Author: Howard Edenberg

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Preprints

Genomewide association study identifies 30 loci associated with bipolar disorder

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Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

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  • Site-wide: 2,604
  • In genomics: 247
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Psychiatric Genomics: An Update and an Agenda

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Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

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  • Site-wide: 5,244
  • In psychiatry and clinical psychology: 20
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  • Site-wide: 14,224

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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  • Site-wide: 9,854
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• Year to date:
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Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)

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  • In genetics: 474
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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

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  • Site-wide: 17,549
  • In genetics: 793
• Year to date:
  • Site-wide: 141,810
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  • Site-wide: 138,357

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

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  • Site-wide: 30,233
  • In genetics: 1,356
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  • Site-wide: 33,508
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Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

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  • In genetics: 1,582
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Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 38,349
  • In genetics: 1,690
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  • Site-wide: 58,352
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  • Site-wide: 96,563

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

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  • Site-wide: 38,834
  • In genetic and genomic medicine: 170
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  • Site-wide: 13,929
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  • Site-wide: 11,705

Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium

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  • In genetics: 1,732
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  • Site-wide: 128,304
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  • Site-wide: 89,246

The Addiction Risk Factor: A Unitary Genetic Vulnerability Characterizes Substance Use Disorders and Their Associations with Common Correlates

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  • Site-wide: 40,790
  • In addiction medicine: 15
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  • Site-wide: 6,897
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Multivariate GWAS elucidates the genetic architecture of alcohol consumption and misuse, corrects biases, and reveals novel associations with disease

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Multi-omics integration analysis identifies novel genes for alcoholism with potential link to neurodegenerative diseases

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Polygenic Prediction of Substance Use Disorders in Clinical and Population Samples

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  • Site-wide: 93,381
  • In genetics: 3,960
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Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

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  • Site-wide: 93,836
  • In genetic and genomic medicine: 458
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  • Site-wide: 49,332
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  • Site-wide: 72,777

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

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  • Site-wide: 96,278
  • In neuroscience: 14,292
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  • Site-wide: 155,692
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  • Site-wide: 154,929

Allele-Specific Expression and High-Throughput Reporter Assay Reveal Functional Variants in Human Brains with Alcohol Use Disorders

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  • Site-wide: 107,415
  • In neuroscience: 16,092
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Characterization of Age and Polarity at Onset in Bipolar Disorder

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  • Site-wide: 109,219
  • In psychiatry and clinical psychology: 485
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Multi-trait genome-wide association study of opioid addiction: OPRM1 and Beyond

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  • Site-wide: 133,508
  • In addiction medicine: 71
• Year to date:
  • Site-wide: 44,624
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A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

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  • Site-wide: 138,773
  • In psychiatry and clinical psychology: 745
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Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use

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  • Site-wide: 152,488
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  • Site-wide: 78,121