomics: 3,669
  • Year to date:
    • Site-wide: 146,837
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    • Site-wide: 160,307

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

genetics more details view paper
  • Downloaded 668 times
  • Download rankings, all-time:
    • Site-wide: 51,071
    • In genetics: 2,175
  • Year to date:
    • Site-wide: 128,438
  • Since beginning of last month:
    • Site-wide: 142,249

Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior

genetics more details view paper
  • Downloaded 628 times
  • Download rankings, all-time:
    • Site-wide: 55,475
    • In genetics: 2,351
  • Year to date:
    • Site-wide: 144,633
  • Since beginning of last month:
    • Site-wide: 123,647

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

genetic and genomic medicine more details view paper
  • Downloaded 597 times
  • Download rankings, all-time:
    • Site-wide: 59,195
    • In genetic and genomic medicine: 281
  • Year to date:
    • Site-wide: 24,097
  • Since beginning of last month:
    • Site-wide: 22,587

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

genetics more details view paper
  • Downloaded 571 times
  • Download rankings, all-time:
    • Site-wide: 62,602
    • In genetics: 2,663
  • Year to date:
    • Site-wide: 30,052
  • Since beginning of last month:
    • Site-wide: 83,982

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

genomics more details view paper
  • Downloaded 569 times
  • Download rankings, all-time:
    • Site-wide: 62,851
    • In genomics: 4,483
  • Year to date:
    • Site-wide: 136,691
  • Since beginning of last month:
    • Site-wide: 84,288

Bidirectional Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of intermediate potential

genetic and genomic medicine more details view paper
  • Downloaded 490 times
  • Download rankings, all-time:
    • Site-wide: 74,882
    • In genetic and genomic medicine: 368
  • Year to date:
    • Site-wide: 16,575
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    • Site-wide: 21,841

Threshold trait architecture of Hsp90-buffered variation

genetics more details view paper
  • Downloaded 478 times
  • Download rankings, all-time:
    • Site-wide: 77,134
    • In genetics: 3,263
  • Year to date:
    • Site-wide: 141,859
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    • Site-wide: 126,741

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

genomics more details view paper
  • Downloaded 463 times
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    • Site-wide: 79,795
    • In genomics: 5,232
  • Year to date:
    • Site-wide: 39,125
  • Since beginning of last month:
    • Site-wide: 18,268

Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

genetics more details view paper
  • Downloaded 431 times
  • Download rankings, all-time:
    • Site-wide: 86,042
    • In genetics: 3,602
  • Year to date:
    • Site-wide: 137,441
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    • Site-wide: 153,591

Multi-ethnic genome-wide association study of decomposed cardioelectric phenotypes illustrates strategies to identify and characterize evidence of shared genetic effects for complex traits

epidemiology more details view paper
  • Downloaded 419 times
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    • Site-wide: 88,428
    • In epidemiology: 3,807
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    • Site-wide: 147,292

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries

bioinformatics more details view paper
  • Downloaded 409 times
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    • Site-wide: 90,594
    • In bioinformatics: 7,995
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    • Site-wide: 90,506
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    • Site-wide: 149,140

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

genetics more details view paper
  • Downloaded 373 times
  • Download rankings, all-time:
    • Site-wide: 98,499
    • In genetics: 4,085
  • Year to date:
    • Site-wide: 25,281
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    • Site-wide: 1,937

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

genetic and genomic medicine more details view paper
  • Downloaded 371 times
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    • Site-wide: 99,194
    • In genetic and genomic medicine: 527
  • Year to date:
    • Site-wide: 25,465
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    • Site-wide: 50,625

A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping

genetics more details view paper
  • Downloaded 357 times
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    • Site-wide: 102,464
    • In genetics: 4,227
  • Year to date:
    • Site-wide: 26,969
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    • Site-wide: 55,414

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

epidemiology more details view paper
  • Downloaded 344 times
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    • Site-wide: 105,481
    • In epidemiology: 4,473
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    • Site-wide: 139,227
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    • Site-wide: 148,801

GWAS of QRS Duration Identifies New Loci Specific to Hispanic/Latino Populations

genetics more details view paper
  • Downloaded 324 times
  • Download rankings, all-time:
    • Site-wide: 110,676
    • In genetics: 4,534
  • Year to date:
    • Site-wide: 137,961
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    • Site-wide: 62,700

Genetic architectures of proximal and distal colorectal cancer are partly distinct

genetic and genomic medicine more details view paper
  • Downloaded 308 times
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    • Site-wide: 114,626
    • In genetic and genomic medicine: 647
  • Year to date:
    • Site-wide: 109,733
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    • Site-wide: 149,234

Monogenic and Polygenic Contributions to QTc Prolongation in the Population

genetic and genomic medicine more details view paper
  • Downloaded 293 times
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    • Site-wide: 118,620
    • In genetic and genomic medicine: 670
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    • Site-wide: 35,697
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    • Site-wide: 73,692

A framework for detecting noncoding rare variant associations of large-scale whole-genome sequencing studies

genetics more details view paper
  • Downloaded 291 times
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    • Site-wide: 119,151
    • In genetics: 4,833
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    • Site-wide: 36,060
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BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

genetic and genomic medicine more details view paper
  • Downloaded 290 times
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    • Site-wide: 119,458
    • In genetic and genomic medicine: 675
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    • Site-wide: 36,175
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    • Site-wide: 82,740

Broad Clinical Manifestations of Polygenic Risk for Coronary Artery Disease in the Women's Health Initiative

genetic and genomic medicine more details view paper
  • Downloaded 270 times
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    • Site-wide: 124,795
    • In genetic and genomic medicine: 720
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    • Site-wide: 40,058
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    • Site-wide: 61,717

Endophenotype Effect Sizes Provide Evidence Supporting Variant Pathogenicity in Monogenic Disease Susceptibility Genes

genetic and genomic medicine more details view paper
  • Downloaded 242 times
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    • Site-wide: 132,143
    • In genetic and genomic medicine: 772
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    • Site-wide: 46,085
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    • Site-wide: 95,800

A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood

genetic and genomic medicine more details view paper
  • Downloaded 207 times
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    • Site-wide: 140,881
    • In genetic and genomic medicine: 828
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    • Site-wide: 56,311
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Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

genetic and genomic medicine more details view paper
  • Downloaded 96 times
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    • Site-wide: 161,006
    • In genetic and genomic medicine: 1,036
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    • Site-wide: 118,852
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    • Site-wide: 19,182

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