Author: Laura D Howe

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Preprints

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

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Mendelian randomisation for mediation analysis: current methods and challenges for implementation

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  • Site-wide: 10,798
  • In genetics: 401
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The causes and consequences of Alzheimer's disease: A Mendelian randomization analysis

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  • In genetic and genomic medicine: 118
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Education, intelligence and Alzheimer's disease: Evidence from a multivariable two-sample Mendelian randomization study

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  • Site-wide: 31,661
  • In genetics: 1,254
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Using genetic instruments to estimate interactions in Mendelian Randomization studies

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The Causal Effect Of Educational Attainment On Alzheimer's Disease: A Two-Sample Mendelian Randomization Study

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  • Site-wide: 40,862
  • In epidemiology: 2,109
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  • Site-wide: 111,804
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Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses

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  • In epidemiology: 2,778
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The UK Coronavirus Job Retention Scheme and changes in diet, physical activity and sleep during the COVID-19 pandemic: Evidence from eight longitudinal studies

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  • In epidemiology: 2,975
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Is disrupted sleep a risk factor for Alzheimers disease? Evidence from a two-sample Mendelian randomization analysis

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  • Site-wide: 72,959
  • In epidemiology: 3,265
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What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality

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  • In epidemiology: 3,550
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The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes: Mendelian Randomization in UK Biobank

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  • Site-wide: 84,220
  • In public and global health: 1,321
• Year to date:
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  • Site-wide: 125,347

Interrogating structural inequalities in COVID-19 Mortality in England and Wales

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  • Site-wide: 85,249
  • In epidemiology: 3,706
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  • Site-wide: 149,887

Is genetic liability to ADHD and ASD causally linked to educational attainment?

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  • Site-wide: 85,165
  • In genetics: 3,202
• Year to date:
  • Site-wide: 166,228
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Adverse childhood experiences: associations with educational attainment and adolescent health, and the role of family and socioeconomic factors. Analysis of a prospective cohort study.

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  • In epidemiology: 3,908
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  • Site-wide: 96,501
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Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank

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  • Site-wide: 88,528
  • In epidemiology: 3,791
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Educational inequalities in statin treatment for preventing cardiovascular disease: cross-sectional analysis of UK Biobank

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  • Site-wide: 98,217
  • In epidemiology: 4,235
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  • Site-wide: 128,972
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  • Site-wide: 106,858

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

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  • Site-wide: 98,540
  • In epidemiology: 4,147
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  • Site-wide: 165,169
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Causal effects of circulating cytokine concentrations on risk of Alzheimers disease: A bidirectional two-sample Mendelian randomization study

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  • Site-wide: 107,077
  • In genetic and genomic medicine: 672
• Year to date:
  • Site-wide: 75,139
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  • Site-wide: 92,164

Cross-sectional association of blood pressure variability and night-time dipping with cardiac structure in adolescents

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  • Site-wide: 107,659
  • In epidemiology: 4,613
• Year to date:
  • Site-wide: 39,732
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The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis

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  • Site-wide: 111,308
  • In genetic and genomic medicine: 725
• Year to date:
  • Site-wide: 62,435
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Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

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  • Site-wide: 114,563
  • In genetics: 4,364
• Year to date:
  • Site-wide: 104,021
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The role of school enjoyment in the association between externalising and depressive symptoms and academic attainment: findings from a UK prospective cohort study

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  • Site-wide: 116,373
  • In epidemiology: 4,877
• Year to date:
  • Site-wide: 129,289
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  • Site-wide: 162,961

Associations of socioeconomic position and adverse childhood experiences with health-related behaviour changes and changes to employment during the first COVID-19 lockdown in the UK

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  • Site-wide: 116,474
  • In epidemiology: 5,102
• Year to date:
  • Site-wide: 47,934
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  • Site-wide: 50,379

Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study

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  • Site-wide: 119,996
  • In epidemiology: 5,155
• Year to date:
  • Site-wide: 144,763
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  • Site-wide: 79,147

Educational attainment as a modifier of the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank

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  • Site-wide: 122,012
  • In genetic and genomic medicine: 792
• Year to date:
  • Site-wide: 46,291
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  • Site-wide: 151,634

Robust causal inference for long-term policy decisions: cost effectiveness of interventions for obesity using Mendelian randomization

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  • Site-wide: 121,942
  • In epidemiology: 5,043
• Year to date:
  • Site-wide: 122,109
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  • Site-wide: 91,253

The UK COVID-19 furlough scheme and associations with smoking, alcohol consumption and vaping: evidence from 8 UK longitudinal population surveys.

