Author: Tõnu Esko

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Preprints

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

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  • Site-wide: 851
  • In genomics: 54
• Year to date:
  • Site-wide: 1,238
• Since beginning of last month:
  • Site-wide: 1,284

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

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  • Site-wide: 3,992
  • In genetics: 136
• Year to date:
  • Site-wide: 50,998
• Since beginning of last month:
  • Site-wide: 116,752

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,241
  • In psychiatry and clinical psychology: 20
• Year to date:
  • Site-wide: 2,015
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  • Site-wide: 13,699

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

• Downloaded 2,977 times
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  • Site-wide: 5,281
  • In genetics: 213
• Year to date:
  • Site-wide: 4,924
• Since beginning of last month:
  • Site-wide: 21,489

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

• Downloaded 2,351 times
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  • Site-wide: 7,444
  • In genetics: 320
• Year to date:
  • Site-wide: 115,011
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  • Site-wide: 100,499

Cell specific eQTL analysis without sorting cells

• Downloaded 2,025 times
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  • Site-wide: 9,249
  • In genetics: 386
• Year to date:
  • Site-wide: 145,825
• Since beginning of last month:
  • Site-wide: 143,048

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

• Downloaded 1,855 times
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  • Site-wide: 10,539
  • In genetics: 458
• Year to date:
  • Site-wide: 75,674
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  • Site-wide: 91,701

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

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  • Site-wide: 11,475
  • In genetics: 494
• Year to date:
  • Site-wide: 68,498
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  • Site-wide: 117,493

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 14,099
  • In genetics: 626
• Year to date:
  • Site-wide: 107,833
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  • Site-wide: 77,410

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

• Downloaded 1,294 times
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  • Site-wide: 18,032
  • In genomics: 1,732
• Year to date:
  • Site-wide: 107,128
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  • Site-wide: 116,585

Haplotype sharing provides insights into fine-scale population history and disease in Finland

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  • Site-wide: 21,064
  • In genetics: 941
• Year to date:
  • Site-wide: 99,315
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  • Site-wide: 143,304

Mega-analysis of 31,396 individuals from 6 countries uncovers strong gene-environment interaction for human fertility

• Downloaded 1,074 times
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  • Site-wide: 23,808
  • In genomics: 2,219
• Year to date:
  • Site-wide: 117,001
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  • Site-wide: 110,374

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 1,028 times
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  • Site-wide: 25,439
  • In genetics: 1,131
• Year to date:
  • Site-wide: 111,762
• Since beginning of last month:
  • Site-wide: 98,529

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 817 times
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  • Site-wide: 35,362
  • In genetics: 1,582
• Year to date:
  • Site-wide: 30,338
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  • Site-wide: 43,655

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

• Downloaded 782 times
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  • Site-wide: 37,615
  • In genetics: 1,666
• Year to date:
  • Site-wide: 153,342
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  • Site-wide: 143,154

Functional and evolutionary impact of polymorphic inversions in the human genome

• Downloaded 781 times
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  • Site-wide: 37,706
  • In genomics: 3,101
• Year to date:
  • Site-wide: 122,494
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  • Site-wide: 111,148

Genome-wide Association Study of Clinical Features in the Schizophrenia Psychiatric Genomics Consortium: Confirmation of Polygenic Effect on Negative Symptoms

• Downloaded 754 times
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  • Site-wide: 39,649
  • In genetics: 1,741
• Year to date:
  • Site-wide: 110,776
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  • Site-wide: 92,360

Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19

• Downloaded 742 times
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  • Site-wide: 40,458
  • In infectious diseases: 2,904
• Year to date:
  • Site-wide: 6,825
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  • Site-wide: 7,856

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening

• Downloaded 552 times
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  • Site-wide: 59,391
  • In genetics: 2,563
• Year to date:
  • Site-wide: 124,379
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  • Site-wide: 90,828

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

• Downloaded 532 times
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  • Site-wide: 62,081
  • In genomics: 4,478
• Year to date:
  • Site-wide: 146,492
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  • Site-wide: 127,631

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 373 times
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  • Site-wide: 89,563
  • In genomics: 5,692
• Year to date:
  • Site-wide: 47,872
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  • Site-wide: 20,979

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

• Downloaded 273 times
• Download rankings, all-time:
  • Site-wide: 113,446
  • In genetic and genomic medicine: 604
• Year to date:
  • Site-wide: 29,532
• Since beginning of last month:
  • Site-wide: 21,746