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  • Site-wide: 122,119
  • In epidemiology: 5,312
• Year to date:
  • Site-wide: 48,220
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  • Site-wide: 62,857

Joint modelling of individual trajectories, within-individual variability and a later outcome: systolic blood pressure through childhood and left ventricular mass in early adulthood

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  • Site-wide: 123,249
  • In epidemiology: 5,065
• Year to date:
  • Site-wide: 141,081
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  • Site-wide: 142,138

How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis

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  • Site-wide: 131,817
  • In epidemiology: 5,361
• Year to date:
  • Site-wide: 140,856
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  • Site-wide: 163,457

Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence

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  • Site-wide: 133,803
  • In epidemiology: 5,531
• Year to date:
  • Site-wide: 181,533
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  • Site-wide: 117,231

The role of the metabolic profile in mediating the relationship between body mass index and left ventricular mass in adolescents: analysis of a prospective cohort study

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  • Site-wide: 139,151
  • In epidemiology: 5,725
• Year to date:
  • Site-wide: 147,545
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  • Site-wide: 120,524

Age at period cessation and trajectories of cardiovascular risk factors across mid and later life: a prospective cohort study

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  • Site-wide: 139,508
  • In epidemiology: 5,701
• Year to date:
  • Site-wide: 170,794
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  • Site-wide: 134,881

Testosterone and socioeconomic position: Mendelian Randomization in 306,248 men and women participants of UK Biobank

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  • Site-wide: 141,542
  • In epidemiology: 5,825
• Year to date:
  • Site-wide: 139,931
• Since beginning of last month:
  • Site-wide: 185,910

Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children

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  • Site-wide: 148,937
  • In epidemiology: 6,043
• Year to date:
  • Site-wide: 197,251
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  • Site-wide: 176,706

Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study

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  • Site-wide: 149,838
  • In genomics: 7,644
• Year to date:
  • Site-wide: 161,960
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  • Site-wide: 178,497

Maternal prenatal anxiety and depression and trajectories of cardiometabolic risk factors across childhood and adolescence: a prospective cohort study

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  • Site-wide: 150,940
  • In pediatrics: 292
• Year to date:
  • Site-wide: 163,630
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Mitochondrial DNA haplogroups and trajectories of cardiometabolic risk factors during childhood and adolescence: a prospective cohort study

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  • Site-wide: 159,915
  • In epidemiology: 6,569
• Year to date:
  • Site-wide: 112,296
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  • Site-wide: 172,027

The causal effects of body mass index (BMI) on childhood symptoms of depression, anxiety disorder, and attention-deficit hyperactivity disorder: a within family Mendelian randomization study

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  • Site-wide: 174,523
  • In epidemiology: None
• Year to date:
  • Site-wide: 83,459
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  • Site-wide: 19,166

Establishing the causal role of intimate partner violence and abuse on depressive symptoms in young adults: a population-based cohort study

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  • Site-wide: 174,658
  • In epidemiology: 6,934
• Year to date:
  • Site-wide: 153,574
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  • Site-wide: 171,068

Continuing inequalities in COVID-19 mortality in England and Wales, and the changing importance of regional, over local, deprivation

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  • Site-wide: 176,394
  • In epidemiology: 7,033
• Year to date:
  • Site-wide: 38,773
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  • Site-wide: 141,536

The relationships between women's reproductive factors: a Mendelian randomization analysis.

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  • Site-wide: 182,421
  • In epidemiology: 7,254
• Year to date:
  • Site-wide: 106,615
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  • Site-wide: 108,169

Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular disease in the UK Biobank

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  • Site-wide: 185,035
  • In cardiovascular medicine: 659
• Year to date:
  • Site-wide: 49,595
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  • Site-wide: 92,775

Categories of intimate partner violence and abuse (IPVA) among young women and men: Latent Class Analysis of psychological, physical, and sexual victimisation and perpetration in a UK birth cohort

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  • Site-wide: 186,719
  • In epidemiology: 7,378
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  • Site-wide: 83,691

Puberty Timing and Markers of Cardiovascular Structure and Function at 25 Years: A Prospective Cohort Study

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  • Site-wide: 187,284
  • In epidemiology: 7,298
• Year to date:
  • Site-wide: 186,057
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Socioeconomic inequality in SARS-CoV-2 testing and COVID-19 outcomes in UK Biobank over the first year of the pandemic: can inequalities be explained byselection bias?

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  • Site-wide: 195,401
  • In epidemiology: 7,561
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  • Site-wide: 72,319
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The causal effect of cigarette smoking on healthcare costs

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  • Site-wide: 200,903
  • In health economics: 294
• Year to date:
  • Site-wide: 93,807
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Educational Inequality in Multimorbidity: Causality and Causal Pathways. A Mendelian Randomisation Study in UK Biobank

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  • Site-wide: 203,811
  • In epidemiology: 7,877
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Mediators of the association between childhood BMI and educational attainment: analysis of a UK prospective cohort study

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  • Site-wide: 204,957
  • In epidemiology: 7,875
• Year to date:
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Sex-specific associations of childhood socioeconomic position and trajectories of metabolic traits across early life: prospective cohort study

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  • Site-wide: 207,529
  • In epidemiology: 7,904
• Year to date:
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